Papers by Roger R Connelly, Sr.
Cancer, 1973
Availa 11 le Eflidern io logic In f wma t ion and Its Implications Cancer of the pancreas is the ... more Availa 11 le Eflidern io logic In f wma t ion and Its Implications Cancer of the pancreas is the fourth leading cause of death a m o n g all sites of cancer i n the United States. Very little is known about the epidemiology of the disease. Available d a t a on incidence and mortality are examined to determine epidemiologic patterns. Racial differences in incidence/mortality d a t a and their relation t o industrial hazards, quality of medical care, a n d geographic distribu-:ion af cancer are discussed. T h e need for more definitive studies is noted, and suggestions for areas of f u t u r e work are made. ANCER OF T H E PANCREAS IS THE FOURTH C leading cause of death among all sites of cancer in the United States.'o This year approximately 19,000 persons will die of the disease in this country. The incidence and associated mortality of the disease are rising, while attempts at earlier diagnosis and better treatment have not kept pace. There has been no appreciable change in prognosis. T h e I-year and 5-year relative survival rates have been about 10% and 2%, respectively, for the past three c1ecades.l Information on the epidemiology of the disease is scanty. Our purpose here is to describe trends and patterns in reported incidence and mortality data for pancreatic cancer and, by posing questions and speculating on the meanings of the data, to help stimulate ideas €or future study. SOURCES OF DATA When studying the etiology of a disease, we ideally wish to know the incidence rate, i.e., Based on papers presentecl at the American Cancer Society Conference on Cancer of the Pancreas, March 1972.
JNCI: Journal of the National Cancer Institute, 1961
Gastroenterology, 1968
for permission to utilize data from the Connecticut Tumor Registry. The authors also wish to than... more for permission to utilize data from the Connecticut Tumor Registry. The authors also wish to thank Mrs. Barbara Hooper and Miss Arline Di-Marzio for secretarial assistance. 677 ' 40. The Portland Smgical Society. 1967. A tenyear experience with carcinoma of t he pancreas. Arch. Surg. (Chicago) 94: 322-325.
SUMMARY-This study conArms the major finding of Ederer and Mers-heimer that, among surgically tre... more SUMMARY-This study conArms the major finding of Ederer and Mers-heimer that, among surgically treated patients with cancer of the lung, women have a more favorable prognosis, particularly when there is no evidence of spread beyond the lung. When adjustment was made for "normal mortality expectation " through the use of the relative survival rate, liHle correlation was found between age at diagnosis and survival. A marked difference was found between male and female patients with respect to histologic type. Adenocarcinomas and alveolar cell tumors accounted for a larger proportion of cases in women. Among patients with adenocarcinomas and alveolar cell tumors, survival rates were substantially higher in women-in localized cases as well as for all stages combined. Among patients with epidermoid carcinomas, survival rates in men and women were similar. Lobectomy was employed more frequently in treatment of women. This was associat~d with more frequent occurrence of adenocarci...
Medical Imaging 1999: Image Display, 1999
ABSTRACT
Oncology Reports, 2003
Several investigators have reported the correlation of p53 and bcl-2 immunoreactivity with post o... more Several investigators have reported the correlation of p53 and bcl-2 immunoreactivity with post operative prostate specific antigen (PSA) recurrence. Focal and or clustered expression is typical for these biomarkers. The purpose of this study was to compare the effectiveness of tissue microarrays to detect p53 and bcl-2 overexpression and their prognostic significance. Tissue microarrays (TMA) of 99 patients with mean follow-up of 61 months contained 760 samples from 241 carcinomas, 431 benign glands, and 88 foci of prostatic intraepithelial neoplasia (PIN). Overexpression of p53 was seen in 43.3% of 97 patients, whereas bcl-2 overexpression was noted in 23.7% of 97 patients using TMA technology, compared to 66.0% and 26.9%, respectively in the corresponding radical prosta tectomy samples. The tissue microarray technology is a powerful tool to study the multifocal and heterogeneous nature of prostate cancer. However, the prognostic value of p53 and bcl-2 could not be confirmed using this technology in contrast to radical prostatectomy sections. The TMA technique is probably more informative and reliable in evaluating the prognostic value of homogeneously expressed biomarkers.
Cancer, 2001
BACKGROUND. The objective was to compare the changes in pathologic and clinical data over time fo... more BACKGROUND. The objective was to compare the changes in pathologic and clinical data over time for African-American (AA) and white men with prostate carcinoma undergoing radical prostatectomy in an attempt to determine the early impact of prostate specific antigen (PSA). METHODS. Data from 195 AA and 587 white men who underwent radical prostatectomy from 1988 to 1999 in an equal access, tertiary, military medical facility were collected. Statistical analysis was used to determine the significance of the changes in the rates of extracapsular extension (ECE), positive margins, pretreatment PSA levels, and age at the time of surgery for each race over time. RESULTS. Comparing 1988-99 results, the authors found that the percentage of AA men with ECE decreased from 100% to 34.8% (P ϭ 0.007), and for white men from 56.9% to 43.2% (P ϭ 0.269). The percentage of AA men with positive margins decreased from 100% to 26.1% (P Ͻ 0.0001), and for white men from 41.2% to 27.0% (P ϭ 0.021).
