Papers by Marina Santaella
: These authors contributed equally to this work. Abstract: Breast milk (BM) is considered as a r... more : These authors contributed equally to this work. Abstract: Breast milk (BM) is considered as a reference for infant nutrition. The role of bioactive components, such as cytokines, hormones, growth factors (GFs) and fatty acids (FAs) is poorly known, but they might be implicated in immune response development. The aim of this study was to identify the lipid profile and the spectrum of cytokines and neuronal GF in BM samples and analyse the influence of gestational age and lactation time on these components. This study used a longitudinal prospective method for the characterization of cytokines, FAs and GFs global profiles in 120 BM samples from 40 healthy mothers (20 preterm and 20 term) collected as colostrum, transitional and mature milk. The cytokines were analysed by protein array (Ray Bior Human Cytokine Array G6. Ray Biotech, Inc. Norcross, GA, USA) and the FAs were analysed by gas chromatography. The FA profile was similar between the term and the preterm BM samples. Omega-3-α-linoleic and docosahexaenoic acid (DHA) and omega-6-linoleic acid were the most abundant in the term and preterm samples during lactation. Omega-3 ETA and omega-3 EPA we
La enfermedad de hígado graso no alcohólico (HGNA) es una patología muy común en países occidenta... more La enfermedad de hígado graso no alcohólico (HGNA) es una patología muy común en países occidentales, afectando al 20-30% de la población adulta, constituyendo un problema para la salud pública a nivel mundial. El HGNA se define como la acumulación de lípidos dentro de los hepatocitos (superior al 5% del peso del hígado), asociado a la dieta, en ausencia de una ingesta excesiva de alcohol y sin alguna otra causa patológica [1-3]. De acuerdo a lo reportado por Abenavoli et al. [1] y Than y Newsome [2] el HGNA se ha encontrado en un 80-90% en personas con obesidad, en un 30-50% en pacientes con diabetes y por encima de un 90% en pacientes con hiperlipidemia. Estudios han estimado que del 2-3% de los pacientes con HGNA desarrollan esteatohepatitis no alcohólica (EHNA), en la cual ya hay presencia de inflamación del hepatocito, y ésta a su vez puede progresar a fibrosis avanzada, cirrosis y en daños más graves, que derivan en hepatocarcinoma [4,5]. En Estados Unidos la EHNA es la tercer...
Participation par une presentation par affiche au niveau 1ere Journee Nationale sur la Nutrition ... more Participation par une presentation par affiche au niveau 1ere Journee Nationale sur la Nutrition et la Securite Alimentaire (JNNSA-2017), le 10 Decembre 2017 a l’Universite Hadj Lakhdar Batna 1.
Food & Function, 2016
The plausible mechanisms of the hypocholesterolemic effect of tomato juice have been studied eval... more The plausible mechanisms of the hypocholesterolemic effect of tomato juice have been studied evaluating the activity of HMGCR in liver and the propionic acid formation in feces.
Aquaculture Research, 2016
Mención internacional y cum laude Resumen La acuicultura es el sector de producción animal que má... more Mención internacional y cum laude Resumen La acuicultura es el sector de producción animal que más rápidamente está creciendo en el mundo. La producción global de peces se ha incrementado con una tasa anual del 8,7% desde 1970 y representa más del 45% del suministro mundial total de pescado, mostrándose como única alternativa frente al futuro déficit de este recurso.
Journal of Trace Elements in Medicine and Biology
Background and objectives: Bakery products are widely consumed in the mediterranean diet, especia... more Background and objectives: Bakery products are widely consumed in the mediterranean diet, especially by children and adolescents. However, products such as cookies have also been associated with high consumption of simple sugars, saturated fat and a higher intake of energy. The aim of this study was to modify the nutritional profile of cookies by replacement of fat, reduction of simple sugars and addition of inulin as source of fibre in order to make them healthier, without decreasing the sensory quality. Methods: The nutritional composition of cookies elaborated with wheat flour, margarine, sugar, chocolate drops and eggs was analyzed. Margarine was replaced by “high oleic sunflower oil” (HOSO). Simple sugars were reduced in 31%. Chicory inulin, due to its textural properties and partial sweetness, was added in order to increase fiber content and as an alternative to fat and sugar. Proximal analys was determined by AOAC methods, fatty acid profile by GC and simple sugars by HPLC. S...
