Papers by Pierre Othniel Moreau
Journal of Immunology, Feb 1, 1963
Previously it had been reported (1) that 6-to 12-month-old roosters showed an excellent antibody ... more Previously it had been reported (1) that 6-to 12-month-old roosters showed an excellent antibody response to injections of infective or inactivated preparations of the three types of poliovirus. One dose of 1.0 ml of undiluted trivalent Salk polio vaccine inoculated intravenously gave an antibody response in roosters which was similar to that of three intramuscular doses given to monkeys. The present report deals with the elaboration of an antigenicity test for the Salk polio vaccine using 12 roosters instead of 12 monkeys in each test. Groups of monkeys and roosters were inoculated with different lots of Salk trivalent vaccine and the antibody titer of their sera was compared with that of a reference monkey antiserum. Antibody titratious performed with the plaque neutralization test confirmed the results obtained with the tube-culture neutralization test. MATERIALS AND METHODS Viruses. Stock viruses of the Mahoney, MEF-1 and Saukett strains were employed. Vaccines. Commercially produced Salk vaccines containing the Mahoney, MEF-1 and Saukett strains were used. Roosters. These were 6-to 12-month-old White Leghorn birds and were supplied by the same breeder. Monkeys. I~hesus monkeys (Macacus mulatta) weighing between 5 and 8 lb were used. Immunization. Monkeys were immunized according to the U. S. Minimum Requirements for Poliomyelitis Vaccine Production and Testing (2). Each of a group of 12 monkeys received a series of three 1.0-ml doses intramuscularly of undiluted vaccine spaced at weekly intervals. Blood samples were taken before the first inoculation and 7 days after the third injection. A group of 12 roosters was inoculated each with one dose of 1.0 ml of undiluted vaccine intravenously. The birds were bled before and 7 days after the inoculation.
at: is onlineArteriosclerosis, Thrombosis, and Vascular Biology Information about subscribing to ... more at: is onlineArteriosclerosis, Thrombosis, and Vascular Biology Information about subscribing to Subscriptions:
Pierre Moreau1,2, B.Pharm., Ph.D., Diane Lamarre3,4, B.Pharm., M.Sc. 1Doyen, Faculte de pharmacie... more Pierre Moreau1,2, B.Pharm., Ph.D., Diane Lamarre3,4, B.Pharm., M.Sc. 1Doyen, Faculte de pharmacie, Universite de Montreal, Montreal (Quebec) Canada; 2Professeur titulaire, Faculte de pharmacie, Universite de Montreal, Montreal (Quebec) Canada; 3Presidente, Ordre des pharmaciens du Quebec, Montreal (Quebec) Canada; 4Professeure titulaire de clinique, Faculte de pharmacie, Universite de Montreal, Montreal (Quebec) Canada
Résumé : Un système de santé efficace doit veiller à la promotion, au rétablissement et à la cons... more Résumé : Un système de santé efficace doit veiller à la promotion, au rétablissement et à la conservation de la santé en comptant, entre autres, sur l’intégration efficace et concertée d’un ensemble de professionnels organisés en équipes multidisciplinaires et interdisciplinaires. Parmi ces professionnels, le pharmacien a un rôle primordial à jouer. En Haïti, il est un des moins sollicités. Dans cet article, nous examinons l’évolution du rôle du pharmacien haïtien et les conséquences de son absence dans le système de santé. En nous basant sur l’évolution du rôle du pharmacien dans les pays développés, nous allons analyser comment et pourquoi la modernisation de la profession est un impératif dans l’établissement d’un système de santé efficace en Haïti et proposer diverses mesures visant l’intégration et la participation de ce professionnel de la santé au système.
