We report a high-performance magnetic nanoparticle as a hyperthermic agent under low applied fiel... more We report a high-performance magnetic nanoparticle as a hyperthermic agent under low applied field and frequency. CTAB (cetyltrimethylammonium bromide)-coated Ni x Zn 1Àx Fe 2 O 4 nanoparticles of average particle size < 25 nm with various stoichiometric ratios were successfully synthesized using a coprecipitation technique. Characterization results indicate a close interaction of CTAB ions with the surface metal ions resulting in a cation distribution deviating from their equilibrium positions. Magnetic measurements were done at 300 K and 5 K using a superconducting quantum interference device. Saturation magnetization gradually increases with increasing substitution of Ni 2+ ions with Zn 2+ ions, attributed to the cation distribution and high super-exchange interaction between the A-and B-sites. The average size of the nanoparticles is estimated to be <10 nm with a magnetically dead layer (>1 nm @ 300 K), reflecting the effect of CTAB coating on the surface of the nanoparticles. The magnetocrystalline anisotropy (K eff), obtained from the law of approach to saturation, is inversely proportional to the M s value. The increasing incorporation of Ni 2+ ions in the lattice system is found to influence various structural parameters, which is reflected in the magnetic performance of the nanoparticles. A specific absorption rate of 347 W g À1 and intrinsic loss power of 4.6 nH m 2 kg À1 was attained with a minimal concentration of 2 mg ml À1 in a very short time period of 1.5 min in Ni 0.75 Zn 0.25 Fe 2 O 4 nanoparticles.
Carbon nanotube (CNT) has been evolved as a novel material in diverse applications since its disc... more Carbon nanotube (CNT) has been evolved as a novel material in diverse applications since its discovery. Functionalization of multi-walled carbon nanotube (MWCNT) with different functional groups namely carboxylic, amine and polyethylene glycol (PEG) has been the central point of this work. The functionalized MWCNTs were made nanocomposite with manganese ferrite nanoparticles, synthesized through solvothermal method. Formations of crystalline ferrites were confirmed through X-ray diffractograms (XRD), which shows formation of spinel cubic phase. Uniform size distribution of manganese ferrite (MnFe 2 O 4) nanoparticles synthesized by solvothermal method was confirmed by high resolution transmission electron microscope (HRTEM) images. Fourier transformed infra-red spectroscopy (FTIR) was employed to study the vibrational features of the functionalized MWCNT and MWCNT/ MnFe 2 O 4 nanocomposites. Vibrating sample magnetometer (VSM) study shows the ferromagnetic behavior of the MWCNT/MnFe 2 O 4 nanocomposites. Functionalized MWCNT/MnFe 2 O 4 nanocomposites were subjected to hyperthermia studies with minimal concentration (2mg/ml) and magnetic heating efficiency has been studied.
We investigate the efficacy of polyethylene glycol (PEG) and amine-functionalized MWCNT decorated... more We investigate the efficacy of polyethylene glycol (PEG) and amine-functionalized MWCNT decorated with MnFe 2 O 4 nanocomposites as heating material for magnetic hyperthermia applications. Samples are prepared by a standard solvothermal method. Phase formation of MnFe 2 O 4 has been confirmed by X-ray diffractogram and attachment of nanoparticles on the surface of functionalized MWCNT is evident from transmission electron microscopic image of nanocomposite. Fourier transform infrared spectrum of PEG-functionalized MWCNT and amine-functionalized MWCNT confirmed the presence of PEG and amine group, respectively. As desirable for stability in magnetic hyperthermia, vibration sample magnetometer study suggests superparamagnetic behaviour of all the samples at temperatures 300 K, 200 K and 100 K except at 5 K, which is below blocking temperature as confirmed by ZFC-FC curves. Estimated Curie temperature (T C) and room temperature effective anisotropy is found to increase in nanocomposites, highest for amine-functionalized MWCNT/MnFe 2 O 4 nanocomposite. A clear correlation between effective anisotropy and heat generation capability (SAR/ILP) has been observed: higher the anisotropy, higher is the heat generation capability (SAR/ILP).
Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in th... more Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in the magnetic hyperthermia as well as imaging applications. In the present study, the effect of yttrium concentration on the magnetic characteristics of the iron oxide based nanomaterials was analyzed to assess their potential for the hyperthermia applications. The Sol-gel method was used to synthesize the Yttrium Iron Garnet (YIG) based nanoparticles, using different molar ratios of Fe and Y precursors, followed by the calcination at 900, 1000 and 1100°C. XRD analysis determined the formation of the pure phase of yttrium iron garnet Y 3 Fe 5 O 12 (YIG) at 0.5 molar ratio of yttrium at all the calcination temperatures and pure phase of yttrium iron perovskite YFeO 3 (YIP) for 1 molar ratio of yttrium at 1000 and 1100°C. The mean particle size was observed in the range of 100 to 400 nm. The magnetic characterization studies showed the highest saturation magnetization for the sample containing 0.5 molar ratio of the yttrium calcinated at 1000°C. The magnetization values were linearly related to the contents of YIG phases in the synthesized samples. Induction heating of YIG resulted in the hyperthermia temperature (42 to 44°C) in 13 min with the SAR values 114.65 W/g at 1 mg/ml. The prepared samples showed no in-vitro toxic effects on the MG63 cells (> 90% cell viability). In addition, in-vitro treatment at hyperthermia temperature for 15 min reduced cell viability of cancer cells (A549) to 55%, while no toxic effect was observed on MG 63 cells. The present study postulates Yttrium Iron Garnet as an effective therapeutic agent for hyperthermia cancer treatment.
In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe... more In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe2O4) nanocomposite and its probable application in hyperthermia. MnFe2O4 nanoparticles were synthesized by co-precipitation method. X ray diffractogram (XRD) confirms the formation of cubic phase of MnFe2O4 with preferred crystallographic orientation along (311) plane. High resolution electron microscope (HRTEM) image of the composites confirms the presence of MnFe2O4 spherical nanoparticles on the surface of CNT which are bound strongly to the surface. MWCNT-MnFe2O4 nanocomposite were prepared after acid functionalization of MWCNT. Vibrational features of the synthesized samples were confirmed through Fourier transformed infra-red spectroscopy (FTIR). FTIR spectra of acid functionalized MWCNT shows a peak positioned at ∼1620cm−1 which corresponds to C=O functional group of carboxylic acid. Prepared MnFe2O4 nanoparticles and MWCNT-MnFe2O4 nanocomposites were subjected to hyperthermia studies.In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe2O4) nanocomposite and its probable application in hyperthermia. MnFe2O4 nanoparticles were synthesized by co-precipitation method. X ray diffractogram (XRD) confirms the formation of cubic phase of MnFe2O4 with preferred crystallographic orientation along (311) plane. High resolution electron microscope (HRTEM) image of the composites confirms the presence of MnFe2O4 spherical nanoparticles on the surface of CNT which are bound strongly to the surface. MWCNT-MnFe2O4 nanocomposite were prepared after acid functionalization of MWCNT. Vibrational features of the synthesized samples were confirmed through Fourier transformed infra-red spectroscopy (FTIR). FTIR spectra of acid functionalized MWCNT shows a peak positioned at ∼1620cm−1 which corresponds to C=O functional group of carboxylic acid. Prepared MnFe2O4 nanoparticles and MWCNT-MnFe2O4 nanocomposites were subjected to hyperthermia studies.
Sol–gel (45 − x)SiO224.5CaO24.5Na2O6P2O5xFe2O3 (0 ≤ x ≤ 15 wt%) glass-ceramics for bone regenerat... more Sol–gel (45 − x)SiO224.5CaO24.5Na2O6P2O5xFe2O3 (0 ≤ x ≤ 15 wt%) glass-ceramics for bone regeneration and hyperthermia applications.