Annals of Internal Medicine, 1989
To determine what factors correlated with the failure of the survivors of childhood cancer to ack... more To determine what factors correlated with the failure of the survivors of childhood cancer to acknowledge their diagnosis. A follow-up interview with 1928 adults who survived childhood cancer to evaluate the late effects of cancer and its treatment. Cancer was diagnosed in these survivors between 1945 and 1974 before they reached age 20: subjects had to have survived for at least 5 years and to have reached age 21. Fourteen percent of the survivors of malignancies at sites other than the central nervous system said that they had not had cancer. This proportion differed according to the survivors' race, the type of tumor and its treatment, the level of their father's education, the year of diagnosis, and the center where the tumor was diagnosed. Among survivors who knew that they had cancer previously, however, most (81%) correctly identified the type of treatment they had received. Physicians should be aware that a substantial proportion of long-term survivors of childhood cancer may not reveal their past history of cancer and its treatment, and possible clues to the cause of the presenting condition may thus be missed.
American Journal of Industrial Medicine, 1986
Mesothelioma incidence rates based on data from population-based cancer registries in New York St... more Mesothelioma incidence rates based on data from population-based cancer registries in New York State (exclusive of New York City), Los Angeles County, California, and the SEER Program of the National Cancer Institute were analyzed for trends, using original cancer registry diagnoses. Results indicate a significant increase in incidence during 1973-80 for pleural mesothelioma among white males older than 55 at time of diagnosis but not for other age-race-sex-site subgroups. A histopathologic review of New York State and Los Angeles County cases by two independent pathologists, expert in the diagnosis of mesothelioma, lowered the overall estimates but a significant upward trend remained. The observed trend does not appear to be related to changes in diagnostic practice. The results of a five-member panel of expert pathologists will be published in a separate methodology paper.
The American Journal of Human Genetics, 1998
The Journal of Urology, 1968
American Journal of Obstetrics and Gynecology, Mar 31, 1992
Basic Life Sciences, Feb 1, 1982
Urologic Oncology, 2003
Radical retropubic prostatectomy (RRP) pathology from African American (AA) and White men from 19... more Radical retropubic prostatectomy (RRP) pathology from African American (AA) and White men from 1988 to 1999 was examined to determine if the pre-treatment factors PSA, clinical stage, biopsy grade, age at surgery, and year of surgery (YOS) were predictive of extracapsular extension (ECE) and positive margins for each ethnic group. Clinical and pathologic data was collected on 179 AA and 548 white men undergoing RRP from 1988 to 1999 at a tertiary military medical facility. Logistic regression with multivariate analysis was used to determine which pre-operative data-points were predictive of pathologic ECE and positive margins for each ethnic group. PSA, biopsy grade, age, and YOS (more recent years had better surgical pathology) were predictive of ECE for AA and white men. PSA, biopsy grade, and YOS were predictive of positive margins for AA men, while PSA and YOS were predictive of positive margins for white men. PSA continues to be a strong predictor of ECE and positive margins for both AA and white men. However, we describe for the first time, YOS being predictive of ECE and positive margins for both AA and White men, using multivariate regression analysis. This is thought to be reflective of the improving public awareness of prostate cancer that has occurred during the PSA-era, resulting in patients participating in screening programs and being diagnosed earlier. Close follow-up of these patients is warranted to determine if the improved pathologic stage of those patients treated more recently translates into improved disease-specific mortality.
Urology, Nov 1, 2002
Objectives. To determine how the implementation of prostate-specific antigen (PSA) testing has af... more Objectives. To determine how the implementation of prostate-specific antigen (PSA) testing has affected disease-specific survival and other characteristics of prostate cancer. Methods.
Cancer Research, May 1, 1974
Reports of 4,529 cases of infectious mononucleosis diag nosed during the years 1948-1964 among re... more Reports of 4,529 cases of infectious mononucleosis diag nosed during the years 1948-1964 among residents of Connecticut were identified through existing records and matched against a register of cancer cases covering the same population. The overall cancer risk following infectious mononucleosis was increased with 33 cancers observed compared to 24.4 expected for a relative risk of 1.4. Although this increased cancer risk was not large and may easily have occurred by chance, larger relative risks were found for certain forms of cancer, particularly malignant lymphomas (7 observed, 1.9 expected, relative risk = 3.7). The most provocative finding of this study was that five cases of Hodgkin's disease developed subsequent to infec tious mononucleosis.
Medical and Pediatric Oncology, 1992
Because of their increased risk for second cancers, childhood cancer survivors are people who rea... more Because of their increased risk for second cancers, childhood cancer survivors are people who really should not smoke, but available evidence suggests that they do. We studied the smoking habits of long-term childhood cancer survivors in data collected from 1289 adult survivors of childhood cancer and 1930 of their sibling controls. Survivors were diagnosed with cancer between 1945 and 1974 when they were less than 20 years old. Using matched analyses that controlled for the influence of family, survivors were 8% less likely than controls to be current smokers, 13% less likely to be ever-smokers, but 12% less likely to have quit smoking; these differences were not statistically significant. In a logistic regression analysis there was a significant difference by year of diagnosis for current smoking rate ratios (RR); survivors were less likely to be current smokers if diagnosed in recent years (RR = 0.76; 95% confidence intervals = 0.58-0.98, between 1965-74) and quite similar to controls if diagnosed in earlier years (RR = 1.05 between 1945 and 1954). In our group of long-term cancer survivors, the reduction in current smoking came about because survivors were more inclined never to start smoking than controls. Once addicted to tobacco, they were less likely to quit. While the fact that survivors are less likely to start smoking is encouraging, the persistence of smoking habits strongly suggests the need for continuing efforts to prevent smoking in this most vulnerable group.
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Papers by Roger R Connelly, Sr.