Papers by Morteza Alijanpour
Journal of Research in Medical Sciences
DOAJ (DOAJ: Directory of Open Access Journals), Nov 1, 2022
International Journal of Pediatrics, 2020
Background: COVID-19 can make various symptoms in children. The aim of the study was evaluation o... more Background: COVID-19 can make various symptoms in children. The aim of the study was evaluation of multiorgan presentation of children with COVID-19 infection in Amirkola Children’s Hospital in Babol. Materials and Methods: This study was conducted by retrospective and data extract from medical records. All children with suspected COVID-19 infection who were referred to Amirkola Children’s Hospital in Babol (north of Iran) from March 4, 2020 to May 30, 2020 were enrolled. Clinical features of the respiratory and digestive system and Multisystem Inflammatory Syndrome in Children (MIS-c) were assessed. In all children WBC, RBC, Hb, MCV, Lymphocyte, CRP, ESR, ALT, AST, PT, PTT and platelets were also evaluated. Data analysis was conducted with SPSS software. P<0.05 was considered as significant level. Results: Totally 37 children were recruited to the study. Most common clinical symptoms in children were fever (86.5%), weakness (75.7%) anorexia (73%) abdominal pain (48.6.9%), diarr...
Archives of Iranian medicine, 2018
BACKGROUND Rickets is failure in mineralization of growing bone and cartilage due to extreme vita... more BACKGROUND Rickets is failure in mineralization of growing bone and cartilage due to extreme vitamin D deficiency (VDD). The study aimed to identify rickets among vitamin D deficient children and determine any relationship between clinical findings and paraclinical evidence. METHODS This study was conducted in two stages. In the first stage, blood was drawn from 406 children aged 30-72 months for measurement of 25(OH)D level. Of these children, 108 had 25(OH)D levels of <20 ng/dL and were evaluated physically for signs and symptoms scores (0-1) of VDD and rickets. Biochemical analysis and radiography of the child's left wrist and hand was performed. RESULTS Of the 119 children (29.67%) with 25(OH)D levels of <20 ng/dL, 42 (10.3%) had vitamin D levels of ≤15 ng/dL. There was no correlation between serum 25(OH)D level and levels of calcium (Ca) (r = -0.16), alkaline phosphatase (ALP) (r = -0.12), P (r = 0.13), and parathyroid hormone (PTH) (r = -0.15,) in children with VDD. ...
Background: Diabetic ketoacidosis (DKA) is the final consequence and lifethreatening complication... more Background: Diabetic ketoacidosis (DKA) is the final consequence and lifethreatening complication of severe insulin deficiency in type 1 diabetes with occurrence of 20-40%. The aim of this study was to investigate the incidence and predisposing factors of DKA and its consequences. Methods: This retrospective study was performed on 128 diabetic patients in Amirkola Children’s Hospital in 2005-2013. Patients' data were recorded in a predetermined questionnaire. The data were analyzed using SPSS.18. Results: Of all 128 hospitalized diabetic patients, 103 patients (80.5%) were referred for the first time and 25 (19.5%) patients were previously treated with insulin. Of total 128 patients, 71 (55.5%) had some degree of ketoacidosis that severe ketoacidosis was the most common form (in 36 cases; 50.7%). Among patients with the diagnosis of ketoacidosis (71 patients), 54 patients (76%) presented with DKA as the first symptom of diabetes. Generally, the predisposing factors of ketoacidos...
International Journal of Pediatrics, 2019
Background Considering the increasing prevalence of type 1 diabetes mellitus (T1DM) as an autoimm... more Background Considering the increasing prevalence of type 1 diabetes mellitus (T1DM) as an autoimmune disease in recent years and the positive effects of vitamin D (VD) on this disease, especially the preventive effect of VD on progressive reduction of pancreatic β-cells, we aimed to investigate the effect of VD on pancreatic β-cell function in T1DM patients. Materials and Methods From Sep 2016 to Nov 2017, this single-blind clinical trial study was performed on patients who have affected with T1DM in the last five years, referred to Endocrinology Clinic of Amirkola Children's Hospital in Babol city of Iran. The patients with VD level less than 30 ng/mL were treated with 50, 000IU Pearl VD for 9 months. The patients' C-peptide, 25 (OH) D, HbA1C and total daily dose(TDD) insulin were compared at the beginning and end of the study. Data were analyzed using SPSS software version 22.0. Results By examining all 30 randomly selected children meeting the inclusion criteria, it was f...
