Papers by NAVNEET KUMAR VERMA
CERN European Organization for Nuclear Research - Zenodo, Dec 9, 2022
Eupatorium odoratum, also known as Chromolaena odorata (Family: Asteraceae), is a traditional med... more Eupatorium odoratum, also known as Chromolaena odorata (Family: Asteraceae), is a traditional medicinal plant that is well-known for its capacity to cure wounds. Particularly, the various components of this herb have been utilised to treat skin infections, burns, and wounds. It has also been demonstrated to have antioxidant, anti-hepatotoxic, anti-inflammatory, anticancer, and anti-diabetic properties. Alkaloids, flavonoids, flavanone, essential oils, phenolics, saponins, tannins, and terpenoids are some of its phytochemical constituents. The plant also contains significant amounts of eupolin, chromomoric acid, quercetagetin, and quercetin, all of which support the plant's therapeutic qualities. The ethnopharmacological qualities of this plant, including its antibacterial, anti-inflammatory, antioxidant, and analgesic action, have been amply documented in the literature. Additionally, it may be used medicinally to treat skin infections, wound healing, and stomach issues. The therapeutic qualities of C. odorata are said to have largely been influenced by the presence of different active chemical components in its leaves and root extracts, including phenolic, essential oils, and flavonoid chemicals. As a result, the goal of this review is to provide an overview of the bioactivities, phytochemical components, and potential therapeutic qualities of C. odorata.
International journal of health sciences
Introduction: Tuberculosis is a chronic, highly contagious disease caused by the Bacillus Mycobac... more Introduction: Tuberculosis is a chronic, highly contagious disease caused by the Bacillus Mycobacterium tuberculosis and spreads from person to person through air. Tuberculosis affects lungs majorly but also affects other parts of the body, such as brain, intestine, spine and kidney. The main cause for patient’s non-adherence to anti-tuberculosis therapy is ADRs of varying degrees of severity such as hepatotoxicity etc. Aim: This study aimed to provide proper understanding of Adverse drug reactions resulted due to Anti-TB drug therapy in TB patients based on various studies done on Anti-TB agents induced ADRs. Conclusion:Anti- Tuberculosisdrug (Anti-TB)could cause several ADRs both mild and severe types majority of ADR were wild, more attention is needed to prevent ADR and enhance current Anti-TB therapy. The study suggests that for more better in depth understanding and prevention of Anti-TB drug ADR many more studies with larger population is needed, also the current Anti-TB thera...
International journal of health sciences
Objectives- The objective of this survey is to find the various Covid-19 vaccine complication in ... more Objectives- The objective of this survey is to find the various Covid-19 vaccine complication in India and to spread awareness among people about adverse effects and their reporting also to study the rare side effects so to minimize the chances to harmful effects. Methods-Online surveys and questionnaires have been used to collect data from various peoples or subjects. Key findings- Majorly mild adverse effects have been reported, very few severe cases had reported and no rare side effect have been found in this survey. Adverse events those who have been found during the clinal trails had reported no new adverse reported in population of survey involved. Conclusion- The vaccine that have been administered by the population are safer but some precautionary measure must be taken and special attention to be given for elderly person and pregnant ladies and those who are already having any health-related issues while vaccinating them.
International journal of health sciences
The Piper betelplant is an evergreen and perennial creeper which is used in several traditional m... more The Piper betelplant is an evergreen and perennial creeper which is used in several traditional medicines to cure various diseases. The liquid extract of the plant has been used traditionally in curing inflammationand infection of the respiratory tract, cough, dyspnoea, indigestion,diphtheria, hysteria as well as general and sexual debility. The Indian traditional system ofmedicine has identified the Piper betelleaves with digestive and pancreatic lipasestimulant activities. In the present study, 14-day subacute toxicity assays were carried out.The crude extract did not produce toxic symptoms in mice in dose up to 2000mg/kg. This was also contirmed by hematological and histopathology examination.Piper betelshowed hypotensive, cardiac, and respiratory depressant effectssmooth and skeletal muscles relaxant actions, antimicrobial, fungicidal,and nematocidal activity.Piper betel leaves extract contains large number of bioactive molecule like polyphenol, alkaloids, steroids, saponin, and...
