Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish p... more Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish patients: effect of ecNOS polymorphism on left ventricular hypertrophy
BULGULAR: Hastalardan sadece iki tanesi kadındı. Ortalama yaş 71.9±7.2 yıl olarak bulundu. Hastal... more BULGULAR: Hastalardan sadece iki tanesi kadındı. Ortalama yaş 71.9±7.2 yıl olarak bulundu. Hastaların %47.4'ünde diyabet ve %52.6'sında hipertansiyon saptandı. Sadece 1 hasta hiç sigara içmemişti. Plaklarda sodyum (Na), magnezyum (Mg), potasyum (K), kalsiyum (Ca), fosfor (P), demir (Fe), bakır (Cu), bor (B), manganez (Mn), çinko (Zn), alüminyum (Al), sülfür (S), krom (Cr), nikel (Ni), platin (Pt), antimon (Sb), selenyum (Se) elementleri farklı konsantrasyonda saptandı fakat arsenik (As), bizmut (Bi), kadmiyum (Cd), kobalt (Co), molibden (Mo), kurşun (Pb) seviyeleri ICP-OES sisteminin belirleme limitinin altında saptandı. Hastalarda varyasyon olmakla birlikte en yoğun olarak Ca ve P saptandı.
Inferior vena cava agenesis (IVCA) is a rare entitiy wity many patients remain clinically silent ... more Inferior vena cava agenesis (IVCA) is a rare entitiy wity many patients remain clinically silent and found incidentally on radiological imaging studiesas a result of the compensatory enlargements of many collateral veins to maintain venous return. However, IVCA may also be diagnosed following serious acute complications, particularly unprovoked proximal iliofemoral deep vein thromboses (DVT) in young individuals. Herein, we report a 25-year old postpartum female patient presented with acute swelling on the right lower extremity and diagnosed with IVCA following acute occlusive iliofemoral DVTs.We aimed to emphasize the importance of radiological evaluation and management of these patients with some considerations out of routine practice.
The American Journal of Tropical Medicine and Hygiene, 2021
ABSTRACTTwo cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one durin... more ABSTRACTTwo cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one during initial presentation and one 10 days after COVID-19 diagnosis. Hiccups in both patients were resistant to treatment and responded only to chlorpromazine. COVID-19 patients may present with hiccups and also may have hiccups after treatment. Resistant hiccups without any underlying disease other than COVID-19 should be considered in association with COVID-19 and may respond well to chlorpromazine.
Brugada Syndrome and acute myocardial infarction related ventricular fibrillation have similar pa... more Brugada Syndrome and acute myocardial infarction related ventricular fibrillation have similar pathophysiology. In this report, we present a case of acute coronary syndrome with Brugada like ECG complicated by malignant ventricular arrhythmias.
Results: Ang II stimulation induced umbilical artery aneurysm formation characterised by marked v... more Results: Ang II stimulation induced umbilical artery aneurysm formation characterised by marked vessel dilatation (90%;p<0.05;n¼6) and concomitant decrease in medial thickness (49%;p<0.05;n¼6), medial elastin content (61%;p<0.05;n¼6), and medial cell density (34%;p<0.05;n¼5), compared to untreated arteries (Figure 1). Such changes are indicative of aneurysm formation and progression in humans and mouse models, and were reversed by addition of recombinant TIMP-3 (5nM); reduced vessel dilatation (42%;p<0.05;n¼4) and increased medial thickness (93% p<0.05;n¼4) and elastin content (168%;p<0.05;n¼4). Supportingly, CaCl2 pre-treatment of umbilical arteries induced aneurysm formation as evidenced by reduced medial thickness (44%;p<0.05;n¼6), medial elastin content (33%;p<0.01;n¼6), and medial cell density (50%;p<0.05;n¼6), although vessel area was unchanged.
