Background: Roads and vehicles which are for making life comfortable and faster, can result in mi... more Background: Roads and vehicles which are for making life comfortable and faster, can result in miserable life when one meet a road traffic accident. By 2020 road traffic accident is projected to become the third leading contributor to the global burden of disease in the world and 6 th place as a major cause of mortality worldwide. Motor cyclists are about 25 times more risk than passenger car occupants to die because of road traffic accidents. The objectives of the study were, to study pattern of two wheeler road traffic accidents in rural setting. Methods: The present research is a retrospective analysis of all the two-wheeler accidents victim admitted in emergency, during the period ranging from September 2015 to February 2016. Results: Among the total 2,544 patient of RTA admitted within the study period; 1,257 patients (i.e.49.41%) were due to two-wheeler accidents. Next is pedestrian (n=516, 20.2%), light motor vehicle (n=464, 18.23%), and heavy motor vehicle accidents contribute (n=307, 12.06%). Conclusions: lack of road driving sense and lack of knowledge of traffic rules. Regarding the type of vehicles involved in these accidents, the maximum number of accidents was due to two wheeler vehicles (scooter/motorcycle).
Background: Mode of communication in emergency is of prime importance when it comes to patient ma... more Background: Mode of communication in emergency is of prime importance when it comes to patient management or reporting of the patient. An expert opinion and timely information to senior consultants is to be always soughed whenever in doubt. A common electronic media platform can be very beneficial in such circumstances. Methods: All the residents and consultants of emergency team were connected on a common platform using WhatsApp and upload of information was done by residents on duty which was cleared by consultants. Results: A decrease in response time about diagnosis or management of patient was observed to be decreased along with more clear and visual information was available to seniors for their advice. A common platform for reporting and consultation was more appreciated among surgeons and Orthopedician. Conclusions: Using a common electronic platform for communication may be felt cumbersome with some amount of extra burden but definitely results into more accurate delivery of care to patients with in time expert opinion.
Uterine fibroids are the most common of all the benign neoplasms affecting females in reproductiv... more Uterine fibroids are the most common of all the benign neoplasms affecting females in reproductive age groups. The subserous types of fibroids are rare in incidence but sometimes they present with rare complications as torsion of its pedicle or detachment from uterus resulting in a wandering variety of fibroid. Hemoperitoneum because of rupture of surface veins over these subserosal fibroids is very rarely encountered and reported. These patients usually present to emergency department with features of acute abdomen with hemorrhagic shock and need an urgent surgical intervention to take care of the problem.
EuroSimE 2009 - 10th International Conference on Thermal, Mechanical and Multi-Physics Simulation and Experiments in Microelectronics and Microsystems, 2009
Background: In India majority of the dengue outbreaks are attributed to DENV-2 and DENV-3. Howeve... more Background: In India majority of the dengue outbreaks are attributed to DENV-2 and DENV-3. However, DENV-1 is increasingly being implicated as a major serotype during recent outbreaks in India, including the Delhi outbreak in 2006. In Lucknow, we found a similar trend. We sequenced our strains to determine if similar strain is circulating here. In the present study, we sequenced C-prM gene junction of 5 DENV-1 isolated from Lucknow, India. For comparison, we retrieved 23 other Indian and 31 global reference sequences from NCBI database, making sure that Indian and global isolates from all decades are available for comparative analysis. Methods and Findings: 298 samples from clinically suspected cases were tested by IgM MAC ELISA, Viral culture and RT PCR, Real time PCR. 66 cases came out to be positive by various methods. Five serum samples found positive for DENV- 1 RNA were further sequenced for analysis. On sequence analysis, we observed that the Lucknow DENV-1 sequences showed s...
Dengue has re-emerged as an important arboviral disease causing significant morbidity. It has bec... more Dengue has re-emerged as an important arboviral disease causing significant morbidity. It has become hyperendemic in the Indian subcontinent with all four known dengue serotypes circulating. Multiple sequence alignments and phylogenetic trees of DENV-3 were constructed to determine the extent of the isolated dengue virus genetic heterogeneity and phylogeny. Sequencing and phylogenetic analysis of the C-prM gene junction revealed an active circulation of a new lineage of DENV-3 (genotype III) in this region of India. Continuous epidemiological surveillance to monitor the incursion and spread of dengue virus genotypes in this region of India is needed.
The Journal of Infection in Developing Countries, 2010
Background: Classification of symptomatic dengue according to current World Health Organization (... more Background: Classification of symptomatic dengue according to current World Health Organization (WHO) criteria is not straightforward. In this prospective study of dengue infection during an epidemic in India in 2004, we applied the WHO classification of dengue to assess its usefulness for our patients. Methodology: The study included 145 clinically suspected cases of dengue infection of all ages. Dengue was confirmed by serological methods (IgM ELISA and HI test). WHO criteria were applied to classify dengue positive patients into Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Clinical and laboratory parameters were compared between dengue patients with bleeding and those without bleeding. Results: Out of the 50 serologically positive cases of dengue enrolled in the study, only 3 met the WHO criteria for DHF and 1 met the criteria for DSS; however, 21 (42%) cases had one or more bleeding manifestations. Conclusion: By using WHO criteria of DHF on...