Liposomes are a novel drug delivery system (NDDS), in which the medication is encapsulated in a v... more Liposomes are a novel drug delivery system (NDDS), in which the medication is encapsulated in a vesicl e. It has been a study interest in the development of a NDDS. Liposomes are colloidal spheres of cholesterol surfactants, sphingolipids, glycolipids, long chain fatty acids and even membrane proteins and drug molecules or it is also called vesicular system. It is differ in size, composition and charge. It is a drug carri variety of molecules such as small drug molecules, proteins, nucleotides and even plasmids. Few drugs are also formulated as liposomes to improve their therapeuti c index. Consequently a number of vesicular drug delivery liposomes, niosomes, transfersomes, and pharmacosomes were developed. The focus of this review is to the various method of preparation, cha racterization of liposomes, advantages and brings o ut the
Application of erythrocytes, the most abundant cells of the human body with desirable physiologic... more Application of erythrocytes, the most abundant cells of the human body with desirable physiologic and morphologic characteristics, in drug delivery has been exploited extensively. Among the various carriers used for targeting drugs to various body tissues, the cellular carriers meet several criteria desirable in clinical applications, among the most important being biocompatibility of carrier and its degradation products. Leucocytes, platelets, erythrocytes, nanoerythrocytes, hepatocytes, and fibroblasts etc. have been proposed as cellular carrier systems. Among these, the erythrocytes have been the most investigated and have found to possess greater potential in drug delivery. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biological, antigens, anticancer drug and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. Erythrocytes, also known as red blood cells, and have been extensively st...
International Journal of Pharmaceutical Sciences and Nanotechnology, 2015
Microspheres are the novel drug delivery system. A well considered controlled drug delivery syste... more Microspheres are the novel drug delivery system. A well considered controlled drug delivery system can overcome some of the problems of predictable therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release approach. A Microspheres has its drug dispersed throughout the particle i.e., the internal structure is a matrix of drug and polymeric excipients. It is the reliable means to deliver the drug to the target site with specificity, if modified and to maintain the desired concentration at the site of interest without untoward effects. Microspheres are typically free flowing powders consisting of synthetic polymers which are biodegradable in nature. Microspheres are particles between 0.1 and 200 μm in size. Microspheres received much consideration not only for prolonged release, but also for targeting of anticancer drugs to the tumor. Microspheres are spher...
International Journal of Pharmaceutical Sciences and Nanotechnology, 2019
This article describes the innovative approaches to overcome the cationic toxicity inherently ass... more This article describes the innovative approaches to overcome the cationic toxicity inherently associated with the dendrimers. A dendrimer is a macromolecule characterized by its highly branched 3D structure that provides a high degree of surface functionality and versatility. The toxicity is attributed to the interaction of surface cationic charge of dendrimers with negatively charged biological membranes in vivo. Dendrimer toxicity in biological system is generally characterized by hemolytic toxicity, cytotoxicity and hematological toxicity. To minimize this toxicity, two strategies have been utilized; first, designing and synthesis of biocompatible dendrimers; and second, masking of peripheral charge of dendrimers by surface engineering. Biocompatible dendrimers can be synthesized by employing biodegradable core and branching units or utilizing intermediates of various metabolic pathways. Dendrimer biocompatibility has been evaluated in vitro and in vivo for efficient presentation...
Ethosomes are novel lipid vesicular carriers containing a relatively high percentage of ethanol a... more Ethosomes are novel lipid vesicular carriers containing a relatively high percentage of ethanol and the novel approach for the current drug delivery as a transdermal drug delivery system which is employed for the assessment of the targeted drug to the site of action. There are many application in the development of the formulation for the better release to the systemic circulation. The therapeutic effect of these category of formulation totally depends upon the medium of the drug release, in which we can observe the amount of drug in the formulation and drug released to the site of action. Ethosomes are vesicular carrier comprise of hydroalcoholic or hydro/alcoholic/glycolic phospholipid in which the concentration of alcohols or their combination is relatively high. Ethosomes can entrap drug molecule with various physicochemical characteristics i.e. of hydrophilic, lipophilic, or amphiphilic. These formulations are better alternative of oral drug delivery in that patients, those can...
