Skip to main content

Pratik Shah

Followers

0

Following

1

Public Views

Uploads

Papers by Pratik Shah

Are Virtual Influencers More Effective In Real-World Advertisement Settings?

Journal of advertising research, Jun 24, 2024

Post-marketing safety evaluation of recombinant anti-rho (D) immunoglobulin for the prevention of maternal rh-isoimmunization: A prospective, multi-centre, phase IV study

Indian Journal of Obstetrics and Gynecology Research, Nov 14, 2023

Background: AntiD ® is a recombinant anti-D immunoglobulin approved as an immunoprophylaxis treat... more Background: AntiD ® is a recombinant anti-D immunoglobulin approved as an immunoprophylaxis treatment in Rh-negative mothers carrying an Rh-positive fetus. This study was conducted to assess the safety and tolerability of AntiD in clinical settings. Materials and Methods: This was a prospective, multicenter, phase IV, post-marketing safety study of AntiD. The study was conducted at 29 hospitals in India as per regulatory requirements. Three hundred eligible Rh-negative women were administered a single intramuscular dose of either 150 mcg or 300 mcg AntiD within 72 hours of a sensitizing event as per the approved indication. Safety and tolerability were evaluated based on the assessment of adverse events (AEs) and serious adverse events (SAEs) reported during the study. Results: Out of the 300 participants enrolled, 290 completed the study procedures. A total of 54 AEs and 34 treatment-emergent adverse events (TEAEs) were reported by 47 (15.7%) and 30 (10.0%) participants, respectively. Most reported TEAEs were mild, unrelated to the study drug, and were completely resolved during the study. Except for two participants with clinically significant hematological and urinalysis findings consistent with their underlying medical conditions, none of the participants exhibited abnormal clinical or laboratory parameters. Conclusion: Based on the assessment of the different safety parameters, AntiD administered at a dose of either 150 mcg or 300 mcg did not raise any new or significant safety concerns. The current study demonstrated that AntiD is well-tolerated and safe to use for anti-D prophylaxis as per product label indications for the prevention of Rh-isoimmunization in a clinical setting. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Genetic Algorithm based Approach to Select Suitable Cover Image for Image Steganography

Steganography is used to perform covert communication. The advantage of steganography over other ... more Steganography is used to perform covert communication. The advantage of steganography over other secret communication techniques is its ability to conceal the presence of covert communication. In image steganography, the secret information is concealed in the cover image, in such a way that it produces very negligible change in the cover image. A vast amount of research is performed in image steganography but very limited studies have explored the possibility of choosing a cover image for steganography which provides better compatibility with the secret data. In this paper, we propose a genetic algorithm based technique for selecting a cover image from a database of images. The selected cover image is most compatible with the given secret data. We further explore the possibility of rearranging the secret data to increase the imperceptibility of the stego image.

Vector Graph Representation for Deformation Transfer Using Poisson Interpolation

Given an action sequence of a source object, the deformation transfer (DT) generates similar acti... more Given an action sequence of a source object, the deformation transfer (DT) generates similar action sequence for a target object. Usually, the 3D shape model of an object is stored as a mesh. In this work, we propose a vector graph (VG) representation for deformation transfer framework. Furthermore, the VG representation is suitable even for problems involving skeleton of the shape, for example human gait. We pose the deformation transfer as the Poisson interpolation problem. The cue about the intermediate poses of the target object is captured by the temporal gradient of the source pose sequence. With an assumption that the reference poses of the target and the source are similar, and given the initial and final pose of the target, Poisson interpolation generates intermediate deformed poses of the target corresponding to the source deformation sequence. The proposed deformation transfer scheme preserves target shape. Moreover, the source sequence gradient information guiding the process of deformation ensures that the target deformation sequence imitates the source action. The qualitative and quantitative comparisons of the proposed method with three state-of-the-art methods also show the effectiveness of the proposed method.

Langerhans Cell Histiocytosis Presenting as a Unifocal Eosinophilic Granuloma in the Body of the Mandible: A Rare Report

Otorhinolaryngology clinics : an international journal, Mar 1, 2013

Introduction: Langerhans cell histiocytosis (LCH) is a relatively rare and unique benign disease ... more Introduction: Langerhans cell histiocytosis (LCH) is a relatively rare and unique benign disease characterized by an abnormal proliferation of immature dendritic cells which usually affects children and young adults. Jaws are involved in less than 10% of children with the disease. Objective: To add on to the literature one more case of this rare and unique disease which accounts for less than 1% of all bone tumors and also to discuss its oral manifestation and management.

A prospective study of USG guided pigtail catheter drainage in management of liver abscess

International Journal of Research in Medical Sciences, 2015

Liver abscesses, both amoebic and pyogenic, continue to be an important cause of morbidity and mo... more Liver abscesses, both amoebic and pyogenic, continue to be an important cause of morbidity and mortality in tropical countries. 1 However, recent advances in interventional radiology, intensive care, progress in antibiotic therapy, liberal use of sonography and computerized tomography scanning of the abdomen have ABSTRACT Background: Treatment of the liver abscess of any etiology has evolved in the recent years. Percutaneous drainage of liver abscess has been an important advancement in the treatment of pyogenic liver abscesses. Aim: to evaluate and assess response, morbidity and complication rates of percutaneous pig tail catheter drainage in treatment of liver abscess. Methods: During a period of 27 months, 25 patients with liquefied liver abscess ≥5x5 cm underwent percutaneous drainage under sonographic guidance. Results: 18 had solitary abscess, while 7 had multiple abscesses. Pigtail catheters of various sizes (10 F or 12 F) were introduced in these patients using the Seldinger technique. The volume of pus drained ranged from 150 to 400 ml, while the period of catheter drainage ranged from 6 to 17 days. Complications were minor and included catheter blockage in 2 patients and tract pain in 8 patients. There was no mortality associated with this procedure. This study shows a success rate of 96% (successful treatment in 24 out of 25 patients). Conclusion: Percutaneous catheter drainage of liver abscesses is successful with a low morbidity and mortality and should be the first line of management in liquefied moderate to large sized liver abscesses.

