Poster: "ECR 2015 / C-0091 / Fluorodeoxiglucose positron emission tomography (FDG- PET) in t... more Poster: "ECR 2015 / C-0091 / Fluorodeoxiglucose positron emission tomography (FDG- PET) in the diagnosis of mild to moderate dementia" by: "A. Peter, M. A. Lucic, S. Lucic, M. Semnic; Novi Sad/RS"
2.2. Radiologic examinations These examinations were mainly related to magnetic resonance imaging... more 2.2. Radiologic examinations These examinations were mainly related to magnetic resonance imaging (MRI) and angiography (MRA), and rarely to computerized tomography (CT) and angiography (CTA), as well as to digital subtraction angiography (DSA) and Doppler sonography. As regards MRI examination, the following sequences and procedures were applied.
Background/Aim. Although considered rare, gliomas cause morbidity and mortality disproportionate ... more Background/Aim. Although considered rare, gliomas cause morbidity and mortality disproportionate to their incidence. The aim of the study was to determine whether pre and post-therapeutic metric values, derived from the FDG PET/CT maximal standardized uptake value (SU-Vmax) and calculated ratios between tumor and normal brain tissue, may provide a predictive/prognostic biomarker information in estimating overall survival of glioblastoma patients. Methods. In 26 out of 31 patients with glioblastoma treated with standard Stupp protocol after maximal safe reductive surgery, we performed a baseline 18F-FDG PET/CT examination before commencing combined and concomitant chemotherapy/radiotherapy (pre-therapy FDG PET/CT) and a second examination three months after the therapy completion (post-therapy FDG PET/CT). Two-graded SUVmax values and a calculated ratio of uptake in tumor-to-normal-tissue (T/N ratio) value, divided into two grades by the calculated cut-off value, were measured in all...
Цель исследования. Изучалась возможность визуализации рака молочной железы у собак с помощью МРТ ... more Цель исследования. Изучалась возможность визуализации рака молочной железы у собак с помощью МРТ с контрастным усилением вновь предложенным парамагнитным контрастным средством (ПМКС)-Mn-димеркаптосукционатом (Mn-ДМСА 2 , TM Сукциманг). Материалы и методы. У семи животных с впервые выявленным раком молочной железы, в состоянии медикаментозного сна (инфузия пропофола), была выполнена МР-томография с Mn-ДМСА 2 , вводимым внутривенно, в виде 0,5 М раствора, 0,1 ммоль/кг массы тела, в Т1-взвешенном режиме, до и спустя 12-17 мин после введения Mn-ДМСА 2. TR=450-600 мс, TE=12-15 мс, в матрицу 256×256 при размере поля сканирования до 250×380 мм, среза 2,5-4 мм, с использованием Toshiba Titan Vantage (Toshiba Medical, 1,5 Т, у пяти животных) и Magnetom Open (Siemens Medical, 0,2 Т, у двух животных). Накопление Mn-ДМСА 2 оценивалось по индексу усиления, как отношение интенсивности на элемент изображения после введения Mn-ДМСА 2 к исходному. Результаты. Во всех случаях зрительно отмечено накопление Mn-ДМСА 2 в области первичных опухолей, и метастазов в лимфатических узлах и головном мозге. Индексы усиления изображения составили: для первичной опухоли (n=7)-1,52±0,19 (1,35; 1,83), для метастазов в лимфатические узлы (n=12)-1,37±0,14 (1,12; 1,64), для метастазов в головной мозг в периферической зоне метастаза (n=11)-1,48±0,15 (1,29; 2,37), и для центральной зоны метастаза (n=11)-2,76±0,12 (1,48; 3,21). Не отмечалось никаких осложнений и побочных действий введения Mn-ДМСА 2. Заключение. Mn-ДМСА 2 представляет собой парамагнитный негадолиниевый контрастный препарат, пригодный для выявления как первичной опухоли, так и метастатических поражений при раке молочной железы. Ключевые слова: МРТ, парамагнитное контрастное усиление, рак молочной железы, Mn-димеркаптосукцинат Конфликт интересов: авторы заявили об отсутствии конфликта интересов.
