Papers by Russia Ha-Vinh Leuchter
Swiss Journal of Psychology
. The Other Race Effect (ORE), i.e., recognition facilitation for own-race faces, is a well-estab... more . The Other Race Effect (ORE), i.e., recognition facilitation for own-race faces, is a well-established phenomenon with broad evidence in adults and infants. Nevertheless, the ORE in older children is poorly understood, and even less so for emotional face processing. This research samples 87 9-year-old children from Vietnamese and Swiss schools. In two separate studies, we evaluated the children’s abilities to perceive the disappearance of emotions in Asian and Caucasian faces in an offset task. The first study evaluated an “emotional ORE” in Vietnamese-Asian, Swiss-Caucasian, and Swiss-Multicultural children. Offset times showed an emotional ORE in Vietnamese-Asian children living in an ethnically homogeneous environment, whereas mixed ethnicities in Swiss children seem to have balanced performance between face types. The second study compared socioemotionally trained versus untrained Vietnamese-Asian children. Vietnamese children showed a strong emotional ORE and tend to increase their sensitivity to emotion offset after training. Moreover, an effect of emotion consistent with previous observation in adults could suggest a cultural sensitivity to disapproval signs. Taken together, the results suggest that 9-year-old children can present an emotional ORE, but that a heterogeneous environment or an emotional training could strengthen face-processing abilities without reducing skills on their own-group.
Scientific Reports
Very preterm (VPT) young adolescents are at high risk of executive, behavioural and socio-emotion... more Very preterm (VPT) young adolescents are at high risk of executive, behavioural and socio-emotional difficulties. Previous research has shown significant evidence of the benefits of mindfulness-based intervention (MBI) on these abilities. This study aims to assess the association between the effects of MBI on neurobehavioral functioning and changes in white-matter microstructure in VPT young adolescents who completed an 8-week MBI program. Neurobehavioural assessments (i.e., neuropsychological testing, parents- and self-reported questionnaires) and multi-shell diffusion MRI were performed before and after MBI in 32 VPT young adolescents. Combined diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) measures were extracted on well-defined white matter tracts (TractSeg). A multivariate data-driven approach (partial least squares correlation) was used to explore associations between MBI-related changes on neurobehavioural measures and microstruc...
Pediatric Research
Background Children born very preterm (VPT; <32 weeks’ gestation) are at high risk of neurodev... more Background Children born very preterm (VPT; <32 weeks’ gestation) are at high risk of neurodevelopmental and behavioural difficulties associated with atypical brain maturation, including socio-emotional difficulties. The analysis of large-scale brain network dynamics during rest allows us to investigate brain functional connectivity and its association with behavioural outcomes. Methods Dynamic functional connectivity was extracted by using the innovation-driven co-activation patterns framework in VPT and full-term children aged 6–9 to explore changes in spatial organisation, laterality and temporal dynamics of spontaneous large-scale brain activity (VPT, n = 28; full-term, n = 12). Multivariate analysis was used to explore potential biomarkers for socio-emotional difficulties in VPT children. Results The spatial organisation of the 13 retrieved functional networks was comparable across groups. Dynamic features and lateralisation of network brain activity were also comparable for...
Children born very preterm (VPT; < 32 completed weeks of gestation) are at high risk of neurod... more Children born very preterm (VPT; < 32 completed weeks of gestation) are at high risk of neurodevelopmental and neurobehavioral difficulties associated with atypical brain maturation. The analysis of large-scale brain network dynamics during rest allows to investigate brain functional connectivity and their association with behavioural outcomes. Of interest, prematurity has been associated with atypical socio-emotional development with significant implications for the forming of peer relationships, adaptive functioning, academic achievement and mental health. In this study, we extracted dynamic functional connectivity by using the innovation-driven co-activation patterns (iCAPs) framework in preterm and full-term children aged 6 to 9 to explore changes in spatial organisation, laterality and temporal dynamics of spontaneous large-scale brain activity. Multivariate pattern analysis was used to explore potential biomarkers for socio-emotional difficulties in preterm children. Result...
