L a piel es un órgano frecuentemente afectado en los individuos que presentan infecciones recurre... more L a piel es un órgano frecuentemente afectado en los individuos que presentan infecciones recurrentes. Con el fin de conocer el comporta miento epidemiológico y estimar la prevalencia de las infecciones dermatológicas bacterianas aeróbicas y micó ticas, en los pacientes remitidos al programa de vigilancia "Detección y Manejo del Síndrome de Infección Recurrente (SIR)", se realizó un estudio descriptivo retrospectivo, entre julio de 1994 y julio de 1999.
Penetration of the aminoglycoside, amikacin, into the cerebrospinal fluid (CSF) of twenty childre... more Penetration of the aminoglycoside, amikacin, into the cerebrospinal fluid (CSF) of twenty children with acute bacterial meningitis was studied at various times after intramuscular administration and at various stages of therapy. Six of the patients were evaluated during therapy with amikacin at 7–5 mg/kg (intramuscularly) every 12 hours plus ampicillin every 6 hours at 300 mglkg/day (intravenously); thirteen of the remaining fourteen patients were treated with ampicillin alone, but were given a single intramuscular dose of 7–5 mg/kg of amikacin for evaluation of CSF concentration. Amikacin concentration in CSF with respect to time after administration followed essentially the same pattern as in serum. A minimum concentration of 2 μg/ml was found in 76% of the CSF samples obtained between 0.5 and 7 hours after administration. A mean amikacin serum/CSF ratio of 3:1 was demonstrated up to 7 hours after dose in all patients who underwent clinical improvement. Patient response was predic...
Biomédica : revista del Instituto Nacional de Salud, 2002
Recurrent infections are a frequent cause of medical visits. They can be due to a heterogeneous g... more Recurrent infections are a frequent cause of medical visits. They can be due to a heterogeneous group of dysfunctions that increase the susceptibility to pathogenic and opportunistic microorganisms, such as immunological deficiencies. To define an opportune rational treatment and to guide the molecular diagnosis of primary immunodeficiency diseases, we establish a program for the phenotypic diagnosis of these illnesses in Antioquia, Colombia, including clinical and laboratory evaluations of patients who present recurrent infections with abnormal evolution. Between August 1, 1994 and July 31, 2002, phenotypic diagnosis of primary immunodeficiency was made in 98 patients. Similar to data reported in the literature, antibody deficiencies were the most frequent (40.8%), followed by combined deficiencies (21.4%). This phenotypic characterization has allowed for appropriate treatments for each patient and, in some cases, functional and molecular studies that can lead to a definite molecul...
Resumo: Las inmunodeficiencias primarias son defectos genéticos que comprometen la función de alg... more Resumo: Las inmunodeficiencias primarias son defectos genéticos que comprometen la función de alguna de las proteínas involucradas en la respuesta inmunológica; por ello, los pacientes presentan una frecuencia anormal de infecciones severas recurrentes, ...
El síndrome de infección recurrente constituye una causa importante de morbilidad y mortalidad, t... more El síndrome de infección recurrente constituye una causa importante de morbilidad y mortalidad, tanto en países desarrollados como en vías de desarrollo, lo cual implica altos costos sociales y económicos para los distintos servicios de salud. Prácticamente todos ...
L a piel es un órgano frecuentemente afectado en los individuos que presentan infecciones recurre... more L a piel es un órgano frecuentemente afectado en los individuos que presentan infecciones recurrentes. Con el fin de conocer el comporta miento epidemiológico y estimar la prevalencia de las infecciones dermatológicas bacterianas aeróbicas y micó ticas, en los pacientes remitidos al programa de vigilancia "Detección y Manejo del Síndrome de Infección Recurrente (SIR)", se realizó un estudio descriptivo retrospectivo, entre julio de 1994 y julio de 1999.
Penetration of the aminoglycoside, amikacin, into the cerebrospinal fluid (CSF) of twenty childre... more Penetration of the aminoglycoside, amikacin, into the cerebrospinal fluid (CSF) of twenty children with acute bacterial meningitis was studied at various times after intramuscular administration and at various stages of therapy. Six of the patients were evaluated during therapy with amikacin at 7–5 mg/kg (intramuscularly) every 12 hours plus ampicillin every 6 hours at 300 mglkg/day (intravenously); thirteen of the remaining fourteen patients were treated with ampicillin alone, but were given a single intramuscular dose of 7–5 mg/kg of amikacin for evaluation of CSF concentration. Amikacin concentration in CSF with respect to time after administration followed essentially the same pattern as in serum. A minimum concentration of 2 μg/ml was found in 76% of the CSF samples obtained between 0.5 and 7 hours after administration. A mean amikacin serum/CSF ratio of 3:1 was demonstrated up to 7 hours after dose in all patients who underwent clinical improvement. Patient response was predic...
Biomédica : revista del Instituto Nacional de Salud, 2002
Recurrent infections are a frequent cause of medical visits. They can be due to a heterogeneous g... more Recurrent infections are a frequent cause of medical visits. They can be due to a heterogeneous group of dysfunctions that increase the susceptibility to pathogenic and opportunistic microorganisms, such as immunological deficiencies. To define an opportune rational treatment and to guide the molecular diagnosis of primary immunodeficiency diseases, we establish a program for the phenotypic diagnosis of these illnesses in Antioquia, Colombia, including clinical and laboratory evaluations of patients who present recurrent infections with abnormal evolution. Between August 1, 1994 and July 31, 2002, phenotypic diagnosis of primary immunodeficiency was made in 98 patients. Similar to data reported in the literature, antibody deficiencies were the most frequent (40.8%), followed by combined deficiencies (21.4%). This phenotypic characterization has allowed for appropriate treatments for each patient and, in some cases, functional and molecular studies that can lead to a definite molecul...
Resumo: Las inmunodeficiencias primarias son defectos genéticos que comprometen la función de alg... more Resumo: Las inmunodeficiencias primarias son defectos genéticos que comprometen la función de alguna de las proteínas involucradas en la respuesta inmunológica; por ello, los pacientes presentan una frecuencia anormal de infecciones severas recurrentes, ...
El síndrome de infección recurrente constituye una causa importante de morbilidad y mortalidad, t... more El síndrome de infección recurrente constituye una causa importante de morbilidad y mortalidad, tanto en países desarrollados como en vías de desarrollo, lo cual implica altos costos sociales y económicos para los distintos servicios de salud. Prácticamente todos ...
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