Introduction Iron deficiency anaemia (IDA) is one of the most common health problems worldwide, i... more Introduction Iron deficiency anaemia (IDA) is one of the most common health problems worldwide, its prevalence is up to 1 in 5 of the general population. The diagnosis of absolute iron deficiency is easy unless the condition is masked by inflammatory conditions. All cases of iron deficiency should be assessed for treatment and underlying cause.In developing countries, iron deficiency anemia is nutritional, resulting from reduced intake of bioavailable iron , and often associated with infections causing hemorrhages, such as hookworm infestation . In Western societies, other than in individuals at risk, iron depletion results from chronic bleeding and/or reduced iron absorption, disorders that may be more relevant than anemia itself.The association between IDA and lymphocytopenia is poorly addressed in the literature. Objective: To assess the prevalence of lymphocytopenia in a large cohort with IDA and to study the effect of iron replacement on lymphocytes count. Materials and Methods...
Introduction Severe IDA can cause many complications and impair the quality of life. Iron is an e... more Introduction Severe IDA can cause many complications and impair the quality of life. Iron is an essential micronutrient required for catalysis, DNA synthesis, redox reactions and oxygen transport1. It is important for an early step in embryonic haematopoiesis, which is common for all developing blood cells. The link between IDA and leukopenia is not well recognized in the literature. Objectives To assess the prevalence and clinical significance of leukopenia in patients with IDA and effect of iron replacement and correction of anemia on the WBCs count. Materials and Methods We retrospectively reviewed the electronic medical records of all patients attended haematology clinic with the diagnosis of iron deficiency anemia (IDA) over 2 years in Hamad Medical Corporation, Qatar. All other causes of anemia and patients with systemic or chronic diseases were excluded. Age, nationality, BMI, Complete blood count and iron parameters were collected before and after treatment with IV iron ther...
Prevalence of Thrombocytopenia among Iron Deficiency Anemia in Arab population in Qatar INTRODUCT... more Prevalence of Thrombocytopenia among Iron Deficiency Anemia in Arab population in Qatar INTRODUCTION / BACKGROUND Iron deficiency anemia is a common cause of anemia, and account for almost half of the causes of all anemias. It is well known and common that iron deficiency anemia can be with thrombocytosis, A study reviewed 450 patients with a diagnosis of anemia between 2002 and 2006 was performed in which 143 of them were having IDA found that 31% of them were having associated thrombocytosis (4). A retrospective study conducted in Turkey found that Iron deficiency anemia and thrombocytopenia found in 13 from 615 patients (2.1%) (5). IDA and thrombocytopenia are found in certain ethnicity where we don t have data from studies about Arab Population. Materials and Methods We retrospectively reviewed the electronic medical records of patients attended hematology/ IV iron room clinics with the diagnosis of IDA over 2 years from the period between December 2017 to December 2019 in Hamad...
INTRODUCTION Iron deficiency is the most prevalent nutritional deficiency worldwide. Iron deficie... more INTRODUCTION Iron deficiency is the most prevalent nutritional deficiency worldwide. Iron deficiency anemia (IDA) is the most common type of anemia, its prevalence is 1 out of 5 of the population. IDA is a well-known cause of reactive thrombocytosis which is mostly asymptomatic. Only few observational studies and case reports have described thromboembolic events in the context of this reactive thrombocytosis in the absence of other hypercoagulable states OBJECTIVES To assess the frequency of thromboembolic events in Arab patients with reactive thrombocytosis secondary to iron deficiency anemia (IDA). METHODS We retrospectively reviewed thromboembolic events in iron-deficient patients with reactive thrombocytosis. Our study sample included female patients who received iron replacement for IDA between April 2018 and March 2020 at Hamad Medical Corporation, Doha, Qatar. We excluded pregnant, non-Arab patients and patients under 18 or over 65 years of age. Reactive thrombocytosis was de...
