Papers by Oksana Sulaieva
Frontiers in digital health, May 30, 2024
Lìkarsʹka sprava/Lìkarsʹka sprava, Mar 29, 2024
Shìdnoukraïnsʹkij medičnij žurnal, Dec 31, 2022
Narrative Inquiry in Bioethics
Frontiers in Immunology, 2013
St open, Apr 5, 2023
Aim: To investigate the impact of Russian invasion on Ukrainian healthcare services related to cy... more Aim: To investigate the impact of Russian invasion on Ukrainian healthcare services related to cytopathology screening and diagnostics.Methods: The workload and output of the cytopathological laboratory located in Kyiv before and during 8 months of Russian invasion were analyzed. The laboratory performance was assessed by the total number of cytologic cases, the turn-around time (TAT) index, and the percentage of timely reported test results. The geographic distribution of cases was also analyzed.Results: There was a significant decline in the workload of the laboratory during the first two months of the war, and the numbers of cytopathology specimens fell to less than one third of prewar levels, and the TAT was prolonged. Since May 2022, the efficiency and quality of cytopathologic testing has been largely restored in most parts of Ukraine, only to be affected again by increased Russian bombardment toward the end of summer 2022. The number of cytology specimens was reduced and the source of cytology specimens changed from the prewar conditions reflecting the relocation of the CSD Lab to western Ukraine.Conclusion: Cytolopathological screening and diagnostics were seriously disrupted in Ukraine during the Russian invasion resulting in a decreased volume of cytology specimens received in the CSD Lab during the early months of the war. By adapting to the war conditions and reorganizing the cytology services, CSD Lab has continued providing cytology services at a level of efficiency similar to those of the prewar period. However, the volume of cytology specimens remains much smaller than before war, indicating that the cytology services have been adversely affected by the war.
Svìt medicini ta bìologìï, 2017
Svìt medicini ta bìologìï, 2017
American Journal of Clinical and Experimental Medicine, 2014
Biomedicine & Pharmacotherapy
Molecules
Phytoestrogen resveratrol (R) has been demonstrated to benefit human reproductive health. However... more Phytoestrogen resveratrol (R) has been demonstrated to benefit human reproductive health. However, R bioavailability and pharmacokinetics are still problematic under oral supplementation. We used an experimental vaginal gel with R and hyaluronic acid (HA) to improve bioavailability and pharmacokinetic properties. The study aimed to assess the impact of vaginal R-HA gel on the reproductive system in ovariectomized rats. Methods: The study was carried out on Wistar female rats. It investigated the body weight, tail temperature, vaginal pH, estrogen and progesterone blood levels, and immunohistochemical biomarkers (COX2, Casp-3, Bcl-2, and VEGF). Animals were divided into control animals; ovariectomized rats (OVX); and OVX group treated with vaginal 0.5% R-HA gel (0.5%, 0.1 mL, daily 28 days). Results: The R-HA gel’s therapeutic effect was manifested by slowing weight gain by 17% (p < 0.001), less pronounced symptom of fever at the root of the tail by 9% (p < 0.001) and lowering ...
Russian Journal of Gastroenterology, Hepatology, Coloproctology
The aim of review. To assess protective mechanisms and efficacy of gaseous mediators based antiin... more The aim of review. To assess protective mechanisms and efficacy of gaseous mediators based antiinflammatory therapy. Key points. Nowadays there are no reasonable and effective methods of prevention and treatment of NSAID-induced intestinal lesions. The discovery of powerful anti-inflammatory and cytoprotective effects of endogenous gaseous mediators (nitric oxide, hydrogen sulfide, carbon monoxide) led to development of new combined nonsteroidal anti-inflammatory drugs (NSAIDs), which in addition to cyclooxygenase inhibitor include gas-releasing molecules. One of such molecules is hydrogen sulfide (H2S) - the gaseous mediator that is produced under physiological conditions. H2S provides a powerful cytoprotective, antiinflammatory and antioxidant effects, optimizes the intestinal microbiota and improves gastroinesinal protection directly and through stimulation of other cytoprotectors, including prostaglandins, carbon monoxide and nitric oxide. Conclusion. Application of H2S-releasin...