Management of Extensive Blowout Fracture of Combined Orbital Floor and Medial Wall: A Challenge in Reconstruction

Otorhinolaryngology clinics : an international journal, 2014

Orbital blowout fractures are common sequelae of blunt trauma to periocular region. Combined orbi... more Orbital blowout fractures are common sequelae of blunt trauma to periocular region. Combined orbital floor and medial wall fractures are more complicated than either alone, because there may not be adequate peripheral bony support for standard implants. The transition zone between orbital floor and medial wall is difficult to visualize intraoperatively and makes even more difficult to visualize in dissection further posteriorly. In our case, patient sustained orbital blowout fracture with herniation of periorbital tissue in maxillary sinus as well as ethmoidal sinus. After undergoing successful orbital reconstruction surgery, eyeball was repositioned to its original position. There was no enophthalmos and patient had no restriction in eye movement and perception to light was similar in both the eyes. Pupillary reflex to light was brisk and similar in both the eyes.

Simultaneous UV Spectrophotometric Method for Estimation of Enalapril Maleate and Lercanidipine HCl in Synthetic Mixture

Research Journal of Pharmacy and Technology, Jul 28, 2011

Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedu... more Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Enalapril Maleate and Lercanidipine HCl in Synthetic mixture form have been developed. First method employs formation and solving of simultaneous equation using 209 nm and 238 nm as two analytical wavelengths for both drugs in methanol. The second method is Q value analysis based on measurement of absorptivity at 216 nm (as an iso-absorptive point) and 209 nm. Enalapril Maleate and Lercanidipine HCL at their respective λ max 209 and 238 nm and at isoabsorptive point 216 nm shows linearity in a concentration range of 4–14 μg/mL. Recovery studies range from 98.15 to 101.14% for Enalapril Maleate and 98.77% to 101.1% for Lercanidipine HCl in case of simultaneous equation method and 98.29% to 100.23% for Enalapril Maleate and 99.85% to 101.16 for Lercanidipine HCL in case of Q -analysis method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction

Formulation and evaluation of bioadhesive buccal drug delivery of repaglinide tablets

Asian Journal of Pharmaceutics, 2012

T he purpose of this research was to formulate and evaluate bioadhesive buccal tablets of repagli... more T he purpose of this research was to formulate and evaluate bioadhesive buccal tablets of repaglinide using HPMC K15M as a sustained release polymer, chitosan as a bioadhesive polymer and ethyl cellulose as an impermeable backing layer. The tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, swelling index, in vitro drug release, ex vivo mucoadhesion time and ex vivo drug permeation. A 3 2 full factorial design was used in present study for optimization. Tablets containing HPMC K15M and chitosan in the ratio of 1:1 and lactose as a filler (F2) had the maximum percentage of in vitro drug release. The swelling index, friability and in vitro drug release was affected by type of filler as dicalcium phosphate (DCP) had good binding ability compared to lactose. The surface pH of all tablets was found to be satisfactory (between 6.26 and 7.01), close to neutral pH; hence buccal cavity irritation should not occur with these tablets. F2 batch was considered optimum based on good bioadhesive strength (17.83±0.51 gm) and maximum similarity factor (64.43). The drug release from optimum batch followed zero order kinetics with non-Fickian diffusion. Drugexcipients compatibility study showed no interaction between drug and excipients. Stability study of optimized formulation showed that tablets were stable at accelerated environment condition. Thus, buccal adhesive tablet of repaglinide could be an alternative route to bypass hepatic first pass metabolism and to improve bioavailability of repaglinide.

Diabetic ketoacidosis: an unusual presentation of acromegaly

Case Reports, Jun 11, 2013

Computer aided tool design for micro-ECM

International Journal of Precision Technology, 2020

This paper reports the development of a computer aided system for micro-ECM process to design too... more This paper reports the development of a computer aided system for micro-ECM process to design tools to produce accurate internal features on workpiece. Mathematical model has been developed to compute the inter-electrode gap (IEG) for chosen shape of tool and process conditions. Axi-symmetric tools of different profiles such as cylindrical, conical, hemispherical have been analysed to predict the shapes of work cavities. Model is validated with the reported results and some experiments conducted by us on typical tool shapes. Parametric studies have been carried out to study influence of various process variables on the accuracy of cavity shapes. Based on these studies, guidelines for improving profile accuracy in micro-ECM have been suggested.

