We aim to evaluate feasibility of using orbital diffusion tensor imaging (DTI) magnetic resonance... more We aim to evaluate feasibility of using orbital diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) of extraocular muscles (EOMs) in patients with Graves’ orbitopathy (GO) versus clinical activity score (CAS) in early detection of GO activity. This case control study was conducted on 20 consecutive patients (10 males, 10 females with a mean age of 35.50±13.65 years) with Graves’ orbitopathy and 10 age- and sex-matched volunteers without any thyroid abnormality as a health control (HC). The patients and HCs underwent DTI MRI of the orbit in the coronal plane. The mean diffusivity (MD) was calculated. Thyroid stimulating hormone receptor antibody (TRAb) was measured using third generation thyroid binding inhibiting immunoglobulin (TBII) with ELISA method. CAS score, according to the standardized criteria of the European Group on Graves Orbitopathy (EUGOGO), was calculated for the patients. GO patients’ EOMs showed significantly higher MD values and higher compared to HCs’ ...
Background: Occupational stress is often used as a term to denote the emotions people feel in ups... more Background: Occupational stress is often used as a term to denote the emotions people feel in upsetting circumstances. Teaching staff in faculty are stressed also are additional seemingly to be unhealthy, poorly motivated and fewer productive and fewer safe at work. Aim: the study aimed to assess impact of occupational stress among teaching staff members. Design: A quasi-experimental design was utilized in this study. Setting: the study was conducted in the faculty of nursing at Suez Canal University. Subject: all teaching staff members working in the previous study setting. Tools of the study: Two tools were used to conduct this study; tool I: occupational stress questionnaire which was used to assess stress level, tool II: observation checklist which was used to assess occupational stressors Results: The study revealed that, above half of the studied group (56.1%) was high occupational stress level in preprogram, with stress slightly decrease in the post immediate program (52.6%) and high decreased (12.3%) in the follow-up, with significant difference between pre/ post and follow up phases of program implementation (p<0.0001). The total mean score for occupational stressors among studied sample was high in administrative stressors (35.532±6.8430) and was also high in organization stressors (27.035±5.0339). While, lowest was in social stressors (8.906±2.1808). Conclusion: There was statistically significant improvement in teaching staff occupational stress level before and after the implemented program Recommendation: providing occupation stress management program periodically to improving personal coping mechanism and institute work/life balance strategies.
BACKGROUND Thyroid dysfunction and insulin resistance (IR) are common findings in patients with E... more BACKGROUND Thyroid dysfunction and insulin resistance (IR) are common findings in patients with ESRD. We aimed to evaluate thyroid dysfunction and IR in ESRD before and after 1 year of starting hemodialysis (HD). METHODS This was a prospective study that recruited newly starting HD patients who fulfilled the inclusion criteria. Patients were evaluated for TSH, free T4, free T3, fasting insulin, fasting glucose, HOMA-IR, serum ferritin, and hs-CRP levels before starting their first dialysis session and after 1 year of regular HD. RESULTS Eighty-one patients have completed the 1-year follow-up period. After 1 year of regular HD, there were statistically significant increments of hs-CRP, serum ferritin, and TSH levels. On the other hand, fasting insulin level and HOMA-IR showed statistically significant increments after 1 year of starting HD. After 1 year of regular HD, TSH level showed a positive correlation with hs-CRP and serum ferritin level, while free T3 was negatively correlated with HOMA-IR. On the other hand, there was a significant positive correlation between HOMA-IR, hs-CRP, and serum ferritin levels, while HOMA-IR was negatively correlated with Kt/V. CONCLUSIONS This study suggests overlapping complex pathogenesis of thyroid dysfunction, chronic inflammation, and IR in chronic HD patients.