Introduction Iron deficiency anaemia (IDA) is one of the most common health problems worldwide, i... more Introduction Iron deficiency anaemia (IDA) is one of the most common health problems worldwide, its prevalence is up to 1 in 5 of the general population. The diagnosis of absolute iron deficiency is easy unless the condition is masked by inflammatory conditions. All cases of iron deficiency should be assessed for treatment and underlying cause.In developing countries, iron deficiency anemia is nutritional, resulting from reduced intake of bioavailable iron , and often associated with infections causing hemorrhages, such as hookworm infestation . In Western societies, other than in individuals at risk, iron depletion results from chronic bleeding and/or reduced iron absorption, disorders that may be more relevant than anemia itself.The association between IDA and lymphocytopenia is poorly addressed in the literature. Objective: To assess the prevalence of lymphocytopenia in a large cohort with IDA and to study the effect of iron replacement on lymphocytes count. Materials and Methods...
Case Report IJCR (2020) 4:161 COVID-19 infection In Beta Thalassemia Major: Case series COVID-19 ... more Case Report IJCR (2020) 4:161 COVID-19 infection In Beta Thalassemia Major: Case series COVID-19 infection was first described in Wuhan, China after an increasing spread of atypical pneumonia of unknown pathogen. Unfortunately, this novel virus continues spreading causing a pandemic. Thalassemia considered one of the most common hemoglobinopathies. Beta thalassemia is the commonest type with a variety in clinical picture due to the deference in homozygous. A lot of vulnerable categories were at high risk of getting infected with the coronavirus and more even its complication. Despite the conflicting data and ongoing research on this topic, thalassemia patients were categorized among the high-risk population. Here we present a case series describing the clinical progression of two splenectomised patients who has transfusion dependent beta thalassemia major.
COVID-19 infection was first described in Wuhan, China after an increasing spread of atypical pne... more COVID-19 infection was first described in Wuhan, China after an increasing spread of atypical pneumonia of unknown pathogen. Unfortunately, this novel virus continues spreading causing a pandemic. Thalassemia considered one of the most common hemoglobinopathies. Beta thalassemia is the commonest type with a variety in clinical picture due to the deference in homozygous. A lot of vulnerable categories were at high risk of getting infected with the coronavirus and more even its complication. Despite the conflicting data and ongoing research on this topic, thalassemia patients were categorized among the high-risk population. Here we present a case series describing the clinical progression of two splenectomised patients who has transfusion dependent beta thalassemia major.
IntroductionIron deficiency anemia (IDA) is the most common cause of anemia in both developed and... more IntroductionIron deficiency anemia (IDA) is the most common cause of anemia in both developed and developing countries. Leukopenia is an infrequent side effect of iron therapy reported in the literature as sporadic cases. We conducted a study to clarify this issue and to check its consequences in a big cohort of patients with IDA.ObjectiveTo assess the relationship between iron therapy (intravenous) and leukopenia, neutropenia or lymphocytopenia, and its clinical impact, if any, on patients.Materials and Methodsthis is a retrospective study conducted in Hamad Medical Corporation, Doha/Qatar. the clinical and biochemical data of 1567 females with IDA who attended the hematology clinic and were treated with intravenous iron therapy were collected and analysed. Complete and differential blood counts and iron profile were studied before and after iron treatment. In addition, cases who developed infections during the time of leukopenia were noted and checked for possible complications.Re...
Introduction Iron deficiency anemia (IDA) is a major public health issue, with widespread prevale... more Introduction Iron deficiency anemia (IDA) is a major public health issue, with widespread prevalence and negative impact on health care system. IDA occurs when iron stores diminish to the level that disturbs erythropoiesis and causes anemia. Neutropenia is an abnormal reduction in the number of neutrophils. A little is known about the association between iron deficiency anemia and neutropenia. The aim of this study is to investigate the prevalence of neutropenia in a large cohort of adult patients with IDA and to find possible correlation between neutrophil levels with haemoglobin concentration and iron stores. We studied associated infections in this neutropenic group. Materials and Methods We retrospectively reviewed the electronic medical records of 1567 patients attended haematology clinic with the diagnosis of IDA ((haemoglobin level less than 12 gm/dl for women, less than 13 gm/dl for men) over the past 2 years in Hamad Medical Corporation, Qatar. Other causes of anemia and an...
To optimize care for patients with hemoglobinopathies, frequent screening for COVID‐19 is prudent... more To optimize care for patients with hemoglobinopathies, frequent screening for COVID‐19 is prudent as viral kinetics in asplenic patients are unknown and differentiating prolonged viral shedding versus reinfection remains a challenge.