Zinc ion substituted cobalt ferrite fibers (Co1-xZnxFe2O4, for x = 0.1, 0.2, 0.3, 0.4, and 0.5) h... more Zinc ion substituted cobalt ferrite fibers (Co1-xZnxFe2O4, for x = 0.1, 0.2, 0.3, 0.4, and 0.5) have been synthesized by using the electrospinning technique. The fiber was annealed at 800 °C temperature to study its effect on the magnetic properties and hyperthermia action. Its crystal structure has been studied by the analysis of X-ray Diffraction (XRD) pattern. It crystalizes to Fd3¯\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\bar 3$$\end{document}m space group. The crystal structure analysis has been performed by employing Rietveld refinement analysis of XRD pattern. The Field Emission Scanning Electron Microscopy (FE-SEM) and Transmission Electron Microscopy (TEM) study have been carried out to explore the microstructure and morphology of the fiber. The magnetic properties of fiber have been modified by the zinc ion substitution at the cobalt site. The magnetocrystalline anisotropy properties have been studied by using the Law of Approach to Saturation Magnetization. The magnetocrystalline anisotropy constnt and saturation magnetization decrease with the increase of zinc ion percentage in cobalt ferrite. The hyperthermia effect of cobalt zinc ferrite fiber with its magnetocrystalline anisotropy has been explored. The Specific Absorption Rate (SAR) and Intrinsic power loss (ILP) parameters have been determined to explore the heating effect of magnetic fibers. The SAR and ILP values are varying from 295 to 725 W/g and 1.16–10.69 nHm2/kg, respectively, for different substitutions of zinc ion. Graphical abstract Graphical abstract Fabrication of zinc substituted cobalt ferrite fiber by electrospinning method. Magnetic anisotropy study by Law of Approach to Saturation magnetization. Hyperthermia study of zinc substituted cobalt ferrite fiber. Linear response theory and Box-Lucas model has been used for SAR calculation. Fabrication of zinc substituted cobalt ferrite fiber by electrospinning method. Magnetic anisotropy study by Law of Approach to Saturation magnetization. Hyperthermia study of zinc substituted cobalt ferrite fiber. Linear response theory and Box-Lucas model has been used for SAR calculation.
Nickel–zinc ferrite nanoparticles coated with cetyltrimethylammonium bromide provide sufficient h... more Nickel–zinc ferrite nanoparticles coated with cetyltrimethylammonium bromide provide sufficient heat generation rate for hypothermia with only 2 mg ml−1, some of the lowest amount reported to date, under low applied field and frequency.
Abstract Nickel ferrite fiber (NFO–F) was synthesized using the electrospinning technique and ann... more Abstract Nickel ferrite fiber (NFO–F) was synthesized using the electrospinning technique and annealed at five different temperatures (500, 600, 700, 800, and 900 °C) to study its effect on crystal structure and magnetic properties. The X-Ray diffraction pattern analysis was carried out to explore its crystal structure. The morphology and microstructure of fibers were studied by employing the Field Emission Scanning Electron Microscopy technique. The crystallinity of the material increases with the increase of annealing temperature from 500 to 900 °C. The saturation magnetization of nickel ferrite fiber increases from 31.1 to 54.0 emu/g with the increase in annealing temperature. The anisotropy constant for NFO–F calculated using the Law of Approach to Saturation (LA) and it shows the highest value for 900 °C annealed sample. Hence, the hyperthermia property of NFO–NF annealed at 900 °C has been explored. The Specific Absorption Rate (SAR) of NFO–NF calculated using Linear Response Theory and the Box-Lucas models.
Abstract An attempt has been made to bridge between the influence of surface modification at nano... more Abstract An attempt has been made to bridge between the influence of surface modification at nanoscale and the biomedical applicability of multifunctional nanocomposite. Fe3O4 synthesized via solvothermal route has been made nanocomposite with Polyethylene glycol (PEG) and Amine functionalized Multiwall Carbon nanotube (MWCNT). Formation of Fe3O4 phase has been confirmed by X-ray diffraction (XRD). Functionalization of MWCNT with PEG and Amine has been recognized by Fourier transform infrared (FTIR) Spectra. Thermogravimetric analysis (TGA) discerned the adhesion of functional groups onto MWCNT and also the loading of functionalized MWCNT in the nanocomposite. Besides the visible evidence of interaction of spherical Fe3O4 onto walls of MWCNT provided by High-resolution transmission electron microscopy (HRTEM), there are other inferences led by the influence of this functionalized group. Crystallographic information from Rietveld analysis of the XRD pattern infers the impact of functionalized MWCNT on cation distribution in the Fe3O4 spinel structure. Vibrating sample magnetometer (VSM) studies revealed near superparamagnetic nature of as-synthesized samples, with 17% rise and 19% fall in the Coercivity of PEG-o-MWCNT/Fe3O4 and Amine-o-MWCNT/Fe3O4 than bare Fe3O4 respectively. A comparison of the Specific absorption rate suggested that under an oscillating magnetic field, nanocomposites are capable as an agent of heat generation as bare Fe3O4, even better at the higher field amplitude for tuning with magnetic anisotropy.
Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in th... more Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in the magnetic hyperthermia as well as imaging applications. In the present study, the effect of yttrium concentration on the magnetic characteristics of the iron oxide based nanomaterials was analyzed to assess their potential for the hyperthermia applications. The Sol-gel method was used to synthesize the Yttrium Iron Garnet (YIG) based nanoparticles, using different molar ratios of Fe and Y precursors, followed by the calcination at 900, 1000 and 1100°C. XRD analysis determined the formation of the pure phase of yttrium iron garnet Y 3 Fe 5 O 12 (YIG) at 0.5 molar ratio of yttrium at all the calcination temperatures and pure phase of yttrium iron perovskite YFeO 3 (YIP) for 1 molar ratio of yttrium at 1000 and 1100°C. The mean particle size was observed in the range of 100 to 400 nm. The magnetic characterization studies showed the highest saturation magnetization for the sample containing 0.5 molar ratio of the yttrium calcinated at 1000°C. The magnetization values were linearly related to the contents of YIG phases in the synthesized samples. Induction heating of YIG resulted in the hyperthermia temperature (42 to 44°C) in 13 min with the SAR values 114.65 W/g at 1 mg/ml. The prepared samples showed no in-vitro toxic effects on the MG63 cells (> 90% cell viability). In addition, in-vitro treatment at hyperthermia temperature for 15 min reduced cell viability of cancer cells (A549) to 55%, while no toxic effect was observed on MG 63 cells. The present study postulates Yttrium Iron Garnet as an effective therapeutic agent for hyperthermia cancer treatment.
In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe... more In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe2O4) nanocomposite and its probable application in hyperthermia. MnFe2O4 nanoparticles were synthesized by co-precipitation method. X ray diffractogram (XRD) confirms the formation of cubic phase of MnFe2O4 with preferred crystallographic orientation along (311) plane. High resolution electron microscope (HRTEM) image of the composites confirms the presence of MnFe2O4 spherical nanoparticles on the surface of CNT which are bound strongly to the surface. MWCNT-MnFe2O4 nanocomposite were prepared after acid functionalization of MWCNT. Vibrational features of the synthesized samples were confirmed through Fourier transformed infra-red spectroscopy (FTIR). FTIR spectra of acid functionalized MWCNT shows a peak positioned at ∼1620cm−1 which corresponds to C=O functional group of carboxylic acid. Prepared MnFe2O4 nanoparticles and MWCNT-MnFe2O4 nanocomposites were subjected to hyperthermia studies.In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe2O4) nanocomposite and its probable application in hyperthermia. MnFe2O4 nanoparticles were synthesized by co-precipitation method. X ray diffractogram (XRD) confirms the formation of cubic phase of MnFe2O4 with preferred crystallographic orientation along (311) plane. High resolution electron microscope (HRTEM) image of the composites confirms the presence of MnFe2O4 spherical nanoparticles on the surface of CNT which are bound strongly to the surface. MWCNT-MnFe2O4 nanocomposite were prepared after acid functionalization of MWCNT. Vibrational features of the synthesized samples were confirmed through Fourier transformed infra-red spectroscopy (FTIR). FTIR spectra of acid functionalized MWCNT shows a peak positioned at ∼1620cm−1 which corresponds to C=O functional group of carboxylic acid. Prepared MnFe2O4 nanoparticles and MWCNT-MnFe2O4 nanocomposites were subjected to hyperthermia studies.