Quick Response Code Abstract: Formulation of drugs in liposomes has provided an opportunity to en... more Quick Response Code Abstract: Formulation of drugs in liposomes has provided an opportunity to enhance the therapeutic indices of various agents mainly through alteration in their bio distribution. Liposomes are a novel drug delivery system (NDDS), they are vesicular structures consisting of bilayer which form spontaneously when phospholipids are dispersed in water. They are microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid bilayers. The goal of any drug delivery system is spatial placement and temporal delivery of the medicament. Research works are going on to prepare an ideal drug delivery system which satisfies these needs. Liposomes are small vesicles (100 nm) composed various lipid molecules which build their membrane bilayers. These formulations are mainly composed of phosphatidylcholine and other constituents such as cholesterol and lipidconjugated hydrophilic polymers. Liposomes are biodegradable and biocompatible in nature.
Triazines are a diverse class of compounds that possess three consecutively bonded nitrogen atoms... more Triazines are a diverse class of compounds that possess three consecutively bonded nitrogen atoms. Triazenes have been utilized in a variety of research areas. In organic synthesis, they have been used as protecting groups for aromatic amines, as linkers in solid-phase peptide synthesis and as synthons for novel heterocyclic compounds. In the present research work, we synthesized a series of novel Benzothiazole derivatives and Triazene derivatives by using some sulfa drugs. The Benzothiazole derivatives such as substituted 2-amino benzothiazole synthesized by a different procedure in which some sulfa drugs were reacted with ammonium thiocynate and prepared substituted phenylthiourea. The cyclization of substituted phenylthiourea prepared in the presence of bromine solution with chloroform and then prepared Benzothiazole nucleus. Triazene derivatives such as substituted 4-[1(E)-3,3 dimethyl-1-triazen-1-yl] synthesized by a different procedure in which some sulfa drugs were reacted wi...
Quick Response Code Abstract : Myristica fragrans is commonly named nutmeg or mace belongs to fam... more Quick Response Code Abstract : Myristica fragrans is commonly named nutmeg or mace belongs to family Myristicaceae. It is an aromatic evergreen tree with spreading branches and a yellow fleshy fruit similar in appearance to an apricot or peach. Myristica fragrans essential oil has antimicrobial, antiseptic, antiparasitic, anti-inflammatory, and antioxidant properties. We have recently demonstrated that hydrodistillation of nutmeg essential oil by applying magnesium aluminometasilicate as an excipient significantly increases both the content and amount of bioactive substances in the oil and hydrolats. In this study, we aimed to compare the antioxidant, antimicrobial, and anti-inflammatory activity of hydrolats and essential oil obtained by hydrodistillation in the presence and absence of magnesium aluminometasilicate as an excipient. Caribbean islands of Grenada and Trinidad are also influential in growing this aromatic tree commercially. It belongs to Myristicaceae family and is the...
Journal of Medical pharmaceutical and allied sciences, 2021
The present summarized paper on medicinal plants that have been reported by researchers on experi... more The present summarized paper on medicinal plants that have been reported by researchers on experimental or clinical anti-diabetic evidence and that have been used in traditional systems of medicine. A diabetes mellitus disease is one of the most frequent non-communicable diseases worldwide. A complete review was conducted to pile up information about anti-diabetic medicinal plants. It is a metabolic disorder disease of the endocrine system and affecting almost 10% of the population all over the world also the number of those affected is increasing day by day. In this review covered the following sections such as anti-diabetic medicinal plant, bioactive molecules, and experimental model. Future perspectives of Anti-diabetic bioactive molecules and are also discussed.