Hematologic malignancies are becoming more prevalent, manifesting in various clinical scenarios. ... more Hematologic malignancies are becoming more prevalent, manifesting in various clinical scenarios. Chronic myelogenous leukemia (CML) is usually diagnosed on routine complete blood count as it is typically asymptomatic. However, it can cause multiple signs and symptoms. We present a patient with appendicitis revealing CML during his workup for abdominal pain.
All people including those with Haemoglobinopathies are at risk of COVID-19 infection. Though tho... more All people including those with Haemoglobinopathies are at risk of COVID-19 infection. Though those patients were considered vulnerable, a clear prognosis, as well as the possibility of reinfection, was not mentioned before. We report here the first case of Thalassemia beta major who had COVID-19 reinfection detected by screening. Introduction: Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-COV2) was responsible for the latest outbreak recently, presenting as mainly respiratory symptoms and carrying high mortality rate[1]. COVID-19 put all people at risk of being infected including haemoglobinopathies patients. Multiple factors among those patients increase their risk for infections yet the occurrence of reinfection and it is implication on them, and the community were not described before. Thalassemia is one of the most common haemoglobinopathies and requires lifelong management and follow up. Splenectomy, regular blood transfusion and iron chelation therapy are essential components in the management plan. Unfortunately, they cause some complications on the long term and might raise the slurpability of current reinfection[2]. The impact of these factors on COVID-19 infection is not well known yet. Here we present a case of 31-year-old splenectomized lady with transfusion dependent Beta Thalassemia Major had COVID-19 infection recurrence detected by screening. In this article we are discussing the possibility behind COVID-19 reinfection in thalassemia patients. Case presentation: A 31-year-old Pakistani lady with past medical history of transfusion dependent Beta Thalassemia major, type II diabetes Mellitus and hypothyroidism visited our hematology department for follow up and routine blood transfusion. Due to the ongoing spread of COVID-19 infection in Qatar, PCR via nasopharyngeal swap was done as part of the local screening plan before admission in day care for the blood transfusion and tested positive.
Introduction Iron deficiency anaemia (IDA) is one of the most common health problems worldwide, i... more Introduction Iron deficiency anaemia (IDA) is one of the most common health problems worldwide, its prevalence is up to 1 in 5 of the general population. The diagnosis of absolute iron deficiency is easy unless the condition is masked by inflammatory conditions. All cases of iron deficiency should be assessed for treatment and underlying cause.In developing countries, iron deficiency anemia is nutritional, resulting from reduced intake of bioavailable iron , and often associated with infections causing hemorrhages, such as hookworm infestation . In Western societies, other than in individuals at risk, iron depletion results from chronic bleeding and/or reduced iron absorption, disorders that may be more relevant than anemia itself.The association between IDA and lymphocytopenia is poorly addressed in the literature. Objective: To assess the prevalence of lymphocytopenia in a large cohort with IDA and to study the effect of iron replacement on lymphocytes count. Materials and Methods...
Introduction Severe IDA can cause many complications and impair the quality of life. Iron is an e... more Introduction Severe IDA can cause many complications and impair the quality of life. Iron is an essential micronutrient required for catalysis, DNA synthesis, redox reactions and oxygen transport1. It is important for an early step in embryonic haematopoiesis, which is common for all developing blood cells. The link between IDA and leukopenia is not well recognized in the literature. Objectives To assess the prevalence and clinical significance of leukopenia in patients with IDA and effect of iron replacement and correction of anemia on the WBCs count. Materials and Methods We retrospectively reviewed the electronic medical records of all patients attended haematology clinic with the diagnosis of iron deficiency anemia (IDA) over 2 years in Hamad Medical Corporation, Qatar. All other causes of anemia and patients with systemic or chronic diseases were excluded. Age, nationality, BMI, Complete blood count and iron parameters were collected before and after treatment with IV iron ther...