Aim: The goal of the study is to assess changes in claudication walking time measured on treadmil... more Aim: The goal of the study is to assess changes in claudication walking time measured on treadmill and in community setting outdoor walking after a 12-week supervised treadmill training in patients with claudication. Methods: The study included 30 patients (17 males) aged 70.6 ±6.98 with claudication due to peripheral artery disease. Patients were randomised into training (n¼14) and control (n¼16) groups. Changes in claudication onset time (COT), maximum claudication time (MCT) during graded treadmill test walked to maximum claudication and the highest measured time (HMT) obtained during community setting outdoor walking were assessed before and after the programme. Outdoor walking was conducted for 60 minutes and a GPS device was used. The HMT was determined as the highest time between two stops induced by lower extremity pain. Results: Post-training COT, MCT and HMT were prolonged by 113% (p<0.01), 84% (p<0.01) and 33% (p>0.05), respectively. No significant changes were observed in the control group with a tendency to MCT and HMD aggravation. There was no correlation between post-training changes in MCT and HMT (p>0.05). Conclusions: Twelve-week supervised treadmill training improves walking abilities measured on a treadmill, but not in community setting outdoor walking in patients with claudication. Perhaps this results from the specificity of treadmill training. It would be interesting to assess changes in outdoor walking abilities, after training in community setting, e.g. after Nordic Walking training. According to the authors' knowledge, it is the first study to assess post-training changes in outdoor walking in patients with claudication.
Population studies revealed that metal exposure through food, environment, and smoking was relate... more Population studies revealed that metal exposure through food, environment, and smoking was related with increased risk of cardiovascular disease. In this study, we determined complex chemical elements in surgical carotid endarterectomy specimens and carotid tissues from autopsies without atherosclerosis. Atherosclerotic plaques from 41 endarterectomies and normal carotid tissue from 30 autopsies were collected and elemental composition was determined by inductively coupled plasma optical emission spectrometry (ICP-OES) method. Eleven (26.8%) patients never smoked in carotid endarterectomy group. One patient was brass souvenir worker and one was goldsmith and others did not have direct contact with metals in the carotid endarterectomy group.
Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish p... more Negative association of endothelial nitric oxide gene polymorphism with hypertension in Turkish patients: effect of ecNOS polymorphism on left ventricular hypertrophy
BULGULAR: Hastalardan sadece iki tanesi kadındı. Ortalama yaş 71.9±7.2 yıl olarak bulundu. Hastal... more BULGULAR: Hastalardan sadece iki tanesi kadındı. Ortalama yaş 71.9±7.2 yıl olarak bulundu. Hastaların %47.4'ünde diyabet ve %52.6'sında hipertansiyon saptandı. Sadece 1 hasta hiç sigara içmemişti. Plaklarda sodyum (Na), magnezyum (Mg), potasyum (K), kalsiyum (Ca), fosfor (P), demir (Fe), bakır (Cu), bor (B), manganez (Mn), çinko (Zn), alüminyum (Al), sülfür (S), krom (Cr), nikel (Ni), platin (Pt), antimon (Sb), selenyum (Se) elementleri farklı konsantrasyonda saptandı fakat arsenik (As), bizmut (Bi), kadmiyum (Cd), kobalt (Co), molibden (Mo), kurşun (Pb) seviyeleri ICP-OES sisteminin belirleme limitinin altında saptandı. Hastalarda varyasyon olmakla birlikte en yoğun olarak Ca ve P saptandı.
Inferior vena cava agenesis (IVCA) is a rare entitiy wity many patients remain clinically silent ... more Inferior vena cava agenesis (IVCA) is a rare entitiy wity many patients remain clinically silent and found incidentally on radiological imaging studiesas a result of the compensatory enlargements of many collateral veins to maintain venous return. However, IVCA may also be diagnosed following serious acute complications, particularly unprovoked proximal iliofemoral deep vein thromboses (DVT) in young individuals. Herein, we report a 25-year old postpartum female patient presented with acute swelling on the right lower extremity and diagnosed with IVCA following acute occlusive iliofemoral DVTs.We aimed to emphasize the importance of radiological evaluation and management of these patients with some considerations out of routine practice.
