Many pharmaceuticals cannot access brain, though, has potential for treatment and this is mainly ... more Many pharmaceuticals cannot access brain, though, has potential for treatment and this is mainly due to the potential blood brain barrier. To have a successful delivery, the challenges of anatomical and physiological aspects of those barriers need to be addressed. Though a considerable efforts were made in convincing those barriers, still designing a suitable delivery remains a major challenge. This review lists various strategies for the drug delivery to the brain. Sophisticated approaches like intracerebral delivery, intranasal delivery, barrier disruptions, receptor mediated transport, prodrugs, chemical drug delivery and many more were discussed. Limitations of some strategies were also discussed. Understanding the strategies along with the suitability of the therapeutic agent to undergo those strategic modifications would certainly promises the success of a brain drug delivery program. This a review made here would help the researcher in understanding the barrier and further mo...
Now a day’s most of the investigations are focused only on the development of various drug delive... more Now a day’s most of the investigations are focused only on the development of various drug delivery systems for targeting of the desired tissue to achieving required therapeutic concentration with less amount of dose. Targeting of an active biomolecule from efficient drug delivery where pharmacological agent directed specifically to its target site can be approached by either chemical modification or by appropriate carrier. Here erythrocytes have proved that they have potential carrier capabilities. Such drug-loaded carrier erythrocytes are biocompatible and biodegradable, and possess very long circulation half lives. And which are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers, which are called as resealed erythrocytes. The present article gives information about morphology, isola tion, properties, and methods of drug loading, character...
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the re... more The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.
The volatile oil of Boswellia serrata. Roxb [1]., showed significant antiulcer activity in albino... more The volatile oil of Boswellia serrata. Roxb [1]., showed significant antiulcer activity in albino rats by pyloric ligationmodel. The albino rats of either sex were divided in to three groups the animals were deprived of food for 24 hours before the commencement of experiment. The drugs were given intraperitoneally . The animals were sacrificed 6 hours after pylori ligation to observe gastric lesion. The gastric juice was collected and its pH determined titrimetrically by using 0.01N sodium hydroxide solution. The acid secretion and after index were analyzed by student ÂÂtÂÂ test. It showed significant antiulcer activity. The extract reduces the gastric activity and ulceration by histaminergic mechanism by H2 receptor blockade.
Blood Brain Barrier (BBB) is a potential barrier and a challenging process for designing of new d... more Blood Brain Barrier (BBB) is a potential barrier and a challenging process for designing of new drug delivery. Loperamide (Lp) though an opiatic drug cannot elicit CNS effect due to the efflux of P glycoprotein (Pgly) present in the endothelials of BBB. But Polysorbate 80 has blocks P glycoprotein efflux thus enhancing the delivery of drug to brain. In our study we have formulated polysorbate 80 coated liposomes (PCL) and evaluated for the actinociceptive response (Eddys hot plate and Tail Flick). Zetapotential (ZP) and Poly Dispersity Index (PDI) by zetasizer, mean particle diameter by Photon Correlation Spectroscopy (PCS), particle size distribution by Transmission Electron Microscopy (TEM) and brain quantification study by LC-MS/MS for PCls were done. We found in actinociceptive study, animal showed appreciable rise in analgesic activity for PCL from control in Eddys hot plate (55.35%) (p < 0.01) and in Tail Flick test (68.8 %) (p < 0. 01). Particle size analysis confirmed ...
The objective of the present study was preparation and invitro evaluation of sustained release mi... more The objective of the present study was preparation and invitro evaluation of sustained release microsp heres of aceclofenac. Generally administration of microspher es will provide the localization of active substanc e at the site of action for prolonged period of the time. The micros pheres of aceclofenac was prepared by emulsion cross linking method and solvent evaporation technique by using different grades of gelatin with varying concentra tions and Eudragit (S-100,L-100) polymers respectively. The f ormulations were evaluated for particle size distri bution analysis, flow properties like Angle of repose, bul k density, tapped density, true density, Hausner’s Ratio, Carr’s index, microencapsulation efficiency, Scanning elec tron microscopy(SEM) and invitro release studies. T he optimized formulation showed good invitro sustained release activity of the drug Aceclofenac.
