Diagnostic Microbiology and Infectious Disease, 2017
Few studies have evaluated the clinical impact of polymerase chain reaction for Staphylococcus au... more Few studies have evaluated the clinical impact of polymerase chain reaction for Staphylococcus aureus bloodstream infections in resource-limited settings that lack direct antimicrobial stewardship intervention. This retrospective cohort study compared patients with standard microbiological identification (n=343) to those with additional identification by polymerase chain reaction (n=130). The primary analysis was conducted on a subset of patients who received treatment with optimal therapy (n=295). Time to initiation of optimal therapy was similar between groups but substantially shorter in the PCR group for those infected with methicillin susceptible Staphylococcus aureus (median 40.0 hours vs. 28.3 hours, P=0.001). After controlling for confounding factors including infectious diseases consultation, the PCR group had a shorter time to initiation of optimal therapy by 9.7 hours (95% CI 4.3 to 15.0 hours). Clinical outcomes were similar in the non-PCR and PCR groups. While time to initiation of optimal therapy was shorter in the PCR group, greater reductions may be realized through additional education, direct antimicrobial stewardship intervention, or additional clinician notification.
Diagnostic Microbiology and Infectious Disease, 2017
Few studies have evaluated the clinical impact of polymerase chain reaction for Staphylococcus au... more Few studies have evaluated the clinical impact of polymerase chain reaction for Staphylococcus aureus bloodstream infections in resource-limited settings that lack direct antimicrobial stewardship intervention. This retrospective cohort study compared patients with standard microbiological identification (n=343) to those with additional identification by polymerase chain reaction (n=130). The primary analysis was conducted on a subset of patients who received treatment with optimal therapy (n=295). Time to initiation of optimal therapy was similar between groups but substantially shorter in the PCR group for those infected with methicillin susceptible Staphylococcus aureus (median 40.0 hours vs. 28.3 hours, P=0.001). After controlling for confounding factors including infectious diseases consultation, the PCR group had a shorter time to initiation of optimal therapy by 9.7 hours (95% CI 4.3 to 15.0 hours). Clinical outcomes were similar in the non-PCR and PCR groups. While time to initiation of optimal therapy was shorter in the PCR group, greater reductions may be realized through additional education, direct antimicrobial stewardship intervention, or additional clinician notification.
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