International Journal of Pediatrics, 2020
Background Hashimoto's thyroiditis (HT) is a common cause of thyroid diseases in children and... more Background Hashimoto's thyroiditis (HT) is a common cause of thyroid diseases in children and the role of vitamin D (VD) is controversial. Therefore, the aim of this study was to investigate the influence of VD therapy on HT in children with hypovitaminosis D. Materials and Methods This randomized clinical trial study was conducted on 30 patients referred to Endocrine Clinic of Amirkola Children's Hospital (ACH) of Babol in Iran. The serum levels of calcium, T4, TSH, Anti thyroid peroxidase antibody (TPOAb), and Anti thyroglobulin antibody (TgAb) were checked, and ultimately the HT was diagnosed based on thyroid sonography and these findings. According to normal range of calcium>8.4 mg/dl and low level of VD, the patients were divided into deficient ( Results The mean of anti-Tg and anti-TPO statistically decreased was 801.63±1172.29 vs. 492.38±1021.48 (p=0.01), and 728.21±1004.28 vs. 441.57±603.26 (p=0.01) before and after intervention, respectively so that this reductio...
BACKGROUND AND OBJECTIVE: Inborn errors of metabolism (IEM) are one of the differential diagnoses... more BACKGROUND AND OBJECTIVE: Inborn errors of metabolism (IEM) are one of the differential diagnoses of neonates hospitalized with symptoms of neonatal sepsis. Maple syrup urine disease (MSUD) is a rare, autosomal recessive, inborn error of metabolism with high prevalence in populations with high inbreeding coefficient. In this study, the prevalence of this disease in newborns admitted to the Amirkola children's hospital in Mazandaran province in 2002-2012 has been investigated. METHODS: In this descriptive study, records of neonates admitted with nonspecific symptoms of IEM were studied. Patients with diagnosis of MSUD according to elevated levels of branched-chain amino acids in quantitative analysis of serum and/or urine amino acids were investigated for age, sex, consanguinity and location of parents, clinical signs, type of treatment and outcomes for hospitalization. FINDINGS: From 3154 neonates admitted to this hospital in this time period, 16 cases were diagnosed as MSUD (0.5%). According to the total number of births in the province during the study period (427420 people), prevalence of MSUD was 1 in 26,714 births in the whole province. Double volume exchange transfusion done in addition to drug treatment for 69%of cases (11 cases) which led to disease control and patient discharge in 73% of cases (8 cases). CONCLUSION: The results of this study showed that maple syrup urine disease prevalence in the study area is high. Implementation of the screening program for MSUD in this area and prenatal tests for families of index cases are recommended.
International Journal of Pediatrics, 2020
Background Herbal remedies have been implicated as adjunctive therapies in the treatment of neona... more Background Herbal remedies have been implicated as adjunctive therapies in the treatment of neonatal jaundice over the years. The aim of this review was to investigate the therapeutic effects of herbal medicines on neonatal jaundice. Materials and Methods In this systematic review, a search process was performed in online databases of Scopus, Medline, Web of Science and Cochrane Library based on PRISMA guidelines. Components for searching were “neonatal jaundice” and “herbal medicine”. Relevant articles with language English published between January 1900 and October 2020 were extracted. The quality of the articles was assessed by the CONSORT checklist. Results Finally, according to including criteria, 9 studies with a total of 1323 neonates were selected. The herbal remedies used by researchers for treatment of neonatal jaundice included bilinester drop, alhagi pseudoalhagi, and zizyphus jujuba were used in 8 of 9 studies. In 5 of these 8 studies bilineaster significantly reduced ...
Journal of Pediatrics Review, 2018
Background: Methylmalonate-semialdehyde Dehydrogenase Deficiency (MMSDHD) is an uncommon autosoma... more Background: Methylmalonate-semialdehyde Dehydrogenase Deficiency (MMSDHD) is an uncommon autosomal recessive disorder. MMSDH is an enzyme encoded by the protein coding gene ALDH6A1 in humans. Case Presentation: We present a 4-year-old boy with elevated liver enzymes, 3-hydroxyisobutyric aciduria (MMSDHD) and cardiac symptoms. He had a mutated ALDH6A1 gene, c.184c>G (p.Pro62Ala). Conclusions: This is one of the rare case reports in the world and the first one in Iran that reports MMSDHD with cardiac disease.