Nasal drug delivery system (NDDS) has been used as a substitute route for the systemic accessibil... more Nasal drug delivery system (NDDS) has been used as a substitute route for the systemic accessibility of drugs restricted to intravenous administration. This is due to the porous endothelial membrane, large surface area, high total blood flow, the avoidance of first-pass metabolism, and ready accessibility. The nasal administration of drugs, including various compound, peptide and protein drugs, for systemic medication has been widely investigated in recent years. Drugs are cleared rapidly from the nasal cavity after intranasal administration, resulting in rapid systemic drug absorption. Several approaches are here discussed for increasing the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption. The article highlights the importance and advantages of the drug delivery systems applied via the nasal route, which have bioadhesive properties. Bioadhesive or more appropriately, mucoadhesive systems have been prepared for both oral and peror...
The origin of ginseng dates back to prehistory. In China, Shennong also known as Emperor Yan, the... more The origin of ginseng dates back to prehistory. In China, Shennong also known as Emperor Yan, the Yellow Emperor, or one of the"Three Emperors"(the Emperor who is said to have started herbal medicine about 5,500 years ago) is reported to have tasted hundreds of plants to discover many medicinal herbs. For many many years, mankind has been using various plants as nutrient, beverage, cosmetics, dye and medicine to maintain health and to improve quality of life. In Asia, particularly, Panax ginseng C.A. Meyer is considered to be the most precious plant among herbs, and ginseng has been in the spotlight worldwide. Even in the Western world, where there are greatly advanced research facilities and highly qualified manpower available, and are regarded to be capable of conquering any hard-to-cure ailments, many people has recently been reported to use herbal medicine, particularly ginseng. In the present compilation of papers, many scientists contributed papers pertaining to"...
Microsponges, the drug release technology has become more spirited and rapidly on the rise. Diffe... more Microsponges, the drug release technology has become more spirited and rapidly on the rise. Different drug delivery systems are being incorporated to optimize the efficiency and cost-effectiveness of the rehabilitation. In malevolence of presence of these technologies the drug delivery systems are unsuccessful to reach the systemic circulation in adequate amounts in control manner in few cases like Peptides and proteins. Conventional topical formulations have also many problems, such as producing a highly concentrated layer of active ingredient resulting irritation and allergic reactions etc. To control the delivery rate of active agents to a encoded site in human body has been one of the major challenges for drug industry. This review article focus on the Novel approaches to product formulation incorporating Microsponges technology may offers better entrapment of ingredients, reduced side effects, increased elegance, and enhanced formulation flexibility.
Dispersion of phospholipids in water, which spontaneously form a closed structure with environmen... more Dispersion of phospholipids in water, which spontaneously form a closed structure with environment bounded by phospholipids bilayer membranes, this vesicular system is called as liposome [1]. Liposomes are the small vesicle of spherical shape that can be produced from cholesterols, non sphingolipids, glycolipids, long chain fatty acids and even membrane proteins [2]. Liposomes are the drug carrier loaded with great variety of molecules such as small drug molecules, proteins, nucleotides and even plasmids. Liposomes were discovered about 40 years ago by A.D. biology, biochemistry and medicine today. In 1960s, liposome has been used as a carrier to transport a wide variety of compounds in its aqueous compartment. Liposome can be formulated and processed to di composition, charge and lamellarity. To date liposomal formulations of anti been commercialized [4]. The clinical potential of liposomes as a vehicle for replacement therapy in genetic deficiencies of lysosomal enzymes was first established in 1970s [5, 6]. Considerable progress was made during 1970s and 1980s in the field of liposome stability leading to long circulation times of liposomes after intravenous administration resulting in the improvement in doxorubicin had been formulated as liposome in 1980s to improve the therapeutic index. There are several mechanisms by which liposomes act within and outside the body which are as follows [7]: Liposomes are a novel drug delivery system (NDDS), in which the medication is encapsulated in a vesicle. It has been a study interest in the development of a NDDS. Liposomes are surfactants, sphingolipids, glycolipids, long chain fatty acids and even membrane proteins and drug molecules or it is also called vesicular system. It is differ in size, composition and charge. It is a drug carri variety of molecules such as small drug molecules, proteins, nucleotides and even plasmids. Few drugs are also formulated as liposomes to improve their therapeutic index. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes, transfersomes, and pharmacosomes were developed. The focus of this review is to the various method of preparation, characterization of liposomes, advantages and brings out the application vesicular systems.
Uploads
Papers by NAVNEET KUMAR VERMA