Nanomaterials
Maxillary sinus augmentation is a commonly used procedure for the placement of dental implants. H... more Maxillary sinus augmentation is a commonly used procedure for the placement of dental implants. However, the use of natural and synthetic materials in this procedure has resulted in postoperative complications ranging from 12% to 38%. To address this issue, we developed a novel calcium deficient HA/β-TCP bone grafting nanomaterial using a two-step synthesis method with appropriate structural and chemical parameters for sinus lifting applications. We demonstrated that our nanomaterial exhibits high biocompatibility, enhances cell proliferation, and stimulates collagen expression. Furthermore, the degradation of β-TCP in our nanomaterial promotes blood clot formation, which supports cell aggregation and new bone growth. In a clinical trial involving eight cases, we observed the formation of compact bone tissue 8 months after the operation, allowing for the successful installation of dental implants without any early postoperative complications. Our results suggest that our novel bone ...
Cytopathology
The Covid‐19 pandemic and ongoing war in Ukraine caused unprecedented disruption in healthcare, i... more The Covid‐19 pandemic and ongoing war in Ukraine caused unprecedented disruption in healthcare, including cytopathology activities. This paper elucidates the effect of two consecutive disasters—the COVID‐19 pandemic followed by the war—on cytopathology practice in Ukraine through a single‐centre retrospective study. Total testing volumes, geographic distribution, and indicators of laboratory operations were assessed during three periods of 3 months each: the first 3 months of the acute phase of the war (March‐May 2022, period 1); summer (June‐August 2022, period 2); and the fall (September‐November 2022, period 3, associated with massive attacks on the energy infrastructure in Ukraine). These data were compared with the corresponding periods in 2020, during the COVID‐19 pandemic, and in 2021, the post‐lockdown period. The ongoing war in Ukraine has caused a dramatic disruption in routine health maintenance and cytological practice. A net decline in both PAP testing and non‐gynaecolo...
St open
Aim: To investigate the impact of Russian invasion on Ukrainian healthcare services related to cy... more Aim: To investigate the impact of Russian invasion on Ukrainian healthcare services related to cytopathology screening and diagnostics.Methods: The workload and output of the cytopathological laboratory located in Kyiv before and during 8 months of Russian invasion were analyzed. The laboratory performance was assessed by the total number of cytologic cases, the turn-around time (TAT) index, and the percentage of timely reported test results. The geographic distribution of cases was also analyzed.Results: There was a significant decline in the workload of the laboratory during the first two months of the war, and the numbers of cytopathology specimens fell to less than one third of prewar levels, and the TAT was prolonged. Since May 2022, the efficiency and quality of cytopathologic testing has been largely restored in most parts of Ukraine, only to be affected again by increased Russian bombardment toward the end of summer 2022. The number of cytology specimens was reduced and the ...
Cells
In this study, we investigated the relationship between the tumor immune microenvironment (TIME),... more In this study, we investigated the relationship between the tumor immune microenvironment (TIME), histological differentiation and hypoxia in patients with muscular-invasive urothelial carcinomas (MIUC) after radical cystectomy. Forty-two cases of pT2-3N0M0 MIUCs underwent clinical, histological and immunohistochemical evaluation by counting CD8+, FOXP3+, CD68+, CD163+ cells and polymorphonuclear leukocytes (PMN) in intra-tumoral and peritumoral areas, assessing PD-L1 and GLUT1 expression for defining the impact of tumor immune contexture on patients’ outcomes. Five-year survival rates and overall survival were calculated. Most of the MIUCs demonstrated the immune-desert or immune-excluded TIME, reflecting altered mechanisms of T-cells’ activation or traffic into tumors. Tumor immune contexture was closely related to histological differentiation. CD8+ cells were scant in MIUCs with papillary and squamous differentiation, while basal-like or mesenchymal-like histological differentiat...
T aim of this study was to evaluate sex diffrerences in microsatellite instability frequency and ... more T aim of this study was to evaluate sex diffrerences in microsatellite instability frequency and clinicopathological features of colorectal carcinoma (CRC). 177 patients (88 females and 89 males) with CRC who underwent microsatellite instability (MSI) testing were enrolled in this study. The overall incidence of MSI-H status among observed patients with CRC was 14.7%. The frequency of MSI was significantly higher in men (25.35%), comparing with women (10%) (P=0.0369). The MSI-H status was associated with the younger age (P=0.0020) in men. In addition, vast majority of MSI-H tumors were found in proximal part of large intestine (P<0.0001). In most of cases, MSI was due to lack of MLH1 and PMS2 expression (64%). MLH1 deficiency was higher in men rather than women (70.6% vs. 50%). In contrast, women demonstrated more often lack of MSH2+MSH6 (37.5% vs. 11.8%). Lack of MSH2 and MSH6 extression, as well as isolated block of PMS2 expression, were associated with the highest tumor grade ...
Journal of Health Science, 2014
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Papers by Oksana Sulaieva