Papers by PAULA ANDREA ROZO HERNANDEZ
There is ample research about immigrant students’ experiences in the school system (Womach, 2020)... more There is ample research about immigrant students’ experiences in the school system (Womach, 2020), as well as the impact of trauma on learning (Gerrish, 2020), however there is limited research that reports on the experiences of school staff and what their needs are in order to best support immigrant students. The present study utilizes qualitative research methods to explore the experiences of school staff who engage with immigrant students who have experienced trauma. Researchers recruited public school employees from Lewiston and Portland school districts in Maine for participation in the study. The roles of the employees included teachers, social workers, administrators, and guidance counselors. Researchers are conducting semi-structured interviews to best understand the challenges they experience and whether they feel supported and effective in their role. Researchers will use thematic analysis to identify themes across participant responses. By obtaining knowledge about the st...
Journal of Applied Research and Technology, 2020
The Vertex Bisection Problem (VBP) consists in partitioning a generic graph into two equallysized... more The Vertex Bisection Problem (VBP) consists in partitioning a generic graph into two equallysized subgraphs and such that the number of vertices in with at least one adjacent vertex in is minimized. This problem is NP-hard with practical applications in the telecommunication industry. In this article we propose a new constructive algorithm for VBP based on the Greedy Randomized Adaptive Search Procedure (GRASP) methodology. We call our algorithm CVBP. We compare CVBP with a previously published GRASP-based constructive algorithm (LIT) in order to assess the performance of our algorithm in practice. The results of the experiment showed that CVBP outperformed LIT by 75.83 % in solution quality. The validation of the experimental evidence was performed by the well-known Wilcoxon Signed Rank Sum Test. The test found statistical significance for a confidence level of 99.99 %. Therefore, we consider that our constructive heuristic is a good alternative to stochastically solve the Vertex Bisection Problem.
Iatreia, 2013
Allelic variations in genes of pro-inflammatory and anti-inflammatory cytokines, and their associ... more Allelic variations in genes of pro-inflammatory and anti-inflammatory cytokines, and their association with the susceptibility to sepsis and its clinical course Sepsis is the main cause of mortality in intensive care units. Therefore, many efforts to develop therapeutic approaches have been made without significant progress. The balance between
Gerencia Y Politicas De Salud, Jan 6, 2011
Iv Simposio De Metodologia De Las Ciencias Del Comportamiento 1997 Isbn 84 7684 850 1 Pags 69 73, 1997
International Journal of Experimental Pathology
Background: This study evaluated the clinical and molecular characteristics associated with CA-MR... more Background: This study evaluated the clinical and molecular characteristics associated with CA-MRSA infections among patients admitted to hospitals in Colombia. Methods: A multicenter prospective cohort study was conducted in seven tertiary hospitals. Clinical and demographics data were obtained. Strains were tested for staphylococcal chromosomal cassette mec (SCCmec) and pulsed-field gel electrophoresis (PFGE) types, and presence of Panton-Valentine leukocidin (PVL) genes. Results: From June 2006 to May 2007 were included 41 patients.17of these cases were classified as hospital-onset CA-MRSA infections. Mean age was 49.6 +- 21.5 years; 58.5% was female; 56.1% had skin and soft tissue infections, 19.5 % surgical site infections and 12.2% bloodstream infections. Underlying conditions was presented in 19 (46.3%) of patients: solid organ malignancy 14.5%, diabetes 9,8%, chronic renal disease 7,3%. Specific risk factors with community-onset CA-MRSA infections were: hospitalization durin...
Neurochemical Research, 2000
Neuronal cells display different subsets of dynamic microtubules. In axons and extending neurites... more Neuronal cells display different subsets of dynamic microtubules. In axons and extending neurites, this intrinsic dynamics is modulated by the microtubule-associated protein tau. Moreover, posttranslational modifications of tubulin, namely acetylation, tyrosination or glutamylation are directly involved in determining the stability of neuronal microtubules. Studies were carried out to analyze the interaction patterns of tau with subsets of microtubules in N2A
Biomédica : revista del Instituto Nacional de Salud, 2002
The reconstruction of Giardia lamblia life cycle in vitro is an excellent tool for the study of t... more The reconstruction of Giardia lamblia life cycle in vitro is an excellent tool for the study of the parasite's molecular biology. The present work describes techniques developed that better define parasite differentiation. An encystation protocol is presented along with a method for isolation and purification of the produced cysts. The cyst morphology at the light microscopy level is identical to that of in vivo cysts. A two-dimension protein map obtained by high-resolution electrophoresis indicated that most of the parasite's proteins are acid. Based on this result, the two dimension gel electrophoresis used a pH 4-7 gradient in the first, isoelectric focusing dimension. Differences in protein expression during the stages of encystation were clearly discerned, as well as images of the parasite obtained by light and by transmission electron microscopy that describe the morphological and the ultrastructural changes that occur as the cysts are produced in vitro.