Now a day’s most of the investigations are focused only on the development of various drug delive... more Now a day’s most of the investigations are focused only on the development of various drug delivery systems for targeting of the desired tissue to achieving required therapeutic concentration with less amount of dose. Targeting of an active biomolecule from efficient drug delivery where pharmacological agent directed specifically to its target site can be approached by either chemical modification or by appropriate carrier. Here erythrocytes have proved that they have potential carrier capabilities. Such drug-loaded carrier erythrocytes are biocompatible and biodegradable, and possess very long circulation half lives. And which are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers, which are called as resealed erythrocytes. The present article gives information about morphology, isola tion, properties, and methods of drug loading, character...
The aim of the present study was to prepare and evaluate Dopamine (Dp) liposome using polysorbate... more The aim of the present study was to prepare and evaluate Dopamine (Dp) liposome using polysorbate 80 (PS80) which enabled the targeted delivery of drug across Blood Brain Barrier (BBB) in the effective treatment of Parkinson disease as L dopa drug conventionally used for Parkinson’s disease produces “wearing off” adverse reactions. Dp loaded liposome were prepared with various concentration of PS80 by Reverse Phase Evaporation technique. The formation of liposome was confirmed by scanning electron microscopy (SEM). The drug and the excipient compatibility was analysed by FTIR, DSC and XRD studies. FTIR indicated that there was no loss in chemical integrity of the drug upon fabrication into liposome. DSC and XRD results demonstrated that the drug was changed from the crystalline form to the amorphous form in the formulation. Among all the formulations, LSP4 showed higher Entrapment efficiency (EE) of 68% and increases the animal locomotion in psychopharmacological study (18.3%). Dp L...
Many pharmaceuticals cannot access brain, though, has potential for treatment and this is mainly ... more Many pharmaceuticals cannot access brain, though, has potential for treatment and this is mainly due to the potential blood brain barrier. To have a successful delivery, the challenges of anatomical and physiological aspects of those barriers need to be addressed. Though a considerable efforts were made in convincing those barriers, still designing a suitable delivery remains a major challenge. This review lists various strategies for the drug delivery to the brain. Sophisticated approaches like intracerebral delivery, intranasal delivery, barrier disruptions, receptor mediated transport, prodrugs, chemical drug delivery and many more were discussed. Limitations of some strategies were also discussed. Understanding the strategies along with the suitability of the therapeutic agent to undergo those strategic modifications would certainly promises the success of a brain drug delivery program. This a review made here would help the researcher in understanding the barrier and further mo...
Now a day’s pulmonary drug delivery remains the favourite route for administration of various dru... more Now a day’s pulmonary drug delivery remains the favourite route for administration of various drugs. Pulmonary route has concerned as a tremendous scientific and biomedical importance in recent years due to its unique properties such as a large absorptive area of up to 100m2 and it has particularly thin 0.1 μm - 0.2 μm absorptive mucosal membrane and good blood supply. Targeted drug delivery to the lungs has evolved to be one of the most widely investigated systemic or local drug delivery approach. As time goes on, the drug delivery systems (DDS) for the treatment of pulmonary diseases are increased due to their potential for localized topical therapy in the lungs. This route also makes it possible to deposit drugs more site-specific at high concentrations within the diseased lung thereby reducing the overall amount of drug given to patients, as well as increasing local drug activity while reducing systemic side effects and first-pass metabolism. Generally half of all pharmaceutical...
The Internet Journal of Third World Medicine, 2008
To investigate the prevailing prescribing practices in the treatment of depression and to determi... more To investigate the prevailing prescribing practices in the treatment of depression and to determine whether these practices reflects research findings. Patient profiles were reviewed retrospectively between February 2006 to January 2007 in private hospital at Chennai. The total study population includes 750 patient. According to this study , SSRIs agent are favored as first line treatment in a first episode of depression and are prescribed more frequently because the side effects are better tolerated than the older drugs. At the time this study was conducted, the newer antidepressants SSRIs and the SNRIs were prescribed in the majority of cases.. The study data demonstrated significant problems in the dose and duration of antidepressant treatment in this population. The results of the present study should be used as a discussion tool by pharmacists with physicians in order to optimize prescription habits for antidepressant usage.