Modified Mc-Gregor’s fan flap for lower lip reconstruction: a two years institutional experience

International Surgery Journal, Feb 26, 2018

Fan flaps done during the period of January 2015 to December 2016 were prospectively followed. Th... more Fan flaps done during the period of January 2015 to December 2016 were prospectively followed. The site of lesions on the lower lip, condition of the remnant buccal mucosa, post excisional defect size and oral ABSTRACT Background: Aim of the study was to evaluate the modified fan flaps done during the past two years with regard to applicability, reliability, functional perspective and complications. Methods: All the cases of lower lip defects which were reconstructed using modified Mc Gregor's fan flaps were included and followed up prospectively at periodic intervals up to 2 years. The indications, applicability to defect size, postoperative aesthetic and functional results and drawbacks were noted. Results: Total 21 modified fan flaps were done during this period. All were done for squamous cell carcinoma affecting lower lip. All the flaps survived, four patients had marginal mucosal loss of neovermilion which healed by secondary intention, 1 case of Bilateral modified Gilles fan flap developed little microstomia, 1 flap with bilateral fan flap had dehiscence of suture line leading to significant morbidity which later had to be closed by secondary resuturing. Conclusions: The modified Mc-Gregors fan flaps are safe and reliable flap for lower lip reconstruction in terms of acceptability and function.

Experiment Study on Strength Characteristics of Concrete Using Waste Marble Powder

Zenodo (CERN European Organization for Nuclear Research), Jul 20, 2018

The field of cosmetics is fast massive important now a days. The conventional methods of measures... more The field of cosmetics is fast massive important now a days. The conventional methods of measures required several modifications in harmony to satisfy the necessities of the society. Waxes control constantly been a central ingredient of the cosmetic preparations. Pure and mock waxes are old since an extensive break of time. This study aims to look into the modification of Rice Bran Fatty Acid and its incorporation in cosmetic preparations. Rice Bran Fatty Acid is a by-product generated during refining of Rice Bran Oil industry. In this crude rice bran set was purified processed and was analyzed for its physico-chemical properties it was in preparing a mixture of skin cosmetics. Instinctive waxes are employed since slow phase of time. But studies reveals that Rice Bran Fatty Acid endow with a find emollient make happen as contrasted to put on waxes. One such natural product is Rice Bran Fatty Gel. And the petroleum fractions are use in the cosmetic preparations these days. Due to limited resources they will soon be unavailable for our use. So instead of that we can use Synthesized Rice Bran Gel.

$Research paper thumbnail of Validated high-performance thin-layer chromatographic (HPTLC) method for simultaneous determination of nadifloxacin, mometasone furoate, and miconazole nitrate cream using fractional factorial design$

Validated high-performance thin-layer chromatographic (HPTLC) method for simultaneous determination of nadifloxacin, mometasone furoate, and miconazole nitrate cream using fractional factorial design

Journal of Food and Drug Analysis, Jul 1, 2016

A high-performance thin-layer chromatographic method for simultaneous determination of nadifloxac... more A high-performance thin-layer chromatographic method for simultaneous determination of nadifloxacin, mometasone furoate, and miconazole nitrate was developed and validated as per International Conference on Harmonization guidelines. High-performance thinlayer chromatographic separation was performed on aluminum plates precoated with silica gel 60F 254 and methanol:ethyl acetate:toluene: acetonitrile:3M ammonium formate in water (1:2.5:6.0:0.3:0.2, % v/v) as optimized mobile phase at detection wavelength of 224 nm. The retardation factor (R f) values for nadifloxacin, mometasone furoate, and miconazole nitrate were 0.23, 0.70, and 0.59, respectively. Percent recoveries in terms of accuracy for the marketed formulation were found to be 98.35e99.76%, 99.36e99.65%, and 99.16e100.25% for nadifloxacin, mometasone furoate, and miconazole nitrate, respectively. The pooled percent relative standard deviation for repeatability and intermediate precision studies was found to be < 2% for three target analytes. The effect of four independent variables, methanol content in total mobile phase, wavelength, chamber saturation time, and solvent front, was evaluated by fractional factorial design for robustness testing. Amongst all four factors, volume of methanol in mobile phase appeared to have a possibly significant effect on retention factor of miconazole nitrate compared with the other two drugs nadifloxacin and mometasone furoate, and therefore it was important to be carefully controlled. In summary, a novel, simple, accurate, reproducible, and robust highperformance thin-layer chromatographic method was developed, which would be of use in quality control of these cream formulations.

Diagnostic Utility of Typhoid Elisa Test In Comparison to Other Conventional Methods for Diagnosis of Typhoid Fever

International journal of scientific research, Jun 1, 2012

Typhoid fever is endemic in many parts of the world and continues to be one of the leading causes... more Typhoid fever is endemic in many parts of the world and continues to be one of the leading causes of morbid- ity and mortality in our country. We have studied typhoid IgM ELISA test, a rapid serological test for diagnosis of typhoid fever and its usefulness for an early diagnosis, its sensitivity and specificity as compared to widal test. Out of 100 samples 22 (22%) cases were positive by blood culture, 30 (30%) were positive with Widal test and 36 (36%) were positive with typhoid ELISA test. The sensitivity, specificity, positive and negative predictive value of Widal test was 63.6%, 79.4%, 46.6% and 88.5% respectively. The sensitivity, specificity, positive and negative predictive value of typhoid IgM ELISA test was 95.4%, 80.7%, 58.3% and 98.4% re- spectively proving the superiority of typhoid IgM ELISA test. 1 . Recent surveillance studies have indicated that infection by S. Typhi causes 21 million illnesses and 200,000 deaths annually 1 . There are at least 17 million new cases of typhoid globally. India is the second most populous country of the world with majority inhabiting the rural areas with little access to modern diagnostic tools. Blood culture and widal test are routinely employed investigations for diagnosis of typhoid fever in all clinical settings 2 . Widal test has been used in the diagnosis of typhoid illness for long time but it remains a serological test with a moderate sensitivity and specificity 3 . Therefore, a fast, reliable, and easy to perform test with a higher sensitivity and specificity than Widal test is required, for rapid diagnosis and management of typhoid cases, thereby enabling clinicians to initiate an early therapy, reducing morbidity and its complications. Typhoid IgM ELISA is a rapid serological test for the diagnosis of typhoid fever 4 . In view of this, we observed that typhoid ELISA is a superior diagnostic tool assuming blood culture as a gold standard for enteric fever, as compare to con- ventional Widal test which has low sensitivity and specificity 5 .

