Papers by Nurul Ain Ismail
Journal of Medicine and Life
Medicinal plants have been widely used in healthcare based on traditional knowledge. We investiga... more Medicinal plants have been widely used in healthcare based on traditional knowledge. We investigated the antimicrobial activities and phytochemical contents of a plant known as Blumea balsamifera (B. balsamifera), which Sabah native people have used for health benefits. Methanolic extracts and fractions of the leaves of B. balsamifera were tested for their phytochemical contents and their antimicrobial activities against four Gram-negative and five Gram-positive strains of bacteria. The extracts of B. balsamifera showed antimicrobial activities against three Gram-positive, and one Gram-negative bacteria, with the zone of inhibition ranging from 7.8 mm±0.41 to 10.5 mm±0.71. Fraction CE.F7 exerted the broadest antimicrobial activity towards four Gram-positive or Gram-negative bacteria. The phytochemical constituents identified in the extracts were alkaloid, flavonoid, steroid, and cardiac glycosides. The plant extract demonstrated antimicrobial activities and contained multiple phytoc...
Journal of Pharmacy and Nutrition Sciences, 2021
Cancer is a leading cause of death worldwide and caused by dysregulated signal transduction from ... more Cancer is a leading cause of death worldwide and caused by dysregulated signal transduction from kinase and phosphatases. Inhibitors of kinase and phosphatase have demonstrated anticancer properties. Therefore, this study aimed to investigate the antikinase, antiphosphatase and cytotoxic properties of Mallotus mollissimus (M. mollissimus) and Solanum erianthum (S. erianthum). Toxic activities against PP1, MKK1 and MSG5 assays were demonstrated by S. erianthum methanol extract. Bioassay-guided fractionation of the methanolic extracts showed that chloroform fraction (CE) of M. mollissimus exhibited toxic activity against PP1. Meanwhile, CE of S. erianthum showed positive activity on PP1 assay. Column chromatography separation of the CE has revealed that fractions F1 and F2 of M. mollissimus are toxic against PP1. Meanwhile, F1 and F2 CE fractions of S. erianthum were positive against PP1 and F9 fraction showed toxic activity in PP1 assay. Chloroform extracts of both plants exhibit cyt...
Uploads
Papers by Nurul Ain Ismail