Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic aci... more Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic acids have been studied. Results of investigations on the antitubercular and antiinflammatory activity of the obtained compounds are discussed.
Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific liter... more Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific literature. Only some years ago the situation turned over when based on preliminary virtual screening we obtained hydrochlorides of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid as potential opioid receptor antagonists . Further pharmacological research has confirmed the presence of "calculated" Pain and Treatment 22
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific liter... more Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific literature. Only some years ago the situation turned over when based on preliminary virtual screening we obtained hydrochlorides of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid as potential opioid receptor antagonists . Further pharmacological research has confirmed the presence of "calculated" Pain and Treatment 22
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2014
Adequacy of hemodialysis improves patient survival, quality of life and biochemical outcomes and ... more Adequacy of hemodialysis improves patient survival, quality of life and biochemical outcomes and minimizes disease complications and hospitalizations. This study was an observational cross-sectional study that was conducted in July 2012. Blood tests, weight and blood pressure were measured before and after hemodialysis. Single-pool Kt/V and urea reduction ratio (URR) were calculated. The targets based on the National Kidney Foundation Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guidelines were Kt/V ≥ 1.2 and URR ≥ 65%. Of the 64 patients, 41 (64.1%) were males. The mean age of the patients was 58.13 ± 17.2 years. The mean body mass index (BMI) was 25.04 ± 5.01 kg/m 2 . The mean Kt/V and URR were 1.06 ± 0.05 and 54.4 ± 19.3, respectively. There was no significant difference between men and women (1.06 ± 0.47 versus 1.04 ± 0.55, P = 0.863) and (54.7 ± 19.59 versus 53.81 ± 19.17, P = 0.296). Only 25 (39.1%) patients achieved the Kt/V goal and only 22 (34.4%) had targe...
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific liter... more Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific literature. Only some years ago the situation turned over when based on preliminary virtual screening we obtained hydrochlorides of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid as potential opioid receptor antagonists . Further pharmacological research has confirmed the presence of "calculated" Pain and Treatment 22
Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic aci... more Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic acids have been studied. Results of investigations on the antitubercular and antiinflammatory activity of the obtained compounds are discussed.
Being guided by the methodological principles of "chiral switches", the synthesis of S-and Renant... more Being guided by the methodological principles of "chiral switches", the synthesis of S-and Renantiomers of 1-allyl-4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (1ethylpyrrolidin-2-ylmethyl)-amide hydrochloride has been carried out. According to the results of the biological research, it has been found that the ability of the optical isomers obtained to block opioid receptors remains at the racemate level. It is important for future research conclusionthe asymmetrical carbon atom in these compounds is not the site of binding with the target receptor.
Single-crystal X-ray study T = 290 K Mean '(C±C) = 0.002 A Ê R factor = 0.038 wR factor = 0.072 D... more Single-crystal X-ray study T = 290 K Mean '(C±C) = 0.002 A Ê R factor = 0.038 wR factor = 0.072 Data-to-parameter ratio = 20.3
Acta Crystallographica Section E Structure Reports Online, 2001
ABSTRACT The title molecule, C16H19ClN2O2, contains three planar fragments, i.e. the quinoline s... more ABSTRACT The title molecule, C16H19ClN2O2, contains three planar fragments, i.e. the quinoline system (A), the butylamino group (B) and the carboxyl group (C). Angles A/B and A/C are 9.1 (2) and 79.08 (4)°, respectively. The alternation of the bond lengths in the quinoline bicycle correlates with literature data.
Natural plants products are one of the famous and commonly utilized remedies used in fighting dis... more Natural plants products are one of the famous and commonly utilized remedies used in fighting diseases. This study was conducted to evaluate antioxidant activity of plants commonly used in Palestine (Urtica urens, Rumex cyprius and Borago officinalis). Free radical scavenging activity method was evaluated by using 2,2-diphenyl-1-picryl-hydrazyl-hydrate. The result show that the overall antioxidant activity of Rumex cyprius was the highest among the plants, followed by Urtica urens, and Borago officinalis; respectively. The (IC50) values of the methanolic extracts were 29.70±0.60μg/ml, 5.07±0.49μg/ml, 39.92± 0.52 μg/ml for Urtica urens, Rumex cyprius and Borago officinalis respectively. The results of this study revealed that these edible plants have high antioxidant activity and therefore they can provide natural sources of antioxidants and can be useful in preventing various diseases including cancer. These exhibited properties propose that such plants extracts can possibly be used...
