Papers by Qazi Shamima Akhter
This study was done to assess the hypercoagulability and the risk of thromboembolism in women tak... more This study was done to assess the hypercoagulability and the risk of thromboembolism in women taking oral contraceptive pill for prolonged period of time. This cross sectional study was done in the department of Physiology, Dhaka Medical College, Dhaka from Jan 2012 to Dec 2012. Ninety female subjects with the age range from 25-45 years, were taken as a study population. Among them, 60 women taking oral contraceptives for prolonged period of time ( > 1 years) were included for the study group and age matched 30 women of OCP nonusers were taken as a control. Study subjects were divided into two groups according to their duration of oral pill use: group BI ( 1 to 5 years users) were 30 women and group B2 ( >5 to 10 years users) were 30 women. Prothrombin time and activated partial thromboplastin time were estimated in all groups. Statistical analysis was done by unpaired Student's ? t' test and Pearson's Correlation Coefficient test. In this study, the mean (*SD) PT levels in group B1 & B2 were shortened than that of group A which were statistically highly significant (P < 0.001). Within the study groups, PT levels were positively correlated (r=+0.027) with the group B1 and negatively correlated (r= -0.163) with the group B2. But both the relationships were statistically non significant. The mean (+SD) AM' level in group B1 was shortened than that of group A but the result was not statistically significant. The mean (*SD) AM' level in group B2 was shortened than that of group A but the result was statistically highly significant (P<0.001). Within the study groups, APPT levels were negatively correlated with the group B1 (r= -0.268) and also group B2 (r= -0.122). But both the relationships were statistically non significant. My present study revealed that prolonged duration of OCP use ( at least for 5 years) increases the risk of hypercoagulable state and thromboembolism in women.
<jats:p>Secondary hyperparathyroidism is the first and most recognizable complication of ch... more <jats:p>Secondary hyperparathyroidism is the first and most recognizable complication of chronic kidney disease (CKD) because parathyroid hormone (PTH) plays a compensatory role to maintain calcium and phosphate homeostasis. Progressive renal failure give rise to a steady increase in parathyroid hormone concentration. which is related to occurrence of renal bone disease. The objective of this study was to find out the httact parathyroid hormone level in different stages of chronic kidney disease patients. This cross sectional study was carried ow in the department of physiology. Dhaka Medical College from January to December 2009. 100 chronic kidney disease patients aged 20 to 60 years were selected as experimental group and 20 apparently healthy subjects were in control group and were matched for age and body weight. Patients were divided into three stages based on their creatinine clearance rate (Ccr). Group B, includes 34 patients marked as stage 11 with Ccr 60-89 ml/min, Group Ba Group B3 consists of 36 and 30 patients each and marked as stage 111 and stage IV with Ccr 30-59 mIhnin and 15-29 Skills respectively. Intact PTH was measured by chemiluminescent hnutuno assay method. Statistical analysis was done by unpaired Student's "1"- test and pearson's Correlation test. Mean serum PTH level was significantly higher in all experimental groups than that of control group (p&lt; 0.001). High level of Pal was found in 74% patients in stage 11, 81% in stage III and 97% patients in stage IV. Again, a significant negative correlation of parathyroid hormone with Ccr was observed in patients with CKD in all three stages. From the findings of the present study it may be concluded that intact PTH level progressively increases from early stage to late stage of chronic kidney disease.</jats:p>
Zenodo (CERN European Organization for Nuclear Research), Mar 30, 2022
Surgical menopause can be defined as cessation of menstruation due to surgical removal of the ute... more Surgical menopause can be defined as cessation of menstruation due to surgical removal of the uterus (hysterectomy), leaving one or both ovaries, or the removal of both ovaries. Women who undergo hysterectomy alone are known to attain menopause 3.7 years earlier than those who attain natural menopause due to decrease blood supply to ovaries. These women face severe postmenopausal symptoms due to deficiency of serum estradiol. Deficiency of serum estradiol is also associated increase bone resorption and decrease renal excretion of phosphate resulting hyperphosphatemia. Thus, increase risk of osteopenia and osteoporosis may present in surgical menopausal women. Very few studies are conducted to know the effect of endocrinological changes associated with hysterectomy on the serum level of phosphate. Hence the present study was conducted to compare the serum phosphate level in surgical (hysterectomies) and natural menopausal women. This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, and Dhaka from July 2016 to June 2017. A total number of 60 women were selected with age ranging from 30 to 55 years. Among them, 40 menopausal women were considered as the study group B and 20 apparently healthy pre-menopausal women were considered as control group A. Study group B was again subdivided into group B1 and B2. Group B1 consisted of 20 natural menopausal women and group B2 consisted of 20 surgical menopausal (hysterectomies) women. Serum phosphate level was measured by Beckman Coulter AU680. Statistical analysis was done by one-way ANOVA followed by Bonferroni test. In this study, serum phosphate level was significantly (p < 0.05) increase in surgical menopausal women than natural menopausal women. Again, this study showed that 55.0% surgical menopausal and 40.0% natural menopausal women had serum phosphate level >4.7 mg/dl. From this study, it can be concluded that after hysterectomy serum phosphate level significantly increase which might be due to hormonal imbalance.