The American Journal of Tropical Medicine and Hygiene, 2021
ABSTRACTTwo cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one durin... more ABSTRACTTwo cases are presented with coronavirus disease 19 (COVID-19)-related hiccups: one during initial presentation and one 10 days after COVID-19 diagnosis. Hiccups in both patients were resistant to treatment and responded only to chlorpromazine. COVID-19 patients may present with hiccups and also may have hiccups after treatment. Resistant hiccups without any underlying disease other than COVID-19 should be considered in association with COVID-19 and may respond well to chlorpromazine.
Brugada Syndrome and acute myocardial infarction related ventricular fibrillation have similar pa... more Brugada Syndrome and acute myocardial infarction related ventricular fibrillation have similar pathophysiology. In this report, we present a case of acute coronary syndrome with Brugada like ECG complicated by malignant ventricular arrhythmias.
Results: Ang II stimulation induced umbilical artery aneurysm formation characterised by marked v... more Results: Ang II stimulation induced umbilical artery aneurysm formation characterised by marked vessel dilatation (90%;p<0.05;n¼6) and concomitant decrease in medial thickness (49%;p<0.05;n¼6), medial elastin content (61%;p<0.05;n¼6), and medial cell density (34%;p<0.05;n¼5), compared to untreated arteries (Figure 1). Such changes are indicative of aneurysm formation and progression in humans and mouse models, and were reversed by addition of recombinant TIMP-3 (5nM); reduced vessel dilatation (42%;p<0.05;n¼4) and increased medial thickness (93% p<0.05;n¼4) and elastin content (168%;p<0.05;n¼4). Supportingly, CaCl2 pre-treatment of umbilical arteries induced aneurysm formation as evidenced by reduced medial thickness (44%;p<0.05;n¼6), medial elastin content (33%;p<0.01;n¼6), and medial cell density (50%;p<0.05;n¼6), although vessel area was unchanged.
Aim: The goal of the study is to assess changes in claudication walking time measured on treadmil... more Aim: The goal of the study is to assess changes in claudication walking time measured on treadmill and in community setting outdoor walking after a 12-week supervised treadmill training in patients with claudication. Methods: The study included 30 patients (17 males) aged 70.6 ±6.98 with claudication due to peripheral artery disease. Patients were randomised into training (n¼14) and control (n¼16) groups. Changes in claudication onset time (COT), maximum claudication time (MCT) during graded treadmill test walked to maximum claudication and the highest measured time (HMT) obtained during community setting outdoor walking were assessed before and after the programme. Outdoor walking was conducted for 60 minutes and a GPS device was used. The HMT was determined as the highest time between two stops induced by lower extremity pain. Results: Post-training COT, MCT and HMT were prolonged by 113% (p<0.01), 84% (p<0.01) and 33% (p>0.05), respectively. No significant changes were observed in the control group with a tendency to MCT and HMD aggravation. There was no correlation between post-training changes in MCT and HMT (p>0.05). Conclusions: Twelve-week supervised treadmill training improves walking abilities measured on a treadmill, but not in community setting outdoor walking in patients with claudication. Perhaps this results from the specificity of treadmill training. It would be interesting to assess changes in outdoor walking abilities, after training in community setting, e.g. after Nordic Walking training. According to the authors' knowledge, it is the first study to assess post-training changes in outdoor walking in patients with claudication.
Population studies revealed that metal exposure through food, environment, and smoking was relate... more Population studies revealed that metal exposure through food, environment, and smoking was related with increased risk of cardiovascular disease. In this study, we determined complex chemical elements in surgical carotid endarterectomy specimens and carotid tissues from autopsies without atherosclerosis. Atherosclerotic plaques from 41 endarterectomies and normal carotid tissue from 30 autopsies were collected and elemental composition was determined by inductively coupled plasma optical emission spectrometry (ICP-OES) method. Eleven (26.8%) patients never smoked in carotid endarterectomy group. One patient was brass souvenir worker and one was goldsmith and others did not have direct contact with metals in the carotid endarterectomy group.
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