An 11-year-old boy underwent enucleation of his left eye for an intraocular tumor. Examination sh... more An 11-year-old boy underwent enucleation of his left eye for an intraocular tumor. Examination showed a small, round blue cell tumor arising in the peripheral retina near the ciliary body. Immunohistochemical stain results were positive for neuron-specific enolase, synaptophysin, cluster of differentiation 99 (CD99), Friend leukemia integration 1, and CD56. Ultrastructural findings included occasional intracytoplasmic dense core granules. Polymerase chain reaction of the tumor showed a Ewing sarcoma/Friend leukemia integration gene fusion product. The tumor was classified as a primitive neuroectodermal tumor/Ewing sarcoma of the retina and should be distinguished from retinoblastoma. To our knowledge, this is the first case of primary primitive neuroectodermal tumor of the retina.
Türk Üroloji Dergisi/Turkish Journal of Urology, 2016
Objective: In this study we aimed to compare renal functions in patients who underwent robotic pa... more Objective: In this study we aimed to compare renal functions in patients who underwent robotic partial nephrectomy (RPN) with on-clamp and zero-ischemia techniques. Material and methods: Between 2009 and 2015, 12 off-clamp and 22 on-clamp RPN procedures were performed on a total of 34 patients in two centers. The main outcome parameters examined were serum creatinine, and estimated glomerular filtration rate (eGFR) during preoperative, immediate postoperative periods, and at postoperative 3 rd months. Results: There were no statistically significant differences between on-clamp and zero-ischemia groups regarding age, ASA score, BMI, PADUA and R.E.N.A.L. nephrometry scores, operation time and tumor size (p>0.05). Significant differences were found in the duration of hospital stay (3.8±0.9 days vs. 3.0±0.9 days) and amount of blood loss (85.9±49.6 mL vs. 183.3±176.2 mL) between the on-clamp and zero-ischemia groups (p<0.05). Statistically significant differences were found between preoperative and immediate postoperative periods, in terms of eGFR and serum creatinine levels in both groups. Moreover, statistically significant differences were found between preoperative and postoperative 3 rd month periods, in the on-clamp group in terms of eGFR and serum creatinine levels. In the zero-ischemia group, the decrease in eGFR and serum creatinine levels at postoperative 3 rd month relative to the preoperative period was not statistically significant. Conclusion: Off-clamp RPN technique is superior, in short-term outcomes involving renal functions, compared to on clamp approach. However, long-term data regarding the renal functions should be evaluated to arrive at a definitive decision.
Amaç: Radikal sistektomi yapılan hastalarda patolojik evre ve lenf nodu tutulumu arasındaki ilişk... more Amaç: Radikal sistektomi yapılan hastalarda patolojik evre ve lenf nodu tutulumu arasındaki ilişkiyi inceledik. Gereç ve Yöntem: Mart 2005-Ocak 2012 tarihleri arasında radikal sistektomi yapılan 125 hastanın klinik ve patolojik özellikleri retrospektif olarak incelendi. Bulgular: Radikal sistektomi yapılan 125 hastada ortalama yaş 61,7 (38-88) bulundu. Hastaların 7'si (%5,6) kadın, 118'i (% 94,4) erkekti. Çıkarılan lenf nodu(LN) sayısı ortanca 16 (2-81), LN tutulumu saptanan hastalarda pozitif LN sayısı ortanca 2 (1-29) saptandı. 24 (%19,2) hastada patolojik incelemede tümör saptanmadı (pT0). Hastaların ikisinde pT0 olmasına rağmen LN metastazı saptandı (pT0N1). Bu hastaların birinde neoadjuvan kemoterapi (NAKT) öyküsü vardı. Lenf nodu dansitesi (pozitif LN/toplam LN) ortanca:0,14 (0,03-1) bulundu. Patoloji bulguları Tablo 1'de özetlendi. Tartışma: Lenf nodu metastazı radikal sistektomi yapılan, pT2b ve daha ileri evre hastalıkta görülebilmekle birlikte pT0 hastalıkta da lenf nodu metastazı saptanabilmektedir.
Chronic infections with hepatitis C virus (HCV) are frequently pronounced in the etiology of mali... more Chronic infections with hepatitis C virus (HCV) are frequently pronounced in the etiology of malignancies especially in hepatocellular carcinoma. The association between HCV and risk of renal cell carcinoma (RCC) development has been stated recently. The authors ...