To assess the growth and pubertal development among a group of patients with β-thalassemia major ... more To assess the growth and pubertal development among a group of patients with β-thalassemia major (β-TM) and to evaluate the role of the pituitary gland and liver MRI signal intensity (SI) reduction in assessing and predicting the clinical severity of growth and pubertal dysfunctions. Thirty-eight patients with β-TM were examined and divided into two groups: Group I patients were of normal height and puberty and Group II patients had short statures and hypogonadism. Laboratory investigations included serum ferritin, LH, FSH, prolactin, TSH, and basal and dynamic growth hormones. Pituitary and liver MRIs were performed to assess the pituitary to fat (P/F) and liver to muscle (L/M) signal intensities (SI), respectively. Fifteen healthy and sex- and age-matched subjects were included as controls. Both patient groups had significantly elevated serum ferritin and significantly decreased prolactin and IGF1 compared to control subjects. Group II showed a significant reduction in LH, FSH, and IGF1 and a significant increase in ferritin in comparison with Group I and the control group, and it had a highly significant reduction in both P/F and L/M SI in comparison with Group I (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001 and 0.008, respectively). The reduced P/F ratio was significantly correlated with FSH and LH, and a cutoff for a P/F ratio ≥0.94 was obtained to differentiate between Groups I and II. MRI in conjunction with the P/F signal intensity ratio is a useful and noninvasive tool for the early diagnosis of pituitary iron overload.
The ENDURUNS project is a European Research project of the Horizon 2020 framework, which has as i... more The ENDURUNS project is a European Research project of the Horizon 2020 framework, which has as its main objective to achieve the optimum and intelligent use of green hydrogen energy for long-term ocean surveys. The ENDURUNS system comprises an Unmanned Surface Vehicle (USV) and an Autonomous Underwater Vehicle (AUV) with gliding capability. The power pack of the USV integrates Li-ion batteries with photovoltaic panels, whilst the AUV employs Li-ion batteries and a hydrogen fuel cell. It is essential to develop a continuous monitoring ca-pability for the different systems of the vehicles. Data transmission between the devices onboard presents challenges due to the volume and structure of the different datasets. A telecommunications network has been designed to manage the operational components considered in the project. The autonomous vehicles perform measurements, providing their position and other data wirelessly. The system will generate a great volume of various signals during t...
We aim to evaluate feasibility of using orbital diffusion tensor imaging (DTI) magnetic resonance... more We aim to evaluate feasibility of using orbital diffusion tensor imaging (DTI) magnetic resonance imaging (MRI) of extraocular muscles (EOMs) in patients with Graves’ orbitopathy (GO) versus clinical activity score (CAS) in early detection of GO activity. This case control study was conducted on 20 consecutive patients (10 males, 10 females with a mean age of 35.50±13.65 years) with Graves’ orbitopathy and 10 age- and sex-matched volunteers without any thyroid abnormality as a health control (HC). The patients and HCs underwent DTI MRI of the orbit in the coronal plane. The mean diffusivity (MD) was calculated. Thyroid stimulating hormone receptor antibody (TRAb) was measured using third generation thyroid binding inhibiting immunoglobulin (TBII) with ELISA method. CAS score, according to the standardized criteria of the European Group on Graves Orbitopathy (EUGOGO), was calculated for the patients. GO patients’ EOMs showed significantly higher MD values and higher compared to HCs’ ...
Background: Occupational stress is often used as a term to denote the emotions people feel in ups... more Background: Occupational stress is often used as a term to denote the emotions people feel in upsetting circumstances. Teaching staff in faculty are stressed also are additional seemingly to be unhealthy, poorly motivated and fewer productive and fewer safe at work. Aim: the study aimed to assess impact of occupational stress among teaching staff members. Design: A quasi-experimental design was utilized in this study. Setting: the study was conducted in the faculty of nursing at Suez Canal University. Subject: all teaching staff members working in the previous study setting. Tools of the study: Two tools were used to conduct this study; tool I: occupational stress questionnaire which was used to assess stress level, tool II: observation checklist which was used to assess occupational stressors Results: The study revealed that, above half of the studied group (56.1%) was high occupational stress level in preprogram, with stress slightly decrease in the post immediate program (52.6%) and high decreased (12.3%) in the follow-up, with significant difference between pre/ post and follow up phases of program implementation (p<0.0001). The total mean score for occupational stressors among studied sample was high in administrative stressors (35.532±6.8430) and was also high in organization stressors (27.035±5.0339). While, lowest was in social stressors (8.906±2.1808). Conclusion: There was statistically significant improvement in teaching staff occupational stress level before and after the implemented program Recommendation: providing occupation stress management program periodically to improving personal coping mechanism and institute work/life balance strategies.