Saving Section 5: Lessons from Consent Decrees and Ex parte Young

Social Science Research Network, 2005

This Article compares the relatively broad federal court authority to enter relief against States... more This Article compares the relatively broad federal court authority to enter relief against States under Ex parte Young with Congress's more limited authority to enact enforcement legislation (namely civil rights statutes) against the States under Section 5 of the Fourteenth Amendment. By exploring these two bodies of law under the same rubric, the Article exposes the unsupportable nature of the Supreme Court's jurisprudence in this area-a jurisprudence that grants considerable discretion to federal district court judges to order prophylactic relief for federal-law violations by States while narrowly limiting congressional power to prevent or remedy such conduct. The inconsistency is most stark in the consent decree context, where Supreme Court doctrine effectively permits district courts' unchecked authority to enter and enforce prophylactic remedies against States. This inconsistent treatment is problematic from both federalism and separation-of-powers perspectives.

Diffuse Idiopathic Skeletal Hyperostosis (DISH) – a Rare Presentation of the Disease

Indian journal of applied research, Oct 1, 2011

Diffuse idiopathic skeletal hyperostosis (DISH) also known as Forestier's disease, is a disor... more Diffuse idiopathic skeletal hyperostosis (DISH) also known as Forestier's disease, is a disorder of unknown etiology that is characterized by back pain and spinal stiffness. The condition is recognized radiographically by the presence of "flowing" ossification along the anterolateral margins of at least four contiguous vertebrae (candle wax dripping appearance) and the absence of changes of spondyloarthropathy or degenerative spondylosis. Even in patients who present with either lumbar or cervical complaints, radiographic findings are almost universally seen on the right side of the thoracic spine. It is characterized by a tendency toward ossification of ligaments (enthesopathy). It most characteristi- cally affects the spine. Ossification of the longitudinal ligaments (especially the anterior ligaments) of the spine produces a tortuous paravertebral mass anterior to and distinct from the vertebral bodies. The zygapophyseal and sacroiliac joints are not involved in DISH, and the intervening intervertebral disk space is preserved. But our patient presented with hip and knee pain rather than the usual spine complaints.

A Secure Spatial Domain Image Steganography Using Genetic Algorithm and Linear Congruential Generator

Advances in intelligent systems and computing, Dec 28, 2017

Significant increase in data traffic over the Internet has given rise to many data security issue... more Significant increase in data traffic over the Internet has given rise to many data security issues. Steganography is a technique which is used to hide the existence of secret communication. Hence, it is extensively used to solve the issues related to data security. In this paper, a secure and lossless spatial domain image steganography technique is proposed. Stream of secret data is hidden in quarter part of image by identifying suitable locations to hide 2 bits of secret data in each pixel, resulting in generation of coefficients corresponding to the location of match. These coefficients are hidden in remaining part of image using LSB replacement steganography. Genetic algorithm is used to find best possible location to hide these coefficients in the image, making the proposed technique very secure and almost impossible to extract secret data from it. The result of the proposed technique is compared with LSB replacement steganography where in same amount of secret data is embedded. It is observed that the proposed technique is much superior as compared to LSB steganography. It provides improvement in MSE and PSNR values; in addition, the degradation in histogram is also minimal thus eliminating histogram attack. Average PSNR value of stego-image obtained from proposed technique is 53.11 dB at two bits per pixel data embedding rate compared to 52.21 obtained by LSB technique.

Topics in voice echo cancellation

Acoustic echo cancellation (AEC) is a well studied problem. The underlying assumption in most ech... more

Friction stir welding of aluminium alloys: An overview of experimental findings – Process, variables, development and applications

Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, Apr 14, 2017

The never ending appetite of the mankind to produce more and more competitive products results in... more The never ending appetite of the mankind to produce more and more competitive products results in continuous development of newer and newer manufacturing processes. One of such a kind, a solid state welding process highly appreciated for joining of a variety of aluminium and copper alloys, is friction stir welding. The process is also an accomplished method for joining dissimilar materials efficiently. The process finds its major application for joining hard-to-weld metals, especially the precipitation hardenable aluminium alloys and is widely adopted by industries for the welding of such aluminium alloys. However, the process has still not found an economical way for welding of steels and hence found limited applications in industries for welding steels. This paper aims at providing a comprehensive review of the work undertaken in the field of friction stir welding and provides an insight into the friction stir welding of aluminium alloys. The article pays critical attention and analytical evaluation of classification of aluminium alloys, friction stir welding process parameters, the mechanical testing and properties of the friction stir welding joints, macrostructure and microstructure evolution during friction stir welding, friction stir welding defects and industrial applications of the process. The friction stir welding process variants are discussed as well. Special accentuation has been given to (i) effect of friction stir welding parameters on the microstructure evolved and thus the ultimate mechanical properties (viz. tensile strength, hardness, fatigue strength, fracture toughness and residual stresses), (ii) the texture formation, microstructure refinement and the role of intermetallics. However, studies related to welding of dissimilar aluminium alloys, temperature, and heat transfer modeling and material flow are out of the scope of this paper. Finally, the directions of future research are examined.

Are Virtual Influencers More Effective In Real-World Advertisement Settings?

