Papers by Ruben Dario Gomez Luna
Revista colombiana de cirugia, Apr 30, 2018
Cirugía y Cirujanos, 2021
Objetivo: Evaluar la aparición de reflujo gastroesofágico (RGE) posterior a gastrectomía en manga... more Objetivo: Evaluar la aparición de reflujo gastroesofágico (RGE) posterior a gastrectomía en manga como manejo para la obesidad, con el Gastroesophageal Reflux Disease Questionnaire (GerdQ). Método: Estudio retrospectivo de pacientes llevados a gastrectomía en manga durante 2016 y 2017, habiendo descartado RGE con endoscopia digestiva alta prequirúrgica, y evaluación posoperatoria con la escala GerdQ. Resultados: Se incluyeron en el estudio 129 pacientes, con un promedio de edad de 45 años, el 77.5% de sexo masculino y como comorbilidad más frecuente hipotiroidismo (25.6%) e hipertensión arterial (23.3%). El 12.4% tenían un puntaje ≥ 8, 14 eran mujeres y 2 hombres, y no hubo relación estadísticamente significativa con el índice de masa corporal preoperatorio. Conclusiones: Estandarizar la técnica de manga gástrica en los servicios de cirugía bariátrica, teniendo en cuenta los factores técnicos asociados a RGE posoperatorio de novo, disminuye la aparición de RGE según lo evaluado por la escala GerdQ.
Revista Colombiana de Nefrología, 2015
Los pacientes sometidos a trasplantes de órgano sólido tienen mayor riesgo de desarrollar patolog... more Los pacientes sometidos a trasplantes de órgano sólido tienen mayor riesgo de desarrollar patologías malignas e infecciosas en relación con la magnitud y el tiempo de la terapia inmunosupresora. Las infecciones cutáneas son una de las complicaciones más usuales en este tipo de pacientes, siendo las verrugas virales la presentación clínica más frecuente, causadas por el virus del papiloma humano, un virus ADN perteneciente a la familia de los Papillomaviridae, del cual existen cerca de 100 serotipos, algunos conocidos con alto potencial oncogénico, conun elevado riesgo de desarrollar malignidad a nivel anorrectal o cervical. Rara vez estas lesiones se manifiestan antes del primer año del trasplante y su frecuencia aumenta en relación directa a la antigüedad del trasplante, hasta afectar cerca del 80% de los pacientes tras el quinto año postrasplante. En general logran ser tratadas exitosamente con tratamientos convencionales, como crioterapia, curetaje y algunos compuestos tópicos como retinoides, imiquimod y, recientemente, se han descrito casos de tratamiento exitoso con cidofovir. Se describe un caso el cual fue refractario al tratamiento convencional y en que se plantean nuevas estrategias de manejo.
Revista Colombiana De Cardiologia, Jun 1, 2012
Revista Urologia Colombiana, 2012
Diseño del estudio: Observacional descriptivo Nivel de evidencia: III El autor declara que no tie... more Diseño del estudio: Observacional descriptivo Nivel de evidencia: III El autor declara que no tiene conflicto de interés.
Revista Colombiana de Cardiología, 2012
Cirugía ( …, 1990
Base de dados : LILACS. Pesquisa : 85731 [Identificador único]. Referências encontradas : 1 [refi... more Base de dados : LILACS. Pesquisa : 85731 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 85731. ...
Modern Pathology, 2010
Gene amplification is a process that is characterized by an increase in the copy number of a rest... more Gene amplification is a process that is characterized by an increase in the copy number of a restricted region in a chromosome arm, and is frequently associated with an overexpression of the corresponding amplified gene. Amplified DNA can be organized either as extrachromosomal elements, repeated units at a single locus or scattered throughout the genome. The amplification of the gene for epidermal growth factor receptor (EGFR) is a common finding in glioblastomas and the amplified gene copies appears as double minutes. The aim of this study was to investigate the different patterns of EGFR amplification in 40 cases of glioblastoma using FISH analysis in metaphases and paraffin sections, and to investigate the relationship of gene copy number with gene expression profile. The analysis of copy number alterations of EGFR was validated by quantitative PCR and SNP microarrays. We observed that in 42% of the cases, the type of amplification of EGFR was as double minute chromosomes. In addition, we detected another type of amplification, with extra copies of EGFR inserted in different loci of chromosome 7, present in 28% of cases. In this form of amplification, the number of copies is small, and the percentage of cells with EGFR amplification is rarely more than 15%. This model of amplification could correspond to a variant of the insertion mechanism, or a consequence of a process of duplication. Our results suggest that this mechanism could represent an early stage of amplification in glioblastomas. Overall, we found a close correlation between EGFR gene copy-number alterations and the level of EGFR protein expression. However, all cases with a high level of mRNA exhibited strong expression for the EGFR protein, and most cases with a low level of mRNA showed no overexpression of EGFR protein.
