Papers by Purificacion Cuadrado
Current medicinal chemistry, Jan 7, 2018
Protein-based polymers are some of the most promising candidates for a new generation of innovati... more Protein-based polymers are some of the most promising candidates for a new generation of innovative biomaterials as recent advances in genetic-engineering and biotechnological techniques mean that protein-based biomaterials can be designed and constructed with a high degree of complexity and accuracy. Moreover, their sequences, which are derived from structural protein-based modules, can easily be modified to include bioactive motifs that improve their functions and material-host interactions, thereby satisfying fundamental biological requirements. The accuracy with which these advanced polypeptides can be produced, and their versatility, self-assembly behavior, stimuli-responsiveness and biocompatibility, means that they have attracted increasing attention for use in biomedical applications such as cell culture, tissue engineering, protein purification, surface engineering and controlled drug delivery. The biopolymers discussed in this review are elastin-derived protein-based polym...
Http Dx Doi Org 10 1080 00397918708063972, Dec 5, 2006
Organic Preparations and Procedures International
Organic Preparations and Procedures International, 1988
Journal of Heterocyclic Chemistry, 1988
Tetrahedron Lett, 2000
Trimethyl- or dimethylphenylsilylepoxides react with lithium phenylsulfide to give regio- and ste... more Trimethyl- or dimethylphenylsilylepoxides react with lithium phenylsulfide to give regio- and stereodefined vinyl sulfides resulting from α-ring opening and Peterson elimination. When the epoxide bears the bulky tert-butyldiphenylsilyl group the reaction is more puzzling. Depending on the β-substitution and the presence of aluminium chloride, we obtained silyl enol ethers, α-silylaldehydes or α-hydroxy-β-phenylthiosilanes, all resulting from β-opening.
Tetrahedron Lett, 1997
Silyl epoxides 1a-e react with lithium diphenylphosphide and then with methyl iodide to give viny... more Silyl epoxides 1a-e react with lithium diphenylphosphide and then with methyl iodide to give vinylphosphonium iodides resulting from α-opening of the epoxide ring and subsequent Peterson elimination. In the same conditions, the E-β-phenyl-α-tert-butyldiphenylsilylepoxide 1f leads to the corresponding silyl enol ether 5 by β-opening followed by Brook rearrangement. Both processes are regio- and stereospecific. © 1997 Elsevier Science Ltd.
Chemistry (Weinheim an der Bergstrasse, Germany), Jan 20, 2004
Unsubstituted or alpha- and beta-C-substituted silylepoxides react stereospecifically with lithiu... more Unsubstituted or alpha- and beta-C-substituted silylepoxides react stereospecifically with lithium diphenylphosphide, optionally followed by methylation, to give vinylphosphonium iodides or vinylphosphine oxides resulting from alpha-opening and silyl enol ethers, vinylsilanes or alpha-hydroxysilanes by beta-opening. On the other hand, alpha,beta- or alpha,alpha-disilylepoxides afforded beta-silyl vinylphosphine oxides or alpha-silylated silyl enol ethers by alpha- and beta-cleavage, respectively. All compounds are interesting synthons in organic chemistry.
Tetrahedron Letters, 2001
Unsubstituted and a or b C-substituted epoxystannanes react with lithium phenylsulfide to give re... more Unsubstituted and a or b C-substituted epoxystannanes react with lithium phenylsulfide to give regio-and stereodefined a-phenylthio-b-hydroxystannanes resulting from a-opening with inversion of configuration. On the other hand, aor b-trans-silyl epoxystannanes afford stereospecific aor b-silylated vinylsulfides formed by nucleophilic attack at the carbon which bears the tin group and subsequent syn-elimination of HOSnBu 3 . Both types of products are interesting synthons in organic chemistry.
Tetrahedron Letters, 1997
AIMIWJ3: Silylepoxidesla-e react with lithiumdiphenylpho.sphide and then with methyliodideto give... more AIMIWJ3: Silylepoxidesla-e react with lithiumdiphenylpho.sphide and then with methyliodideto give vinylphosphooium iodides resulting horn a-opening of the epoxide ring snd subsequentPeterson elimination.In the ssme conditions,the~~-pkyla-teri-btyltipkyltilyl~tide If leadsto the corresponding silyl enolether 5 by~-openingfollowed by Brookrearrangement.Both proasses are regio-and stereospecific.Q 1997Elsevier ScienceLtd.
ChemInform, 2008
Reactions of Lithium Silylcuprates with Pyrazolium and Indazolium Salts.
Tetrahedron Letters, 2000
Trimethyl-or dimethylphenylsilylepoxides react with lithium phenylsulfide to give regio-and stere... more Trimethyl-or dimethylphenylsilylepoxides react with lithium phenylsulfide to give regio-and stereodefined vinyl sulfides resulting from α-ring opening and Peterson elimination. When the epoxide bears the bulky tertbutyldiphenylsilyl group the reaction is more puzzling. Depending on the β-substitution and the presence of aluminium chloride, we obtained silyl enol ethers, α-silylaldehydes or α-hydroxy-β-phenylthiosilanes, all resulting from β-opening.
Tetrahedron Letters, 1998
1,3,5-trisubstituted-2-methylpyrazolium iodides react with dimethylphenylsilyl-and twtbutyldiphen... more 1,3,5-trisubstituted-2-methylpyrazolium iodides react with dimethylphenylsilyl-and twtbutyldiphenylsilyllithium leading, in general, to one of the corresponding S-silyl-3-pyrazolines The silyl group is easily substituted by electrophiles to give 5-tinctionalized 3-pyrazolines.Moreover. 5-silyl-3pyrazolines undergo thermic ring opening with silicon-rearrangement affording a-silylated P-diimines 0
Uploads
Papers by Purificacion Cuadrado