Bangladesh Journal of Physiology and Pharmacology, Nov 2, 2014
Heart rate variability (HRV) has been considered as an indicator of autonomic nerve function stat... more Heart rate variability (HRV) has been considered as an indicator of autonomic nerve function status. We aimed to find out the reference values of heart rate variability by power spectral analysis in our healthy population of different age. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from the period of July 2012 to June 2013. For this, 180 subjects were selected with the age ranging from 15-60 years. All the study subjects were divided into 3 different groups according to age (Group A: 15-30 years; Group B: 31-45 years; Group C: 46-60 years). Each group contained 60 subjects of which 30 were male and 30 were female. The subjects were selected from different areas of Dhaka city by personal contacts. Analysis of HRV parameters were done in Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. For statistical analysis, one way ANOVA, unpaired Students ttest and Pearson's correlation coefficient test were performed by using SPSS (version-17) as applicable. LF nu, LF power and LF/HF were significantly (p<0.001) higher in group C in comparison to those of group A and B. Again Total power, HF power, HF nu (p<0.001) were significantly higher in group A and B in comparison to that of group C. This study concludes that cardiac parasympathetic activity was decreased and sympathetic activity was increased with aging.
Zenodo (CERN European Organization for Nuclear Research), Sep 30, 2021
Background and objectives: ABO blood group distribution defers with racial and geographic variati... more Background and objectives: ABO blood group distribution defers with racial and geographic variations. They are related with diseases like cardiovascular diseases, cerebral thromboembolism. Prothrombin time may varies among ABO blood group system which may increase the future risk of thrombosis. The present study is to assess prothrombin time among ABO blood groups in healthy adults. Materials and methods: A prospective type of analytical cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2019 to June 2020. After obtaining ethical clearance, a total 190 healthy adults were selected from different areas of Dhaka city based on inclusion and exclusion criteria, with age ranging from 18-45 years. The subjects were interviewed and detailed history regarding personal, family, medical and drug were taken. Prior to sample collection, informed written consent was taken from the participants. Individuals of blood group A was selected as group A, blood group B as group B, blood group AB as group AB and blood group O as group O. Prothrombin time was measured in the
Proceedings of The Physiological Society, 2014
Scholars international journal of anatomy and physiology, Dec 10, 2022
Introduction: Pregnancy is a physiological process. Preeclampsia is the commonest complication du... more Introduction: Pregnancy is a physiological process. Preeclampsia is the commonest complication during pregnancy. This condition might severely affect the health of mothers and their newborns. Newborn of mothers with preeclampsia are more liable for intrauterine growth retardation and may be delivered prematurely. Aim of the Study: The aim of this study was to evaluate the platelet count and mean platelet volume in newborn of preeclamptic mother. Methods: This cross-sectional study was conducted in the
International journal of human and health sciences, Sep 18, 2022