Scientific Reports, 2021
Very preterm (VPT) children and adolescents show executive, behavioural and socio-emotional diffi... more Very preterm (VPT) children and adolescents show executive, behavioural and socio-emotional difficulties that persists into adulthood. This study aims to assess the effectiveness of a mindfulness-based intervention (MBI) in improving these competencies in VPT young adolescents using a randomised controlled trial design. 56 young adolescents aged 10–14 years, born before 32 gestational weeks, were randomly assigned to an “intervention” or a “waiting” group and completed an 8-week MBI in a cross-over design. Executive, behavioural and socio-emotional competencies were assessed at three different time points via parent and self-reported questionnaires, neuropsychological testing and computerised tasks. The data were analysed using an intention-to-treat approach with linear regression modelling. Our findings show a beneficial effect of MBI on executive, behavioural and socio-emotional competencies in VPT young adolescents measured by parent questionnaires. Increased executive competenci...
NeuroImage: Clinical, 2021
Preterm birth is one of the main causes for neurodevelopmental problems, and has been associated ... more Preterm birth is one of the main causes for neurodevelopmental problems, and has been associated with a wide range of impairments in cognitive functions including executive functions and memory. One of the factors contributing to these adverse outcomes is the intrinsic vulnerability of the premature brain. Neuroimaging studies have highlighted structural and functional alterations in several brain regions in preterm individuals across lifetime. The orbitofrontal cortex (OFC) is crucial for a multitude of complex and adaptive behaviours, and its structure is particularly affected by premature birth. Nevertheless, studies on the functional impact of prematurity on the OFC are still missing. Orbitofrontal Reality filtering (ORFi) refers to the ability to distinguish if a thought is relevant to present reality or not. It can be tested using a continuous recognition task and is mediated by the OFC in adults and typically developing young adolescents. Therefore, the ORFi task was used to investigate whether OFC functioning is affected by prematurity. We compared the neural correlates of ORFi in 35 young adolescents born preterm (below 32 weeks of gestation) and aged 10 to 14 years with 25 full term-born controls. Our findings indicate that OFC activation was required only in the full-term group, whereas preterm young adolescents did not involve OFC in processing the ORFi task, despite being able to correctly perform it.
JAMA, 2014
IMPORTANCE Premature infants are at risk of developing encephalopathy of prematurity, which is as... more IMPORTANCE Premature infants are at risk of developing encephalopathy of prematurity, which is associated with long-term neurodevelopmental delay. Erythropoietin was shown to be neuroprotective in experimental and retrospective clinical studies. OBJECTIVE To determine if there is an association between early high-dose recombinant human erythropoietin treatment in preterm infants and biomarkers of encephalopathy of prematurity on magnetic resonance imaging (MRI) at term-equivalent age. DESIGN, SETTING, AND PARTICIPANTS A total of 495 infants were included in a randomized, double-blind, placebo-controlled study conducted in Switzerland between 2005 and 2012. In a nonrandomized subset of 165 infants (n=77 erythropoietin; n=88 placebo), brain abnormalities were evaluated on MRI acquired at term-equivalent age. INTERVENTIONS Participants were randomly assigned to receive recombinant human erythropoietin (3000 IU/kg; n=256) or placebo (n=239) intravenously before 3 hours, at 12 to 18 hours, and at 36 to 42 hours after birth. MAIN OUTCOMES AND MEASURES The primary outcome of the trial, neurodevelopment at 24 months, has not yet been assessed. The secondary outcome, white matter disease of the preterm infant, was semiquantitatively assessed from MRI at term-equivalent age based on an established scoring method. The resulting white matter injury and gray matter injury scores were categorized as normal or abnormal according to thresholds established in the literature by correlation with neurodevelopmental outcome. RESULTS At term-equivalent age, compared with untreated controls, fewer infants treated with recombinant human erythropoietin had abnormal scores for white matter injury, white matter signal intensity, periventricular white matter loss, and gray matter injury. Outcomes No. (%) With Abnormal Score Birth Weight-Adjusted Risk Ratio (95% CI) Erythropoietin Group (n=77) Placebo Group (n=88) White matter injury 17 (22) 32 (36) 0.58 (0.35-0.96) White matter signal intensity 2 (3) 10 (11) 0.20 (0.05-0.90) Periventricular white matter loss 14 (18) 29 (33) 0.53 (0.30-0.92) Gray matter injury 5 (7) 17 (19) 0.34 (0.13-0.89) CONCLUSIONS AND RELEVANCE In an analysis of secondary outcomes of a randomized clinical trial of preterm infants, high-dose erythropoietin treatment within 42 hours after birth was associated with a reduced risk of brain injury on MRI. These findings require assessment in a randomized trial designed primarily to assess this outcome as well as investigation of the association with neurodevelopmental outcomes.