Aim of the study. We have carried out the synthesis of complex of Manganese(II) with dimercaptosu... more Aim of the study. We have carried out the synthesis of complex of Manganese(II) with dimercaptosuccinic acid (DMSA), applied the quantum chemistry analysis for evaluation of most stable form of the Mn- DMSA complex and studied it’s uptake and imaging properties in normal and tumoral tissues in veterinary patients (cats with tumors)Material and methods. The synthesis of the 2.3-dimercaptosuccinic acid (COOH-CHSH-CHSH-COOH) has been carried out using modified technique proposed by A.I. Busev [Busev A.I. 1972]. Using phantoms filled in with 0.05 mM – 16 mM solutions of the agent we quantified the R1 relaxivity. Imaging properties of the 0.5 M solution of the Mn-(DMSA)2 were evaluated when performing the contrastenhanced studies in veterinary patients (cats with adenofibrous tumors and angiofibromas, nine animals) using T1-w spin-echo mode.Results. As result of quantum chemistry analysis it was shown that the most stable complex of Mn(II) with DMSA is the molecule Mn-(DMSA)2. The R1 re...
In the modern ages of rapid technological and computational advances, development of numerous nov... more In the modern ages of rapid technological and computational advances, development of numerous novel diagnostic imaging techniques have enabled not only visual detection of disease processes, but also provided the tools to achieve quantified functional, structural, dynamic, metabolic, and molecular information. A pathway toward the quantitative imaging by use of quantitative imaging biomarkers analysis has been widely opened, enabling further development of radiomics, radiogenomics, and radioproteinomics analysis in addition, and initiating the dawn of theranostics, eventually bringing the wishful personalised medicine concept closer to reality.
Introduction. Dyke-Davidoff-Masson syndrome is an uncommon neurological disorder clinically prese... more Introduction. Dyke-Davidoff-Masson syndrome is an uncommon neurological disorder clinically presented with seizures, various degrees of mental retardation, motor weakness and sometimes body asymmetry. Typical neuroimaging features include cerebral hemiatrophy with ipsilateral hyper pneumatization of paranasal sinuses. The purpose of this report was to present a rare cause of seizures revealed by magnetic resonance imaging. Case Report. We report a case of a 17-year-old boy admitted to hospital due to a severe headache. He had been treated because of partial epileptic seizures for six years. Neuropsychological examination revealed mild mental retardation, mild speech and reading difficulties and discrete right-sided hemiparesis. Typical magnetic resonance imaging features confirmed clinical suspicion of Dyke-Davidoff-Masson syndrome, revealing left frontal lobe atrophy, with consecutive widening of the left lateral ventricle frontal horn, thickening of the near?by frontal squama and ...
Case studies of unusual traits can provide unique snapshots of the effects of modified systems. I... more Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is af...
Pattern of brain asymmetries varies with handedness, gender, age, and with variety of genetic and... more Pattern of brain asymmetries varies with handedness, gender, age, and with variety of genetic and social factors. Large-scale neuroimaging analyses can optimize the detection of asymmetric features and confirm the factors that might modulate pattern of brain asymmetries. We attempted to evaluate eventual differences between genders in hemodynamic responses to a simple language task. 12 healthy right-handed volunteers (age 24-46), 6 men and 6 women underwent fMRI scanning while performing the simple cognitive - language processing task - silent number counting in Serbian. Group analysis of hemodynamic responses shows activation in expected brain language areas of inferior frontal gyrus (IFG) and superior temporal gyrus (STG) in both hemispheres. In the male group, aside from dedicated language areas in IFG and STG, activation was noted in right frontal region and interhemispheric supplementary motor area. On the other hand, in the female group, besides activation in dedicated languag...