We report a high-performance magnetic nanoparticle as a hyperthermic agent under low applied fiel... more We report a high-performance magnetic nanoparticle as a hyperthermic agent under low applied field and frequency. CTAB (cetyltrimethylammonium bromide)-coated Ni x Zn 1Àx Fe 2 O 4 nanoparticles of average particle size < 25 nm with various stoichiometric ratios were successfully synthesized using a coprecipitation technique. Characterization results indicate a close interaction of CTAB ions with the surface metal ions resulting in a cation distribution deviating from their equilibrium positions. Magnetic measurements were done at 300 K and 5 K using a superconducting quantum interference device. Saturation magnetization gradually increases with increasing substitution of Ni 2+ ions with Zn 2+ ions, attributed to the cation distribution and high super-exchange interaction between the A-and B-sites. The average size of the nanoparticles is estimated to be <10 nm with a magnetically dead layer (>1 nm @ 300 K), reflecting the effect of CTAB coating on the surface of the nanoparticles. The magnetocrystalline anisotropy (K eff), obtained from the law of approach to saturation, is inversely proportional to the M s value. The increasing incorporation of Ni 2+ ions in the lattice system is found to influence various structural parameters, which is reflected in the magnetic performance of the nanoparticles. A specific absorption rate of 347 W g À1 and intrinsic loss power of 4.6 nH m 2 kg À1 was attained with a minimal concentration of 2 mg ml À1 in a very short time period of 1.5 min in Ni 0.75 Zn 0.25 Fe 2 O 4 nanoparticles.
Carbon nanotube (CNT) has been evolved as a novel material in diverse applications since its disc... more Carbon nanotube (CNT) has been evolved as a novel material in diverse applications since its discovery. Functionalization of multi-walled carbon nanotube (MWCNT) with different functional groups namely carboxylic, amine and polyethylene glycol (PEG) has been the central point of this work. The functionalized MWCNTs were made nanocomposite with manganese ferrite nanoparticles, synthesized through solvothermal method. Formations of crystalline ferrites were confirmed through X-ray diffractograms (XRD), which shows formation of spinel cubic phase. Uniform size distribution of manganese ferrite (MnFe 2 O 4) nanoparticles synthesized by solvothermal method was confirmed by high resolution transmission electron microscope (HRTEM) images. Fourier transformed infra-red spectroscopy (FTIR) was employed to study the vibrational features of the functionalized MWCNT and MWCNT/ MnFe 2 O 4 nanocomposites. Vibrating sample magnetometer (VSM) study shows the ferromagnetic behavior of the MWCNT/MnFe 2 O 4 nanocomposites. Functionalized MWCNT/MnFe 2 O 4 nanocomposites were subjected to hyperthermia studies with minimal concentration (2mg/ml) and magnetic heating efficiency has been studied.
We investigate the efficacy of polyethylene glycol (PEG) and amine-functionalized MWCNT decorated... more We investigate the efficacy of polyethylene glycol (PEG) and amine-functionalized MWCNT decorated with MnFe 2 O 4 nanocomposites as heating material for magnetic hyperthermia applications. Samples are prepared by a standard solvothermal method. Phase formation of MnFe 2 O 4 has been confirmed by X-ray diffractogram and attachment of nanoparticles on the surface of functionalized MWCNT is evident from transmission electron microscopic image of nanocomposite. Fourier transform infrared spectrum of PEG-functionalized MWCNT and amine-functionalized MWCNT confirmed the presence of PEG and amine group, respectively. As desirable for stability in magnetic hyperthermia, vibration sample magnetometer study suggests superparamagnetic behaviour of all the samples at temperatures 300 K, 200 K and 100 K except at 5 K, which is below blocking temperature as confirmed by ZFC-FC curves. Estimated Curie temperature (T C) and room temperature effective anisotropy is found to increase in nanocomposites, highest for amine-functionalized MWCNT/MnFe 2 O 4 nanocomposite. A clear correlation between effective anisotropy and heat generation capability (SAR/ILP) has been observed: higher the anisotropy, higher is the heat generation capability (SAR/ILP).
Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in th... more Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in the magnetic hyperthermia as well as imaging applications. In the present study, the effect of yttrium concentration on the magnetic characteristics of the iron oxide based nanomaterials was analyzed to assess their potential for the hyperthermia applications. The Sol-gel method was used to synthesize the Yttrium Iron Garnet (YIG) based nanoparticles, using different molar ratios of Fe and Y precursors, followed by the calcination at 900, 1000 and 1100°C. XRD analysis determined the formation of the pure phase of yttrium iron garnet Y 3 Fe 5 O 12 (YIG) at 0.5 molar ratio of yttrium at all the calcination temperatures and pure phase of yttrium iron perovskite YFeO 3 (YIP) for 1 molar ratio of yttrium at 1000 and 1100°C. The mean particle size was observed in the range of 100 to 400 nm. The magnetic characterization studies showed the highest saturation magnetization for the sample containing 0.5 molar ratio of the yttrium calcinated at 1000°C. The magnetization values were linearly related to the contents of YIG phases in the synthesized samples. Induction heating of YIG resulted in the hyperthermia temperature (42 to 44°C) in 13 min with the SAR values 114.65 W/g at 1 mg/ml. The prepared samples showed no in-vitro toxic effects on the MG63 cells (> 90% cell viability). In addition, in-vitro treatment at hyperthermia temperature for 15 min reduced cell viability of cancer cells (A549) to 55%, while no toxic effect was observed on MG 63 cells. The present study postulates Yttrium Iron Garnet as an effective therapeutic agent for hyperthermia cancer treatment.
In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe... more In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe2O4) nanocomposite and its probable application in hyperthermia. MnFe2O4 nanoparticles were synthesized by co-precipitation method. X ray diffractogram (XRD) confirms the formation of cubic phase of MnFe2O4 with preferred crystallographic orientation along (311) plane. High resolution electron microscope (HRTEM) image of the composites confirms the presence of MnFe2O4 spherical nanoparticles on the surface of CNT which are bound strongly to the surface. MWCNT-MnFe2O4 nanocomposite were prepared after acid functionalization of MWCNT. Vibrational features of the synthesized samples were confirmed through Fourier transformed infra-red spectroscopy (FTIR). FTIR spectra of acid functionalized MWCNT shows a peak positioned at ∼1620cm−1 which corresponds to C=O functional group of carboxylic acid. Prepared MnFe2O4 nanoparticles and MWCNT-MnFe2O4 nanocomposites were subjected to hyperthermia studies.In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe2O4) nanocomposite and its probable application in hyperthermia. MnFe2O4 nanoparticles were synthesized by co-precipitation method. X ray diffractogram (XRD) confirms the formation of cubic phase of MnFe2O4 with preferred crystallographic orientation along (311) plane. High resolution electron microscope (HRTEM) image of the composites confirms the presence of MnFe2O4 spherical nanoparticles on the surface of CNT which are bound strongly to the surface. MWCNT-MnFe2O4 nanocomposite were prepared after acid functionalization of MWCNT. Vibrational features of the synthesized samples were confirmed through Fourier transformed infra-red spectroscopy (FTIR). FTIR spectra of acid functionalized MWCNT shows a peak positioned at ∼1620cm−1 which corresponds to C=O functional group of carboxylic acid. Prepared MnFe2O4 nanoparticles and MWCNT-MnFe2O4 nanocomposites were subjected to hyperthermia studies.
Sol–gel (45 − x)SiO224.5CaO24.5Na2O6P2O5xFe2O3 (0 ≤ x ≤ 15 wt%) glass-ceramics for bone regenerat... more Sol–gel (45 − x)SiO224.5CaO24.5Na2O6P2O5xFe2O3 (0 ≤ x ≤ 15 wt%) glass-ceramics for bone regeneration and hyperthermia applications.