Purpose: To deliver loperamide (Lp) into mice brain using polysorbate 80 (PS80)-coated liposomes ... more Purpose: To deliver loperamide (Lp) into mice brain using polysorbate 80 (PS80)-coated liposomes that inhibits P-glycoprotein (P-gp) efflux. Method: Lp loaded liposomes were prepared by reverse phase evaporation technique using lecithin (Lec) and cholesterol (Ch). The efficacy of PS80-coated Lp liposomes (PLs) in mice was evaluated using central analgesic models (Eddy's hot plate method and tail immersion test) and peripheral analgesic model (acetic acid-induced writhing). Results: PLs showed maximum possible response (MPR) of 58.33 % at 60 min in Eddy's hot plate study. In the tail immersion test, PLs showed MPR of 67.64 and 69.24 % at 60 and 90 min, respectively, relative to control group. This confirms the potential of PLs to deliver Lp to the brain by inhibiting P-gp efflux. Dose response study using tail flick method confirmed the minimum Lp dose (25 µg/kg, i.v) required to achieve central analgesic activity using PLs. Conclusion: PS80-coated Lp loaded liposomes (PLs) possess a good potential to inhibit P-gp efflux of Lp from brain, and also exhibit both central and peripheral analgesic activity.
Ovarian cancer is one of the leading causes of mortality in women. Early detection and prompt man... more Ovarian cancer is one of the leading causes of mortality in women. Early detection and prompt management is the key to improve survival rate among the affected. 5 year survival rate for epithelial ovarian cancer is reported to be directly related to surgical stage. The majority of epithelial cancers has an exophytic growth on ovarian surface that provide them a direct contact with peritoneal cavity. Methods of detection of microscopic disease in ovarian cancer are therefore of significant interest and may reduce the mortality rate for this disease by enabling an earlier diagnosis of primary recurrent ovarian cancer. Our study aimed at finding the rate of positivism of malignant cells in ascitic or peritoneal washing fluid, to observe correlation between cytologically positive pelvic peritoneal washing and histological types of ovarian tumor, and to correlate the cytological findings with the FIGO staging of the tumor.
Asian Journal of Pharmaceutical and Clinical Research, Jul 1, 2014
The aim of the present study is to formulate and evaluate carbopol based enteric capsules for sit... more The aim of the present study is to formulate and evaluate carbopol based enteric capsules for site specific drug delivery of Satranidazole to colon which was used in the treatment of amoebiasis. Methodology: 10 different formulations of carbopol based Satranidazole capsules were prepared and coated with different ratios of HPMC and Eudragit S-100. The capsules were evaluated for various physic chemical parameters. The formulations were capable of delaying drug release in the time period of 3-5 h in the simulated physiologic environment of upper gastrointestinal tracts depending on coating ratios of HPMC and Eudragit S-100. Dissolution studies of all the formulations were performed and the cumulative percentage drug release for Satranidazole was calculated. Results: Dissolution studies demonstrate that, these polymeric coated formulations were gastro resistance for 2 h at 0.1 N Hcl and further for 3 h at pH 6.8; since they released only 7-9% of drug in physiological environment of stomach and small intestine. They showed better drug release in colonic region (pH 7.4) only. Bio-adhesive studies and Rheological studies reveal that carbopol is effective in pH 7.4 than 0.1 N Hcl and pH 6.8 buffers. Diffusion studies and Histopathological studies show that the drug can easily penetrate though the mucosal membrane. DSC and IR analysis shows no possibility of interaction between drug and polymers used in the study. Conclusion: Studies demonstrated that the developed system can be a promising device for targeting of Satranidazole to colonic region.
