Reading the facial expression of other people is a fundamental skill for social interaction. Huma... more Reading the facial expression of other people is a fundamental skill for social interaction. Human facial expressions of emotions are readily recognized but may also evoke the same experiential emotional state in the observer. We used event-related functional magnetic resonance imaging and multi-channel electroencephalography to determine in 14 right-handed healthy volunteers (29؎ 6 years) which brain structures mediate the perception of such a shared experiential emotional state. Statistical parametric mapping showed that an area in the dorsal medial frontal cortex was specifically activated during the perception of emotions that reflected the seen happy and sad emotional face expressions. This area mapped to the pre-supplementary motor area which plays a central role in control of behavior. Low resolution brain electromagnetic tomography-based analysis of the encephalographic data revealed that the activation was detected 100 ms after face presentation onset lasting until 740 ms. Our observation substantiates recently emerging evidence suggesting that the subjective perception of an experiential emotional state-empathy-is mediated by the involvement of the dorsal medial frontal cortex.
To determine task-specific activations of the human brain in individual subjects, we applied pixe... more To determine task-specific activations of the human brain in individual subjects, we applied pixel-by-pixel t-map statistics to the regional cerebral perfusion data obtained sequentially by dynamic scanning of [15O]-butanol with positron emission tomography (PET). The listmode data were binned into frames of 2 sec, and multiple corresponding pixel-by-pixel activation-minus-control subtractions were used for t-map calculation. The subtraction frames covering 10-40 sec after tracer arrival in the brain showed the activation-related increase of regional cerebral perfusion. A mismatch of the activation and control data by 2 sec resulted in a mean error of <5% of the integrated activity increase. To validate these results, we simulated images with a spatial resolution and signal-to-noise ratio equivalent to that of the [15O]-butanol subtraction images. By means of these simulated images, we determined the minimal data requirements for t-map analysis, the degree of spatial correlations in the image matrix, and the distribution of noise in the t-maps. The simulation results provided a measure to estimate the significance of regional cerebral perfusion changes recorded with [15O]-butanol. The location and spatial extent of regional cerebral activations obtained from dynamic data corresponded closely to those obtained with quantitative measurements of regional cerebral blood flow (rCBF). Our results show that statistical parametric mapping of [15O]-butanol scanning data allows the detection of significant, task-specific brain activations in single activation-control comparisons in individual subjects.
Recent studies suggest that glucose enhances memory in rodents and humans. The present experiment... more Recent studies suggest that glucose enhances memory in rodents and humans. The present experiment investigated the effects of glucose on memory performance and blood glucose changes in young adults (19-25 years). Subjects ingested (300 ml beverage) three doses of glucose (0, 30, 100 g) in a random, double-blind, triple crossover design. Thirty minutes post-glucose, subjects were shown nouns on a computer monitor and then administered recall and recognition memory tests. Blood samples were drawn at regular intervals. There was no effect of glucose on memory performance, and plasma glucose measures did not correlate with memory test scores. Statistical power was adequate to detect a medium effect. The results contradict the hypothesis that glucose enhances memory performance in young, healthy normal adults.
Progress in Clinical and Biological Research, 1992
Evidence suggests that mental retardation and Alzheimer's disease are etiologically heterogenous ... more Evidence suggests that mental retardation and Alzheimer's disease are etiologically heterogenous disorders, and that both sporadic and heritable causes of each exist. U human model of both mental retardation and Alzheimer's disease exists that avoids problems of etiologic heterogeneity and allows one to study how brain dysfunction results from suboptimal gene expression. Down syndrome (DS), trisomy 21, is a genetic disorder in which an extra portion of chromosome 21 leads to short stature, phenotypic abnormalities,mental retardation and dementia in later life. Because of opportunities available with newer
Recovery of finger movements after hemiparetic stroke has been shown to involve sensorimotor brai... more Recovery of finger movements after hemiparetic stroke has been shown to involve sensorimotor brain areas in perilesional and remote locations. Hand use, however, critically depends on visual guidance in such patients with stroke lesions in the middle cerebral artery territory. Using regional cerebral blood flow measurements, we wished to identify interrelated brain areas that are engaged in relation to manual activity in seven patients after their first hemiparetic brain infarction. During the blind-folded performance of sequential finger movements, the patients differed significantly from healthy controls (n = 7) by the recruitment of a predominantly contralesional network involving visual cortical areas, prefrontal cortex, thalamus, hippocampus, and cerebellum. Greater expression of this cortical-subcortical network correlated with a more severe sensorimotor deficit in the acute stage after stroke reflecting its role for post-stroke recovery. Patients also differed from controls o...
