Context: Post-transplant erythrocytosis (PTE), having an incidence of 10 to 15 % in the transplan... more Context: Post-transplant erythrocytosis (PTE), having an incidence of 10 to 15 % in the transplant population needs close monitoring of hematological parameters for early diagnosis and prevention of life-threatening thrombotic complications. Studies identifying the factors associated with PTE are sparse. Our aim is to study the demographic prole, prevalence, Aims: factors that predict PTE, course of the disease, complications, and response to treatment. Our st Settings and design: udy is a cross-sectional descriptive study involving 83 renal transplant recipients on follow-up at our center. P Materials and methods: atients with hemoglobin levels of more than 17 gm/dl and or hematocrit of more than 51% irrespective of gender were considered to be the PTE group and other patients were considered to be non-PTE group. Data from all patients in the study were collected retrospectively from medical records and analyzed Results: PTE was found in 11(13.2%) patients and their mean age was 3...
IP Journal of Urology, Nephrology and Hepatology Science, Jul 15, 2021
Amyloidoses are disorders of protein folding and metabolism in which insoluble fibrils are deposi... more Amyloidoses are disorders of protein folding and metabolism in which insoluble fibrils are deposited in body organs, causing organ dysfunction. Till date, more than 36 different proteins have been identified as amyloidogenic; and at least 17 of them can cause systemic disease. Out of these, AA amyloidosis is probably the most common type of amyloidosis worldwide, as most reported cases from developing countries are associated with underlying infections. Renal involvement is common (nearly 95 %) in patients with AA amyloidosis, patients present with proteinuria and/or renal failure. The optimal treatment strategy of AA amyloidosis includes control of the underlying inflammatory disease and thereby complete suppression of SAA production. Several drugs have shown anti-amyloid properties in recent times. Recently doxycycline (a tetracycline antibiotic) and ursodeoxycholic acid (UDCA) have been shown to have an anti-amyloid effect through different mechanisms.
Uremic optic neuropathy (UON) is one of the rare causes of vision loss in chronic kidney disease ... more Uremic optic neuropathy (UON) is one of the rare causes of vision loss in chronic kidney disease patients. It is infrequently seen nowadays as most of the patients are dialyzed early owing to better availability of medical services. It is a clinical diagnosis, correlating loss of vision with optic disc edema in a patient with kidney failure which improves noticeably with hemodialysis and steroids. We describe a patient with UON with excellent improvement on timely institution of hemodialysis and steroid therapy.
Background: The coronavirus disease 2019 (COVID-19) vaccine is not readily available in many coun... more Background: The coronavirus disease 2019 (COVID-19) vaccine is not readily available in many countries where dosing interval is spaced more than ideal. Patients with chronic kidney disease, especially those on maintenance hemodialysis, have a tendency for a reduced immune response. This study was undertaken to demonstrate the distinct humoral immune response to the viral vector COVID-19 vaccine in patients with kidney failure receiving maintenance hemodialysis. Methods: The study was carried out with two cohorts: 1) patients receiving maintenance hemodialysis and 2) healthcare workers from the same dialysis center as controls, each group with 72 subjects. Participants received a dose of Covishield ChAdOx1 nCoV-19 coronavirus vaccine. The humoral immunological response was determined using electrochemiluminescence immunoassay which quantitatively measures antibodies to the severe acute respiratory syndrome coronavirus 2 spike protein receptor-binding domain. Results: All study subjec...
Context: Post-transplant erythrocytosis (PTE), having an incidence of 10 to 15 % in the transplan... more Context: Post-transplant erythrocytosis (PTE), having an incidence of 10 to 15 % in the transplant population needs close monitoring of hematological parameters for early diagnosis and prevention of life-threatening thrombotic complications. Studies identifying the factors associated with PTE are sparse. Our aim is to study the demographic prole, prevalence, Aims: factors that predict PTE, course of the disease, complications, and response to treatment. Our st Settings and design: udy is a cross-sectional descriptive study involving 83 renal transplant recipients on follow-up at our center. P Materials and methods: atients with hemoglobin levels of more than 17 gm/dl and or hematocrit of more than 51% irrespective of gender were considered to be the PTE group and other patients were considered to be non-PTE group. Data from all patients in the study were collected retrospectively from medical records and analyzed Results: PTE was found in 11(13.2%) patients and their mean age was 3...
IP Journal of Urology, Nephrology and Hepatology Science, Jul 15, 2021
Amyloidoses are disorders of protein folding and metabolism in which insoluble fibrils are deposi... more Amyloidoses are disorders of protein folding and metabolism in which insoluble fibrils are deposited in body organs, causing organ dysfunction. Till date, more than 36 different proteins have been identified as amyloidogenic; and at least 17 of them can cause systemic disease. Out of these, AA amyloidosis is probably the most common type of amyloidosis worldwide, as most reported cases from developing countries are associated with underlying infections. Renal involvement is common (nearly 95 %) in patients with AA amyloidosis, patients present with proteinuria and/or renal failure. The optimal treatment strategy of AA amyloidosis includes control of the underlying inflammatory disease and thereby complete suppression of SAA production. Several drugs have shown anti-amyloid properties in recent times. Recently doxycycline (a tetracycline antibiotic) and ursodeoxycholic acid (UDCA) have been shown to have an anti-amyloid effect through different mechanisms.
Uremic optic neuropathy (UON) is one of the rare causes of vision loss in chronic kidney disease ... more Uremic optic neuropathy (UON) is one of the rare causes of vision loss in chronic kidney disease patients. It is infrequently seen nowadays as most of the patients are dialyzed early owing to better availability of medical services. It is a clinical diagnosis, correlating loss of vision with optic disc edema in a patient with kidney failure which improves noticeably with hemodialysis and steroids. We describe a patient with UON with excellent improvement on timely institution of hemodialysis and steroid therapy.
Background: The coronavirus disease 2019 (COVID-19) vaccine is not readily available in many coun... more Background: The coronavirus disease 2019 (COVID-19) vaccine is not readily available in many countries where dosing interval is spaced more than ideal. Patients with chronic kidney disease, especially those on maintenance hemodialysis, have a tendency for a reduced immune response. This study was undertaken to demonstrate the distinct humoral immune response to the viral vector COVID-19 vaccine in patients with kidney failure receiving maintenance hemodialysis. Methods: The study was carried out with two cohorts: 1) patients receiving maintenance hemodialysis and 2) healthcare workers from the same dialysis center as controls, each group with 72 subjects. Participants received a dose of Covishield ChAdOx1 nCoV-19 coronavirus vaccine. The humoral immunological response was determined using electrochemiluminescence immunoassay which quantitatively measures antibodies to the severe acute respiratory syndrome coronavirus 2 spike protein receptor-binding domain. Results: All study subjec...
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