Papers by Alberto Oliverio
PARADIGMI, 2012
Per comprendere la complessitŕ dei fenomeni della mente, dell'empatia e della cognizione soci... more Per comprendere la complessitŕ dei fenomeni della mente, dell'empatia e della cognizione sociale č basilare oggi integrare neuroscienze e filosofia. Nonostante la lettura dei risultati neuroscientifici abbia prevalentemente seguito un'ottica darwiniana, la scoperta del mirror neuron system, dopo un primo approccio di tipo analitico, č stata interpretata fin qui in chiave fenomenologica. Il saggio mostra l'incompatibilitŕ tra la "social-embodied cognition" del sistema specchio e la fenomenologia, che si caratterizza fin dall'inizio per la sua critica a ogni scienza empirica e a ogni forma di naturalismo. La struttura intellettualistica della fenomenologia rende l'io trascendentale un surrogato della vecchia anima-sostanza e l'intersoggettivitŕ una meta-in- tersoggettivitŕ. Il saggio propone una lettura darwiniana del sistema specchio, incentrata su una "social-embodied-emotional mind", radicata nella ragione-istinto di Hume e nella rivoluzi...
The Journal of Neuroscience, 2001
This study was supported in part by the 40% Ministero dell'Universitá e della Ricerca Scientifica... more This study was supported in part by the 40% Ministero dell'Universitá e della Ricerca Scientifica e Tecnologica grants "Farmacologia dell'apprendimento e della memoria" and "Neurobiologia delle tossicodipendenze e dei meccanismi di gratificazione naturale" and by a grant from the University of Rome "La Sapienza" (A.O.).
Nature Medicine, 2001
Metachromatic leukodystrophy (MLD) is a lipidosis caused by deficiency of arylsulfatase A (ARSA).... more Metachromatic leukodystrophy (MLD) is a lipidosis caused by deficiency of arylsulfatase A (ARSA). Although the genetics of MLD are known, its pathophysiology is not understood. The disease leads to progressive demyelination and early death and no effective treatment is available. We used lentiviral vectors to deliver a functional ARSA gene (human ARSA) into the brain of adult mice with germ-line inactivation of the mouse gene encoding ARSA, As2. We report sustained expression of active enzyme throughout a large portion of the brain, with long-term protection from development of neuropathology and hippocampal-related learning impairments. We show that selective degeneration of hippocampal neurons is a central step in disease pathogenesis, and provide evidence that in vivo transfer of ARSA by lentiviral vectors reverts the disease phenotype in all investigated areas. Therefore, in vivo gene therapy offers a unique option for MLD and other storage diseases affecting the central nervous system.
International Journal of Neuropharmacology, 1964
ABSTRACT
World Futures, 2017
Musical improvisation is a sophisticated activity in which a performer realizes, real-time, melod... more Musical improvisation is a sophisticated activity in which a performer realizes, real-time, melodic, and rhythmic sequences in harmony with those from other musicians. The study of musical improvisation helps one to understand not only the cognition of creativity, but also the complex neuronal basis of executive functions, the relation between conscious and unconscious action, and even more. So far, the prevailing models, founded on the brain imaging method, have focused on the connection between the cortical areas and their cognitive processes. Little attention, on the other hand, has been given to the huge variety of subcortical activities, especially in the basal ganglia. This fundamental subcortical component, through its implicit procedures and the role it plays in memory, is responsible to produce new information all the time, allowing the prefrontal cortex to transform a huge and disordered amount of data in explicit creative acts. The basal ganglia are strongly related to the activation of chemical signals generated by dissonance or lack of symmetry between perception and expectation, participating even in the responses to environmental demands according to the circumstances. Thus, they interact with the frontal cortex and with the limbic system, playing a key role in planning and selecting appropriate actions and in decision making. In this text, we try to explain in which sense improvisation is connected to the processes of executive functions, to creativity and to the integrated activity of cortical–subcortical areas controlling the free flow of ideas and to expressive spontaneity. Eventually, we purpose a model according to which structure (improvisational field) and process (improvisational time) take part at the centrencephalic space of functional integration, which, through both competing and cooperating dynamics, gives way to spontaneous composition.
Pharmacological Research Communications, 1975
Revue d&'apos;Electroencéphalographie et de Neurophysiologie Clinique, 1977
ABSTRACT
Journal of Heredity, 1975
Differences in forebrain weight, forebrain weight/body weight ratios, and body weight were examin... more Differences in forebrain weight, forebrain weight/body weight ratios, and body weight were examined for the RI strains, their progenitor strains, and reciprocal F1 hybrids. The experiment was done in two widely separated laboratories with identical procedures for feeding, watering, and removal of brain tissue. The resulting strain distribution patterns suggested the influence of two or more loci in each laboratory. However, brain weights differed in the two laboratories. Some of the strains examined exhibited increased weights for the variables under consideration, while others exhibited decreased weights or no change at all. Implications for generalizations drawn from observations obtained in any single laboratory were discussed.
Pharmacology Biochemistry and Behavior, 1986
conditioning of stress-induced analgesia (SIA) resulted in higher tail flick latencies in BALB/c ... more conditioning of stress-induced analgesia (SIA) resulted in higher tail flick latencies in BALB/c mice. Transfer of classical conditioning of SIA was evident when the same repetition rate (pulsed light or pulsed tone) characterized stimuli in different sensory modalities. This finding is discussed in terms of opioid production and of generalization of emotional reactions.
Lebenswelt: Aesthetics and Philosophy of Experience, Jul 7, 2014
COSA SIGNIFICA DESIDERARE? È nella natura del desiderio di non poter essere soddisfatto, e la mag... more COSA SIGNIFICA DESIDERARE? È nella natura del desiderio di non poter essere soddisfatto, e la maggior parte degli uomini vive solo per soddisfarlo Aristotele Per ogni desiderio ci si deve porre questa domanda: che cosa accadrà se il desiderio sarà esaudito, e che cosa se non lo sarà? Epicuro CORE Metadata, citation and similar papers at core.ac.uk
Giornale Italiano Di Psicologia, 2012
For Rivista Per La Formazione, 2011
Filosofia E Questioni Pubbliche, 2000
Neuropsychopharmacology, 2007
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Papers by Alberto Oliverio