Papers by Nicolás Foucras
OASIS, 1999
... Tamaño de la letra: Pequeña Mediana Grande. La problemática de la ampliación europea. Nicolás... more ... Tamaño de la letra: Pequeña Mediana Grande. La problemática de la ampliación europea. Nicolás Foucras, Andrea González, Adriana Medina, Adriana Murcia. Resumen.
Clinical features associated with a successful or unsuccessful response to high dose antiepilepti... more Clinical features associated with a successful or unsuccessful response to high dose antiepileptic drug therapy were evaluated prospectively in 82 patients with chronic complex partial seizures. Complete seizure control was observed during high dose drug therapy in 18 patients at plasma concentrations of either 9-35 ,g/ml phenytoin, 32 and 40 ,g/ml phenobarbitone, 8 gg/ml carbamazepine, or a combination of 25 ,g/ml phenobarbitone and 4 gg/ml carbamazepine. Patients who became free of seizures had a markedly lower number of three seizures (range: 1-29) in the year before the high dose treatment as compared to 40 seizures (range: 3-328) in patients with an increased or unchanged seizure frequency (p < 0.0001). Complex partial seizures without automatism were found only in patients with complete seizure control (22%). Patients whose seizures remained uncontrolled more frequently gave a history of severe depression or psychotic episodes, clusters of complex partial seizures, two or more seizures per day, and an aura preceding the attack. The results suggest that taking a careful history will uncover clinical features associated with a successful or unsuccessful response to high dose antiepileptic drug therapy in an epileptic outpatient with chronic complex partial seizures. Complex partial seizures are frequently found among adult patients with intractable epilepsy.'2 Recent evidence suggests that chronic complex partial seizures can be controlled in 31% of the patients with high dose single antiepileptic drug therapy.3 A predictive assessment of the individual seizure prognosis would be valuable for the clinical management. For evaluation of clinical features associated with a successful or unsuccessful response to high dose antiepileptic drug therapy, we studied 82 paients with chronic complex partial seizures referred to a seizure clinic for diagnostic and therapeutic reevaluation. Patients and methods Eighty two patients underwent diagnostic and therapeutic reevaluation for chronic complex partial seizures in the
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Papers by Nicolás Foucras