Liposomes is a lipid based drug delivery used for loading both hydrophilic and lipophilic drugs 1... more Liposomes is a lipid based drug delivery used for loading both hydrophilic and lipophilic drugs 1. Many researches were made for brain target due to its high lipid nature and its nano sized dimensions. Though liposome could deliver the loaded drug to brain , its lipid and water content has potential to degrade the loaded drug during the formulation and storage 2. Drug interaction studies with the carrier is required for effective and
Many pharmaceuticals cannot access brain, though, has potential for treatment and this is mainly ... more Many pharmaceuticals cannot access brain, though, has potential for treatment and this is mainly due to the potential blood brain barrier. To have a successful delivery, the challenges of anatomical and physiological aspects of those barriers need to be addressed. Though a considerable efforts were made in convincing those barriers, still designing a suitable delivery remains a major challenge. This review lists various strategies for the drug delivery to the brain. Sophisticated approaches like intracerebral delivery, intranasal delivery, barrier disruptions, receptor mediated transport, prodrugs, chemical drug delivery and many more were discussed. Limitations of some strategies were also discussed. Understanding the strategies along with the suitability of the therapeutic agent to undergo those strategic modifications would certainly promises the success of a brain drug delivery program. This a review made here would help the researcher in understanding the barrier and further mo...
Now a day’s most of the investigations are focused only on the development of various drug delive... more Now a day’s most of the investigations are focused only on the development of various drug delivery systems for targeting of the desired tissue to achieving required therapeutic concentration with less amount of dose. Targeting of an active biomolecule from efficient drug delivery where pharmacological agent directed specifically to its target site can be approached by either chemical modification or by appropriate carrier. Here erythrocytes have proved that they have potential carrier capabilities. Such drug-loaded carrier erythrocytes are biocompatible and biodegradable, and possess very long circulation half lives. And which are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers, which are called as resealed erythrocytes. The present article gives information about morphology, isola tion, properties, and methods of drug loading, character...
The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the re... more The purpose of writing this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. This review also summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.
The volatile oil of Boswellia serrata. Roxb [1]., showed significant antiulcer activity in albino... more The volatile oil of Boswellia serrata. Roxb [1]., showed significant antiulcer activity in albino rats by pyloric ligationmodel. The albino rats of either sex were divided in to three groups the animals were deprived of food for 24 hours before the commencement of experiment. The drugs were given intraperitoneally . The animals were sacrificed 6 hours after pylori ligation to observe gastric lesion. The gastric juice was collected and its pH determined titrimetrically by using 0.01N sodium hydroxide solution. The acid secretion and after index were analyzed by student ÂÂtÂÂ test. It showed significant antiulcer activity. The extract reduces the gastric activity and ulceration by histaminergic mechanism by H2 receptor blockade.
Blood Brain Barrier (BBB) is a potential barrier and a challenging process for designing of new d... more Blood Brain Barrier (BBB) is a potential barrier and a challenging process for designing of new drug delivery. Loperamide (Lp) though an opiatic drug cannot elicit CNS effect due to the efflux of P glycoprotein (Pgly) present in the endothelials of BBB. But Polysorbate 80 has blocks P glycoprotein efflux thus enhancing the delivery of drug to brain. In our study we have formulated polysorbate 80 coated liposomes (PCL) and evaluated for the actinociceptive response (Eddys hot plate and Tail Flick). Zetapotential (ZP) and Poly Dispersity Index (PDI) by zetasizer, mean particle diameter by Photon Correlation Spectroscopy (PCS), particle size distribution by Transmission Electron Microscopy (TEM) and brain quantification study by LC-MS/MS for PCls were done. We found in actinociceptive study, animal showed appreciable rise in analgesic activity for PCL from control in Eddys hot plate (55.35%) (p < 0.01) and in Tail Flick test (68.8 %) (p < 0. 01). Particle size analysis confirmed ...
The objective of the present study was preparation and invitro evaluation of sustained release mi... more The objective of the present study was preparation and invitro evaluation of sustained release microsp heres of aceclofenac. Generally administration of microspher es will provide the localization of active substanc e at the site of action for prolonged period of the time. The micros pheres of aceclofenac was prepared by emulsion cross linking method and solvent evaporation technique by using different grades of gelatin with varying concentra tions and Eudragit (S-100,L-100) polymers respectively. The f ormulations were evaluated for particle size distri bution analysis, flow properties like Angle of repose, bul k density, tapped density, true density, Hausner’s Ratio, Carr’s index, microencapsulation efficiency, Scanning elec tron microscopy(SEM) and invitro release studies. T he optimized formulation showed good invitro sustained release activity of the drug Aceclofenac.