Journal of advertising research, Jun 24, 2024

Post-marketing safety evaluation of recombinant anti-rho (D) immunoglobulin for the prevention of maternal rh-isoimmunization: A prospective, multi-centre, phase IV study

Indian Journal of Obstetrics and Gynecology Research, Nov 14, 2023

Background: AntiD ® is a recombinant anti-D immunoglobulin approved as an immunoprophylaxis treat... more Background: AntiD ® is a recombinant anti-D immunoglobulin approved as an immunoprophylaxis treatment in Rh-negative mothers carrying an Rh-positive fetus. This study was conducted to assess the safety and tolerability of AntiD in clinical settings. Materials and Methods: This was a prospective, multicenter, phase IV, post-marketing safety study of AntiD. The study was conducted at 29 hospitals in India as per regulatory requirements. Three hundred eligible Rh-negative women were administered a single intramuscular dose of either 150 mcg or 300 mcg AntiD within 72 hours of a sensitizing event as per the approved indication. Safety and tolerability were evaluated based on the assessment of adverse events (AEs) and serious adverse events (SAEs) reported during the study. Results: Out of the 300 participants enrolled, 290 completed the study procedures. A total of 54 AEs and 34 treatment-emergent adverse events (TEAEs) were reported by 47 (15.7%) and 30 (10.0%) participants, respectively. Most reported TEAEs were mild, unrelated to the study drug, and were completely resolved during the study. Except for two participants with clinically significant hematological and urinalysis findings consistent with their underlying medical conditions, none of the participants exhibited abnormal clinical or laboratory parameters. Conclusion: Based on the assessment of the different safety parameters, AntiD administered at a dose of either 150 mcg or 300 mcg did not raise any new or significant safety concerns. The current study demonstrated that AntiD is well-tolerated and safe to use for anti-D prophylaxis as per product label indications for the prevention of Rh-isoimmunization in a clinical setting. This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Genetic Algorithm based Approach to Select Suitable Cover Image for Image Steganography

Steganography is used to perform covert communication. The advantage of steganography over other ... more Steganography is used to perform covert communication. The advantage of steganography over other secret communication techniques is its ability to conceal the presence of covert communication. In image steganography, the secret information is concealed in the cover image, in such a way that it produces very negligible change in the cover image. A vast amount of research is performed in image steganography but very limited studies have explored the possibility of choosing a cover image for steganography which provides better compatibility with the secret data. In this paper, we propose a genetic algorithm based technique for selecting a cover image from a database of images. The selected cover image is most compatible with the given secret data. We further explore the possibility of rearranging the secret data to increase the imperceptibility of the stego image.

Vector Graph Representation for Deformation Transfer Using Poisson Interpolation

Given an action sequence of a source object, the deformation transfer (DT) generates similar acti... more Given an action sequence of a source object, the deformation transfer (DT) generates similar action sequence for a target object. Usually, the 3D shape model of an object is stored as a mesh. In this work, we propose a vector graph (VG) representation for deformation transfer framework. Furthermore, the VG representation is suitable even for problems involving skeleton of the shape, for example human gait. We pose the deformation transfer as the Poisson interpolation problem. The cue about the intermediate poses of the target object is captured by the temporal gradient of the source pose sequence. With an assumption that the reference poses of the target and the source are similar, and given the initial and final pose of the target, Poisson interpolation generates intermediate deformed poses of the target corresponding to the source deformation sequence. The proposed deformation transfer scheme preserves target shape. Moreover, the source sequence gradient information guiding the process of deformation ensures that the target deformation sequence imitates the source action. The qualitative and quantitative comparisons of the proposed method with three state-of-the-art methods also show the effectiveness of the proposed method.

Langerhans Cell Histiocytosis Presenting as a Unifocal Eosinophilic Granuloma in the Body of the Mandible: A Rare Report

Otorhinolaryngology clinics : an international journal, Mar 1, 2013

Introduction: Langerhans cell histiocytosis (LCH) is a relatively rare and unique benign disease ... more Introduction: Langerhans cell histiocytosis (LCH) is a relatively rare and unique benign disease characterized by an abnormal proliferation of immature dendritic cells which usually affects children and young adults. Jaws are involved in less than 10% of children with the disease. Objective: To add on to the literature one more case of this rare and unique disease which accounts for less than 1% of all bone tumors and also to discuss its oral manifestation and management.

A prospective study of USG guided pigtail catheter drainage in management of liver abscess

International Journal of Research in Medical Sciences, 2015

Liver abscesses, both amoebic and pyogenic, continue to be an important cause of morbidity and mo... more Liver abscesses, both amoebic and pyogenic, continue to be an important cause of morbidity and mortality in tropical countries. 1 However, recent advances in interventional radiology, intensive care, progress in antibiotic therapy, liberal use of sonography and computerized tomography scanning of the abdomen have ABSTRACT Background: Treatment of the liver abscess of any etiology has evolved in the recent years. Percutaneous drainage of liver abscess has been an important advancement in the treatment of pyogenic liver abscesses. Aim: to evaluate and assess response, morbidity and complication rates of percutaneous pig tail catheter drainage in treatment of liver abscess. Methods: During a period of 27 months, 25 patients with liquefied liver abscess ≥5x5 cm underwent percutaneous drainage under sonographic guidance. Results: 18 had solitary abscess, while 7 had multiple abscesses. Pigtail catheters of various sizes (10 F or 12 F) were introduced in these patients using the Seldinger technique. The volume of pus drained ranged from 150 to 400 ml, while the period of catheter drainage ranged from 6 to 17 days. Complications were minor and included catheter blockage in 2 patients and tract pain in 8 patients. There was no mortality associated with this procedure. This study shows a success rate of 96% (successful treatment in 24 out of 25 patients). Conclusion: Percutaneous catheter drainage of liver abscesses is successful with a low morbidity and mortality and should be the first line of management in liquefied moderate to large sized liver abscesses.

