Papers by Octavio Binvignat
PubMed, Mar 1, 1989
The authors studied 400 dry skulls of adult Brazilian individual (135 females and 265 males) belo... more The authors studied 400 dry skulls of adult Brazilian individual (135 females and 265 males) beloging to the collections of the laboratories of Descriptive and Topographic Anatomy of the São Paulo School of Medicine and the Medical School of the University of São Paulo. Metopism was observed in 11 skulls (2.75%, 4 females and 7 males). Incomplete metopic suture was present in 115 skulls (28.75%, 27 females and 88 males). The form of metopic suture was mainly linear (64.35%). The presence of metopism must be remembered, for instance, in skull fractures.
International Journal of Morphology, 2009
International Journal of Morphology, 2009
International Journal of Morphology, 2011
The rate is assessed as per the body fat percentages (%BF) estimated through anthropometric measu... more The rate is assessed as per the body fat percentages (%BF) estimated through anthropometric measurements and manual bioimpedance, according to gender and adiposity rate within the paediatric population. The %BF is assessed by anthropometry using the Slaughter equation for cutaneous skinfolds and manual bioimpedance (Omron model HBF-306INTTM) to 321 students (160 females and 161 males) between 10-18 years. The association degree among the methods was measured using the Pearson correlation coefficient (r). The consistency among methods was analysed through the intra-class correlation coefficient (ICC) and the consistency correlation coefficient of Lin (CCC), grouping the population by gender and adiposity rate. The reference method was the cutaneous skinfolds assessed by the Slaughter equation. Optimum and high adiposity rates were recorded for the studied sample. The r between the bioimpedance and the anthropometry was 0.689, which corresponds to moderate. However, it decreased according to the gender and adiposity rate (females: optimum 0.409 and high 0.610; males: optimum 0.335 and high 0.507). The ICC was 0.668, which also decreased by gender and adiposity rate (females: optimum 0.323 and high 0.578; males: optimum 0.229 and high 0.506). CCC was poor (<0.90) by gender and adiposity rate. The study shows differences for both methods in this age range, which is accentuated by gender and adiposity rate. Therefore, the use of manual bioimpedance as an interchangeable method with the anthropometric measurements in children and adolescents is not suggested as it underestimates the %BF.
Rev. chil. …, 1996
Base de dados : LILACS. Pesquisa : 189286 [Identificador único]. Referências encontradas : 1 [ref... more Base de dados : LILACS. Pesquisa : 189286 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. experimental, Documentos relacionados. Id: 189286. ...
International Journal of Morphology, 2021
RESUMEN: Las ciencias de la comunicación mejoran la organización de la vida en sociedad. En la in... more RESUMEN: Las ciencias de la comunicación mejoran la organización de la vida en sociedad. En la interdisciplinaridad que la caracteriza se nutre también de la anatomía. La simbología gráfica anatómica, por ejemplo, la calavera o cabeza ósea, por su carácter universal, facilita el proceso de comunicación y advierte sobre potenciales daños de la salud, a veces de consideraciones mortales. Este artículo destaca la participación de la anatomía en los procesos de comunicación.
Bioscience Journal, 2017
Two renal arteries supply the human kidneys: one to the right kidney and another to the left kidn... more Two renal arteries supply the human kidneys: one to the right kidney and another to the left kidney, both branches of the abdominal aortic. Renal artery duplication is an anatomical variation, which is a normal flexibility of the topography and morphology in body structures. Functionally, it does not impair the body, as the blood supply is vital to tissue survival. In this context, the case study has great importance, once knowing the variations of the renal vessels assist when structuring surgeries and radiological studies in humans. Variations in vascular anatomy are often found in humans. Several authors characterize it: the prevalence of multiple vessels occurs in approximately 20-50% of cases. This is an observational study; we aimed to describe the anatomical variations concerning the duplicity of the renal artery in human cadavers, focusing on possible implications to clinical and surgical procedures. We dissected and analyzed four urinary block systems in adult cadavers, male, with focus on the vascularization. In these, two right kidneys present double renal arteries. Thus, we can infer that this knowledge can be used to improve surgical interventions, such as transplants.