Background and objectives: Bakery products are widely consumed in the mediterranean diet, especia... more Background and objectives: Bakery products are widely consumed in the mediterranean diet, especially by children and adolescents. However, products such as muffins have also been associated with high consumption of simple sugars, saturated fat and a higher intake of energy. The aim of this study was to modify the nutritional profile of muffins by reduction and replacement of fat, reduction of simple sugars and addition of inulin as source of fibre in order to make them healthier, without decreasing the sensory quality. Methods: The nutritional composition of muffins elaborated with wheat flour, sunflower oil, sugar, eggs and water was analyzed. Sunflower oil was replaced by “high oleic sunflower oil” (HOSO) and reduced its content by 54%. Simple sugars content was reduced by 68%. Chicory inulin, due to its textural properties and partial sweetness, was added in order to increase fiber content and as an alternative to fat and sugar. Proximate analysis was determined by AOAC methods, ...
Therapeutic Uses of Trace Elements, 1996
Infancy is the period of the life in which nutritional demands are the highest, since weight trip... more Infancy is the period of the life in which nutritional demands are the highest, since weight triples and length doubles during the first year of life (1). Due to the rapid growth rate, high amounts of Ca and P are needed to maintain optimal bone development (2). The mineral matrix of fish bone has higher concentrations of both elements than the edible part and can be used to improve the content of these mineral in some infants foods. The aim of the present study was to ascertain the addition of fish bone in the Ca and P contents and in their in vitro availability in three fish-based homogenised infant beikosts. The main difference among these samples was the inclusion or not of fish bones. The beikosts investigated were: sole beikost without bone (SB), sole beikost with bone (SBB) and sole and hake beikost with bone (SHB). We also evaluated the content and in vitro availability of other minerals (Fe, Zn, and Mg) to have a better knowledge of the nutritional value of these beikosts
Meat science, 2013
The aim of this study was to evaluate the effect of the addition of tomato paste (TP) to sausage ... more The aim of this study was to evaluate the effect of the addition of tomato paste (TP) to sausage mortadella in order to improve the nutritional properties and reduce the lipid oxidation associated with the content of lycopene. First, three different mortadellas without colourant were made with 2, 6 and 10% of TP, to optimise technologically the amount of this ingredient. Then, commercial product was compared with 10% of TP mortadella; both products were made with natural colourant. After a proximate analysis only total protein decreased due to the addition of TP. Lycopene content in mortadella and the total antioxidant activity were proportional to the amount of TP added. The presence of TP provided stability during meat grinding, cooking and storage of mortadella by reducing the lipid oxidation. In addition, TP provided yellowness and softness; however, when TP was added together with red colourant, the redness remained constant in the mortadella without effects on the consumer ove...
Food Research International, 2012
The aim of the present study was to determine the levels of β-carotene, lycopene and its isomers,... more The aim of the present study was to determine the levels of β-carotene, lycopene and its isomers, and total and individual phenolic compounds in tomatoes treated with different levels of UV-C radiation (UV-C hormesis). Mature green tomatoes (breaker stage) were exposed to different doses of UV-C irradiation (1.0, 3.0 and 12.2 kJ/m 2). After UV treatment, tomatoes were stored at room temperature for 8 d, and then analyzed for bioactive compounds and antioxidant activity. Exposed tomatoes were compared with control samples stored at different conditions (darkness and day/night cycle). The lycopene content in breaker tomatoes increased almost twofold following UV light treatments, while β-carotene levels decreased, when treated samples were compared with the two control batches. Proportions of Z-lycopene also increased when the tomatoes were exposed to UV for more than 3 h. The UV treatments significantly increased the total phenolic content and the antioxidant capacity of treated tomatoes compared to untreated samples, but no clear effect was observed for individual phenolic compounds. These results suggest that UV-C irradiation of tomatoes could improve the beneficial effect of tomatoes for human health by increasing the levels of certain bioactive compounds.