Electronic systems under extreme shock and vibration environments including shock and vibration m... more Electronic systems under extreme shock and vibration environments including shock and vibration may sustain several failure modes simultaneously. Previous experience of the authors indicates that the dominant failure modes experienced by packages in a drop and shock frame work are in the solder interconnects including cracks at the package and the board interface, pad cratering, copper trace fatigue, and bulk-failure in the solder joint. In this paper, a method has been presented for failure mode classification using a combination of Karhunen Loéve transform with parity-based stepwise supervised training of a perceptrons. Early classification of multiple failure modes in the pre-failure space using supervised neural networks in conjunction with Karhunen Loéve transform is new. Feature space has been formed by joint time frequency analysis. Since the cumulative damage may be accrued under repetitive loading with exposure to multiple shock events, the area array assemblies have been exposed to shock and feature vectors constructed to track damage initiation and progression. Error Back propagation learning algorithm has been used for stepwise parity of each particular failure mode. The classified failure modes and failure regions belonging to each particular failure modes in the feature space are also validated by simulation of the designed neural network used for parity of feature space. Statistical similarity and validation of different classified dominant failure modes is performed by multivariate analysis of variance and Hoteling's T- square. The results of different classified dominant failure modes are also correlated with the experimental cross sections of the failed test assemblies. The methodology adopted in this paper can perform real-time fault monitoring with identification of specific dominant failure mode and is scalable to system level reliability.
Acute lymphoblastic leukaemia (ALL)is one of the commonest malignancies in children. The disease ... more Acute lymphoblastic leukaemia (ALL)is one of the commonest malignancies in children. The disease per se and immunosuppressant cytotoxic drugs administered, together make the patients of ALL very prone to secondary infections. Yeasts recovered from pulmonary tissue are mostly treated as colonisers and left unreported, though they can also be rarely responsible for pneumonia, especially in settings of haematological malignancies. Here we report a case of lung infection due to Candida kefyr in a patient with ALL.
Background: Roads and vehicles which are for making life comfortable and faster, can result in mi... more Background: Roads and vehicles which are for making life comfortable and faster, can result in miserable life when one meet a road traffic accident. By 2020 road traffic accident is projected to become the third leading contributor to the global burden of disease in the world and 6 th place as a major cause of mortality worldwide. Motor cyclists are about 25 times more risk than passenger car occupants to die because of road traffic accidents. The objectives of the study were, to study pattern of two wheeler road traffic accidents in rural setting. Methods: The present research is a retrospective analysis of all the two-wheeler accidents victim admitted in emergency, during the period ranging from September 2015 to February 2016. Results: Among the total 2,544 patient of RTA admitted within the study period; 1,257 patients (i.e.49.41%) were due to two-wheeler accidents. Next is pedestrian (n=516, 20.2%), light motor vehicle (n=464, 18.23%), and heavy motor vehicle accidents contribute (n=307, 12.06%). Conclusions: lack of road driving sense and lack of knowledge of traffic rules. Regarding the type of vehicles involved in these accidents, the maximum number of accidents was due to two wheeler vehicles (scooter/motorcycle).
Background: Mode of communication in emergency is of prime importance when it comes to patient ma... more Background: Mode of communication in emergency is of prime importance when it comes to patient management or reporting of the patient. An expert opinion and timely information to senior consultants is to be always soughed whenever in doubt. A common electronic media platform can be very beneficial in such circumstances. Methods: All the residents and consultants of emergency team were connected on a common platform using WhatsApp and upload of information was done by residents on duty which was cleared by consultants. Results: A decrease in response time about diagnosis or management of patient was observed to be decreased along with more clear and visual information was available to seniors for their advice. A common platform for reporting and consultation was more appreciated among surgeons and Orthopedician. Conclusions: Using a common electronic platform for communication may be felt cumbersome with some amount of extra burden but definitely results into more accurate delivery of care to patients with in time expert opinion.
Uterine fibroids are the most common of all the benign neoplasms affecting females in reproductiv... more Uterine fibroids are the most common of all the benign neoplasms affecting females in reproductive age groups. The subserous types of fibroids are rare in incidence but sometimes they present with rare complications as torsion of its pedicle or detachment from uterus resulting in a wandering variety of fibroid. Hemoperitoneum because of rupture of surface veins over these subserosal fibroids is very rarely encountered and reported. These patients usually present to emergency department with features of acute abdomen with hemorrhagic shock and need an urgent surgical intervention to take care of the problem.