Background: Heart rate variability (HRV) has been considered as an indicator of autonomic nerve f... more Background: Heart rate variability (HRV) has been considered as an indicator of autonomic nerve function status. Objective:To find out the reference values of heart rate variability by time domain measures of HRV inadult Bangladeshi population of both sexes. Methods:This cross-sectional, analytical study was conducted between July 2012 and June 2013. A total of 180 subjects were selected through the Department of Physiology, Dhaka Medical College Dhaka, Bangladesh, with the age ranging from 18 to 60 years. All the study subjects were divided into 3 different groups: group A (18-30 years), group B (31-45 years) and group C (46-60 years). Each group had 60 subjects: 30 males and 30 females. The experimentation of HRV parameters and recording of data were done using RMS Polyrite D (version 2.4) in Autonomic Nerve Function Test Laboratory of the
Zenodo (CERN European Organization for Nuclear Research), Oct 30, 2021
Background and objectives: The prevalence of anxiety disorders is increasing in the world. Studie... more Background and objectives: The prevalence of anxiety disorders is increasing in the world. Studies revealed that generalized anxiety disorder may lead to change in circulating catecholamine levels. Thus, the changes of catecholamine metabolite like urinary vanillylmandelic acid may increase the future risk of thrombotic diseases in patients with generalized anxiety disorder (GAD). The aim of this present study is to evaluate urinary vanillylmandelic acid (VMA) levels in patients with generalized anxiety disorder.
Bangladesh Journal of Physiology and Pharmacology, Nov 1, 2014
Iron deficiency anemia is considered as one of the major public health problem in Bangladesh. Car... more Iron deficiency anemia is considered as one of the major public health problem in Bangladesh. Cardiac autonomic nerve dysfunction may present in iron deficiency anemia which increases the risk and further complications of this disease. Assessment of heart rate variability (HRV) is a non-invasive technique to evaluate cardiac autonomic nerve function status. To assess the cardiac autonomic nerve function status by heart rate variability analysis in female with iron deficiency anemia. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013. For this, 100 female subjects with iron deficiency anemia aged 20-45 years were included in the study group (Group B). The anemic subjects were selected from Outpatient Department of Haematology in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. They were included in the study group on the basis of their pre-performed hemoglobin percentage, total count of RBC and serum ferritin level. Data were collected in pre-designed structured questionnaire by the researcher herself. For comparison, age and sex matched 100 apparently healthy female were selected as control (Group A) by personal contact from the different areas of Dhaka city. Analysis of HRV parameters were done in Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. The HRV parameters were recorded by a 4 active channels, Polyrite-D.For statistical analyses, unpaired Student's t-test and Pearson's correlation coefficient test were performed by using SPSS (version-19) as applicable. Mean resting pulse rate and mean heart rate were significantly (p <0.0001) higher in subjects with iron deficiency anemia in comparison to those of control group. Hemoglobin concentration, total count of RBC, mean R-R interval, SDNN and RMSSD were significantly (p <0.0001) lower in subjects with iron deficiency anemia in comparison to those of healthy control. This study concludes that cardiac parasympathetic activity was reduced in female with iron deficiency anemia.