An 11-year-old boy underwent enucleation of his left eye for an intraocular tumor. Examination sh... more An 11-year-old boy underwent enucleation of his left eye for an intraocular tumor. Examination showed a small, round blue cell tumor arising in the peripheral retina near the ciliary body. Immunohistochemical stain results were positive for neuron-specific enolase, synaptophysin, cluster of differentiation 99 (CD99), Friend leukemia integration 1, and CD56. Ultrastructural findings included occasional intracytoplasmic dense core granules. Polymerase chain reaction of the tumor showed a Ewing sarcoma/Friend leukemia integration gene fusion product. The tumor was classified as a primitive neuroectodermal tumor/Ewing sarcoma of the retina and should be distinguished from retinoblastoma. To our knowledge, this is the first case of primary primitive neuroectodermal tumor of the retina.
Türk Üroloji Dergisi/Turkish Journal of Urology, 2016
Objective: In this study we aimed to compare renal functions in patients who underwent robotic pa... more Objective: In this study we aimed to compare renal functions in patients who underwent robotic partial nephrectomy (RPN) with on-clamp and zero-ischemia techniques. Material and methods: Between 2009 and 2015, 12 off-clamp and 22 on-clamp RPN procedures were performed on a total of 34 patients in two centers. The main outcome parameters examined were serum creatinine, and estimated glomerular filtration rate (eGFR) during preoperative, immediate postoperative periods, and at postoperative 3 rd months. Results: There were no statistically significant differences between on-clamp and zero-ischemia groups regarding age, ASA score, BMI, PADUA and R.E.N.A.L. nephrometry scores, operation time and tumor size (p>0.05). Significant differences were found in the duration of hospital stay (3.8±0.9 days vs. 3.0±0.9 days) and amount of blood loss (85.9±49.6 mL vs. 183.3±176.2 mL) between the on-clamp and zero-ischemia groups (p<0.05). Statistically significant differences were found between preoperative and immediate postoperative periods, in terms of eGFR and serum creatinine levels in both groups. Moreover, statistically significant differences were found between preoperative and postoperative 3 rd month periods, in the on-clamp group in terms of eGFR and serum creatinine levels. In the zero-ischemia group, the decrease in eGFR and serum creatinine levels at postoperative 3 rd month relative to the preoperative period was not statistically significant. Conclusion: Off-clamp RPN technique is superior, in short-term outcomes involving renal functions, compared to on clamp approach. However, long-term data regarding the renal functions should be evaluated to arrive at a definitive decision.
Amaç: Radikal sistektomi yapılan hastalarda patolojik evre ve lenf nodu tutulumu arasındaki ilişk... more Amaç: Radikal sistektomi yapılan hastalarda patolojik evre ve lenf nodu tutulumu arasındaki ilişkiyi inceledik. Gereç ve Yöntem: Mart 2005-Ocak 2012 tarihleri arasında radikal sistektomi yapılan 125 hastanın klinik ve patolojik özellikleri retrospektif olarak incelendi. Bulgular: Radikal sistektomi yapılan 125 hastada ortalama yaş 61,7 (38-88) bulundu. Hastaların 7'si (%5,6) kadın, 118'i (% 94,4) erkekti. Çıkarılan lenf nodu(LN) sayısı ortanca 16 (2-81), LN tutulumu saptanan hastalarda pozitif LN sayısı ortanca 2 (1-29) saptandı. 24 (%19,2) hastada patolojik incelemede tümör saptanmadı (pT0). Hastaların ikisinde pT0 olmasına rağmen LN metastazı saptandı (pT0N1). Bu hastaların birinde neoadjuvan kemoterapi (NAKT) öyküsü vardı. Lenf nodu dansitesi (pozitif LN/toplam LN) ortanca:0,14 (0,03-1) bulundu. Patoloji bulguları Tablo 1'de özetlendi. Tartışma: Lenf nodu metastazı radikal sistektomi yapılan, pT2b ve daha ileri evre hastalıkta görülebilmekle birlikte pT0 hastalıkta da lenf nodu metastazı saptanabilmektedir.
Chronic infections with hepatitis C virus (HCV) are frequently pronounced in the etiology of mali... more Chronic infections with hepatitis C virus (HCV) are frequently pronounced in the etiology of malignancies especially in hepatocellular carcinoma. The association between HCV and risk of renal cell carcinoma (RCC) development has been stated recently. The authors ...
Uploads
Papers by Muhammet Özcan