Food Chemistry, 2012
The objective of this study was to evaluate the effect of sodium alginate obtained from brown sea... more The objective of this study was to evaluate the effect of sodium alginate obtained from brown seaweed as a prebiotic supplement to the feed of reared sea bream (Sparus aurata). Addition of the alginate to a control diet was investigated at both concentrations 2% and 5%. Proximate composition in the flesh were not modified significantly by sodium alginate inclusion in the diet of the sea bream; however the fat and ash content in the specimens supplemented with 5% alginate were found to be significantly higher than those found in individuals who were fed the control diet. No significant differences in mineral content, fatty acid profiles, cholesterol content, texture parameters and sensory acceptability among the three studied groups. Results obtained in this study offer support for the use of alginate as a feed additive in sea bream diets since no significant effects were found in the flesh quality and characteristics of commercial size sea bream.
Food Chemistry, 1998
... All rights reserved Printed in Great Britain 03088146 98 19.00+0.00 Content and in vitro avai... more ... All rights reserved Printed in Great Britain 03088146 98 19.00+0.00 Content and in vitro availability of Fe, Zn, Mg, Ca and P in homogenized fishbased weaning foods after bone addition IsabelMartinez, Marina Santaella, Gaspar Ros Maria Jesus Periago* Department of Food ...
Anales de veterinaria …, 2007
Archivos latinoamericanos de nutrición, 2012
Alpha-Lactalbumin is the main whey protein in human milk rising 2,44 g/L in mature milk. It has a... more Alpha-Lactalbumin is the main whey protein in human milk rising 2,44 g/L in mature milk. It has a key function in the synthesis of lactose from glucose and galactose in the mammary gland although this compound has also other beneficial effects on the infant health due to the high proportion of essential aminoacids (tryptophan and cysteine). It seems also to increase iron absorption in the digestive track, and in in vitro experiments, linked to oleic acid (HAMLET complex), has shown anticarcinogenic effects against cellular tumor such as human papilloma. In addition, this complex has been reported to exhibit antimicrobial properties against Streptococcus pneumoniae, Haemophilus influenzae, enteropathogenic strains of Escherichia coli and Salmonella thypimurium. However, the in vivo synthesis of HAMLET complex during milk digestion has not been proved yet. Infant formula have been improved considerably during the last decades not only adapting nutrient concentrations to infants requir...
Veterinary Research Forum, 2020
The muscle and textural parameters were analyzed in four myotome zones (epaxial upper, hipoaxial ... more The muscle and textural parameters were analyzed in four myotome zones (epaxial upper, hipoaxial upper, epaxial bottom, and hipoaxial bottom) in seven diploids (D) and seven triploids (T) turbot specimens. Diploid specimens showed the highest values of the size and number of white fibers in the epaxial zones, being such values higher in female than male specimens. In triploid specimens, the highest fibers sizes were found in the upper zones (epaxial and hipoaxial), whereas the lowest number and density of fibers were found in the epaxial upper zone. In this latter group (T), the lowest fibers sizes were found in female specimens, whereas the rest of the parameters were usually higher in female than male specimens. When comparing both groups, the hypertrophy was higher in T than D in all zones. In both ploidy groups, the highest textural values were usually observed in the upper epaxial fillet, being slightly higher in female than male specimens. The values of standard length, total ...
International Journal of Molecular Sciences, 2019
The purpose of this work was to evaluate the effect of dietary carotenoids from spinach on the in... more The purpose of this work was to evaluate the effect of dietary carotenoids from spinach on the inflammation and oxidative stress biomarkers, liver lipid profile, and liver transcriptomic and metabolomics profiles in Sprague–Dawley rats with steatosis induced by a high-fat diet. Two concentrations of spinach powder (2.5 and 5%) were used in two types of diet: high-fat (H) and standard (N). Although rats fed diet H showed an accumulation of fat in hepatocytes, they did not show differences in the values of adiponectin, tumor necrosis factor alpha (TNF-α), and oxygen radical absorption (ORAC) in plasma or of isoprostanes in urine compared with animals fed diet N. The consumption of spinach and the accumulation of α and β carotenes and lutein in the liver was inversely correlated with serum total cholesterol and glucose and the content of hepatic cholesterol, increasing monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA) and reducing cholesterol in the livers of rats ...
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Papers by Marina Santaella