Bangladesh Medical Journal, Jan 7, 2016
Heart rate variability (HRV) has been considered as an indicator of autonomic nerve function stat... more Heart rate variability (HRV) has been considered as an indicator of autonomic nerve function status. We aimed to find out the reference values of heart rate variability by power spectral analysis in our healthy population of both sex. This cross sectional study was conducted in the Department of
Saudi journal of medical and pharmaceutical sciences, Dec 10, 2022
Introduction: Preeclampsia is a hypertensive disorder during pregnancy which may severely impact ... more Introduction: Preeclampsia is a hypertensive disorder during pregnancy which may severely impact the health of mothers and their newborns. The newborn of preeclamptic mother should be carefully monitored and managed for the purpose of reducing perinatal mortality and morbidity. Aim of the Study: The aim of this study was to evaluate the changes in cord blood total count of WBC and absolute neutrophil count in newborn of preeclamptic mother. Methods: This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from January 2017 to December 2017. Total 60 newborns were included in this study. The subjects were divided into 2 groups. Group A (Study group): Thirty (30) newborns of preeclamptic mother and Group B (Control group): Thirty (30) newborns of healthy pregnant mother. The subjects were selected from Department of Obstetrics and Gynecology, Dhaka Medical College Hospital, Dhaka on the basis of exclusion and inclusion criteria. Five (5) ml. of cord blood from each newborn was collected in EDTA tube after delivery and haematological test for total WBC count and absolute neutrophil count was done. These parameters were estimated in the Department of Hematology, Dhaka Medical College Hospital, Dhaka. Data were collected in pre-designed structured questionnaire form by the researcher herself. For statistical analysis Unpaired Student"s "t" test, Chi Square test and Pearson"s correlation coefficient (r) test were performed as applicable using SPSS for windows version 16.0. p value <0.05 was accepted as level of significance. Results: In this study, the mean (±SD) maternal systolic blood pressure of the study group A and control group B were 173.00 ± 19.73 and 114.83 ± 11.72 mm Hg respectively. In this study, the mean (±SD) maternal systolic blood pressure was significantly (p<0.001) higher in group A in compared to group B. The mean (±SD) maternal diastolic blood pressure of the study group A and control group B were 108.33 ± 9.52 and 73.33 ± 9.07 mm Hg respectively. In this study, the mean (±SD) maternal diastolic pressure was significantly (p<0.001) higher in group A in comparison to that of group B. The mean (± SD) total count of WBC was 9.62 ± 1.86 × 10 3 /µl and 17.38 ± 3.31 × 10 3 /µl in group A and B respectively. In this study, the mean (±SD) total count of WBC was lower in group A in comparison to that of group B which was statistically significant (p<0.001). In this study, mean (±SD) Absolute Neutrophil Count (ANC) was 5.76±2.01 ×10 3 /µl and 10.45±1.90 ×10 3 /µl in group A and B respectively. In this study, the mean (±SD) absolute neutrophil count was lower in group A in comparison to that of group B which was statistically significant (p<0.001). Maternal systolic blood pressure showed negative correlation (-0.953) with total count of WBC in newborn of preeclamptic mother, which was statistically significant (p<0.001). Maternal diastolic blood pressure showed negative correlation (-0.957) with total WBC count in newborn of preeclamptic mother, which was statistically significant (p<0.001). Maternal systolic blood pressure showed negative correlation (-0.951) with absolute neutrophil count in newborn of preeclamptic mother, which was statistically significant (p<0.001). Maternal diastolic blood pressure showed negative correlation (-0.953) with absolute neutrophil count in newborn of preeclamptic mother, which was statistically significant (p<0.001). Conclusion: The total WBC count and absolute neutrophil count in the cord blood of the newborn of preeclamptic mother were lower than those of healthy pregnant mother, but they were within the normal range, it can be inferred after studying the study's findings. These changes were significantly related to severity of maternal blood pressure.
Journal of Bangladesh Society of Physiologist
Background: In Ayurveda turmeric (Curcuma longa) has been used for cardioprotection. Experimental... more Background: In Ayurveda turmeric (Curcuma longa) has been used for cardioprotection. Experimentally induced myocardial injury is clinically similar to human myocardial infarction. Objective: The study was designed to assess the myocardial salvagingeffect of turmeric (Curcuma longa) on experimentally induced myocardial injury in rats. Methods: This experimental study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka during 2015. Total twenty eight (28) Wistar albino male rats (aged 13±1 weeks; 125±25 gm) were randomly grouped into NS (normal control group), ISO (isoproterenol treated control group),Tm+ISO (turmeric pretreated and isoproterenol treated group) and Am+ISO (amlodipine pretreated and isoproterenol treated group). All the rats were sacrificed on 10th day of experimentation. . Blood samples were collected. Serum carduac troponin I (cTnI) level was estimated by AxSYM methodand serum malondialdehyde (MDA) level was estimated byspectrophotometric me...
