Papers by Mohamed Mohamed El Sadek
Carbohydrate Research, 1997
... INIST Diffusion. 2, Allée du Parc de Brabois F-54514 Vandoeuvre-lès-Nancy Cedex France Phone:... more ... INIST Diffusion. 2, Allée du Parc de Brabois F-54514 Vandoeuvre-lès-Nancy Cedex France Phone: +33 (0)3 83 50 46 64 Fax: +33 (0)3 83 50 46 66. ... Auteur(s) / Author(s). HASSAN SY ; FAIDALLAH HM ; ABDEL MONEIM EL-MASSRY ; EL-SADEK MM ; Revue / Journal Title. ...
Cyclization of acyclic C-glycoside derivatives 1a,b to 2a,b as the major isomers, and 4a,b as the... more Cyclization of acyclic C-glycoside derivatives 1a,b to 2a,b as the major isomers, and 4a,b as the minor isomers were carried out. The isopropylidene derivatives 3a,b were prepared, as well as the hydrazide derivative 6, which was condensed with a variety of aldehydes to give hydrazones 7a-e which were also prepared from the compounds 12a-e. Acetylation of 7a,d gave the corresponding acetyl derivatives 8a,d, respectively. In addition, the dicarbonyl compound 9 was prepared in the hydrate form, which reacted with a number of aroylhydrazines to give the corresponding bisaroylhydrazones 10a-d, which were cyclized into 1,3,4-oxadiazoles 11a-d. Furthermore, two of the prepared compounds were examined to show the ability to activate MAO-B. In addition a number of prepared compounds showed antibacterial and antiviral activities.
Carbohydrate Research, 1976
ABSTRACT
American Journal of …, 2011
Background: Clopidogrel, is a thienopyridine derivative labeled for use to prevent thrombosis aft... more Background: Clopidogrel, is a thienopyridine derivative labeled for use to prevent thrombosis after coronary artery stenting. Pharmacokinetics of clopidogrel is studied indirectly by quantification of carboxylic acid which is a major metabolite of Clopidogrel. Objective: The aim of this work is to develop and validate a rapid, simple and sensitive LC/MS/MS assay method for the determination of Clopidogrel carboxylic acid in human plasma using Clopidogrel-D4-carboxylic acid as internal standard. Methods: Analytes was extracted from 200 μl of plasma by a simple liquid-liquid extraction using diethyl ether-n-hexane (80:20, v/v). The chromatographic separations were achieved on a C18 column using Methanol, de-ionized water and formic acid as a mobile phase at flow rate of 0.5 ml/minute. Analysis was monitored by multiple reactions monitoring mode based on m/z transition of 308.10→113 for Clopidogrel carboxylic acid and 312.10→129 for internal standard. Result: The method had a total run time of about 4 minutes. The lower limit of quantification (LLOQ) was 25 ng/ml showing good linearity over the working range of 25-3000 ng/ml (r ≥ 0.999). The intra-and inter day accuracies were 90%-98% and 92.138%-96.889% respectively (deviation within acceptable range ≤ 10%).Conclusion: It was shown that this method is suitable for pharmacokinetic study following oral administration of Clopidogrel and can be successfully applied to the therapeutic drug monitoring of Clopidogrel in Clopidogrel-treated patients.
Journal of pharmaceutical …, 2004
Three methods are presented for the simultaneous determination of cyproheptadine hydrochloride (C... more Three methods are presented for the simultaneous determination of cyproheptadine hydrochloride (CP), thiamine hydrochloride (B1), riboflavin-5-phosphate sodium dihydrate (B2), nicotinamide (B3), pyridoxine hydrochloride (B6), and sorbic acid (SO). The chromatographic method ...
Pattern Recognition …, 2000
We apply the orthogonal Fourier-Mellin moments (OFMMs) to the specific problem of fully translati... more We apply the orthogonal Fourier-Mellin moments (OFMMs) to the specific problem of fully translation-, scale- and in-plane rotation-invariant detection of human faces in 2D static color images, and compare their performance with that of the generalized Hu's moments or non-orthogonal FMMs. The OFMMs have the advantages of non-redundancy of information, robustness with respect to noise and the ability to reconstruct
Carbohydrate Research, 1997
... INIST Diffusion. 2, Allée du Parc de Brabois F-54514 Vandoeuvre-lès-Nancy Cedex France Phone:... more ... INIST Diffusion. 2, Allée du Parc de Brabois F-54514 Vandoeuvre-lès-Nancy Cedex France Phone: +33 (0)3 83 50 46 64 Fax: +33 (0)3 83 50 46 66. ... Auteur(s) / Author(s). HASSAN SY ; FAIDALLAH HM ; ABDEL MONEIM EL-MASSRY ; EL-SADEK MM ; Revue / Journal Title. ...
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Papers by Mohamed Mohamed El Sadek