Papers by Pembe Keskinoğlu
The Journal of Pediatric Research, 2020
Aim: Vesicoureteral reflux (VUR) and urinary tract infection (UTI) are common problem in children... more Aim: Vesicoureteral reflux (VUR) and urinary tract infection (UTI) are common problem in children. Our goal is to use different models for the clinical decision of differential diagnosis of VUR and UTI in children. Material and Methods: This was a retrospective cross-sectional study enrolled 611 pediatric patients. Detailed information for the patients was obtained from hospital records and patient files. Three models including different variables were evaluated via artificial neural network for differential diagnosis of VUR and recurrent UTI. Clinical findings were included in Model 1, clinical and laboratory findings were included in Model 2, and clinical, laboratory and detailed urinary USG findings were included in Model 3. Crossvalidation technique was used to evaluate predictive models by partitioning the original sample into a training set to train the model, and a test set to evaluate it. Results: Of the 611 children, 425 (69.6%) had VUR and 186 (30.4%) had UTI. Sensitivity of Model 1 and Model 2 were 0.682 and 0.856, respectively. Also, Model 3 showed the best performance and high sensitivity with 0.939 for differential diagnosis. Conclusion: Differential diagnosis between VUR and UTI in children can predict with using clinical, laboratory and USG variables via Artificial Neural Network. The model 3 which was including clinical, laboratory and USG variables together is shown the highest performance and sensitivity.
European Geriatric Medicine, 2015
Turkish Journal of Intensive Care
Objective: BIS is a parameter generated from a mathematical analysis of frontal cortex activity. ... more Objective: BIS is a parameter generated from a mathematical analysis of frontal cortex activity. BIS monitoring has been widely used in cerebral pathologies such as traumatic brain injury, brain death, metabolic coma and barbiturate coma and some studies have reported a good correlation between neurological status and BIS values. We evaluated the validity of BIS monitoring for the detection and diagnosis of brain death in our study. Materials and Methods: Our study was a methodological prospective study. Twenty-eight patients with severe coma (GCS<8) at ICU admission are monitored by BIS. Eight patients were excluded from the study due to varies reasons. Data of twenty patients with brain death were evaluated. Results: The most common diagnoses were intracranial hemorrhage (8 patients-40%) and subarachnoid hemorrhage (8 patients-40%). The most common used ancillary method was computed tomography angiography. BIS and suppression ratio (SR) were determined as 0 and 100 respectively at the moment of brain death diagnosis in 12 of 20 patients, whereas BIS was determined >0 in the remainders. When the ROC curve analysis was performed for the 34041 BIS values of 20 patients, the AUC was found as 0.582 (0.576-0.588), which was statistically significant (p<0.05). There was a strong negative correlation between BIS and SR and it was statistically significant (R:-0.959, p<0.05). Conclusion: BIS is a non-invasive method and it may be used in the ICU. BIS monitoring may be useful, especially in patients with head trauma and GCS=3. BIS monitoring provides information about the neurological prognosis. We consider that BIS monitoring can prevent the loss of time by providing to detect the moment of the brain death and thus facilitating the organ transplantation process and however it can not take the place of the other ancillary methods.
Trakya Universitesi Tip Fakultesi Dergisi, 2006
Gait & Posture, 2020
Conclusion: Overall, Our findings suggest that catechin hydrate inhibits B(a)P-induced lung tumor... more Conclusion: Overall, Our findings suggest that catechin hydrate inhibits B(a)P-induced lung tumor formation by modulating hyperproliferation, inflammation, apoptosis and ALDH1 expression.
Journal of Perinatal Medicine, 2021
Objectives Pregnancy is associated with physiological alterations in insulin sensitivity and lipi... more Objectives Pregnancy is associated with physiological alterations in insulin sensitivity and lipid metabolism. This study investigates the associations between pregestational body mass index (pBMI) and the rate of gestational weight gain (rGWG) in the second trimester with the biomarkers of lipid, fatty acids metabolism and insulin resistance. Methods Sixty nine pregnant women followed. The body weights of the pregnant women were measured and blood samples were obtained at 11–14th and 24–28th weeks of pregnancy. Glucose, total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol, insulin levels and fatty acids were measured. Rate of GWG (kg/week) and The Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) were calculated. The pregnant women were stratified according to their pBMI and the 2nd trimester rGWG. Results The rate of GWG was significantly higher for the group with pBMI<25, compared to the group with pBMI≥25 (p=0.024). Triglyceride, total cholesterol, LD...