Mymensingh medical journal : MMJ, 2017
Hypertension is a chronic and debilitating disease. Its complications give rise to cardiovascular... more Hypertension is a chronic and debilitating disease. Its complications give rise to cardiovascular diseases, stroke in Postmenopausal women. Estrogen deficiency that develops during menopause is likely the etiological factor for development of hypertension in postmenopausal women. Increased incidence of cardiovascular diseases in postmenopausal women may be due to hypertension caused by lower level of estrogen hormone. The study was carried out to observe the association of hypertension with serum estrogen level in postmenopausal women. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, during the period of January 2011 to December 2011. A total number of 90 female subjects were selected from different areas of Dhaka city. Among them, 60 postmenopausal women with age ranging from 50 to 60 years were taken as study group and 30 apparently healthy premenopausal women with age ranging from 20 to 30 years were included as control group...
Mymensingh medical journal : MMJ, 2021
Preeclampsia is a multifactorial disease of unknown etiology and is associated with oxidative str... more Preeclampsia is a multifactorial disease of unknown etiology and is associated with oxidative stress. Some studies observed that alteration of essential trace element may contribute to the development of preeclampsia. The aim of the study was to assess the serum copper (Cu) level and its relation with blood pressure and urinary protein level in preeclampsia. This cross sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from July 2016 to June 2017. Thirty subjects with preeclampsia age ranging from 18 to 40 years were considered as the study group and 30 aged matched healthy pregnant women were considered as control group for comparison. The subjects were selected from Department of Obstetrics and Gynecology of Dhaka Medical College hospital, Dhaka. Serum copper (Cu) level was estimated in the Department of Soil, Water and Environment of University of Dhaka. For statistical analysis, unpaired Students "t" test and Pearson...
Advances in Human Biology, 2021
Brief Communication An industry that has witnessed fast-paced growth worldwide is the cement indu... more Brief Communication An industry that has witnessed fast-paced growth worldwide is the cement industry, with a 4% increase in cement demand per year. [1,2] Cement production in 2019 globally was 4.2 billion metric tons. In Bangladesh, the cement industry plays a vital role in developing the country&#39;s infrastructure. The cement industry sees a 12%-15% growth year to year with a current production capacity of 68 million tons and has 37 active cement manufacturing companies in the country. [3] There has been a 12.67% annual growth rate in the previous 5 years. The demand for cement continues to grow as the country embraces seven mega infrastructure projects such as metro rail, power plants, bridges and rail line development in real estate and commercial projects. [4] Cement is composed of clay and lime. The clay consists of alumina, oxide of iron and silica, while lime contains calcium oxide. [5] The significant oxides found in cement are oxides of aluminium, iron, calcium and silicon. [6] Cement also contains trace elements such as chromium, copper, nickel, zinc, cobalt, lead and arsenic. [7] The manufacturing process of cement results in the emission of metal dust that is non-volatile. [8] The raw materials are mixed and grinded into a homogenous mixture processed in the rotary kiln at 900°C. This is followed by the process of clinkering where Cao, silica, ferrous oxide and alumina react with each other at 1400°C-1500°C. The clinker is cooled and combined with limestone and gypsum, forming Portland cement, stored in bags or silos. [9,10] Dust emission occurs from these kilns and during the steps of grinding, crushing, clinker cooling and handling materials. [11]
Scholars Journal of Applied Medical Sciences
Introduction: Preeclampsia (PE) is one of the commonest complications in pregnancy which is assoc... more Introduction: Preeclampsia (PE) is one of the commonest complications in pregnancy which is associated with perinatal mortality and morbidity. Early hematological screening of the newborn of preeclamptic mother may be helpful to diagnose and treat the newborn of preeclamptic mother for better pregnancy outcome. Aim of the Study: The aim of this study was to evaluate the RBC count and Haemoglobin concentration in newborn of mother with and without preeclampsia. Methods: This cross-sectional study was conducted in the Department of Physiology, Dhaka Medical College, Dhaka, Bangladesh from January 2017 to December 2017. Total 60 newborns were included in this study. The subjects were divided into 2 groups. Group A (Study group): Thirty (30) newborns of preeclamptic mother and Group B (Control group): Thirty (30) newborns of healthy pregnant mother. The subjects were selected from Department of Obstetrics and Gynecology, Dhaka Medical College Hospital, Dhaka on the basis of exclusion an...