Journal of Diabetes & Metabolic Disorders, 2020
Objectives This study aimed to investigate the association between Helicobacter pylori infection ... more Objectives This study aimed to investigate the association between Helicobacter pylori infection with diabetes mellitus type one and the effect of infected Helicobacter pylori on glycemic control. Methods This case control study was conducted on children with and without type 1 diabetes mellitus (T1DM). Demographic data and gastrointestinal symptoms in both groups and glycemic control status and duration of diabetes were recorded in patients with T1DM. Stool test was done on all children to detect Helicobacter pylori antigen. Results Sixty three children with T1DM with a mean of 10.88 ± 2.84 years and 105 control children with an average age 10.17 ± 2.55 years (P = 0/09) were involved in this study. The frequency of Helicobacter pylori infection in patients with T1DM was 17/ 63 (27%) and 25/105 (23.8%) in control group, (P = 0/64). The frequency of bloating, epigastric pain and nausea was not significantly different between the two groups. The frequency of epigastric pain in children with diabetes with helicobacter infection was significantly higher than non-infected children with diabetes (29.4% vs. 2.2%) (P = 0.004).The mean duration of diabetes (P = 0.53), age diagnosis of diabetes (P = 0.09), fasting blood glucose (P = 0.18), glycosylated hemoglobin (P = 0.08) and the daily insulin dose (P = 0.18) in patients with T1DM with and without helicobacter pylori infection had not significantly different. Conclusions There was no significant association between Helicobacter pylori infection and diabetes in children 5-15 years old, and glycemic control status was not difference in patients with T1DM with and without Helicobacter pylori infection.
Iranian Journal of Pediatric Hematology & Oncology, 2019
Background: Thalassemia major (TM) is one of the most common hereditary anemia with multiple endo... more Background: Thalassemia major (TM) is one of the most common hereditary anemia with multiple endocrinopathies (especially hypogonadism). So, we evaluated the rate of delayed puberty (DP) and its relation with serum ferritin level in patients. Materials and Methods: This cross-sectional (descriptive-analytical) study was conducted on 100 patients with TM between 14-64 years old, admitted to Amirkola Thalassemia Center, Babol, Iran, in 2016. The pubertal status, (Marshall-Tanner scale), existance of DP, and its different types were evaluated. Mean serum ferritin level was measured and the data were classified to three groups of <1500, 1500-2500, and >2500 ng/ml. Data were analyzed using SPSS (version20). Results: Out of 100 patients, 64 (64%) and 36 (36%) were female and male, respectively. Considering age, 23, 77 patients (%) were under and over 20 years old, respectively. Totally, 69 (69%) of them had DP, of whom 64 (92.8%) ones had secondary (central) hypogonadotropic hypogon...
Journal of Public Health, 2018
Background The aim of this study was to determine the prevalence of vitamin D deficiency among pr... more Background The aim of this study was to determine the prevalence of vitamin D deficiency among preschool children in rural and urban areas of Northern Iran and need for continuing vitamin D supplementation after 2 years of age. Method A sample of 406 children aged 30–72 months was selected from health centres. Serum levels of 25-hydroxyvitamin D (25OHD), demographic data, anthropometric characteristics and total body surface area, were evaluated. Results Subnormal vitamin D levels were found in 68.94% (269) of children. In multiple logistic regression models, season (P = 0.001) and residency (P = 0.006) were significantly correlated with vitamin D deficiency. Multiple linear regression analysis revealed that age (β = −0.18, P < 0.001), body mass index (β = −1.1, P < 0.001) and sun exposure (β = 0.4, P < 0.001) were significantly associated with 25OHD level. Conclusion Owing to the high prevalence of subnormal vitamin D levels in preschool children, it is recommended that vi...
Pediatric research, Jan 6, 2018
To evaluate the efficacy of stoss therapy using fortified biscuit for vitamin D-deficient childre... more To evaluate the efficacy of stoss therapy using fortified biscuit for vitamin D-deficient children. A total of 108 children aged 30-72 months with vitamin D deficiency were studied in a randomized single-blind clinical trial. The deficient children were assigned to three groups, namely, vitamin D-fortified biscuit (BG), capsule vitamin D (CG), and ampoule vitamin D (AG). Capsules and biscuits containing 50,000 IU of cholecalciferol were consumed twice per week for 3 consecutive weeks. Ampoules with 300,000 IU of cholecalciferol were injected intramuscularly in a single dose. Three weeks after treatment, serum 25(OH)D concentrations were measured, and the three groups were compared. Each method of treatment could increase the mean serum 25(OH)D concentration to optimal level. Serum 25(OH)D concentrations ≥100 ng/mL were observed in six children, including four from AG and two from CG (P = 0.09). The comparison of the mean serum 25(OH)D concentrations after treatment showed between am...