Management of Extensive Blowout Fracture of Combined Orbital Floor and Medial Wall: A Challenge in Reconstruction

Otorhinolaryngology clinics : an international journal, 2014

Orbital blowout fractures are common sequelae of blunt trauma to periocular region. Combined orbi... more Orbital blowout fractures are common sequelae of blunt trauma to periocular region. Combined orbital floor and medial wall fractures are more complicated than either alone, because there may not be adequate peripheral bony support for standard implants. The transition zone between orbital floor and medial wall is difficult to visualize intraoperatively and makes even more difficult to visualize in dissection further posteriorly. In our case, patient sustained orbital blowout fracture with herniation of periorbital tissue in maxillary sinus as well as ethmoidal sinus. After undergoing successful orbital reconstruction surgery, eyeball was repositioned to its original position. There was no enophthalmos and patient had no restriction in eye movement and perception to light was similar in both the eyes. Pupillary reflex to light was brisk and similar in both the eyes.

Simultaneous UV Spectrophotometric Method for Estimation of Enalapril Maleate and Lercanidipine HCl in Synthetic Mixture

Research Journal of Pharmacy and Technology, Jul 28, 2011

Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedu... more Two simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Enalapril Maleate and Lercanidipine HCl in Synthetic mixture form have been developed. First method employs formation and solving of simultaneous equation using 209 nm and 238 nm as two analytical wavelengths for both drugs in methanol. The second method is Q value analysis based on measurement of absorptivity at 216 nm (as an iso-absorptive point) and 209 nm. Enalapril Maleate and Lercanidipine HCL at their respective λ max 209 and 238 nm and at isoabsorptive point 216 nm shows linearity in a concentration range of 4–14 μg/mL. Recovery studies range from 98.15 to 101.14% for Enalapril Maleate and 98.77% to 101.1% for Lercanidipine HCl in case of simultaneous equation method and 98.29% to 100.23% for Enalapril Maleate and 99.85% to 101.16 for Lercanidipine HCL in case of Q -analysis method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction

Formulation and evaluation of bioadhesive buccal drug delivery of repaglinide tablets

Asian Journal of Pharmaceutics, 2012

T he purpose of this research was to formulate and evaluate bioadhesive buccal tablets of repagli... more T he purpose of this research was to formulate and evaluate bioadhesive buccal tablets of repaglinide using HPMC K15M as a sustained release polymer, chitosan as a bioadhesive polymer and ethyl cellulose as an impermeable backing layer. The tablets were evaluated for weight variation, thickness, hardness, friability, surface pH, mucoadhesive strength, swelling index, in vitro drug release, ex vivo mucoadhesion time and ex vivo drug permeation. A 3 2 full factorial design was used in present study for optimization. Tablets containing HPMC K15M and chitosan in the ratio of 1:1 and lactose as a filler (F2) had the maximum percentage of in vitro drug release. The swelling index, friability and in vitro drug release was affected by type of filler as dicalcium phosphate (DCP) had good binding ability compared to lactose. The surface pH of all tablets was found to be satisfactory (between 6.26 and 7.01), close to neutral pH; hence buccal cavity irritation should not occur with these tablets. F2 batch was considered optimum based on good bioadhesive strength (17.83±0.51 gm) and maximum similarity factor (64.43). The drug release from optimum batch followed zero order kinetics with non-Fickian diffusion. Drugexcipients compatibility study showed no interaction between drug and excipients. Stability study of optimized formulation showed that tablets were stable at accelerated environment condition. Thus, buccal adhesive tablet of repaglinide could be an alternative route to bypass hepatic first pass metabolism and to improve bioavailability of repaglinide.

Diabetic ketoacidosis: an unusual presentation of acromegaly

Case Reports, Jun 11, 2013

Computer aided tool design for micro-ECM

International Journal of Precision Technology, 2020

This paper reports the development of a computer aided system for micro-ECM process to design too... more This paper reports the development of a computer aided system for micro-ECM process to design tools to produce accurate internal features on workpiece. Mathematical model has been developed to compute the inter-electrode gap (IEG) for chosen shape of tool and process conditions. Axi-symmetric tools of different profiles such as cylindrical, conical, hemispherical have been analysed to predict the shapes of work cavities. Model is validated with the reported results and some experiments conducted by us on typical tool shapes. Parametric studies have been carried out to study influence of various process variables on the accuracy of cavity shapes. Based on these studies, guidelines for improving profile accuracy in micro-ECM have been suggested.

Modified Mc-Gregor’s fan flap for lower lip reconstruction: a two years institutional experience

International Surgery Journal, Feb 26, 2018

Fan flaps done during the period of January 2015 to December 2016 were prospectively followed. Th... more Fan flaps done during the period of January 2015 to December 2016 were prospectively followed. The site of lesions on the lower lip, condition of the remnant buccal mucosa, post excisional defect size and oral ABSTRACT Background: Aim of the study was to evaluate the modified fan flaps done during the past two years with regard to applicability, reliability, functional perspective and complications. Methods: All the cases of lower lip defects which were reconstructed using modified Mc Gregor's fan flaps were included and followed up prospectively at periodic intervals up to 2 years. The indications, applicability to defect size, postoperative aesthetic and functional results and drawbacks were noted. Results: Total 21 modified fan flaps were done during this period. All were done for squamous cell carcinoma affecting lower lip. All the flaps survived, four patients had marginal mucosal loss of neovermilion which healed by secondary intention, 1 case of Bilateral modified Gilles fan flap developed little microstomia, 1 flap with bilateral fan flap had dehiscence of suture line leading to significant morbidity which later had to be closed by secondary resuturing. Conclusions: The modified Mc-Gregors fan flaps are safe and reliable flap for lower lip reconstruction in terms of acceptability and function.