BACKGROUND Thyroid dysfunction and insulin resistance (IR) are common findings in patients with E... more BACKGROUND Thyroid dysfunction and insulin resistance (IR) are common findings in patients with ESRD. We aimed to evaluate thyroid dysfunction and IR in ESRD before and after 1 year of starting hemodialysis (HD). METHODS This was a prospective study that recruited newly starting HD patients who fulfilled the inclusion criteria. Patients were evaluated for TSH, free T4, free T3, fasting insulin, fasting glucose, HOMA-IR, serum ferritin, and hs-CRP levels before starting their first dialysis session and after 1 year of regular HD. RESULTS Eighty-one patients have completed the 1-year follow-up period. After 1 year of regular HD, there were statistically significant increments of hs-CRP, serum ferritin, and TSH levels. On the other hand, fasting insulin level and HOMA-IR showed statistically significant increments after 1 year of starting HD. After 1 year of regular HD, TSH level showed a positive correlation with hs-CRP and serum ferritin level, while free T3 was negatively correlated with HOMA-IR. On the other hand, there was a significant positive correlation between HOMA-IR, hs-CRP, and serum ferritin levels, while HOMA-IR was negatively correlated with Kt/V. CONCLUSIONS This study suggests overlapping complex pathogenesis of thyroid dysfunction, chronic inflammation, and IR in chronic HD patients.
To assess the growth and pubertal development among a group of patients with β-thalassemia major ... more To assess the growth and pubertal development among a group of patients with β-thalassemia major (β-TM) and to evaluate the role of the pituitary gland and liver MRI signal intensity (SI) reduction in assessing and predicting the clinical severity of growth and pubertal dysfunctions. Thirty-eight patients with β-TM were examined and divided into two groups: Group I patients were of normal height and puberty and Group II patients had short statures and hypogonadism. Laboratory investigations included serum ferritin, LH, FSH, prolactin, TSH, and basal and dynamic growth hormones. Pituitary and liver MRIs were performed to assess the pituitary to fat (P/F) and liver to muscle (L/M) signal intensities (SI), respectively. Fifteen healthy and sex- and age-matched subjects were included as controls. Both patient groups had significantly elevated serum ferritin and significantly decreased prolactin and IGF1 compared to control subjects. Group II showed a significant reduction in LH, FSH, and IGF1 and a significant increase in ferritin in comparison with Group I and the control group, and it had a highly significant reduction in both P/F and L/M SI in comparison with Group I (p &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001 and 0.008, respectively). The reduced P/F ratio was significantly correlated with FSH and LH, and a cutoff for a P/F ratio ≥0.94 was obtained to differentiate between Groups I and II. MRI in conjunction with the P/F signal intensity ratio is a useful and noninvasive tool for the early diagnosis of pituitary iron overload.
The ENDURUNS project is a European Research project of the Horizon 2020 framework, which has as i... more The ENDURUNS project is a European Research project of the Horizon 2020 framework, which has as its main objective to achieve the optimum and intelligent use of green hydrogen energy for long-term ocean surveys. The ENDURUNS system comprises an Unmanned Surface Vehicle (USV) and an Autonomous Underwater Vehicle (AUV) with gliding capability. The power pack of the USV integrates Li-ion batteries with photovoltaic panels, whilst the AUV employs Li-ion batteries and a hydrogen fuel cell. It is essential to develop a continuous monitoring ca-pability for the different systems of the vehicles. Data transmission between the devices onboard presents challenges due to the volume and structure of the different datasets. A telecommunications network has been designed to manage the operational components considered in the project. The autonomous vehicles perform measurements, providing their position and other data wirelessly. The system will generate a great volume of various signals during t...
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Papers by Mohamed Ghonem