EuroSimE 2009 - 10th International Conference on Thermal, Mechanical and Multi-Physics Simulation and Experiments in Microelectronics and Microsystems, 2009
Background: In India majority of the dengue outbreaks are attributed to DENV-2 and DENV-3. Howeve... more Background: In India majority of the dengue outbreaks are attributed to DENV-2 and DENV-3. However, DENV-1 is increasingly being implicated as a major serotype during recent outbreaks in India, including the Delhi outbreak in 2006. In Lucknow, we found a similar trend. We sequenced our strains to determine if similar strain is circulating here. In the present study, we sequenced C-prM gene junction of 5 DENV-1 isolated from Lucknow, India. For comparison, we retrieved 23 other Indian and 31 global reference sequences from NCBI database, making sure that Indian and global isolates from all decades are available for comparative analysis. Methods and Findings: 298 samples from clinically suspected cases were tested by IgM MAC ELISA, Viral culture and RT PCR, Real time PCR. 66 cases came out to be positive by various methods. Five serum samples found positive for DENV- 1 RNA were further sequenced for analysis. On sequence analysis, we observed that the Lucknow DENV-1 sequences showed s...
Dengue has re-emerged as an important arboviral disease causing significant morbidity. It has bec... more Dengue has re-emerged as an important arboviral disease causing significant morbidity. It has become hyperendemic in the Indian subcontinent with all four known dengue serotypes circulating. Multiple sequence alignments and phylogenetic trees of DENV-3 were constructed to determine the extent of the isolated dengue virus genetic heterogeneity and phylogeny. Sequencing and phylogenetic analysis of the C-prM gene junction revealed an active circulation of a new lineage of DENV-3 (genotype III) in this region of India. Continuous epidemiological surveillance to monitor the incursion and spread of dengue virus genotypes in this region of India is needed.
The Journal of Infection in Developing Countries, 2010
Background: Classification of symptomatic dengue according to current World Health Organization (... more Background: Classification of symptomatic dengue according to current World Health Organization (WHO) criteria is not straightforward. In this prospective study of dengue infection during an epidemic in India in 2004, we applied the WHO classification of dengue to assess its usefulness for our patients. Methodology: The study included 145 clinically suspected cases of dengue infection of all ages. Dengue was confirmed by serological methods (IgM ELISA and HI test). WHO criteria were applied to classify dengue positive patients into Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Clinical and laboratory parameters were compared between dengue patients with bleeding and those without bleeding. Results: Out of the 50 serologically positive cases of dengue enrolled in the study, only 3 met the WHO criteria for DHF and 1 met the criteria for DSS; however, 21 (42%) cases had one or more bleeding manifestations. Conclusion: By using WHO criteria of DHF on...
Electronic systems under extreme shock and vibration environments including shock and vibration m... more Electronic systems under extreme shock and vibration environments including shock and vibration may sustain several failure modes simultaneously. Previous experience of the authors indicates that the dominant failure modes experienced by packages in a drop and shock frame work are in the solder interconnects including cracks at the package and the board interface, pad cratering, copper trace fatigue, and bulk-failure in the solder joint. In this paper, a method has been presented for failure mode classification using a combination of Karhunen Loéve transform with parity-based stepwise supervised training of a perceptrons. Early classification of multiple failure modes in the pre-failure space using supervised neural networks in conjunction with Karhunen Loéve transform is new. Feature space has been formed by joint time frequency analysis. Since the cumulative damage may be accrued under repetitive loading with exposure to multiple shock events, the area array assemblies have been exposed to shock and feature vectors constructed to track damage initiation and progression. Error Back propagation learning algorithm has been used for stepwise parity of each particular failure mode. The classified failure modes and failure regions belonging to each particular failure modes in the feature space are also validated by simulation of the designed neural network used for parity of feature space. Statistical similarity and validation of different classified dominant failure modes is performed by multivariate analysis of variance and Hoteling's T- square. The results of different classified dominant failure modes are also correlated with the experimental cross sections of the failed test assemblies. The methodology adopted in this paper can perform real-time fault monitoring with identification of specific dominant failure mode and is scalable to system level reliability.
Acute lymphoblastic leukaemia (ALL)is one of the commonest malignancies in children. The disease ... more Acute lymphoblastic leukaemia (ALL)is one of the commonest malignancies in children. The disease per se and immunosuppressant cytotoxic drugs administered, together make the patients of ALL very prone to secondary infections. Yeasts recovered from pulmonary tissue are mostly treated as colonisers and left unreported, though they can also be rarely responsible for pneumonia, especially in settings of haematological malignancies. Here we report a case of lung infection due to Candida kefyr in a patient with ALL.
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Papers by Prashant Gupta