Experiment Study on Strength Characteristics of Concrete Using Waste Marble Powder

Zenodo (CERN European Organization for Nuclear Research), Jul 20, 2018

The field of cosmetics is fast massive important now a days. The conventional methods of measures... more The field of cosmetics is fast massive important now a days. The conventional methods of measures required several modifications in harmony to satisfy the necessities of the society. Waxes control constantly been a central ingredient of the cosmetic preparations. Pure and mock waxes are old since an extensive break of time. This study aims to look into the modification of Rice Bran Fatty Acid and its incorporation in cosmetic preparations. Rice Bran Fatty Acid is a by-product generated during refining of Rice Bran Oil industry. In this crude rice bran set was purified processed and was analyzed for its physico-chemical properties it was in preparing a mixture of skin cosmetics. Instinctive waxes are employed since slow phase of time. But studies reveals that Rice Bran Fatty Acid endow with a find emollient make happen as contrasted to put on waxes. One such natural product is Rice Bran Fatty Gel. And the petroleum fractions are use in the cosmetic preparations these days. Due to limited resources they will soon be unavailable for our use. So instead of that we can use Synthesized Rice Bran Gel.

$Research paper thumbnail of Validated high-performance thin-layer chromatographic (HPTLC) method for simultaneous determination of nadifloxacin, mometasone furoate, and miconazole nitrate cream using fractional factorial design$

Validated high-performance thin-layer chromatographic (HPTLC) method for simultaneous determination of nadifloxacin, mometasone furoate, and miconazole nitrate cream using fractional factorial design

Journal of Food and Drug Analysis, Jul 1, 2016

A high-performance thin-layer chromatographic method for simultaneous determination of nadifloxac... more A high-performance thin-layer chromatographic method for simultaneous determination of nadifloxacin, mometasone furoate, and miconazole nitrate was developed and validated as per International Conference on Harmonization guidelines. High-performance thinlayer chromatographic separation was performed on aluminum plates precoated with silica gel 60F 254 and methanol:ethyl acetate:toluene: acetonitrile:3M ammonium formate in water (1:2.5:6.0:0.3:0.2, % v/v) as optimized mobile phase at detection wavelength of 224 nm. The retardation factor (R f) values for nadifloxacin, mometasone furoate, and miconazole nitrate were 0.23, 0.70, and 0.59, respectively. Percent recoveries in terms of accuracy for the marketed formulation were found to be 98.35e99.76%, 99.36e99.65%, and 99.16e100.25% for nadifloxacin, mometasone furoate, and miconazole nitrate, respectively. The pooled percent relative standard deviation for repeatability and intermediate precision studies was found to be < 2% for three target analytes. The effect of four independent variables, methanol content in total mobile phase, wavelength, chamber saturation time, and solvent front, was evaluated by fractional factorial design for robustness testing. Amongst all four factors, volume of methanol in mobile phase appeared to have a possibly significant effect on retention factor of miconazole nitrate compared with the other two drugs nadifloxacin and mometasone furoate, and therefore it was important to be carefully controlled. In summary, a novel, simple, accurate, reproducible, and robust highperformance thin-layer chromatographic method was developed, which would be of use in quality control of these cream formulations.

Diagnostic Utility of Typhoid Elisa Test In Comparison to Other Conventional Methods for Diagnosis of Typhoid Fever

International journal of scientific research, Jun 1, 2012

Typhoid fever is endemic in many parts of the world and continues to be one of the leading causes... more Typhoid fever is endemic in many parts of the world and continues to be one of the leading causes of morbid- ity and mortality in our country. We have studied typhoid IgM ELISA test, a rapid serological test for diagnosis of typhoid fever and its usefulness for an early diagnosis, its sensitivity and specificity as compared to widal test. Out of 100 samples 22 (22%) cases were positive by blood culture, 30 (30%) were positive with Widal test and 36 (36%) were positive with typhoid ELISA test. The sensitivity, specificity, positive and negative predictive value of Widal test was 63.6%, 79.4%, 46.6% and 88.5% respectively. The sensitivity, specificity, positive and negative predictive value of typhoid IgM ELISA test was 95.4%, 80.7%, 58.3% and 98.4% re- spectively proving the superiority of typhoid IgM ELISA test. 1 . Recent surveillance studies have indicated that infection by S. Typhi causes 21 million illnesses and 200,000 deaths annually 1 . There are at least 17 million new cases of typhoid globally. India is the second most populous country of the world with majority inhabiting the rural areas with little access to modern diagnostic tools. Blood culture and widal test are routinely employed investigations for diagnosis of typhoid fever in all clinical settings 2 . Widal test has been used in the diagnosis of typhoid illness for long time but it remains a serological test with a moderate sensitivity and specificity 3 . Therefore, a fast, reliable, and easy to perform test with a higher sensitivity and specificity than Widal test is required, for rapid diagnosis and management of typhoid cases, thereby enabling clinicians to initiate an early therapy, reducing morbidity and its complications. Typhoid IgM ELISA is a rapid serological test for the diagnosis of typhoid fever 4 . In view of this, we observed that typhoid ELISA is a superior diagnostic tool assuming blood culture as a gold standard for enteric fever, as compare to con- ventional Widal test which has low sensitivity and specificity 5 .