Clinical Neurology and Neurosurgery, 2019
This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Ear, Nose & Throat Journal, 2019
The purpose of this study was to investigate the effects of craniofacial structure and nasal sept... more The purpose of this study was to investigate the effects of craniofacial structure and nasal septal deviation on frontal sinus morphology 3-dimensionally. This study of anatomy, anthropology, morphology, and radiology included 74 dry skulls as study sample. The craniofacial measurements were made through conventional anthropometric methods by the use of calipers. The nasal septal deviation measurements were done by computerized software on photographs taken from frontal view. Frontal sinus volumes were estimated by the computerized tomography-based volumetry. The relationships between craniofacial structure, nasal septal deviation, and frontal sinus morphology were tested by linear regression and correlation analysis. The analysis of numerical variables and categorical variables within different groups was done by Mann-Whitney U/Kruskal-Wallis, and χ2 tests, respectively. There appeared a positive relationship between the dimensions of the frontal sinuses and the maximal cranial len...
Turk Otolarengoloji Arsivi/Turkish Archives of Otolaryngology, 2017
Objective: The aim of this study was to investigate and compare the auditory findings in vestibul... more Objective: The aim of this study was to investigate and compare the auditory findings in vestibular migraine (VM) and migraine patients without a history of vertigo. Methods: This study was conducted on 44 patients diagnosed with definite VM and 31 patients diagnosed with migraine who were followed and treated between January 2011 and February 2015. Also, 52 healthy subjects were included in this study as a control group. All participants underwent a detailed otorhinolaryngological examination followed by audiological evaluation, including pure tone audiometry, speech reception threshold, speech recognition score, and acoustic immitancemetry. Results: In the VM group, there were 16 patients (36.4%) with tinnitus, while in the other groups we did not observe any patients with tinnitus. The rate of tinnitus in the VM group was significantly higher in comparison to other groups (p<0.05). None of the groups had any patients with permanent or fluctuating sensorineural hearing loss. Conclusion: We conclude that patients with VM should be closely and longitudinally followed up for the early detection of other otological symptoms and possible occurrence of sensorineural hearing loss in the long term.
Clinical Otolaryngology, 2019
ObjectivesThe Sino‐Nasal Outcome Test (SNOT)‐22 is a widely used health‐related quality of life q... more ObjectivesThe Sino‐Nasal Outcome Test (SNOT)‐22 is a widely used health‐related quality of life questionnaire. This study aimed to conduct a translation and validation study of the SNOT‐22 in the Turkish language.DesignWe achieved a convenient translation and cultural adaptation process to translate the original SNOT‐22 into the Turkish language (observational prospective cohort study).SettingThis study was conducted in a single tertiary‐level university hospital.ParticipantsWe performed reliability, validity and responsiveness analyses in 313 participants. One hundred eighty‐nine of the participants were the chronic rhinosinusitis (CRS) group, and 79 healthy volunteers enrolled in the control group. Twenty‐nine participants who underwent endoscopic sinus surgery for CRS were evaluated for pre‐postoperative responsiveness analysis.Main Outcome MeasuresReliability (internal consistency and test‐retest reproducibility), validity, responsiveness, sensitivity and specificity.ResultsThe ...