Pediatric Research, 2013
Clinical Investigation nature publishing group Background: Amplitude-integrated electroencephalog... more Clinical Investigation nature publishing group Background: Amplitude-integrated electroencephalogram (aEEG) is a reliable monitoring tool for electrocortical activity with good predictive value in preterm infants. Magnetic resonance imaging (MRI) is a good neuroimaging tool to detect brain lesions and to evaluate brain maturation. We hypothesized that early aEEG measures, recorded over the first 3 d of life in very preterm infants, correlate with brain maturation and injury score assessed by conventional MRI at term-equivalent age. Methods: Thirty-nine infants born at a mean (range) gestational age (GA) of 29.5 (27.0-31.9) wk and birth weight 1,230 (680-2,020) g had continuous aEEG during the first postnatal 72-84 h. aEEG maturity scores and average maximum and minimum amplitudes were evaluated. Conventional brain MRI was performed at 41.2 (37.1-44.1) wk postmenstrual age (PMA) on a 3T GE system and scored qualitatively for injury and maturation. results: The average aEEG total maturity score and its cycling subscore were positively and significantly associated with the total MRI maturation score after adjustment for GA, morphine sedation, and PMA at MRI examination. No association was found between the aEEG measures and the MRI injury scores. conclusion: Early aEEG maturity seems to relate to structural MRI brain maturation at term-equivalent age in preterm infants.
Early Human Development, 2021
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Revue Médicale Suisse, 2020
MÉDECINE INTÉGRATIVE WWW.REVMED.CH 25 novembre 2020 Mindfulness based interventions for children ... more MÉDECINE INTÉGRATIVE WWW.REVMED.CH 25 novembre 2020 Mindfulness based interventions for children and adolescents Mindfulness based interventions (MBI) are widely available to adults. Programs are also offered to children and adolescents. Interventions in school and clinical settings are increasingly being published in scientific literature. In the school context, the effects are promising on psychological health, such as stress, anxiety, depression or externalized behaviours, and on executive functions, attention, and socio-emotional skills. In the clinical context, MBI has a particular effect on stress/anxiety and depression as well as on the key symptoms of Attention Deficit Hyperactivity Disorder. These results are very encouraging, but all meta-analyses and literature reviews nevertheless emphasize the need for studies with robust methodology before proposing MBI on a large scale for this population.
Clinical Genetics, 2021
Arthrogryposis describes the presence of multiple joint-contractures. Clinical severity of this p... more Arthrogryposis describes the presence of multiple joint-contractures. Clinical severity of this phenotype is variable, and more than 400 causative genes have been proposed. Among these, ERGIC1 is a recently reported candidate encoding a putative transmembrane protein of the ER-Golgi interface. Two homozygous missense variants have been reported in patients with relatively mild non-syndromic arthrogryposis. In a consanguineous family with two affected siblings presenting
Cerebral Cortex, 2020
Maternal voice is a highly relevant stimulus for newborns. Adult voice processing occurs in speci... more Maternal voice is a highly relevant stimulus for newborns. Adult voice processing occurs in specific brain regions. Voice-specific brain areas in newborns and the relevance of an early vocal exposure on these networks have not been defined. This study investigates voice perception in newborns and the impact of prematurity on the cerebral processes. Functional magnetic resonance imaging (fMRI) and high-density electroencephalography (EEG) were used to explore the brain responses to maternal and stranger female voices in full-term newborns and preterm infants at term-equivalent age (TEA). fMRI results and the EEG oddball paradigm showed enhanced processing for voices in preterms at TEA than in full-term infants. Preterm infants showed additional cortical regions involved in voice processing in fMRI and a late mismatch response for maternal voice, considered as a first trace of a recognition process based on memory representation. Full-term newborns showed increased cerebral activity t...