Saving Section 5: Lessons from Consent Decrees and Ex parte Young

Social Science Research Network, 2005

This Article compares the relatively broad federal court authority to enter relief against States... more This Article compares the relatively broad federal court authority to enter relief against States under Ex parte Young with Congress's more limited authority to enact enforcement legislation (namely civil rights statutes) against the States under Section 5 of the Fourteenth Amendment. By exploring these two bodies of law under the same rubric, the Article exposes the unsupportable nature of the Supreme Court's jurisprudence in this area-a jurisprudence that grants considerable discretion to federal district court judges to order prophylactic relief for federal-law violations by States while narrowly limiting congressional power to prevent or remedy such conduct. The inconsistency is most stark in the consent decree context, where Supreme Court doctrine effectively permits district courts' unchecked authority to enter and enforce prophylactic remedies against States. This inconsistent treatment is problematic from both federalism and separation-of-powers perspectives.

Diffuse Idiopathic Skeletal Hyperostosis (DISH) – a Rare Presentation of the Disease

Indian journal of applied research, Oct 1, 2011

Diffuse idiopathic skeletal hyperostosis (DISH) also known as Forestier's disease, is a disor... more Diffuse idiopathic skeletal hyperostosis (DISH) also known as Forestier's disease, is a disorder of unknown etiology that is characterized by back pain and spinal stiffness. The condition is recognized radiographically by the presence of "flowing" ossification along the anterolateral margins of at least four contiguous vertebrae (candle wax dripping appearance) and the absence of changes of spondyloarthropathy or degenerative spondylosis. Even in patients who present with either lumbar or cervical complaints, radiographic findings are almost universally seen on the right side of the thoracic spine. It is characterized by a tendency toward ossification of ligaments (enthesopathy). It most characteristi- cally affects the spine. Ossification of the longitudinal ligaments (especially the anterior ligaments) of the spine produces a tortuous paravertebral mass anterior to and distinct from the vertebral bodies. The zygapophyseal and sacroiliac joints are not involved in DISH, and the intervening intervertebral disk space is preserved. But our patient presented with hip and knee pain rather than the usual spine complaints.

A Secure Spatial Domain Image Steganography Using Genetic Algorithm and Linear Congruential Generator

Advances in intelligent systems and computing, Dec 28, 2017

Significant increase in data traffic over the Internet has given rise to many data security issue... more Significant increase in data traffic over the Internet has given rise to many data security issues. Steganography is a technique which is used to hide the existence of secret communication. Hence, it is extensively used to solve the issues related to data security. In this paper, a secure and lossless spatial domain image steganography technique is proposed. Stream of secret data is hidden in quarter part of image by identifying suitable locations to hide 2 bits of secret data in each pixel, resulting in generation of coefficients corresponding to the location of match. These coefficients are hidden in remaining part of image using LSB replacement steganography. Genetic algorithm is used to find best possible location to hide these coefficients in the image, making the proposed technique very secure and almost impossible to extract secret data from it. The result of the proposed technique is compared with LSB replacement steganography where in same amount of secret data is embedded. It is observed that the proposed technique is much superior as compared to LSB steganography. It provides improvement in MSE and PSNR values; in addition, the degradation in histogram is also minimal thus eliminating histogram attack. Average PSNR value of stego-image obtained from proposed technique is 53.11 dB at two bits per pixel data embedding rate compared to 52.21 obtained by LSB technique.

Topics in voice echo cancellation

Acoustic echo cancellation (AEC) is a well studied problem. The underlying assumption in most ech... more

Friction stir welding of aluminium alloys: An overview of experimental findings – Process, variables, development and applications

Proceedings of the Institution of Mechanical Engineers, Part L: Journal of Materials: Design and Applications, Apr 14, 2017

The never ending appetite of the mankind to produce more and more competitive products results in... more The never ending appetite of the mankind to produce more and more competitive products results in continuous development of newer and newer manufacturing processes. One of such a kind, a solid state welding process highly appreciated for joining of a variety of aluminium and copper alloys, is friction stir welding. The process is also an accomplished method for joining dissimilar materials efficiently. The process finds its major application for joining hard-to-weld metals, especially the precipitation hardenable aluminium alloys and is widely adopted by industries for the welding of such aluminium alloys. However, the process has still not found an economical way for welding of steels and hence found limited applications in industries for welding steels. This paper aims at providing a comprehensive review of the work undertaken in the field of friction stir welding and provides an insight into the friction stir welding of aluminium alloys. The article pays critical attention and analytical evaluation of classification of aluminium alloys, friction stir welding process parameters, the mechanical testing and properties of the friction stir welding joints, macrostructure and microstructure evolution during friction stir welding, friction stir welding defects and industrial applications of the process. The friction stir welding process variants are discussed as well. Special accentuation has been given to (i) effect of friction stir welding parameters on the microstructure evolved and thus the ultimate mechanical properties (viz. tensile strength, hardness, fatigue strength, fracture toughness and residual stresses), (ii) the texture formation, microstructure refinement and the role of intermetallics. However, studies related to welding of dissimilar aluminium alloys, temperature, and heat transfer modeling and material flow are out of the scope of this paper. Finally, the directions of future research are examined.