ABSTRACT Background: The natural antioxidant products in the plant kingdom play an important role... more ABSTRACT Background: The natural antioxidant products in the plant kingdom play an important role in the healthy life style and reduce the risk for various chronic diseases. Objective: The objective of this study was to investigate different antioxidant pharmacological property of methanol extract for fifteen species of Campanula plant from Palestinian flora. Methods: The antioxidant activity of fifteen Campanula species growing wildly in Palestine were studied using 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity and their antioxidant activity was compared to Trolox antioxidant activity. Results: The results clearly demonstrate a very high antioxidant activity of the Campanula sulphurea and Campanula sidoniensis and they showed almost the same antioxidant activity of Trolox. The other twelve species extracts also exhibited excellent antioxidant activity in DPPH radical scavenging activity in comparison with trolox standard. Conclusion: Methanol extract of Campanula can be valuable for treatment of different diseases and could be used as a possible new source of natural antioxidants in the food, nutraceuticals, pharmaceuticals and cosmetic industry.
Asian Journal of Pharmaceutical and Clinical Research, 2015
Medicinal plants and phytogenic products have used for treatment of various diseases from ancient... more Medicinal plants and phytogenic products have used for treatment of various diseases from ancient times in the folklore medicine all over the world. Crude plants extracts are now considered a valuable source for natural products used in the development of medicines against various diseases, for the development of pharmaceutical preparations, and for novel biomedical researches.
Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic aci... more Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic acids have been studied. Results of investigations on the antitubercular and antiinflammatory activity of the obtained compounds are discussed.
Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific liter... more Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific literature. Only some years ago the situation turned over when based on preliminary virtual screening we obtained hydrochlorides of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid as potential opioid receptor antagonists . Further pharmacological research has confirmed the presence of "calculated" Pain and Treatment 22
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific liter... more Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific literature. Only some years ago the situation turned over when based on preliminary virtual screening we obtained hydrochlorides of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid as potential opioid receptor antagonists . Further pharmacological research has confirmed the presence of "calculated" Pain and Treatment 22
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2014
Adequacy of hemodialysis improves patient survival, quality of life and biochemical outcomes and ... more Adequacy of hemodialysis improves patient survival, quality of life and biochemical outcomes and minimizes disease complications and hospitalizations. This study was an observational cross-sectional study that was conducted in July 2012. Blood tests, weight and blood pressure were measured before and after hemodialysis. Single-pool Kt/V and urea reduction ratio (URR) were calculated. The targets based on the National Kidney Foundation Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guidelines were Kt/V ≥ 1.2 and URR ≥ 65%. Of the 64 patients, 41 (64.1%) were males. The mean age of the patients was 58.13 ± 17.2 years. The mean body mass index (BMI) was 25.04 ± 5.01 kg/m 2 . The mean Kt/V and URR were 1.06 ± 0.05 and 54.4 ± 19.3, respectively. There was no significant difference between men and women (1.06 ± 0.47 versus 1.04 ± 0.55, P = 0.863) and (54.7 ± 19.59 versus 53.81 ± 19.17, P = 0.296). Only 25 (39.1%) patients achieved the Kt/V goal and only 22 (34.4%) had targe...
ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance t... more ABSTRACT ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific liter... more Until recently 4-hydroxyquinolin-2-ones have not even mentioned as analgesics in scientific literature. Only some years ago the situation turned over when based on preliminary virtual screening we obtained hydrochlorides of [(alkylamino)alkyl]amides of 1-allyl-4-hydroxy-6,7dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid as potential opioid receptor antagonists . Further pharmacological research has confirmed the presence of "calculated" Pain and Treatment 22
Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic aci... more Various methods of synthesizing amides of 2-hydroxy-4-imino-1,4-dihydroquinoline-3-carboxylic acids have been studied. Results of investigations on the antitubercular and antiinflammatory activity of the obtained compounds are discussed.