Journal of the American Society of Nephrology, 2000
This study investigated the role of renal nitric oxide synthase (NOS), endothelin, and possible m... more This study investigated the role of renal nitric oxide synthase (NOS), endothelin, and possible mechanisms of renovascular dysfunction in salt-sensitive hypertension. Salt-sensitive (DS) and salt-resistant (DR) Dahl rats were treated for 8 wk with high salt diet (4% NaCl) alone or in combination with the ET A receptor antagonist LU135252 (60 mg/kg per d). Salt loading markedly increased NOS activity (pmol citrulline/mg protein per min) in renal cortex and medulla in DR but not in DS rats by 270 and 246%, respectively. Hypertension in DS rats was associated with renal artery hypertrophy, increased vascular and renal endothelin-1 (ET-1) protein content, and glomerulosclerosis. In the renal artery but not in the aorta of hypertensive DS rats, endothelium-dependent relaxation to acetylcholine was unchanged; however, endothelial dysfunc
Saudi Pharmaceutical Journal, 2018
Introduction: Pharmacy practice has considerably evolved from a dispensing role to a patient-cent... more Introduction: Pharmacy practice has considerably evolved from a dispensing role to a patient-centered profession. Kuwait has minimal clinical pharmacy services established in its healthcare settings. Objectives: The objectives of this study were to document existing clinical pharmacy services in public hospitals, identify barriers to their implementation and assess perceptions regarding pharmacists providing clinical services. Material & Method: A cross sectional study using self-administered questionnaires among a total of 166 pharmacists and 284 physicians across 6 public hospitals in Kuwait was conducted. Results: Over half of pharmacists (54%) provided clinical services, with the most common service being education and drug information (86%). Forty percent (40%) of the pharmacists reported that clinical services offered were of their own initiative but most of them (71%) were not sure whether they would offer additional services in the future. The majority of physicians were receptive to an expanded patientcentered role of the pharmacist (97%), believed pharmacists add to patient clinical care (92%) and considered pharmacists members of the healthcare team (96%). Major barriers reported by pharmacists to implement clinical pharmacy services included lack of policy (49%), time (36%) and clinical skills (28%), which is similar to barriers reported by physicians. Conclusion: Although clinical pharmacy is in its infancy in Kuwait, it is well perceived and requested by physicians. Major barriers must be addressed and in this context, having a national framework for pharmacy practice from Ministry of Health, supported by cutting edge education and a pro-active professional association would be key assets to evolve the practice in Kuwait.
Physical Review C, 2019
We extend the parton-hadron-string dynamics (PHSD) transport approach in the partonic sector by e... more We extend the parton-hadron-string dynamics (PHSD) transport approach in the partonic sector by explicitly calculating the total and differential partonic scattering cross sections as a function of temperature T and baryon chemical potential µB on the basis of the effective propagators and couplings from the dynamical quasiparticle model (DQPM) that is matched to reproduce the equation of state of the partonic system above the deconfinement temperature Tc from lattice QCD. We calculate the collisional widths for the partonic degrees of freedom at finite T and µB in the timelike sector and conclude that the quasiparticle limit holds sufficiently well. Furthermore, the ratio of shear viscosity η over entropy density s, i.e., η/s, is evaluated using the collisional widths and compared to lattice QCD calculations for µB = 0 as well. We find that the novel ratio η/s does not differ very much from that calculated within the original DQPM on the basis of the Kubo formalism. Furthermore, there is only a very modest change of η/s with the baryon chemical µB as a function of the scaled temperature T /Tc(µB). This also holds for a variety of hadronic observables from central A + A collisions in the energy range 5 GeV ≤ √ sNN ≤ 200 GeV when implementing the differential cross sections into the PHSD approach. We only observe small differences in the antibaryon sector (p,Λ +Σ 0) at √ sNN = 17.3 GeV and 200 GeV with practically no sensitivity of rapidity and pT distributions to the µB dependence of the partonic cross sections. Small variations in the strangeness sector are obtained in all collisional systems studied (A + A and C + Au); however, it will be very hard to extract a robust signal experimentally. Since we find only small traces of a µB dependence in heavy-ion observables-although the effective partonic masses and widths as well as their partonic cross sections clearly depend on µB-this implies that one needs a sizable partonic density and large space-time QGP volume to explore the dynamics in the partonic phase. These conditions are only fulfilled at high bombarding energies where µB is, however, rather low. On the other hand, when decreasing the bombarding energy and thus increasing µB, the hadronic phase becomes dominant and accordingly it will be difficult to extract signals from the partonic dynamics based on "bulk" observables.