Sex differences in brain hemispheric structure and function have been reported, and sex-related d... more Sex differences in brain hemispheric structure and function have been reported, and sex-related differences in hemispheric interregional correlations were reported in a prior analysis of resting PET glucose metabolic (rCMRglc) data. To explore further the effect of sex on patterns of hemispheric brain functional interactions, we applied a multiple regression/discriminant analysis to resting rCMRglc PET data from young normal men and women to test two hypotheses: (1) women have stronger between-hemisphere functional interactions; (2) men have stronger within-hemisphere functional interactions. Two separate discriminant functions based on these hypotheses distinguished men and women: the first reflected rCMRglc interdependencies between hemispheres and correctly classified all women and 94% of the men; the second reflected rCMRglc interdependencies within the left hemisphere and correctly classified 82% of the women and 88% of the men. Because the discriminant functions successfully distinguished men and women, these results provide support for both hypotheses.
To define brain regions involved in feature extraction or elementary form perception, regional ce... more To define brain regions involved in feature extraction or elementary form perception, regional cerebral blood flow (rCBF) was measured using positron emission tomography (PET) in subjects viewing two classes of achromatic textures. Textures composed of local features (e.g. extended contours and rectangular blocks) produced activation or increased rCBF along the occipitotemporal pathway relative to textures with the same mean luminance, contrast, and spatial-frequency content but lacking organized form elements or local features. Significant activation was observed in striate, extrastriate, lingual, and fusiform cortices as well as the hippocampus and brain stem. On a scan-by-scan basis, increases in rCBF shifted from the occipitotemporal visual cortices to medial temporal (hippocampus) and frontal lobes with increased exposure to only those textures containing local features. These results suggest that local feature extraction occurs throughout the occipitotemporal (ventral) pathway...
" What the Encyclopedia of Sciences and Religions provides In the last quarter century, the ... more " What the Encyclopedia of Sciences and Religions provides In the last quarter century, the academic field of Science and Theology (Religion) has attracted scholars from a wide variety of disciplines. The question raised is, which disciplines are attracted and what do these disciplines have to contribute to the debate? In order to answer this question, the encyclopedia maps the (self)-identified disciplines and religious traditions that participate or might come to participate in the Science and Religion debate. This is done by letting each representative of a discipline and tradition answer specific chosen questions. They have to identify the discipline as a discipline or sub-discipline, or tradition or sub-tradition and also identify the disciplines in relation to the Science and Religion debate. Understandably representatives of several disciplines and traditions answered in the negative to the latter question. Nevertheless, they can still be important for the debate; indeed, scholars and scientists who work in the field of Science and Theology (Religion) may need knowledge beyond their own specific discipline. Therefore the encyclopedia also includes what are called general entries. Such entries may explain specific theories, methods, and topics. The general aim is to provide a starting point for new lines of inquiry. It is an invitation for fresh perspectives on the possibilities for engagement between and across sciences (again which includes the social and human sciences) and religions and theology. This encyclopedia is a comprehensive reference work for scholars interested in the topic of ‘Science and Religion.’ It covers the widest spectrum possible of academic disciplines and religious traditions worldwide, with the intent of laying bare similarities and differences that naturally emerge within and across disciplines and religions today. There are medium to long entries for all potentially relevant academic disciplines and religious traditions worldwide. The A–Z format throughout affords easy and user-friendly access to relevant information. Additionally, a systematic question-answer format across all Sciences and Religions entries affords efficient identification of specific points of agreement, conflict, and disinterest across and between sciences and religions. A Glossary, plus extensive cross-referencing between key words, phrases, and technical language used in the entries facilitates easy searches. We trust that all of the entries have something of value for any interested reader. Anne L.C. Runehov & Lluis Oviedo "
Inquiry into religious experience is informed by conceptualizations of emotion. Although a long h... more Inquiry into religious experience is informed by conceptualizations of emotion. Although a long history of theoretical and empirical work has provided considerable insight into the philosophical, psychological, and (more recently) neurobiological structure of emotion, the role of cognition and feeling in religious emotional states remains poorly conceived, and, hence, so does the concept of religious experience. The lack of a clear understanding of the role of emotion in religious experience is a consequence of a lack of an adequate interdisciplinary account of emotions. Our primary aim here is to examine the consequences of a properly interdisciplinary understanding of emotions for the analysis of religious experience. To this end, we note points of convergence between psychological, philosophical, and neuroscientific accounts of emotion and between such accounts and reports on the neurobiology of religious experience, in particular two recent human brain imaging studies. We conclude that emotions are richer phenomena than either pure feeling or pure thought and that, rightly understood, emotion affords religious experience its distinctive content and quality. Accordingly, we argue that religious experience cannot be reduced to pure feeling or pure thought. Rather, on our analysis, religious experience emerges as "thinking that feels like something."