Ultrasonography of the central nervous system is an integral part of a prenatal scan, and the dev... more Ultrasonography of the central nervous system is an integral part of a prenatal scan, and the development of imaging technologies has led to better diagnostic possibilities. Posterior fossa anomalies have traditionally been divided into Dandy Walke malformation, Dandy Walker variation and megacisterna magna, but this approach, due to diversity of the extensive number of possible disorders covered by this classification, unables accurate prognosis and therefore adequate counselling. An alternative approach to the classification of posterior fossa anomalies is to divide them into agenesis of the vermis, which could be partial or complete, cerebellar hypoplasia, pontocerebellar hypoplasia and cerebellar atrophy. Different ultrasonographic and magnetic resonance imagining of appearances of the posterior fossa anomalies in prenatal period are discussed in the article, as well as possible syndromes and prognosis of different entities. Diversity of anomalies of the central nervous system, ...
Journal of Pediatric Endocrinology and Metabolism, 2012
Bloody nipple discharge is an uncommon fi nding in the pediatric population, without clear diagno... more Bloody nipple discharge is an uncommon fi nding in the pediatric population, without clear diagnostic and therapeutic guidelines established. We noted a case of a 3-month-old male infant who presented with bilateral bloodstained nipple discharge, with unremarkable medical history. Sonographic fi ndings revealed bilaterally dilated ducts and cysts with mixed iso-and hypoechoic intraductal content. Possible causes of this condition include hyperlaxity syndrome with decreased function of elastic fi bers and fi brocystic changes in breasts, and unusual response to maternal hormones, transferred to the neonate either transplacentally or through breastfeeding. Given the most probable benign etiology and self-limiting nature of the described condition, a conservative approach is suggested. Unnecessary invasive procedures should be avoided.
Background: Purpose of the study was to determine whether the native and contrast enhanced MRI pa... more Background: Purpose of the study was to determine whether the native and contrast enhanced MRI pattern of detected intraaxial posterior fossa metastatic tumors may potentially suggest the origin of primary malignoma. Materials and methods: In 99 patients ...
Cerebellar involvement in cognitive functions has been revealed in numerous anatomical, clinical ... more Cerebellar involvement in cognitive functions has been revealed in numerous anatomical, clinical and neuroimaging studies and several hypotheses about potential the role of the cerebellum in higher level brain function have been established. The aim of this study was to show involvement of the cerebellum in simple cognitive tasks. For this matter, we contrasted two tasks from the same semantic domain with specific cognitive content and level of practice: counting forward and counting backward. Twelve volunteers participated in this fMRI study and they were asked to perform both tasks within the same number range (1 to 30 and vice versa). Results showed greater activation in the right cerebellum for the task of counting forward than for counting backward, while for counting backward greater activation was found in prefrontal cortex, supplementary motor area, and anterior cingulate of both hemispheres. Our results correlate with already established hypotheses about cerebellar role in precise and smooth control, not only in well-trained motor but in well trained cognitive tasks as well.
Purpose: To estimate the diagnostic possibilities of magnetic resonance imaging (MRI) techniques ... more Purpose: To estimate the diagnostic possibilities of magnetic resonance imaging (MRI) techniques and threedimensional multivoxel proton magnetic resonance spectroscopy (MRS) in patients with clinical suspicion of prostate carcinoma. Materials and methods: 36 patients suspected to have prostate carcinoma underwent MRI with dynamic contrast enhanced study and MRS at 1.5T MRI unit using a pelvic phased array coil. MRI and MRS results were correlated with pathohystological findings after radical prostatectomy and standard biopsy with 12 or 24 cores or guided biopsy. Results: Out of 44 detected prostate carcinomas, 38 (86.36%) demonstrated low T2W signal intensity while pathognomonic contrast enhancement has been detected in 40 (91%) carcinomas. MRS showed (Cho+Cr)/Ci ratio mean value of 3.52 in carcinoma, and 0.14 in normal prostatic tissue (p<0,01). Conclusion: MR techniques, both nonenhanced and contrast enhanced when combined with MRS can provide reliable diagnostic results in the...