The Turkish Journal of Gastroenterology, 2018
Background/Aims: To translate the University of California, Los Angeles Scleroderma Clinical Tria... more Background/Aims: To translate the University of California, Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT) 2.0 questionnaire from English to Turkish and to validate it. Materials and Methods: UCLA SCTC GIT 2.0 was translated into Turkish using the translation-retranslation method. The available Turkish GIT 2.0 and the Short Form 36 (SF-36) were administered to 97 Turkish-speaking patients with systemic sclerosis (Ssc). Internal consistency reliability and structural validity were assessed by analyzing the correlations between the UCLA SCTC GIT 2.0 and the SF-36 scales. Internal consistency was determined by calculating Cronbach's alpha. For evaluation of reliability, the questionnaire scale was repeatedly applied to a subgroup of patients with a 2-week interval, and the intraclass correlation coefficient (ICC) was calculated. The Spearman's correlation coefficients between the GIT and the SF-36 scores were calculated. Results: A group of 97 patients with Ssc with a mean age of 55.37±11.35 years and a female predominance (87.6%) were included in the study. The Cronbach's alpha value for the UCLA SCTC GIT 2.0 scale was 0.894. ICC was 0.821 (p=0.000). The scale showed acceptable reliability, with the exception of the diarrhea subscale (alpha=0.356). There was a moderate correlation between the total GIT score and the Short Form 36 (SF-36) subscales. All of the items in the scale were included in the validity analysis owing to their reliability. Conclusion: The Turkish GIT 2.0 scale showed good internal consistency, high reliability, and an acceptable validity.
Annals of the Rheumatic Diseases, 2016
Pol III antibodies, patients were divided into two groups a-RNA Pol III(+) SSc-19 pts and a-RNA P... more Pol III antibodies, patients were divided into two groups a-RNA Pol III(+) SSc-19 pts and a-RNA Pol III(−) SSc-107 pts. Results: According to our data a-RNA Pol III antibodies were present in 19/126 patients with SSc (15%), including the a-RNA Pol III 11 were present in 16 and a-RNA Pol III 155 in 14. In this group of 13 (68,4%) pts had no other marker to SSc antibodies as a anticentromere, anti-topoisomerase I. Moreover, in our study group, a-RNA Pol III antibodies were more common in patients with dcSSc (p=0,049), compare to lcSSc. We also showed a significant positive association with a-RNA Pol III antibodies and occurrence of malignancy (p=0,007), SRC (p=0,001) and decreased DLCO (p=0,007). There was no relationship between the presence of a-RNA Pol III and other organ involvement, digital ulcerations or calcinosis. Conclusions: 1. Anti-a-RNA Pol III antibodies are quite common in patients with systemic sclerosis, particularly with diffuse subtype. 2. In more than 50% of patients a-RNA Pol III antibodies may be present as the sole marker to SSc antibodies. 3. In SSc a-RNA Pol III antibodies are frequently associated with malignancy occurrence, kidney and lung involvement.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2016
Background-The antimanic efficacy of a protein kinase C (PKC) inhibitor, tamoxifen, has been test... more Background-The antimanic efficacy of a protein kinase C (PKC) inhibitor, tamoxifen, has been tested in several clinical trials, all reporting positive results. However, mechanisms underlying the observed clinical effects requires further confirmation through studies of biological markers.
European Neuropsychopharmacology, 2015
European Geriatric Medicine, 2015
European Journal of Epidemiology
In order to assess immunity to diphtheria in Izmir, Turkey, a total of 743 persons 1-70 years of ... more In order to assess immunity to diphtheria in Izmir, Turkey, a total of 743 persons 1-70 years of age were selected with cluster sampling. The information on socio-demographic characteristics, vaccination status and diphtheria history was gathered for each participant. Diphtheria antitoxin levels were measured qualitatively by using micro-enzyme immune assay. Of studied population, 79.1% had fully protective antitoxin levels (> or = 0.1 IU/ml). Diphtheria protection rates showed a gradual age-related decrease, reaching minimum in the 30-44 age group, in which 40.2% of these subjects had antibody titre below the full protective level. The diphtheria antitoxin geometric mean titer was highest in the 5-9 year age group (1.05 IU/ml). Then, geometric mean titer decreased with increasing age, and reached the minimum level in the 30-44 age group (0.19 IU/ml). These results suggest that in Izmir, Turkey, full serological protection against diphtheria is only detectable in 60% of the adult...
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Papers by Pembe Keskinoğlu