Prevalence of Thrombocytopenia among Iron Deficiency Anemia in Arab population in Qatar INTRODUCT... more Prevalence of Thrombocytopenia among Iron Deficiency Anemia in Arab population in Qatar INTRODUCTION / BACKGROUND Iron deficiency anemia is a common cause of anemia, and account for almost half of the causes of all anemias. It is well known and common that iron deficiency anemia can be with thrombocytosis, A study reviewed 450 patients with a diagnosis of anemia between 2002 and 2006 was performed in which 143 of them were having IDA found that 31% of them were having associated thrombocytosis (4). A retrospective study conducted in Turkey found that Iron deficiency anemia and thrombocytopenia found in 13 from 615 patients (2.1%) (5). IDA and thrombocytopenia are found in certain ethnicity where we don t have data from studies about Arab Population. Materials and Methods We retrospectively reviewed the electronic medical records of patients attended hematology/ IV iron room clinics with the diagnosis of IDA over 2 years from the period between December 2017 to December 2019 in Hamad...
INTRODUCTION Iron deficiency is the most prevalent nutritional deficiency worldwide. Iron deficie... more INTRODUCTION Iron deficiency is the most prevalent nutritional deficiency worldwide. Iron deficiency anemia (IDA) is the most common type of anemia, its prevalence is 1 out of 5 of the population. IDA is a well-known cause of reactive thrombocytosis which is mostly asymptomatic. Only few observational studies and case reports have described thromboembolic events in the context of this reactive thrombocytosis in the absence of other hypercoagulable states OBJECTIVES To assess the frequency of thromboembolic events in Arab patients with reactive thrombocytosis secondary to iron deficiency anemia (IDA). METHODS We retrospectively reviewed thromboembolic events in iron-deficient patients with reactive thrombocytosis. Our study sample included female patients who received iron replacement for IDA between April 2018 and March 2020 at Hamad Medical Corporation, Doha, Qatar. We excluded pregnant, non-Arab patients and patients under 18 or over 65 years of age. Reactive thrombocytosis was de...
Introduction Iron deficiency anaemia (IDA) is one of the most common health problems worldwide, i... more Introduction Iron deficiency anaemia (IDA) is one of the most common health problems worldwide, its prevalence is up to 1 in 5 of the general population. The diagnosis of absolute iron deficiency is easy unless the condition is masked by inflammatory conditions. All cases of iron deficiency should be assessed for treatment and underlying cause.In developing countries, iron deficiency anemia is nutritional, resulting from reduced intake of bioavailable iron , and often associated with infections causing hemorrhages, such as hookworm infestation . In Western societies, other than in individuals at risk, iron depletion results from chronic bleeding and/or reduced iron absorption, disorders that may be more relevant than anemia itself.The association between IDA and lymphocytopenia is poorly addressed in the literature. Objective: To assess the prevalence of lymphocytopenia in a large cohort with IDA and to study the effect of iron replacement on lymphocytes count. Materials and Methods...
Case Report IJCR (2020) 4:161 COVID-19 infection In Beta Thalassemia Major: Case series COVID-19 ... more Case Report IJCR (2020) 4:161 COVID-19 infection In Beta Thalassemia Major: Case series COVID-19 infection was first described in Wuhan, China after an increasing spread of atypical pneumonia of unknown pathogen. Unfortunately, this novel virus continues spreading causing a pandemic. Thalassemia considered one of the most common hemoglobinopathies. Beta thalassemia is the commonest type with a variety in clinical picture due to the deference in homozygous. A lot of vulnerable categories were at high risk of getting infected with the coronavirus and more even its complication. Despite the conflicting data and ongoing research on this topic, thalassemia patients were categorized among the high-risk population. Here we present a case series describing the clinical progression of two splenectomised patients who has transfusion dependent beta thalassemia major.
COVID-19 infection was first described in Wuhan, China after an increasing spread of atypical pne... more COVID-19 infection was first described in Wuhan, China after an increasing spread of atypical pneumonia of unknown pathogen. Unfortunately, this novel virus continues spreading causing a pandemic. Thalassemia considered one of the most common hemoglobinopathies. Beta thalassemia is the commonest type with a variety in clinical picture due to the deference in homozygous. A lot of vulnerable categories were at high risk of getting infected with the coronavirus and more even its complication. Despite the conflicting data and ongoing research on this topic, thalassemia patients were categorized among the high-risk population. Here we present a case series describing the clinical progression of two splenectomised patients who has transfusion dependent beta thalassemia major.
