Papers by Harry Robberecht
Pharmacology, 1982
Perfusion o f the Fourth Cerebral Ventricle with the Synthetic Opioid Peptide, FK. 33-824. Induce... more Perfusion o f the Fourth Cerebral Ventricle with the Synthetic Opioid Peptide, FK. 33-824. Induces Dose-Related Bradycardia and Naloxone-Reversible Respiratory Depression in the Awake Dog Freye, E.
American Journal of Pharmacology and Toxicology, 2007
Simple, accurate, sensitive and selective methods are described for the quantitative determinatio... more Simple, accurate, sensitive and selective methods are described for the quantitative determination of ten fluoroquinolones (amifloxacin, ciprofloxacin hydrochloride, difloxacin hydrochloride, enoxacin, enrofloxacin, lomefloxacin hydrochloride, levofloxacin, norfloxacin, ofloxacin and pefloxacin mesylate). The methods are based on precipitation of the ion associates formed from the reaction of the cited drugs with silver nitrate, copper acetate and ferric chloride. The formation and solubility of the solid complexes at the optimum conditions of pH and ionic strength values have been studied. The methods depend on direct determination of the ions in the precipitate or indirect determination of the ions in the filtrate by atomic absorption spectroscopy. The optimum conditions for precipitation were carefully studied. Rectilinear calibration graphs were obtained in the range of 10-100 ng.ml-1 for each of the investigated drugs and the limits of detection and quantitation ranged from 1.125 to 2.260, o.937 to 2.754 and from 3.425 to 5.986 ng.ml-1 , respectively. The molar ratios of the formed chelats were determined by Job's method and their association constants were also calculated. The developed methods were applied successfully for the determination of the studied drugs in their pharmaceutical dosage forms with good precision and accuracy compared to official and reported methods as revealed by t-and F-tests. They were also applied for the determination of studied drugs in spiked urine and plasma samples.
Mode operatoire et resultats du dosage par spectrometrie d'absorption atomique du selenium, d... more Mode operatoire et resultats du dosage par spectrometrie d'absorption atomique du selenium, du zinc et du cuivre dans les feuilles de 9 legumes consommes au Zaire
Molecules, 2020
In this study, we critically review the literature concerning the relation of Mg, Fe, Zn, Cu and ... more In this study, we critically review the literature concerning the relation of Mg, Fe, Zn, Cu and Se and attention-deficit/hyperactivity disorder (ADHD). Elemental status is estimated using peripheral blood parameters, hair, urine, daily intake and response to supplementation. The observed associations between concentration levels of the elements Mg, Fe, Zn, Cu and Se and ADHD symptoms are contradictory. This is partly due to the heterogeneity and complexity of the disorder. As a trend, lower ferritin and zinc levels can be observed. However, this correlation is not causative, as illustrated by placebo-controlled trials reporting conflicting evidence on the efficacy of supplementation. Well-defined studies on changes in concentration levels of the elements in relation to ADHD symptoms before and after treatment with therapeutics it will be possible to shed more light on the significance of these elements in this behavioral disorder. The discussion on whether a change in concentration...
Metabolic Syndrome and Related Disorders, 2016
Biomarkers of the metabolic syndrome are divided into four subgroups. Although dividing them in g... more Biomarkers of the metabolic syndrome are divided into four subgroups. Although dividing them in groups has some limitations, it can be used to draw some conclusions. In a first part, the dyslipidemias and markers of oxidative stress are discussed, while inflammatory markers and cardiometabolic biomarkers are reviewed in a second part. For most of them, the biochemical background and clinical significance are discussed, although here also a well-cut separation cannot always be made. Altered levels cannot always be claimed as the cause, risk, or consequence of the syndrome. Several factors are interrelated to each other and act in a concerted, antagonistic, synergistic, or modulating way. Most important conclusions are summarized at the end of every reviewed subgroup. Genetic biomarkers or influences of various food components on concentration levels are not included in this review article.
Trace Elements and Electrolytes, 2008
Journal of trace elements and electrolytes in health and disease, 1994
Selenium levels in venous and capillary whole blood of children were assessed by direct graphite ... more Selenium levels in venous and capillary whole blood of children were assessed by direct graphite furnace atomic absorption spectrometry. Selenium data obtained for both blood samples did not differ statistically (p > 0.05). Capillary blood may therefore be used as an alternative to venous blood, which is more difficult to obtain from children. Whole-blood selenium data for children in the Antwerp region (Belgium) were compared with literature data for children from other countries.
Journal of trace elements and electrolytes in health and disease, 1990
Direct graphite furnace atomic absorption spectrometry after appropriate sample dilution is appli... more Direct graphite furnace atomic absorption spectrometry after appropriate sample dilution is applied to whole blood of Belgian blood bank donors from different geographical areas. Highest values were obtained for the northern part of the country (Flanders). Different consumption habits may explain the significant difference in selenium level found for the two cultural communities (Flemish and Walloon). No sex difference was obtained in both parts of the country and no influence of age was observed for the two communities. Values obtained are compared with literature data on whole blood selenium content for other European countries.
Trace Elements in Man and Animals 10, 2002
Science of The Total Environment, 1993
Daily dietary intake of copper, zinc and selenium for different population groups in Burundi, Afr... more Daily dietary intake of copper, zinc and selenium for different population groups in Burundi, Africa, has been determined, using different sampling strategies, by atomic absorption spectrometry. Recommended daily intakes (RDA, National Academy, USA) are met for copper and zinc. For selenium, especially the rural population risk a deficiency as observed with a daily intake of 17 micrograms. The importance of different types of food in daily intake is discussed. Legumes proved to be an important source of copper, while for selenium fish contributes in a large part in dietary intake. Calculated total daily intakes are compared with intakes recently published for other countries.
Science of The Total Environment, 1995
Copper, zinc and selenium were measured in a total of 47 samples of human milk from five middle-c... more Copper, zinc and selenium were measured in a total of 47 samples of human milk from five middle-class women from Burundi, Africa. Milk samples were taken from day 2 after delivery to 10 months postpartum. Copper and zinc were analyzed by flame atomic absorption spectromet~, while a hydride generation mode was used for selenium. The average copper concentration declined from 0.59 + 0.01 pg ml-' at day 2 to 0.08 k 0.04 fig mi-r after 10 months of lactation. Zinc levels decreased from a mean of 3.8 & 0.5 pg ml-' to 0.75 f 0.02 pg ml-" after 10 months. For selenium, the concentration at day 2 (15.2 k 2.3 ng ml-') declined only after 2 weeks to a value of 5.2 ng ml-' 10 months postpartum. For copper a diurnal variation was observed. Compared to literature data, copper and zinc levels in ~u~ndian women proved to be in the normal range, while selenium concentration levels were at a lower level.
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Papers by Harry Robberecht