Background and Purpose-Recovery from hemiparesis after stroke has been shown to involve reorganiz... more Background and Purpose-Recovery from hemiparesis after stroke has been shown to involve reorganization in motor and premotor cortical areas. However, whether poststroke recovery also depends on changes in remote brain structures, ie, diaschisis, is as yet unresolved. To address this question, we studied regional cerebral blood flow in 7 patients (meanϮSD age, 54Ϯ8 years) after their first hemiparetic stroke. Methods-We analyzed imaging data voxel by voxel using a principal component analysis by which coherent changes in functional networks could be disclosed. Performance was assessed by a motor score and by the finger movement rate during the regional cerebral blood flow measurements. Results-The patients had recovered (PϽ0.001) from severe hemiparesis after on average 6 months and were able to perform sequential finger movements with the recovered hand. Regional cerebral blood flow at rest differentiated patients and controls (PϽ0.05) by a network that was affected by the stroke lesion. During blindfolded performance of sequential finger movements, patients were differentiated from controls (PϽ0.05) by a recovery-related network and a movement-control network. These networks were spatially incongruent, involving motor, sensory, and visual cortex of both cerebral hemispheres, the basal ganglia, thalamus, and cerebellum. The lesion-affected and recovery-related networks overlapped in the contralesional thalamus and extrastriate occipital cortex. Conclusions-Motor recovery after hemiparetic brain infarction is subserved by brain structures in locations remote from the stroke lesion. The topographic overlap of the lesion-affected and recovery-related networks suggests that diaschisis may play a critical role in stroke recovery. (Stroke. 1999;30:1844-1850.
Reading the facial expression of other people is a fundamental skill for social interaction. Huma... more Reading the facial expression of other people is a fundamental skill for social interaction. Human facial expressions of emotions are readily recognized but may also evoke the same experiential emotional state in the observer. We used event-related functional magnetic resonance imaging and multi-channel electroencephalography to determine in 14 right-handed healthy volunteers (29؎ 6 years) which brain structures mediate the perception of such a shared experiential emotional state. Statistical parametric mapping showed that an area in the dorsal medial frontal cortex was specifically activated during the perception of emotions that reflected the seen happy and sad emotional face expressions. This area mapped to the pre-supplementary motor area which plays a central role in control of behavior. Low resolution brain electromagnetic tomography-based analysis of the encephalographic data revealed that the activation was detected 100 ms after face presentation onset lasting until 740 ms. Our observation substantiates recently emerging evidence suggesting that the subjective perception of an experiential emotional state-empathy-is mediated by the involvement of the dorsal medial frontal cortex.
To investigate medial frontal lobe mediation of human empathy, the authors analyzed the activatio... more To investigate medial frontal lobe mediation of human empathy, the authors analyzed the activation areas in statistical parametric maps of 80 studies reporting neural correlates of empathic processing. The meta-analysis revealed 6 spatially distinct activation clusters in the medial part of the frontal lobe dorsal to the intercommissural plane. The most dorsal cluster coincided with the left supplementary motor area (SMA). Rostrally adjacent was a cluster that overlapped with the right pre-SMA. In addition, there were 3 left-hemispheric and 1 right-hemispheric clusters located at the border between the superior frontal and anterior cingulate gyrus. A broad spectrum of cognitive functions were associated with these clusters, including attention to one's own action, which was related to activations in the SMA, and valuation of other people's behavior and ethical categories, which was related to activations in the most rostroventral cluster. These data complement the consistent observation that lesions of the medial prefrontal cortex interfere with a patient's perception of own bodily state, emotional judgments, and spontaneous behavior. The results of the current meta-analysis suggest the medial prefrontal cortex mediates human empathy by virtue of a number of distinctive processing nodes. In this way, the authors' findings suggest differentiated aspects of self-control of behavior.
