Papers by Olaf Sommerburg
Journal of Cystic Fibrosis
Journal of Cystic Fibrosis
Annals of the American Thoracic Society
Annals of the American Thoracic Society
Monatsschrift Kinderheilkunde
Journal of Cystic Fibrosis
Background: In cystic fibrosis newborn screening (CFNBS), immunoreactive trypsinogen (IRT) and pa... more Background: In cystic fibrosis newborn screening (CFNBS), immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) can be used as screening parameters. We evaluated the IRT × PAP product as second-tier parameter in CFNBS in newborns with elevated IRT. Methods: Data on 410,111 screened newborns including 78 patients with classical cystic fibrosis (CF) from two European centers were retrospectively analyzed by discrimination analysis to identify a screening protocol with optimal cutoffs. We also studied differences in PAP measurement methods and the association of IRT and PAP with age. Results: PAP values differed systematically between fluorometric and photometric assays. The IRT × PAP product showed better discrimination for classical CF than PAP only as second-tier screening parameter (p b 0.001). In CF patients, IRT decreased while PAP values remained high over years. In newborns without CF, IRT decreased after birth over weeks while PAP increased within days. Conclusions: The IRT × PAP product performs well as second-tier cutoff parameter for CFNBS. Screening quality parameters depend on the analytic method and on age at blood collection.
The Journal of pediatrics, 2017
Cystic fibrosis (CF) can be difficult to diagnose, even when newborn screening (NBS) tests yield ... more Cystic fibrosis (CF) can be difficult to diagnose, even when newborn screening (NBS) tests yield positive results. This challenge is exacerbated by the multitude of NBS protocols, misunderstandings about screening vs diagnostic tests, and the lack of guidelines for presumptive diagnoses. There is also confusion regarding the designation of age at diagnosis. To improve diagnosis and achieve standardization in definitions worldwide, the CF Foundation convened a committee of 32 experts with a mission to develop clear and actionable consensus guidelines on diagnosis of CF with an emphasis on screened populations, especially the newborn population. A comprehensive literature review was performed with emphasis on relevant articles published during the past decade. After reviewing the common screening protocols and outcome scenarios, 14 of 27 consensus statements were drafted that apply to screened populations. These were approved by 80% or more of the participants. It is recommended that ...
Journal of Cystic Fibrosis, 2016
Background: The relative risk for bone fractures in patients with cystic fibrosis (CF) and its re... more Background: The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. Methods: In a cross-sectional study of 43 CF patients (age, 17.8 ± 6.2 years), rate and location of fractures, bone mass, density, geometry, and strength of the radius as well as forearm muscle size were investigated. Results: The fracture rate in CF was 9.2-fold higher compared to an age-matched German control population. The probability of remaining free of any fracture in CF patients at 25 years was reduced to 39.8% compared to 84.6% in controls (P b 0.001). Assessment of macroscopic bone architecture by DXA and pQCT allowed the differentiation of patients with multiple prevalent fractures with a high sensitivity (up to 100%) and specificity (up to 94.3%). Conclusions: Bone densitometry is a useful tool for noninvasive assessment of fracture risk in CF patients.
European Respiratory Journal, Sep 1, 2013
Multiple breath washout is feasible and detects abnormal lung function in infants and young child... more Multiple breath washout is feasible and detects abnormal lung function in infants and young children with cystic fibrosis in the clinical setting Ms. Mirjam 124 Stahl
Pharmazeutische Zeitung, 2008
European Respiratory Journal, Sep 1, 2014
The Journal of Nutritional Biochemistry, Jan 7, 2005
β-Carotene (BC) and other carotenoids are mainly considered as belonging to the group of micronut... more β-Carotene (BC) and other carotenoids are mainly considered as belonging to the group of micronutrients. As they are contained in fruit and vegetables and thus part of human diet, a regular low-dose intake from natural sources is normally assured. In the last decade high-dose supplementation with synthetic carotenoids has been used successfully in the treatment of diseases believed to be
We identified Inquilinus limosus, a recently described ?-proteobacterium, in sputum of 2 patients... more We identified Inquilinus limosus, a recently described ?-proteobacterium, in sputum of 2 patients with cystic fibrosis whose respiratory tracts were persistently colonized for >9 months. We present data on the epidemiology, antimicrobial susceptibility, and molecular characteristics of I. limosus.
American journal of respiratory and critical care medicine, Jan 15, 2015
European Respiratory Journal, 2015
Oxidative Stress and Disease, 2013
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Papers by Olaf Sommerburg