Pediatric Research, 2020
BACKGROUND: Excessive and inconsolable crying behavior in otherwise healthy infants (a condition ... more BACKGROUND: Excessive and inconsolable crying behavior in otherwise healthy infants (a condition called infant colic (IC)) is very distressing to parents, may lead to maternal depression, and in extreme cases, may result in shaken baby syndrome. Despite the high prevalence of this condition (20% of healthy infants), the underlying neural mechanisms of IC are still unknown. METHODS: By employing the latest magnetic resonance imaging (MRI) techniques in newborns, we prospectively investigated whether newborns' early brain responses to a sensory stimulus (smell) is associated with a subsequent crying behavior. RESULTS: In our sample population of 21 healthy breastfed newborns, those who developed IC at 6 weeks exhibited brain activation and functional connectivity in primary and secondary olfactory brain areas that were distinct from those in babies that did not develop IC. Different activation in brain regions known to be involved in sensory integration was also observed in colicky babies. These responses measured shortly after birth were highly correlated with the mean crying time at 6 weeks of age. CONCLUSIONS: Our results offer novel insights into IC pathophysiology by demonstrating that, shortly after birth, the central nervous system of babies developing IC has already greater reactivity to sensory stimuli than that of their noncolicky peers.
Brain and Behavior, 2020
This is an open access article under the terms of the Creative Commons Attribution License, which... more This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Cerebral Cortex, 2017
The sense of smell is one of the oldest and the most primitive senses mammals possess, it helps t... more The sense of smell is one of the oldest and the most primitive senses mammals possess, it helps to evaluate the surrounding environment. From birth, smell is an important sensory modality, highly relevant for neonatal behavioral adaptation. Even though human newborns seem to be able to perceive and react to olfactory stimuli, there is still a lack of knowledge about the ontogeny of smell and the underlying central processing involved in odor perception in newborns. Brain networks involved in chemosensory perception of odorants are well described in adults, however in newborns there is no evidence that central olfaction is functional given the largely unmyelinated neonatal central nervous system. To examine this question, we used functional magnetic resonance imaging (fMRI) in the newborn to characterize cortical response to olfactory and trigeminal odorants. Here we show that brain response to odors can be measured and localized using functional MRI in newborns. Furthermore, we found that the developing brain, only few days after birth, processes new artificial odorants in similar cortical areas than adults, including piriform cortex, orbitofrontal cortex and insula. Our work provides evidence that human olfaction at birth relies on brain functions that involve all levels of the cortical olfactory system.
Pediatric Research, 2011
Congenital hypothyroidism (CH) can lead to intellectual deficits despite early high-dose treatmen... more Congenital hypothyroidism (CH) can lead to intellectual deficits despite early high-dose treatment. Our study aimed to determine whether motor impairments can occur despite early highdose treatment. Sixty-three children with CH and early (median age of onset of treatment 9 d), high-dose treatment (median starting dose of levothyroxine 14.7 g/kg/d) were tested with the Zurich Neuromotor Assessment (ZNA) at a median age of 13.8 y (range 7.0-14.2 y). Median z-scores in the children with CH were Ϫ0.95 in the pure and Ϫ0.56 in the adaptive fine motor component, significantly lower than in the ZNA test norms (p Ͻ 0.001 and p ϭ 0.01, respectively). The 26 children with athyreosis were more affected than the 33 children with dysgenesis, particularly in the pure motor (Ϫ1.55 versus Ϫ0.76, p ϭ 0.03), adaptive fine motor (Ϫ1.31 versus 0.13, p Ͻ 0.01), and static balance task (Ϫ0.47 versus 0.67, p ϭ 0.01). Boys performed worse than girls. Older age at onset of treatment was related to poorer adaptive fine motor performance. Movement quality (assessed by associated movements) was not affected. We conclude that severe CH can cause neuromotor deficits persisting into adolescence. These deficits cannot completely be reversed by postnatal treatment, but earlier age at treatment may reduce the degree of impairment.
Journal of Pediatric Gastroenterology and Nutrition, 2013
B y definition, colicky babies cry for !3 hours/day, on !3 days/ week for !3 consecutive weeks, b... more B y definition, colicky babies cry for !3 hours/day, on !3 days/ week for !3 consecutive weeks, but fortunately, as for noncolicky babies, the cries slowly lessen after a peak at 6 weeks of life and almost stop after month 3 (1). Another particularity of the cries of the first weeks of life is that they concentrate in late afternoon, when colicky babies seem to be overly alert (2). Some authors, therefore, hypothesize that there is a relation between infant colic and the development of the circadian rhythm (3-5). Close contact between babies and their caregivers is essential for all babies, but what seems to soothe noncolicky babies (eg, hearing their mother's voice, smelling her, being carried or touched) apparently has no impact on severely colicky babies and sometimes even worsens their symptoms. This raises the question whether their
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Papers by Russia Ha-Vinh Leuchter