Patients with left temporal lobe epilepsy demonstrate language impairments that are not well unde... more Patients with left temporal lobe epilepsy demonstrate language impairments that are not well understood[ To explore abnormal patterns of brain functional connections with respect to language processing\ we applied a principal component analysis to resting regional cerebral metabolic data obtained with positron emission tomography in patients with right! and left!sided temporal lobe epilepsy and controls[ Two principal components were expressed di}erentially among the groups[ One principal component comprised a pattern of metabolic interactions involving left inferior frontal and left superior temporal regions*corresponding to Broca|s and Wernicke|s areas\ respectively*and right mesial temporal cortex and right thalamus[ Functional couplings between these brain regions were abnormally enhanced in the left!sided epilepsy patients[ The right thalamicÐleft superior temporal coupling was also abnormally enhanced in the right!sided epilepsy patients\ but di}erentially from that in the left!sided patients[ The other principal component was characterized by a pattern of metabolic interactions involving right and left mid prefrontal and right superior temporal cortex[ Although both the right! and left!sided epilepsy patients showed decreased functional couplings between left mid prefrontal and the other brain regions\ a weaker rightÐleft mid prefrontal coupling in the left!sided epilepsy patients best distinguished them from the right!sided patients[ The two mutually independent\ abnormal metabolic patterns each predicted verbal intelligence de_cits in the patients[ The _ndings suggest a site!dependent reorganization of two independent\ language!subserving pathways in temporal lobe epilepsy[ Þ 0888 Elsevier Science Ltd[ All rights reserved[
Reading the facial expression of other people is a fundamental skill for social interaction. Huma... more Reading the facial expression of other people is a fundamental skill for social interaction. Human facial expressions of emotions are readily recognized but may also evoke the same experiential emotional state in the observer. We used event-related functional magnetic resonance imaging and multi-channel electroencephalography to determine in 14 right-handed healthy volunteers (29؎ 6 years) which brain structures mediate the perception of such a shared experiential emotional state. Statistical parametric mapping showed that an area in the dorsal medial frontal cortex was specifically activated during the perception of emotions that reflected the seen happy and sad emotional face expressions. This area mapped to the pre-supplementary motor area which plays a central role in control of behavior. Low resolution brain electromagnetic tomography-based analysis of the encephalographic data revealed that the activation was detected 100 ms after face presentation onset lasting until 740 ms. Our observation substantiates recently emerging evidence suggesting that the subjective perception of an experiential emotional state-empathy-is mediated by the involvement of the dorsal medial frontal cortex.
To determine task-specific activations of the human brain in individual subjects, we applied pixe... more To determine task-specific activations of the human brain in individual subjects, we applied pixel-by-pixel t-map statistics to the regional cerebral perfusion data obtained sequentially by dynamic scanning of [15O]-butanol with positron emission tomography (PET). The listmode data were binned into frames of 2 sec, and multiple corresponding pixel-by-pixel activation-minus-control subtractions were used for t-map calculation. The subtraction frames covering 10-40 sec after tracer arrival in the brain showed the activation-related increase of regional cerebral perfusion. A mismatch of the activation and control data by 2 sec resulted in a mean error of <5% of the integrated activity increase. To validate these results, we simulated images with a spatial resolution and signal-to-noise ratio equivalent to that of the [15O]-butanol subtraction images. By means of these simulated images, we determined the minimal data requirements for t-map analysis, the degree of spatial correlations in the image matrix, and the distribution of noise in the t-maps. The simulation results provided a measure to estimate the significance of regional cerebral perfusion changes recorded with [15O]-butanol. The location and spatial extent of regional cerebral activations obtained from dynamic data corresponded closely to those obtained with quantitative measurements of regional cerebral blood flow (rCBF). Our results show that statistical parametric mapping of [15O]-butanol scanning data allows the detection of significant, task-specific brain activations in single activation-control comparisons in individual subjects.