Now a day’s most of the investigations are focused only on the development of various drug delive... more Now a day’s most of the investigations are focused only on the development of various drug delivery systems for targeting of the desired tissue to achieving required therapeutic concentration with less amount of dose. Targeting of an active biomolecule from efficient drug delivery where pharmacological agent directed specifically to its target site can be approached by either chemical modification or by appropriate carrier. Here erythrocytes have proved that they have potential carrier capabilities. Such drug-loaded carrier erythrocytes are biocompatible and biodegradable, and possess very long circulation half lives. And which are prepared simply by collecting blood samples from the organism of interest, separating erythrocytes from plasma, entrapping drug in the erythrocytes, and resealing the resultant cellular carriers, which are called as resealed erythrocytes. The present article gives information about morphology, isola tion, properties, and methods of drug loading, character...
The aim of the present study was to prepare and evaluate Dopamine (Dp) liposome using polysorbate... more The aim of the present study was to prepare and evaluate Dopamine (Dp) liposome using polysorbate 80 (PS80) which enabled the targeted delivery of drug across Blood Brain Barrier (BBB) in the effective treatment of Parkinson disease as L dopa drug conventionally used for Parkinson’s disease produces “wearing off” adverse reactions. Dp loaded liposome were prepared with various concentration of PS80 by Reverse Phase Evaporation technique. The formation of liposome was confirmed by scanning electron microscopy (SEM). The drug and the excipient compatibility was analysed by FTIR, DSC and XRD studies. FTIR indicated that there was no loss in chemical integrity of the drug upon fabrication into liposome. DSC and XRD results demonstrated that the drug was changed from the crystalline form to the amorphous form in the formulation. Among all the formulations, LSP4 showed higher Entrapment efficiency (EE) of 68% and increases the animal locomotion in psychopharmacological study (18.3%). Dp L...
Many pharmaceuticals cannot access brain, though, has potential for treatment and this is mainly ... more Many pharmaceuticals cannot access brain, though, has potential for treatment and this is mainly due to the potential blood brain barrier. To have a successful delivery, the challenges of anatomical and physiological aspects of those barriers need to be addressed. Though a considerable efforts were made in convincing those barriers, still designing a suitable delivery remains a major challenge. This review lists various strategies for the drug delivery to the brain. Sophisticated approaches like intracerebral delivery, intranasal delivery, barrier disruptions, receptor mediated transport, prodrugs, chemical drug delivery and many more were discussed. Limitations of some strategies were also discussed. Understanding the strategies along with the suitability of the therapeutic agent to undergo those strategic modifications would certainly promises the success of a brain drug delivery program. This a review made here would help the researcher in understanding the barrier and further mo...
Now a day’s pulmonary drug delivery remains the favourite route for administration of various dru... more Now a day’s pulmonary drug delivery remains the favourite route for administration of various drugs. Pulmonary route has concerned as a tremendous scientific and biomedical importance in recent years due to its unique properties such as a large absorptive area of up to 100m2 and it has particularly thin 0.1 μm - 0.2 μm absorptive mucosal membrane and good blood supply. Targeted drug delivery to the lungs has evolved to be one of the most widely investigated systemic or local drug delivery approach. As time goes on, the drug delivery systems (DDS) for the treatment of pulmonary diseases are increased due to their potential for localized topical therapy in the lungs. This route also makes it possible to deposit drugs more site-specific at high concentrations within the diseased lung thereby reducing the overall amount of drug given to patients, as well as increasing local drug activity while reducing systemic side effects and first-pass metabolism. Generally half of all pharmaceutical...
The Internet Journal of Third World Medicine, 2008
To investigate the prevailing prescribing practices in the treatment of depression and to determi... more To investigate the prevailing prescribing practices in the treatment of depression and to determine whether these practices reflects research findings. Patient profiles were reviewed retrospectively between February 2006 to January 2007 in private hospital at Chennai. The total study population includes 750 patient. According to this study , SSRIs agent are favored as first line treatment in a first episode of depression and are prescribed more frequently because the side effects are better tolerated than the older drugs. At the time this study was conducted, the newer antidepressants SSRIs and the SNRIs were prescribed in the majority of cases.. The study data demonstrated significant problems in the dose and duration of antidepressant treatment in this population. The results of the present study should be used as a discussion tool by pharmacists with physicians in order to optimize prescription habits for antidepressant usage.