Journal of Paediatrics and Child Health, 2014
To evaluate paediatricians&#3... more To evaluate paediatricians' perceived effectiveness of an online psychosocial intervention for children with recurrent abdominal pain (RAP). Also, to explore which elements of this intervention they would consider necessary when applied in the clinical context. A total of 131 paediatricians affiliated to Catalan and Balearic paediatric societies completed an online survey about how effective they would perceive an online psychosocial intervention for RAP (for reducing pain intensity, reducing disability and preventing chronicity) and how this intervention should be carried out. They were asked about the perceived effectiveness of the standard medical treatments they routinely applied for RAP and also their opinion of face-to-face psychosocial interventions. A face-to face psychosocial intervention was considered better (to reduce pain intensity, reduce disability and prevent chronic pain) than an online psychological intervention and the standard medical treatment. Online and face-to-face psychosocial interventions are considered equally useful for children with mild disability, but a face-to-face psychosocial intervention is considered better for those with moderate and severe levels of disability. Paediatricians considered that an online psychosocial intervention for children with RAP should be simple and consistent; it should provide easy access for users; and its interface should be easy to use and attractive. Paediatricians show a positive attitude towards a potential online psychosocial intervention for children and adolescents with RAP. However, they do not use the Internet for offering health care, and they would prefer a face-to-face psychosocial intervention.
Database, 2012
The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, ... more The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, as well as transcriptomic and clinical information from brain tumour patients, with the purpose of improving the diagnostic and prognostic evaluation of future patients. In order to carry this out, among other work, a database-the eTDB-was developed. In addition to complex permission rules and software and management quality control (QC), it was necessary to develop anonymization, processing and data visualization tools for the data uploaded. It was also necessary to develop sophisticated curation strategies that involved on one hand, dedicated fields for QC-generated meta-data and specialized queries and global permissions for senior curators and on the other, to establish a set of metrics to quantify its contents. The indispensable dataset (ID), completeness and pairedness indices were set. The database contains 1317 cases created as a result of the eT project and 304 from a previous project, INTERPRET. The number of cases fulfilling the ID was 656. Completeness and pairedness were heterogeneous, depending on the data type involved.
Arquivos de Gastroenterologia, 2010
CONTEXT: Chronic diseases have an impact on the quality of life of the individuals. OBJECTIVE: To... more CONTEXT: Chronic diseases have an impact on the quality of life of the individuals. OBJECTIVE: To evaluate the quality of life of adults with inflammatory bowel disease by the inflammatory bowel disease questionnaire certified for Portuguese language. METHODS: We interviewed 50 individuals from both genders aged from 18 to 60 years old, with Crohn's disease and ulcerative colitis, regardless of disease activity. RESULTS: The average age of the sample was 42.2 ± 13.6 years old, the disease length was 98.8 ± 74.3 months, and 72% of patients had Crohn's disease and 14% presented disease activity. There was no significant difference in questionnaire scores of patients with different inflammatory bowel disease when they are in the remission phase (172.0 ± 42.4 and 173.6 ± 28.2 for ulcerative colitis and Crohn's disease, respectively, P = 0.886). When compared to scores of patients who were in crisis, it was found that they have a lower quality of life that patients in remissi...
Cuad Med Psicosom Psiquiatr Enl, 2007
... Los hallazgos de investigaciones de labo-ratorio, en las que el dolor es inducido a sujetos s... more ... Los hallazgos de investigaciones de labo-ratorio, en las que el dolor es inducido a sujetos sanos que participan voluntariamente, confir-man la utilidad y versatilidad de la realidad virtual para facilitar el control del dolor. Palabras clave: Dolor. Distracción. Realidad virtual. ...
Uploads
Papers by Ruben Dario Gomez Luna