Recent studies suggest that glucose enhances memory in rodents and humans. The present experiment... more Recent studies suggest that glucose enhances memory in rodents and humans. The present experiment investigated the effects of glucose on memory performance and blood glucose changes in young adults (19-25 years). Subjects ingested (300 ml beverage) three doses of glucose (0, 30, 100 g) in a random, double-blind, triple crossover design. Thirty minutes post-glucose, subjects were shown nouns on a computer monitor and then administered recall and recognition memory tests. Blood samples were drawn at regular intervals. There was no effect of glucose on memory performance, and plasma glucose measures did not correlate with memory test scores. Statistical power was adequate to detect a medium effect. The results contradict the hypothesis that glucose enhances memory performance in young, healthy normal adults.
Progress in Clinical and Biological Research, 1992
Evidence suggests that mental retardation and Alzheimer's disease are etiologically heterogenous ... more Evidence suggests that mental retardation and Alzheimer's disease are etiologically heterogenous disorders, and that both sporadic and heritable causes of each exist. U human model of both mental retardation and Alzheimer's disease exists that avoids problems of etiologic heterogeneity and allows one to study how brain dysfunction results from suboptimal gene expression. Down syndrome (DS), trisomy 21, is a genetic disorder in which an extra portion of chromosome 21 leads to short stature, phenotypic abnormalities,mental retardation and dementia in later life. Because of opportunities available with newer
Recovery of finger movements after hemiparetic stroke has been shown to involve sensorimotor brai... more Recovery of finger movements after hemiparetic stroke has been shown to involve sensorimotor brain areas in perilesional and remote locations. Hand use, however, critically depends on visual guidance in such patients with stroke lesions in the middle cerebral artery territory. Using regional cerebral blood flow measurements, we wished to identify interrelated brain areas that are engaged in relation to manual activity in seven patients after their first hemiparetic brain infarction. During the blind-folded performance of sequential finger movements, the patients differed significantly from healthy controls (n = 7) by the recruitment of a predominantly contralesional network involving visual cortical areas, prefrontal cortex, thalamus, hippocampus, and cerebellum. Greater expression of this cortical-subcortical network correlated with a more severe sensorimotor deficit in the acute stage after stroke reflecting its role for post-stroke recovery. Patients also differed from controls o...
Sex differences in brain hemispheric structure and function have been reported, and sex-related d... more Sex differences in brain hemispheric structure and function have been reported, and sex-related differences in hemispheric interregional correlations were reported in a prior analysis of resting PET glucose metabolic (rCMRglc) data. To explore further the effect of sex on patterns of hemispheric brain functional interactions, we applied a multiple regression/discriminant analysis to resting rCMRglc PET data from young normal men and women to test two hypotheses: (1) women have stronger between-hemisphere functional interactions; (2) men have stronger within-hemisphere functional interactions. Two separate discriminant functions based on these hypotheses distinguished men and women: the first reflected rCMRglc interdependencies between hemispheres and correctly classified all women and 94% of the men; the second reflected rCMRglc interdependencies within the left hemisphere and correctly classified 82% of the women and 88% of the men. Because the discriminant functions successfully distinguished men and women, these results provide support for both hypotheses.
To define brain regions involved in feature extraction or elementary form perception, regional ce... more To define brain regions involved in feature extraction or elementary form perception, regional cerebral blood flow (rCBF) was measured using positron emission tomography (PET) in subjects viewing two classes of achromatic textures. Textures composed of local features (e.g. extended contours and rectangular blocks) produced activation or increased rCBF along the occipitotemporal pathway relative to textures with the same mean luminance, contrast, and spatial-frequency content but lacking organized form elements or local features. Significant activation was observed in striate, extrastriate, lingual, and fusiform cortices as well as the hippocampus and brain stem. On a scan-by-scan basis, increases in rCBF shifted from the occipitotemporal visual cortices to medial temporal (hippocampus) and frontal lobes with increased exposure to only those textures containing local features. These results suggest that local feature extraction occurs throughout the occipitotemporal (ventral) pathway...