Current Pharmaceutical Design, 2020
:The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the agin... more :The global burden of neurodegenerative diseases is alarmingly increasing in parallel to the aging of population. Although the molecular mechanisms leading to neurodegeneration are not completely understood, excitotoxicity, defined as the injury and death of neurons due to excessive or prolonged exposure to excitatory amino acids, has been shown to play a pivotal role. The increased release and/or decreased uptake of glutamate results in dysregulation of neuronal calcium homeostasis, leading to oxidative stress, mitochondrial dysfunctions, disturbances in protein turn-over and neuroinflammation.:Despite the anti-excitotoxic drug memantine has shown modest beneficial effects in some patients with dementia, to date, there is no effective treatment capable of halting or curing neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington’s disease or amyotrophic lateral sclerosis. This has led to a growing body of research focusing on understanding the mechanisms associated with the excitotoxic insult and on uncovering potential therapeutic strategies targeting these mechanisms.:In the present review, we examine the molecular mechanisms related to excitotoxic cell death. Moreover, we provide a comprehensive and updated state of the art of preclinical and clinical investigations targeting excitotoxic- related mechanisms in order to provide an effective treatment against neurodegeneration.
International Journal of Morphology, 2018
Percepción de los estudiantes de anatomía humana frente a un método de enseñanza y aprendizaje ba... more Percepción de los estudiantes de anatomía humana frente a un método de enseñanza y aprendizaje basado en la construcción de un modelo de pelvis.
International Journal of Morphology, 2019
RESUMEN: En este artículo se resaltó la importancia que tiene un buen conocimiento de la anatomía... more RESUMEN: En este artículo se resaltó la importancia que tiene un buen conocimiento de la anatomía humana para una mejor práctica médica, brindando al paciente una mayor seguridad.
Journal of Psychopharmacology, 2018
Neurological and psychiatric disorders are leading contributors to the global disease burden, hav... more Neurological and psychiatric disorders are leading contributors to the global disease burden, having a serious impact on the quality of life of both patients and their relatives. Although the molecular events underlying these heterogeneous diseases remain poorly understood, some studies have raised the idea of common mechanisms involved. In excitotoxicity, there is an excessive activation of glutamate receptors by excitatory amino acids, leading to neuronal damage. Thus, the excessive release of glutamate can lead to a dysregulation of Ca 2+ homeostasis, triggering the production of free radicals and oxidative stress, mitochondrial dysfunction and eventually cell death. Although there is a consensus in considering excitotoxicity as a hallmark in most neurodegenerative diseases, increasing evidence points to the relevant role of this pathological mechanism in other illnesses affecting the central nervous system. Consequently, antagonists of glutamate receptors are used in current treatments or in clinical trials in both neurological and psychiatric disorders. However, drugs modulating other aspects of the excitotoxic mechanism could be more beneficial. This review discusses how excitotoxicity is involved in the pathogenesis of different neurological and psychiatric disorders and the promising strategies targeting the excitotoxic insult.
Rev Paul Med, Apr 1, 1989
International Journal of Morphology, 2015
This study aims to assess the efficiency of using real-scale knee models to learn about the locom... more This study aims to assess the efficiency of using real-scale knee models to learn about the locomotor system. Participants included a total of thirty-nine second year students in a Human Anatomy class of a Biology Teaching course. One week before the intervention, a pre-test was administered to assess the students' prior knowledge. The pre-service biology teachers were provided with a real-scale plaster model of a knee bone and were subsequently required to identify and create their own model of bone, joint and muscle elements. At the end of the intervention, a post-test was performed and opinion survey, in addition to a comparison with other locomotor system structures (four images: knee joint, muscular component of lower limb, shoulder joint and pelvic bone). Students' scores increased significantly in relation to the pre-test, both among the total sample (P=0.000) and between subgroups divided according to participant gender (male P=0.0021; female P=0.0005) as well as compared to other structures (P<0.05). Furthermore, the pre-service biology teachers showed significant increases in their scores on a Likert-type opinion survey, indicating that these types of interventions promote their motivation for the course (89.2%) as well as their learning (97.8%) and would be advisable for future students (95.5%). The results show that the use of real-scale models and associated work fosters student motivation and enhances the learning of human anatomy.
Rev Chil Obstet Ginecol, 1991
Rev Med Chile, Jun 1, 1989
Uploads
Papers by Octavio Binvignat