Journal of Medical Science & Research, 2016
Preeclampsia is a pregnancy specific disease and associated with multisystem complications. This ... more Preeclampsia is a pregnancy specific disease and associated with multisystem complications. This crosssectional study was carried out in the Department of Physiology, Dhaka Medical College (DMC), Dhakafrom January'14 to December'14 to assess the relationship between serum lactate dehydrogenase (LDH) levelwith the severity of the disease in preeclampsia. For this purpose, a total number of 105 pregnant women atthird trimester (28-40 weeks) with age ranging from 18 to 35 years were selected from DMC Hospital,Dhaka. Among them, 70 pregnant women with preeclampsia were selected as study group (Group B) which wasfurther subdivided as mild preeclamptic women (Group B1) and severe preeclamptic women (Group B2)consisting of 35 subjects in each subgroup. Age matched 35 healthy pregnant women were considered ascontrol group (Group A) for comparison. Serum LDH level was estimated by continuous spectrophotometricmethod. In this study, serum LDH level showed positive correlation with pro...
Journal of Herbs, Spices & Medicinal Plants, 2014
ABSTRACT Terminalia chebula extracts were evaluated on 2-acetylaminofluorene (2-AAF)-induced hepa... more ABSTRACT Terminalia chebula extracts were evaluated on 2-acetylaminofluorene (2-AAF)-induced hepatocellular carcinoma in mice. The 25 mg.kg−1 b.w. 2-AAF treatment showed liver aberration and up-regulation of multidrug resistance-1 (MDR1), generation of reactive oxygen species (ROS) and cyclooxygenase-2 (COX-2) expression via phosphorylation of Akt-MAPKs and nuclear translocation of NF-κB. Pre-administration of 50 mg.kg−1 TCE along with 25 mg.kg−1 2-AAF inhibited the expression of MDR1 by preventing ROS generation and COX-2 expression through Akt and MAPK signaling pathway. T. chebula may overcome the 2-AAF-induced oxidative stress and drug resistance in the hepatic tissue of mice and prevent the possible neoplastic transformation leading to hepatocarcinoma.
Journal of Bangladesh Society of Physiologist, 2015
Background: Smoking may cause systemic inflammation, and high level of serum high sensitive Creac... more Background: Smoking may cause systemic inflammation, and high level of serum high sensitive Creactive protein may be found in smoker as an indicator of inflammation. Objective: To assess the serum high sensitive C-reactive protein level in male smokers of Bangladesh. Methods: The present cross sectional study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka between July 2013 and June 2014. Hundred apparently healthy male regular cigarette smokers aged 20 to 40 years who smokes at least 5 sticks of cigarette per day for the last 5 years were included as study group. They were further divided in to 5-10 years, 11-15 years, 16-20 years and 1-10 cigarette sticks, 11-20 cigarette sticks, more than 20 cigarette sticks/day depending on the duration of smoking and also according to consumption of number of sticks/day respectively. Age matched 100 apparently healthy male nonsmokers were included for control. To assess their inflammatory status, serum hs-CRP level was estimated by particles enhanced immunonephelometry using BN Systems in the Department of Microbiology & Immunology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. In addition, BMI and blood pressure were measured by standard method to observe their association with smoking. Results: The mean serum hs-CRP level was significantly higher in male smokers than that of non smokers which was progressively increased with duration of smoking and number of cigarette sticks consumed per day. Again, mean BMI was significantly lower and diastolic blood pressure was significantly higher in male smokers than those of non smokers. Conclusion: The result of this study can be concluded that serum hs-CRP level progressively increases with duration of smoking and number of cigarette sticks consumed per day in male smokers.
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Papers by Qazi Shamima Akhter