" What the Encyclopedia of Sciences and Religions provides In the last quarter century, the ... more " What the Encyclopedia of Sciences and Religions provides In the last quarter century, the academic field of Science and Theology (Religion) has attracted scholars from a wide variety of disciplines. The question raised is, which disciplines are attracted and what do these disciplines have to contribute to the debate? In order to answer this question, the encyclopedia maps the (self)-identified disciplines and religious traditions that participate or might come to participate in the Science and Religion debate. This is done by letting each representative of a discipline and tradition answer specific chosen questions. They have to identify the discipline as a discipline or sub-discipline, or tradition or sub-tradition and also identify the disciplines in relation to the Science and Religion debate. Understandably representatives of several disciplines and traditions answered in the negative to the latter question. Nevertheless, they can still be important for the debate; indeed, scholars and scientists who work in the field of Science and Theology (Religion) may need knowledge beyond their own specific discipline. Therefore the encyclopedia also includes what are called general entries. Such entries may explain specific theories, methods, and topics. The general aim is to provide a starting point for new lines of inquiry. It is an invitation for fresh perspectives on the possibilities for engagement between and across sciences (again which includes the social and human sciences) and religions and theology. This encyclopedia is a comprehensive reference work for scholars interested in the topic of ‘Science and Religion.’ It covers the widest spectrum possible of academic disciplines and religious traditions worldwide, with the intent of laying bare similarities and differences that naturally emerge within and across disciplines and religions today. There are medium to long entries for all potentially relevant academic disciplines and religious traditions worldwide. The A–Z format throughout affords easy and user-friendly access to relevant information. Additionally, a systematic question-answer format across all Sciences and Religions entries affords efficient identification of specific points of agreement, conflict, and disinterest across and between sciences and religions. A Glossary, plus extensive cross-referencing between key words, phrases, and technical language used in the entries facilitates easy searches. We trust that all of the entries have something of value for any interested reader. Anne L.C. Runehov & Lluis Oviedo "
Inquiry into religious experience is informed by conceptualizations of emotion. Although a long h... more Inquiry into religious experience is informed by conceptualizations of emotion. Although a long history of theoretical and empirical work has provided considerable insight into the philosophical, psychological, and (more recently) neurobiological structure of emotion, the role of cognition and feeling in religious emotional states remains poorly conceived, and, hence, so does the concept of religious experience. The lack of a clear understanding of the role of emotion in religious experience is a consequence of a lack of an adequate interdisciplinary account of emotions. Our primary aim here is to examine the consequences of a properly interdisciplinary understanding of emotions for the analysis of religious experience. To this end, we note points of convergence between psychological, philosophical, and neuroscientific accounts of emotion and between such accounts and reports on the neurobiology of religious experience, in particular two recent human brain imaging studies. We conclude that emotions are richer phenomena than either pure feeling or pure thought and that, rightly understood, emotion affords religious experience its distinctive content and quality. Accordingly, we argue that religious experience cannot be reduced to pure feeling or pure thought. Rather, on our analysis, religious experience emerges as "thinking that feels like something."
Background and Purpose-Recovery from hemiparesis after stroke has been shown to involve reorganiz... more Background and Purpose-Recovery from hemiparesis after stroke has been shown to involve reorganization in motor and premotor cortical areas. However, whether poststroke recovery also depends on changes in remote brain structures, ie, diaschisis, is as yet unresolved. To address this question, we studied regional cerebral blood flow in 7 patients (meanϮSD age, 54Ϯ8 years) after their first hemiparetic stroke. Methods-We analyzed imaging data voxel by voxel using a principal component analysis by which coherent changes in functional networks could be disclosed. Performance was assessed by a motor score and by the finger movement rate during the regional cerebral blood flow measurements. Results-The patients had recovered (PϽ0.001) from severe hemiparesis after on average 6 months and were able to perform sequential finger movements with the recovered hand. Regional cerebral blood flow at rest differentiated patients and controls (PϽ0.05) by a network that was affected by the stroke lesion. During blindfolded performance of sequential finger movements, patients were differentiated from controls (PϽ0.05) by a recovery-related network and a movement-control network. These networks were spatially incongruent, involving motor, sensory, and visual cortex of both cerebral hemispheres, the basal ganglia, thalamus, and cerebellum. The lesion-affected and recovery-related networks overlapped in the contralesional thalamus and extrastriate occipital cortex. Conclusions-Motor recovery after hemiparetic brain infarction is subserved by brain structures in locations remote from the stroke lesion. The topographic overlap of the lesion-affected and recovery-related networks suggests that diaschisis may play a critical role in stroke recovery. (Stroke. 1999;30:1844-1850.