Zinc ion substituted cobalt ferrite fibers (Co1-xZnxFe2O4, for x = 0.1, 0.2, 0.3, 0.4, and 0.5) h... more Zinc ion substituted cobalt ferrite fibers (Co1-xZnxFe2O4, for x = 0.1, 0.2, 0.3, 0.4, and 0.5) have been synthesized by using the electrospinning technique. The fiber was annealed at 800 °C temperature to study its effect on the magnetic properties and hyperthermia action. Its crystal structure has been studied by the analysis of X-ray Diffraction (XRD) pattern. It crystalizes to Fd3¯\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\bar 3$$\end{document}m space group. The crystal structure analysis has been performed by employing Rietveld refinement analysis of XRD pattern. The Field Emission Scanning Electron Microscopy (FE-SEM) and Transmission Electron Microscopy (TEM) study have been carried out to explore the microstructure and morphology of the fiber. The magnetic properties of fiber have been modified by the zinc ion substitution at the cobalt site. The magnetocrystalline anisotropy properties have been studied by using the Law of Approach to Saturation Magnetization. The magnetocrystalline anisotropy constnt and saturation magnetization decrease with the increase of zinc ion percentage in cobalt ferrite. The hyperthermia effect of cobalt zinc ferrite fiber with its magnetocrystalline anisotropy has been explored. The Specific Absorption Rate (SAR) and Intrinsic power loss (ILP) parameters have been determined to explore the heating effect of magnetic fibers. The SAR and ILP values are varying from 295 to 725 W/g and 1.16–10.69 nHm2/kg, respectively, for different substitutions of zinc ion. Graphical abstract Graphical abstract Fabrication of zinc substituted cobalt ferrite fiber by electrospinning method. Magnetic anisotropy study by Law of Approach to Saturation magnetization. Hyperthermia study of zinc substituted cobalt ferrite fiber. Linear response theory and Box-Lucas model has been used for SAR calculation. Fabrication of zinc substituted cobalt ferrite fiber by electrospinning method. Magnetic anisotropy study by Law of Approach to Saturation magnetization. Hyperthermia study of zinc substituted cobalt ferrite fiber. Linear response theory and Box-Lucas model has been used for SAR calculation.
Nickel–zinc ferrite nanoparticles coated with cetyltrimethylammonium bromide provide sufficient h... more Nickel–zinc ferrite nanoparticles coated with cetyltrimethylammonium bromide provide sufficient heat generation rate for hypothermia with only 2 mg ml−1, some of the lowest amount reported to date, under low applied field and frequency.
Abstract Nickel ferrite fiber (NFO–F) was synthesized using the electrospinning technique and ann... more Abstract Nickel ferrite fiber (NFO–F) was synthesized using the electrospinning technique and annealed at five different temperatures (500, 600, 700, 800, and 900 °C) to study its effect on crystal structure and magnetic properties. The X-Ray diffraction pattern analysis was carried out to explore its crystal structure. The morphology and microstructure of fibers were studied by employing the Field Emission Scanning Electron Microscopy technique. The crystallinity of the material increases with the increase of annealing temperature from 500 to 900 °C. The saturation magnetization of nickel ferrite fiber increases from 31.1 to 54.0 emu/g with the increase in annealing temperature. The anisotropy constant for NFO–F calculated using the Law of Approach to Saturation (LA) and it shows the highest value for 900 °C annealed sample. Hence, the hyperthermia property of NFO–NF annealed at 900 °C has been explored. The Specific Absorption Rate (SAR) of NFO–NF calculated using Linear Response Theory and the Box-Lucas models.
Abstract An attempt has been made to bridge between the influence of surface modification at nano... more Abstract An attempt has been made to bridge between the influence of surface modification at nanoscale and the biomedical applicability of multifunctional nanocomposite. Fe3O4 synthesized via solvothermal route has been made nanocomposite with Polyethylene glycol (PEG) and Amine functionalized Multiwall Carbon nanotube (MWCNT). Formation of Fe3O4 phase has been confirmed by X-ray diffraction (XRD). Functionalization of MWCNT with PEG and Amine has been recognized by Fourier transform infrared (FTIR) Spectra. Thermogravimetric analysis (TGA) discerned the adhesion of functional groups onto MWCNT and also the loading of functionalized MWCNT in the nanocomposite. Besides the visible evidence of interaction of spherical Fe3O4 onto walls of MWCNT provided by High-resolution transmission electron microscopy (HRTEM), there are other inferences led by the influence of this functionalized group. Crystallographic information from Rietveld analysis of the XRD pattern infers the impact of functionalized MWCNT on cation distribution in the Fe3O4 spinel structure. Vibrating sample magnetometer (VSM) studies revealed near superparamagnetic nature of as-synthesized samples, with 17% rise and 19% fall in the Coercivity of PEG-o-MWCNT/Fe3O4 and Amine-o-MWCNT/Fe3O4 than bare Fe3O4 respectively. A comparison of the Specific absorption rate suggested that under an oscillating magnetic field, nanocomposites are capable as an agent of heat generation as bare Fe3O4, even better at the higher field amplitude for tuning with magnetic anisotropy.
Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in th... more Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in the magnetic hyperthermia as well as imaging applications. In the present study, the effect of yttrium concentration on the magnetic characteristics of the iron oxide based nanomaterials was analyzed to assess their potential for the hyperthermia applications. The Sol-gel method was used to synthesize the Yttrium Iron Garnet (YIG) based nanoparticles, using different molar ratios of Fe and Y precursors, followed by the calcination at 900, 1000 and 1100°C. XRD analysis determined the formation of the pure phase of yttrium iron garnet Y 3 Fe 5 O 12 (YIG) at 0.5 molar ratio of yttrium at all the calcination temperatures and pure phase of yttrium iron perovskite YFeO 3 (YIP) for 1 molar ratio of yttrium at 1000 and 1100°C. The mean particle size was observed in the range of 100 to 400 nm. The magnetic characterization studies showed the highest saturation magnetization for the sample containing 0.5 molar ratio of the yttrium calcinated at 1000°C. The magnetization values were linearly related to the contents of YIG phases in the synthesized samples. Induction heating of YIG resulted in the hyperthermia temperature (42 to 44°C) in 13 min with the SAR values 114.65 W/g at 1 mg/ml. The prepared samples showed no in-vitro toxic effects on the MG63 cells (> 90% cell viability). In addition, in-vitro treatment at hyperthermia temperature for 15 min reduced cell viability of cancer cells (A549) to 55%, while no toxic effect was observed on MG 63 cells. The present study postulates Yttrium Iron Garnet as an effective therapeutic agent for hyperthermia cancer treatment.
In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe... more In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe2O4) nanocomposite and its probable application in hyperthermia. MnFe2O4 nanoparticles were synthesized by co-precipitation method. X ray diffractogram (XRD) confirms the formation of cubic phase of MnFe2O4 with preferred crystallographic orientation along (311) plane. High resolution electron microscope (HRTEM) image of the composites confirms the presence of MnFe2O4 spherical nanoparticles on the surface of CNT which are bound strongly to the surface. MWCNT-MnFe2O4 nanocomposite were prepared after acid functionalization of MWCNT. Vibrational features of the synthesized samples were confirmed through Fourier transformed infra-red spectroscopy (FTIR). FTIR spectra of acid functionalized MWCNT shows a peak positioned at ∼1620cm−1 which corresponds to C=O functional group of carboxylic acid. Prepared MnFe2O4 nanoparticles and MWCNT-MnFe2O4 nanocomposites were subjected to hyperthermia studies.In this work we present synthesis of multi-walled carbon nanotube (MWCNT)-Manganese ferrite (MnFe2O4) nanocomposite and its probable application in hyperthermia. MnFe2O4 nanoparticles were synthesized by co-precipitation method. X ray diffractogram (XRD) confirms the formation of cubic phase of MnFe2O4 with preferred crystallographic orientation along (311) plane. High resolution electron microscope (HRTEM) image of the composites confirms the presence of MnFe2O4 spherical nanoparticles on the surface of CNT which are bound strongly to the surface. MWCNT-MnFe2O4 nanocomposite were prepared after acid functionalization of MWCNT. Vibrational features of the synthesized samples were confirmed through Fourier transformed infra-red spectroscopy (FTIR). FTIR spectra of acid functionalized MWCNT shows a peak positioned at ∼1620cm−1 which corresponds to C=O functional group of carboxylic acid. Prepared MnFe2O4 nanoparticles and MWCNT-MnFe2O4 nanocomposites were subjected to hyperthermia studies.
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