IntroductionIron deficiency anemia (IDA) is the most common cause of anemia in both developed and... more IntroductionIron deficiency anemia (IDA) is the most common cause of anemia in both developed and developing countries. Leukopenia is an infrequent side effect of iron therapy reported in the literature as sporadic cases. We conducted a study to clarify this issue and to check its consequences in a big cohort of patients with IDA.ObjectiveTo assess the relationship between iron therapy (intravenous) and leukopenia, neutropenia or lymphocytopenia, and its clinical impact, if any, on patients.Materials and Methodsthis is a retrospective study conducted in Hamad Medical Corporation, Doha/Qatar. the clinical and biochemical data of 1567 females with IDA who attended the hematology clinic and were treated with intravenous iron therapy were collected and analysed. Complete and differential blood counts and iron profile were studied before and after iron treatment. In addition, cases who developed infections during the time of leukopenia were noted and checked for possible complications.Re...
Introduction Iron deficiency anemia (IDA) is a major public health issue, with widespread prevale... more Introduction Iron deficiency anemia (IDA) is a major public health issue, with widespread prevalence and negative impact on health care system. IDA occurs when iron stores diminish to the level that disturbs erythropoiesis and causes anemia. Neutropenia is an abnormal reduction in the number of neutrophils. A little is known about the association between iron deficiency anemia and neutropenia. The aim of this study is to investigate the prevalence of neutropenia in a large cohort of adult patients with IDA and to find possible correlation between neutrophil levels with haemoglobin concentration and iron stores. We studied associated infections in this neutropenic group. Materials and Methods We retrospectively reviewed the electronic medical records of 1567 patients attended haematology clinic with the diagnosis of IDA ((haemoglobin level less than 12 gm/dl for women, less than 13 gm/dl for men) over the past 2 years in Hamad Medical Corporation, Qatar. Other causes of anemia and an...
To optimize care for patients with hemoglobinopathies, frequent screening for COVID‐19 is prudent... more To optimize care for patients with hemoglobinopathies, frequent screening for COVID‐19 is prudent as viral kinetics in asplenic patients are unknown and differentiating prolonged viral shedding versus reinfection remains a challenge.
Hematologic malignancies are becoming more prevalent, manifesting in various clinical scenarios. ... more Hematologic malignancies are becoming more prevalent, manifesting in various clinical scenarios. Chronic myelogenous leukemia (CML) is usually diagnosed on routine complete blood count as it is typically asymptomatic. However, it can cause multiple signs and symptoms. We present a patient with appendicitis revealing CML during his workup for abdominal pain.
All people including those with Haemoglobinopathies are at risk of COVID-19 infection. Though tho... more All people including those with Haemoglobinopathies are at risk of COVID-19 infection. Though those patients were considered vulnerable, a clear prognosis, as well as the possibility of reinfection, was not mentioned before. We report here the first case of Thalassemia beta major who had COVID-19 reinfection detected by screening. Introduction: Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-COV2) was responsible for the latest outbreak recently, presenting as mainly respiratory symptoms and carrying high mortality rate[1]. COVID-19 put all people at risk of being infected including haemoglobinopathies patients. Multiple factors among those patients increase their risk for infections yet the occurrence of reinfection and it is implication on them, and the community were not described before. Thalassemia is one of the most common haemoglobinopathies and requires lifelong management and follow up. Splenectomy, regular blood transfusion and iron chelation therapy are essential components in the management plan. Unfortunately, they cause some complications on the long term and might raise the slurpability of current reinfection[2]. The impact of these factors on COVID-19 infection is not well known yet. Here we present a case of 31-year-old splenectomized lady with transfusion dependent Beta Thalassemia Major had COVID-19 infection recurrence detected by screening. In this article we are discussing the possibility behind COVID-19 reinfection in thalassemia patients. Case presentation: A 31-year-old Pakistani lady with past medical history of transfusion dependent Beta Thalassemia major, type II diabetes Mellitus and hypothyroidism visited our hematology department for follow up and routine blood transfusion. Due to the ongoing spread of COVID-19 infection in Qatar, PCR via nasopharyngeal swap was done as part of the local screening plan before admission in day care for the blood transfusion and tested positive.
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