Reading the facial expression of other people is a fundamental skill for social interaction. Huma... more Reading the facial expression of other people is a fundamental skill for social interaction. Human facial expressions of emotions are readily recognized but may also evoke the same experiential emotional state in the observer. We used event-related functional magnetic resonance imaging and multi-channel electroencephalography to determine in 14 right-handed healthy volunteers (29؎ 6 years) which brain structures mediate the perception of such a shared experiential emotional state. Statistical parametric mapping showed that an area in the dorsal medial frontal cortex was specifically activated during the perception of emotions that reflected the seen happy and sad emotional face expressions. This area mapped to the pre-supplementary motor area which plays a central role in control of behavior. Low resolution brain electromagnetic tomography-based analysis of the encephalographic data revealed that the activation was detected 100 ms after face presentation onset lasting until 740 ms. Our observation substantiates recently emerging evidence suggesting that the subjective perception of an experiential emotional state-empathy-is mediated by the involvement of the dorsal medial frontal cortex.
To investigate medial frontal lobe mediation of human empathy, the authors analyzed the activatio... more To investigate medial frontal lobe mediation of human empathy, the authors analyzed the activation areas in statistical parametric maps of 80 studies reporting neural correlates of empathic processing. The meta-analysis revealed 6 spatially distinct activation clusters in the medial part of the frontal lobe dorsal to the intercommissural plane. The most dorsal cluster coincided with the left supplementary motor area (SMA). Rostrally adjacent was a cluster that overlapped with the right pre-SMA. In addition, there were 3 left-hemispheric and 1 right-hemispheric clusters located at the border between the superior frontal and anterior cingulate gyrus. A broad spectrum of cognitive functions were associated with these clusters, including attention to one's own action, which was related to activations in the SMA, and valuation of other people's behavior and ethical categories, which was related to activations in the most rostroventral cluster. These data complement the consistent observation that lesions of the medial prefrontal cortex interfere with a patient's perception of own bodily state, emotional judgments, and spontaneous behavior. The results of the current meta-analysis suggest the medial prefrontal cortex mediates human empathy by virtue of a number of distinctive processing nodes. In this way, the authors' findings suggest differentiated aspects of self-control of behavior.
Patients with left temporal lobe epilepsy demonstrate language impairments that are not well unde... more Patients with left temporal lobe epilepsy demonstrate language impairments that are not well understood[ To explore abnormal patterns of brain functional connections with respect to language processing\ we applied a principal component analysis to resting regional cerebral metabolic data obtained with positron emission tomography in patients with right! and left!sided temporal lobe epilepsy and controls[ Two principal components were expressed di}erentially among the groups[ One principal component comprised a pattern of metabolic interactions involving left inferior frontal and left superior temporal regions*corresponding to Broca|s and Wernicke|s areas\ respectively*and right mesial temporal cortex and right thalamus[ Functional couplings between these brain regions were abnormally enhanced in the left!sided epilepsy patients[ The right thalamicÐleft superior temporal coupling was also abnormally enhanced in the right!sided epilepsy patients\ but di}erentially from that in the left!sided patients[ The other principal component was characterized by a pattern of metabolic interactions involving right and left mid prefrontal and right superior temporal cortex[ Although both the right! and left!sided epilepsy patients showed decreased functional couplings between left mid prefrontal and the other brain regions\ a weaker rightÐleft mid prefrontal coupling in the left!sided epilepsy patients best distinguished them from the right!sided patients[ The two mutually independent\ abnormal metabolic patterns each predicted verbal intelligence de_cits in the patients[ The _ndings suggest a site!dependent reorganization of two independent\ language!subserving pathways in temporal lobe epilepsy[ Þ 0888 Elsevier Science Ltd[ All rights reserved[
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