Nuclear Physics A, 2017
Chiral symmetry restoration with increasing temperature Deconfinement phase transition with inc... more Chiral symmetry restoration with increasing temperature Deconfinement phase transition with increasing temperature Introduction Chiral symmetry restoration Results for strangeness in A+A Summary Scalar quark condensate ഥ is viewed as an order parameter for the restoration of chiral symmetry:
Journal of Physics: Conference Series, 2016
The production and dynamics of strange and antistrange hadrons in heavy-ion reactions from √ sNN ... more The production and dynamics of strange and antistrange hadrons in heavy-ion reactions from √ sNN ≈ 3 GeV to 200 GeV is analyzed within the Parton-Hadron-String-Dynamics (PHSD) transport model. The PHSD results for strange baryon and antibaryon production are roughly consistent with the experimental data starting from upper SPS energies. Nevertheless, hadronic final state flavor-exchange reactions are important for the actual abundances, in particular at large rapidities where hadronic dynamics, parton fragmentation and string decay dominate. A striking disagreement between the PHSD results and the available data persists, however, for bombarding energies below √ sNN ≈ 8 GeV where the strangeness production is significantly underestimated as in earlier HSD studies. This finding implies that the strangeness enhancement seen experimentally at FAIR/NICA energies cannot be attributed to a deconfinement phase transition or crossover but probably involves the approximate restoration of chiral symmetry in the hadronic phase.
American Journal of Hypertension, 1995
ABSTRACT The possible involvement of prejunctional α2-adrenergic autoinhibition in hypertension i... more ABSTRACT The possible involvement of prejunctional α2-adrenergic autoinhibition in hypertension is still controversial. The aim of this study was to determine the functional integrity of this regulatory mechanism in conscious DOCA-salt hypertensive rats, a model characterized by an increased sympathetic tone and reactivity. Basal and hemorrhage-induced increases in catecholamine and immunoreactive neuropeptide Y (NPY) levels were compared between control and yohimbine (α2-adrenergic receptor antagonist) pretreated normotensive and DOCA-salt hypertensive rats. DOCA-salt hypertensive rats had higher basal norepinephrine levels (NE), as well as increased NE and epinephrine (EPI) responses to a 15-mL/kg hemorrhage as compared to control normotensive rats. In normotensive animals, yohimbine (0.5 mg/kg, intravenous [iv]) doubled plasma NE, EPI, and NPY levels in basal conditions and in response to the hemorrhage. In contrast, the same treatment had smaller or no effect on basal NE levels and on the hemorrhage-induced responses in DOCA-salt hypertensive rats, although basal EPI levels were increased in this group. These results therefore suggest a decreased function of the prejunctional α2-adrenergic autoinhibitory mechanism at the level of sympathetic nerve terminals and adrenal medulla during sympathetic hyperactivity in DOCA-salt hypertension. This dysfunction could in part explain the hyperactivity and hyperreactivity of the sympathetic nervous system observed in this model, and thus contribute to the elevation of blood pressure in DOCA-salt hypertension.
Circulation, Nov 22, 2011
Revue Du Notariat Belge, Dec 1, 2013
Peer reviewe
Etude sur les sujets suivants : 1. Lire et comprendre un arrêt de la Cour de cassation; 2. Typolo... more Etude sur les sujets suivants : 1. Lire et comprendre un arrêt de la Cour de cassation; 2. Typologie des règles fondée sur leur caractère d'ordre public, simplement impératif et supplétif; 3. La réception de la preuve illicite; 4. La production d'attestations
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Papers by Pierre Othniel Moreau