Journal of Alzheimer's disease : JAD, 2009
Alzheimer's disease (AD) is characterized by the accumulation of protein filaments, namely ex... more Alzheimer's disease (AD) is characterized by the accumulation of protein filaments, namely extracellular amyloid-beta (Abeta) fibrils and intracellular neurofibrillary tangles, which are composed of aggregated hyperphosphorylated tau. Tau hyperphosphorylation is the product of deregulated Ser/Thr kinases such as cdk5 and GSK3beta. In addition, tau hyperphosphorylation also occurs at Tyr residues. To find a link between Abeta and tau phosphorylation, we investigated the effects of short-term Abeta treatments on SHSY-5Y cells. We analyzed phosphorylated tau variants in lipid rafts and the possible role of Tyr18 and Ser396/404 tau phosphorylation in Abeta-induced signaling cascades. After 2 min of Abeta treatment, phospho-Tyr18-tau and its association with rafts increased. Phospho-Ser 396/404-tau became detectable in rafts after 10 min treatment, which temporally correlated with the detection of cdk5 and p35 activator in lipid rafts. To determine the role of cdk5 in tau phosphoryla...
Studies in Computational Intelligence, 2014
This chapter deals with the containership stowage problem. It is an NP-hard combinatorial optimiz... more This chapter deals with the containership stowage problem. It is an NP-hard combinatorial optimization whose goal is to find optimal plans for stowing containers into a containership with low operational costs, subject to a set of structural and operational constraints. In order to optimize a stowage planning, like in the literature, we have developed an approach that decomposes the problem hierarchically. This approach divides the problem into two phases: the first one consists of generating a relaxed initial solution, and the second phase is intended to make this solution feasible. In this chapter, we focus on the first phase of this approach, and a new loading procedure to generate an initial solution is proposed. This procedure produces solutions in short running time, so that, it could be applied to solve real instances.
Disease models & mechanisms
Tumor suppressor proteins protect cells and tissues from malignant transformation. Among their di... more Tumor suppressor proteins protect cells and tissues from malignant transformation. Among their diverse actions, many of these proteins interact with the microtubule cytoskeleton. This review focuses on the interactions of several tumor suppressors with microtubules and speculates on how disruption of microtubule-dependent processes may contribute to cancer development and spread. We conclude that several tumor suppressors stabilize microtubules and organize microtubule arrays, functions that are likely to be important in preventing tumorigenesis. How tumor suppressors link microtubule stability with cell fate, and how their mutation affects the response of cancer cells to anti-microtubule chemotherapy drugs, remains unclear; these should prove fertile areas for future research.
Reproductive sciences (Thousand Oaks, Calif.), Jan 16, 2014
Biomédica, 2002
Giardia lamblia in vitro encystation: two dimensional electrophoresis analysis of differences in ... more Giardia lamblia in vitro encystation: two dimensional electrophoresis analysis of differences in protein expression The reconstruction of Giardia lamblia life cycle in vitro is an excellent tool for the study of the parasite's molecular biology. The present work describes techniques developed that better define parasite differentiation. An encystation protocol is presented along with a method for isolation and purification of the produced cysts. The cyst morphology at the light microscopy level is identical to that of in vivo cysts. A two-dimension protein map obtained by high-resolution electrophoresis indicated that most of the parasite's proteins are acid. Based on this result, the two dimension gel electrophoresis used a pH 4-7 gradient in the first, isoelectric focusing dimension. Differences in protein expression during the stages of encystation were clearly discerned, as well as images of the parasite obtained by light and by transmission electron microscopy that describe the morphological and the ultrastructural changes that occur as the cysts are produced in vitro.
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Papers by PAULA ANDREA ROZO HERNANDEZ