Journal of Babol University of Medical Sciences, 2018
Background: Type 1 diabetes mellitus (T1DM) as an autoimmune disorder is associated with other au... more Background: Type 1 diabetes mellitus (T1DM) as an autoimmune disorder is associated with other autoimmune diseases such as autoimmune thyroid (AIT) disease. The aim of this study was to determine the prevalence of AIT in children who were referred to Amirkola Endocrine Clinic (north of Iran). Methods: This cross-sectional study was carried out on 100 diabetic children aged 1-15 years during 2008-2013, who were referred to the pediatric endocrine clinic. Serum levels of anti-thyroid peroxidase (Anti-TPO) and anti-thyroglobulin (antiTg) antibodies and Thyrotropin Stimulating Hormone (TSH) were measured by Immune Chemiluminescence assay, and demographic information was obtained from patients'medical records. The collected data were analyzed using SPSS 18. Results: AIT was found in 13% of patients (8% female and 5% male). Significant levels were found for Anti-TPO (3%), anti-Tg (2%), and both antibodies (8%) in patients with AIT. Thyroid dysfunction was observed in 8 of 13 patients ...
Laboratory Medicine, 2022
Objective Maple syrup urine disease (MSUD; OMIM #248600) is an autosomal recessive metabolic diso... more Objective Maple syrup urine disease (MSUD; OMIM #248600) is an autosomal recessive metabolic disorder in the catabolism of branched-chain amino acids (leucine, isoleucine, and valine) and may be lethal if untreated in affected newborns. Methods Single-nucleotide polymorphism haplotyping and Sanger sequencing of BCKDHA, BCKDHB, and DBT genes were performed in a cohort of 10 MSUD patients. Results We identified a 16.6 Mb homozygous region harboring the DBT gene in an Iranian girl presenting with MSUD. Sanger sequencing revealed a pathogenic homozygous variant (NM_001918.3: c.1174A > C) in the DBT gene. We further found a controversial variant (rs12021720: c.1150 A > G) in the DBT gene. This substitution (p.Ser384Gly) is highly debated in literature. Bioinformatics and cosegregation analysis, along with identifying the real pathogenic variants (c.1174 A > C), lead to terminate these various interpretations of c.1150 A > G variant. Conclusion Our study introduced c.1150 A &g...
Caspian Journal of Internal Medicine, 2021
Background: Congenital hypothyroidism (CH) is one of the most common endocrine diseases and one o... more Background: Congenital hypothyroidism (CH) is one of the most common endocrine diseases and one of the major causes of mental retardation in children. So we aimed to evaluate the developmental outcome of children with CH. Methods: This case-control study was performed on two 3-6-year-old groups of 100 patients. The case group was children with CH, referred to Endocrine Clinic of Amirkola Children's Hospital (2011-2017) and the control group was healthy children and normal from other states. The Denver developmental screening test-II (DDST_II) was used to assess the developmental factors and disorders in four areas of gross motor, fine motor, personal-social and language. Data were analyzed by SPSS 21 using descriptive statistics, t-test and chi-square, and a p<0.05 was considered significant. Results: The mean age of 200 children in the case and control groups was 54.62±15.72 and 59.68±15.64 months, respectively. In the case group, 45% and 55% of them had transient and perman...
Tacrolimus is a main drug for induction and maintenance immunosuppression for patients with kidne... more Tacrolimus is a main drug for induction and maintenance immunosuppression for patients with kidney transplants in many centers. One of important side effect of drug is post-transplant diabetes mellitus. Of course, diabetes ketoacidosis (DKA) is rare. In this report, a 12-yearold girl with DKA was presented after 45 days of kidney transplantation.
caspian journal of internal medicine, 2022
Background: The growth and development of children affect biochemical variables. This population-... more Background: The growth and development of children affect biochemical variables. This population-based study was designed to evaluate the reference interval for alkaline phosphatase (ALP) routinely measured in the clinical laboratory. Methods: For this examination, 873 cases were selected among the healthy children and adolescents aged 1-18 years who referred to the endocrinology clinic of Amirkola Children&#39;s Hospital for growth evaluation. After overnight fasting, early morning blood samples were obtained to measure the ALP level and other biochemical parameters using an automatic biochemical analyzer. Subjects were categorized by age, sex, and body mass index (BMI) values. The age groups were categorized as follows: 1-4 years, 5-8 years, 9-13 years, and 14-18 years. Results: There was a significant difference among the age and sex categories; on the contrary, there was no meaningful variation between the two groups categorized by BMI. The reference range for ALP was 474.14-517.71 U/L for children aged 1-4 years, 273.47-871.44 U/L for 5-8 years, 215.04-893.69 U/L for 9-13 years, and 228.9-739.22 U/L for 14-18 years. Also, significant positive correlation was found between ALP with length (P=0.000, r=0.134), weight (=0.04, r=0.073), phosphorus (P) (P=0.001, r=0.122), and alanine aminotransferase (SGPT) (P=0.000, r=0.142) respectively. Conclusion: This project&#39;s data established a reference interval for ALP in healthy children and adolescents, which will prepare a basis for diagnosis and monitoring liver- or bone-related disorders.
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Papers by Morteza Alijanpour