Being guided by the methodological principles of "chiral switches", the synthesis of S-and Renant... more Being guided by the methodological principles of "chiral switches", the synthesis of S-and Renantiomers of 1-allyl-4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (1ethylpyrrolidin-2-ylmethyl)-amide hydrochloride has been carried out. According to the results of the biological research, it has been found that the ability of the optical isomers obtained to block opioid receptors remains at the racemate level. It is important for future research conclusionthe asymmetrical carbon atom in these compounds is not the site of binding with the target receptor.
Single-crystal X-ray study T = 290 K Mean '(C±C) = 0.002 A Ê R factor = 0.038 wR factor = 0.072 D... more Single-crystal X-ray study T = 290 K Mean '(C±C) = 0.002 A Ê R factor = 0.038 wR factor = 0.072 Data-to-parameter ratio = 20.3
Acta Crystallographica Section E Structure Reports Online, 2001
ABSTRACT The title molecule, C16H19ClN2O2, contains three planar fragments, i.e. the quinoline s... more ABSTRACT The title molecule, C16H19ClN2O2, contains three planar fragments, i.e. the quinoline system (A), the butylamino group (B) and the carboxyl group (C). Angles A/B and A/C are 9.1 (2) and 79.08 (4)°, respectively. The alternation of the bond lengths in the quinoline bicycle correlates with literature data.
Natural plants products are one of the famous and commonly utilized remedies used in fighting dis... more Natural plants products are one of the famous and commonly utilized remedies used in fighting diseases. This study was conducted to evaluate antioxidant activity of plants commonly used in Palestine (Urtica urens, Rumex cyprius and Borago officinalis). Free radical scavenging activity method was evaluated by using 2,2-diphenyl-1-picryl-hydrazyl-hydrate. The result show that the overall antioxidant activity of Rumex cyprius was the highest among the plants, followed by Urtica urens, and Borago officinalis; respectively. The (IC50) values of the methanolic extracts were 29.70±0.60μg/ml, 5.07±0.49μg/ml, 39.92± 0.52 μg/ml for Urtica urens, Rumex cyprius and Borago officinalis respectively. The results of this study revealed that these edible plants have high antioxidant activity and therefore they can provide natural sources of antioxidants and can be useful in preventing various diseases including cancer. These exhibited properties propose that such plants extracts can possibly be used...
ABSTRACT Background: The natural antioxidant products in the plant kingdom play an important role... more ABSTRACT Background: The natural antioxidant products in the plant kingdom play an important role in the healthy life style and reduce the risk for various chronic diseases. Objective: The objective of this study was to investigate different antioxidant pharmacological property of methanol extract for fifteen species of Campanula plant from Palestinian flora. Methods: The antioxidant activity of fifteen Campanula species growing wildly in Palestine were studied using 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity and their antioxidant activity was compared to Trolox antioxidant activity. Results: The results clearly demonstrate a very high antioxidant activity of the Campanula sulphurea and Campanula sidoniensis and they showed almost the same antioxidant activity of Trolox. The other twelve species extracts also exhibited excellent antioxidant activity in DPPH radical scavenging activity in comparison with trolox standard. Conclusion: Methanol extract of Campanula can be valuable for treatment of different diseases and could be used as a possible new source of natural antioxidants in the food, nutraceuticals, pharmaceuticals and cosmetic industry.
Asian Journal of Pharmaceutical and Clinical Research, 2015
Medicinal plants and phytogenic products have used for treatment of various diseases from ancient... more Medicinal plants and phytogenic products have used for treatment of various diseases from ancient times in the folklore medicine all over the world. Crude plants extracts are now considered a valuable source for natural products used in the development of medicines against various diseases, for the development of pharmaceutical preparations, and for novel biomedical researches.
Uploads
Papers by Nidal Jaradat