Background: Poor patient acceptance is a major barrier to effective colorectal cancer (CRC) green... more Background: Poor patient acceptance is a major barrier to effective colorectal cancer (CRC) greening. SBDNA is a novel CRC screening strategy that offers a convenient, non-invasive and potentially more acceptable alternative to existing screening tests. The objective of this study was to indirectly assess patient acceptance by comparing patient perceptions of SBDNA, FOBT and CS and eliciting preferences. Methods: A prospective survey was conducted among previously unscreened, asymptomatic average-risk subjects 50 years of age and older panicipating in a multi-center comparison of SBDNA (PreGen-Phis TM) and FOBT (Hemoccult If) for detecting CRC neoplasia. Evahiable subjects completed a 25-item questionnaire within 48hrs after undergoing a screening colonoscopy, which served as the reference standard for SBDNA and FOBT test performance. Respondents were asked to rate each of the 3 screening tests on a variety of features using a 5-point ordinal scale and select a preferred strategy. Results: A total of 2,388 subjects completed the survey. SBDNA received higher mean ratings (p<0.001) than FOBT for simplicity of the stool sample collection process, comfort, perceived accuracy and likelihood of repeating the test if recommended by their doctor. SBDNA and FOBT received similar ratings for simplicity of prep instructions, lost time from work or other activities, perceived invasiveness, perceived embarrassment and perceived anxiety over the prep and test itself. FOBT was never rated higher than SBDNA with respect to any feature. When compared with CS, SBDNA received higher ratings (p<~0.001) for all of the alorementioned test features except accuracy, where CS was rated higher (p<~O.001). Overall, a higher percentage (p<0.001) of patients preferred SBDNA (50.1%) to both FOBT (34.6%) and CS (15.3%) for their routine screening program. Conclusions: Average risk patients perceive SBDNA to have a number of advantages over both FOBT and CS. Moreover, our data suggest that SBDNA may be a preferred strategy for routine CRC screening.
With the aim to capture and subsequent selective trapping of CO2, a nanocomposite has been develo... more With the aim to capture and subsequent selective trapping of CO2, a nanocomposite has been developed through selective modification of the outer surface of the halloysite nanotubes (HNTs) with an organosilane to make the nanocomposite a novel solid-phase adsorbent to adsorb CO2 from the atmosphere at standard ambient temperature and pressure. The preferential adsorption of three major abundant isotopes of CO2 (12C16O2, 13C16O2 and 12C16O18O) from the ambient air by amine functionalized HNTs has been explored using an optical cavity-enhanced integrated cavity output spectroscopy. CO2 adsorption/desorption cycling measurements demonstrate that the adsorbent can be regenerated at relatively low temperature and thus, recycled repeatedly to capture atmospheric CO2. The amine grafted halloysite shows excellent stability even in oxidative environments and has high efficacy of CO2 capture, introducing a new route to the adsorption of isotope selective atmospheric CO2.
Background: Poor patient acceptance is a major barrier to effective colorectal cancer (CRC) green... more Background: Poor patient acceptance is a major barrier to effective colorectal cancer (CRC) greening. SBDNA is a novel CRC screening strategy that offers a convenient, non-invasive and potentially more acceptable alternative to existing screening tests. The objective of this study was to indirectly assess patient acceptance by comparing patient perceptions of SBDNA, FOBT and CS and eliciting preferences. Methods: A prospective survey was conducted among previously unscreened, asymptomatic average-risk subjects 50 years of age and older panicipating in a multi-center comparison of SBDNA (PreGen-Phis TM) and FOBT (Hemoccult If) for detecting CRC neoplasia. Evahiable subjects completed a 25-item questionnaire within 48hrs after undergoing a screening colonoscopy, which served as the reference standard for SBDNA and FOBT test performance. Respondents were asked to rate each of the 3 screening tests on a variety of features using a 5-point ordinal scale and select a preferred strategy. Results: A total of 2,388 subjects completed the survey. SBDNA received higher mean ratings (p<0.001) than FOBT for simplicity of the stool sample collection process, comfort, perceived accuracy and likelihood of repeating the test if recommended by their doctor. SBDNA and FOBT received similar ratings for simplicity of prep instructions, lost time from work or other activities, perceived invasiveness, perceived embarrassment and perceived anxiety over the prep and test itself. FOBT was never rated higher than SBDNA with respect to any feature. When compared with CS, SBDNA received higher ratings (p<~0.001) for all of the alorementioned test features except accuracy, where CS was rated higher (p<~O.001). Overall, a higher percentage (p<0.001) of patients preferred SBDNA (50.1%) to both FOBT (34.6%) and CS (15.3%) for their routine screening program. Conclusions: Average risk patients perceive SBDNA to have a number of advantages over both FOBT and CS. Moreover, our data suggest that SBDNA may be a preferred strategy for routine CRC screening.
With the aim to capture and subsequent selective trapping of CO2, a nanocomposite has been develo... more With the aim to capture and subsequent selective trapping of CO2, a nanocomposite has been developed through selective modification of the outer surface of the halloysite nanotubes (HNTs) with an organosilane to make the nanocomposite a novel solid-phase adsorbent to adsorb CO2 from the atmosphere at standard ambient temperature and pressure. The preferential adsorption of three major abundant isotopes of CO2 (12C16O2, 13C16O2 and 12C16O18O) from the ambient air by amine functionalized HNTs has been explored using an optical cavity-enhanced integrated cavity output spectroscopy. CO2 adsorption/desorption cycling measurements demonstrate that the adsorbent can be regenerated at relatively low temperature and thus, recycled repeatedly to capture atmospheric CO2. The amine grafted halloysite shows excellent stability even in oxidative environments and has high efficacy of CO2 capture, introducing a new route to the adsorption of isotope selective atmospheric CO2.
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