Purpose: To deliver loperamide (Lp) into mice brain using polysorbate 80 (PS80)-coated liposomes ... more Purpose: To deliver loperamide (Lp) into mice brain using polysorbate 80 (PS80)-coated liposomes that inhibits P-glycoprotein (P-gp) efflux. Method: Lp loaded liposomes were prepared by reverse phase evaporation technique using lecithin (Lec) and cholesterol (Ch). The efficacy of PS80-coated Lp liposomes (PLs) in mice was evaluated using central analgesic models (Eddy's hot plate method and tail immersion test) and peripheral analgesic model (acetic acid-induced writhing). Results: PLs showed maximum possible response (MPR) of 58.33 % at 60 min in Eddy's hot plate study. In the tail immersion test, PLs showed MPR of 67.64 and 69.24 % at 60 and 90 min, respectively, relative to control group. This confirms the potential of PLs to deliver Lp to the brain by inhibiting P-gp efflux. Dose response study using tail flick method confirmed the minimum Lp dose (25 µg/kg, i.v) required to achieve central analgesic activity using PLs. Conclusion: PS80-coated Lp loaded liposomes (PLs) possess a good potential to inhibit P-gp efflux of Lp from brain, and also exhibit both central and peripheral analgesic activity.
Ovarian cancer is one of the leading causes of mortality in women. Early detection and prompt man... more Ovarian cancer is one of the leading causes of mortality in women. Early detection and prompt management is the key to improve survival rate among the affected. 5 year survival rate for epithelial ovarian cancer is reported to be directly related to surgical stage. The majority of epithelial cancers has an exophytic growth on ovarian surface that provide them a direct contact with peritoneal cavity. Methods of detection of microscopic disease in ovarian cancer are therefore of significant interest and may reduce the mortality rate for this disease by enabling an earlier diagnosis of primary recurrent ovarian cancer. Our study aimed at finding the rate of positivism of malignant cells in ascitic or peritoneal washing fluid, to observe correlation between cytologically positive pelvic peritoneal washing and histological types of ovarian tumor, and to correlate the cytological findings with the FIGO staging of the tumor.
Asian Journal of Pharmaceutical and Clinical Research, Jul 1, 2014
The aim of the present study is to formulate and evaluate carbopol based enteric capsules for sit... more The aim of the present study is to formulate and evaluate carbopol based enteric capsules for site specific drug delivery of Satranidazole to colon which was used in the treatment of amoebiasis. Methodology: 10 different formulations of carbopol based Satranidazole capsules were prepared and coated with different ratios of HPMC and Eudragit S-100. The capsules were evaluated for various physic chemical parameters. The formulations were capable of delaying drug release in the time period of 3-5 h in the simulated physiologic environment of upper gastrointestinal tracts depending on coating ratios of HPMC and Eudragit S-100. Dissolution studies of all the formulations were performed and the cumulative percentage drug release for Satranidazole was calculated. Results: Dissolution studies demonstrate that, these polymeric coated formulations were gastro resistance for 2 h at 0.1 N Hcl and further for 3 h at pH 6.8; since they released only 7-9% of drug in physiological environment of stomach and small intestine. They showed better drug release in colonic region (pH 7.4) only. Bio-adhesive studies and Rheological studies reveal that carbopol is effective in pH 7.4 than 0.1 N Hcl and pH 6.8 buffers. Diffusion studies and Histopathological studies show that the drug can easily penetrate though the mucosal membrane. DSC and IR analysis shows no possibility of interaction between drug and polymers used in the study. Conclusion: Studies demonstrated that the developed system can be a promising device for targeting of Satranidazole to colonic region.
Liposomes is a lipid based drug delivery used for loading both hydrophilic and lipophilic drugs 1... more Liposomes is a lipid based drug delivery used for loading both hydrophilic and lipophilic drugs 1. Many researches were made for brain target due to its high lipid nature and its nano sized dimensions. Though liposome could deliver the loaded drug to brain , its lipid and water content has potential to degrade the loaded drug during the formulation and storage 2. Drug interaction studies with the carrier is required for effective and
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