Journal of Basic and Clinical Health Sciences, 2022
Objective: Colorectal cancer (CRC).is the second and third most common diagnosed cancer in women ... more Objective: Colorectal cancer (CRC).is the second and third most common diagnosed cancer in women and men in worldwide, respectively. Nutrition, one of the modifiable risk factors, especially Mediterranean diet (MD) model, is an important place in the prevention of CRC. The aim of this study is to determine the frequency of risk factors in patients without CRC and to evaluate the relationship.between CRC risk factors and having knowledge about nutrition compatible with the MD, and early detection methods. Meterials and Methods: In this study, the relationship between.MD and CRC risk was evaluated using CRC risk factors. A online survey consisting of 47 questions was prepared to collect the study data. Nutritional habits were evaluated using the “Mediterranean Diet Adherence Scale”. Statistical analyses was performed that calculating all scores of CRC risk, MD compatibility, knowledge level about CRC and the attitude towards early diagnosis methods. In data analysis, descriptive stati...
Most of the gastrointestinal stromal tumors (GISTs) have gain-of-function mutations in the KIT ge... more Most of the gastrointestinal stromal tumors (GISTs) have gain-of-function mutations in the KIT gene, which can be used as a prognostic marker for the biological behavior of tumors, predictive marker for the response of tyrosine kinase inhibitors, and diagnostic marker. Researchers have focused on PDGFRA mutations because of both their prognostic and predictive potential and DOG1 positivity for diagnosis on GISTs. The aim of this study is to investigate the effect DOG1, PDGFRA, and KIT mutations on the prediction of the outcome for GIST management. Polymerase chain reaction was performed for KIT gene exons 9, 11, 13, and 17 and PDGFRA gene exons 12 and 18 with the genomic DNA of 46 GIST patients, and amplicons were sequenced in both directions. Immunocytochemical stainings were done by using primary antibodies. Molecular analysis revealed that the KIT mutation was observed in 63% of all cases, while the PDGFRA mutation was observed in 23.9% of cases. Significant relationships were fo...
Journal of Basic and Clinical Health Sciences, 2022
Objective: Colorectal cancer (CRC).is the second and third most common diagnosed cancer in women ... more Objective: Colorectal cancer (CRC).is the second and third most common diagnosed cancer in women and men in worldwide, respectively. Nutrition, one of the modifiable risk factors, especially Mediterranean diet (MD) model, is an important place in the prevention of CRC. The aim of this study is to determine the frequency of risk factors in patients without CRC and to evaluate the relationship.between CRC risk factors and having knowledge about nutrition compatible with the MD, and early detection methods. Meterials and Methods: In this study, the relationship between.MD and CRC risk was evaluated using CRC risk factors. A online survey consisting of 47 questions was prepared to collect the study data. Nutritional habits were evaluated using the “Mediterranean Diet Adherence Scale”. Statistical analyses was performed that calculating all scores of CRC risk, MD compatibility, knowledge level about CRC and the attitude towards early diagnosis methods. In data analysis, descriptive stati...
Most of the gastrointestinal stromal tumors (GISTs) have gain-of-function mutations in the KIT ge... more Most of the gastrointestinal stromal tumors (GISTs) have gain-of-function mutations in the KIT gene, which can be used as a prognostic marker for the biological behavior of tumors, predictive marker for the response of tyrosine kinase inhibitors, and diagnostic marker. Researchers have focused on PDGFRA mutations because of both their prognostic and predictive potential and DOG1 positivity for diagnosis on GISTs. The aim of this study is to investigate the effect DOG1, PDGFRA, and KIT mutations on the prediction of the outcome for GIST management. Polymerase chain reaction was performed for KIT gene exons 9, 11, 13, and 17 and PDGFRA gene exons 12 and 18 with the genomic DNA of 46 GIST patients, and amplicons were sequenced in both directions. Immunocytochemical stainings were done by using primary antibodies. Molecular analysis revealed that the KIT mutation was observed in 63% of all cases, while the PDGFRA mutation was observed in 23.9% of cases. Significant relationships were fo...
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