A wide spectrum of nowadays availible radiological and imaging methods in the diagnostic evaluati... more A wide spectrum of nowadays availible radiological and imaging methods in the diagnostic evaluation of patients with colorectal cancer enabled not only the improvement of primary colorectal malignancy detection, precise staging, regional involvement and metastatic spread assessment, but also the posttherapeutical estimation and follow- up. Having in mind that the exact diagnostic assessment of colorectal carcinoma by use of different imaging modalities still raises a lots of contradictories, in this report we have tried to present the possibilities of newer imaging techniques in the diagnostic evaluation of the patients with colorectal cancer.
To establish the possibilities of functional magnetic resonance (fMRI) in the assesment of preser... more To establish the possibilities of functional magnetic resonance (fMRI) in the assesment of preservation of the motor and speech brain functions in the primary brain tumour patients planed for neurosurgery. Methods and material: fMRI of motor and/or speech areas was performed on 3T MRI unit in 17 patients with primary brain tumours and dominant focal epileptic symptomatology. Results: None of the patients demonstrated motor neurologic deficit before the operation, while in one patient a moderate speech disorder was noted. Operative treatment has been performed in 11/17 patients, and in 6/11 patients total tumour resection has been performed. Motor deficit has not been noted in any of the patients. Transitory speech deficit was noted in 3/11 patients, while 1/11 patients demonstrated a permanent but mild speech deficit. Conclusion: fMRI may be of significant help in the assessment of potential postoperative neurological deficit risks, enabling the optimization of neurosurgical resecti...
The paper is aimed at determining diagnostic quality of the images in different chest CT examinat... more The paper is aimed at determining diagnostic quality of the images in different chest CT examination protocols. Two groups of patients underwent scanning based on two different protocols using Siemens Somatom 4 Plus scanner in the spiral mode. The study included the total of 64 patients divided in two groups according to their body weight (BW). Group one included 34 patients weighing above 80 kg and they were scanned according to the standard protocol. Group two comprised 30 patients weighting below 80 kg and they were scanned using the same protocol however with reduction of tube current of 13 mA. All the scans were subsequently reconstructed using noise-reduction filter (enhancement of low contrast resolution).
The aim of the study was to determine the possibilities of two differently acquired two-dimension... more The aim of the study was to determine the possibilities of two differently acquired two-dimensional fast imaging with steady-state precession (FISP 2D) magnetic resonance sequences in estimation of the third ventricle floor fenestration patency after endoscopic third ventriculostomy (ETV) in the subjects with aqueductal stenosis/obstruction. Fifty eight subjects (37 males, 21 females, mean age 27 years) with previously successfully performed ETV underwent brain MRI on 1.5T MR imager 3-6 months after the procedure. Two different FISP 2D sequences (one included in the standard vendor provided software package, and the other, experimentally developed by our team) were performed respectively at two fixed slice positions: midsagittal and perpendicular to the ETV fenestration, and displayed in a closed-loop cinematographic format in order to estimate the patency. The ventricular volume reduction has been observed as well. Cerebrospinal fluid (CSF) flow through the ETV fenestration was obs...
Background: Pretreatment differentiation between glioblastoma and metastasis is a frequently enco... more Background: Pretreatment differentiation between glioblastoma and metastasis is a frequently encountered dilemma in neurosurgical practice. Distinction is required for precise planning of resection or radiotherapy, and also for defining further diagnostic procedures. Morphology and spectroscopy imaging features are not specific and frequently overlap. This limitation of magnetic resonance imaging and magnetic resonance spectroscopy was the reason to initiate this study. The aim of the present study was to determine whether the dataset of diffusion tensor imaging metrics contains information which may be used for the distinction between primary and secondary intra-axial neoplasms. Methods: Two diffusion tensor imaging parameters were measured in 81 patients with an expansive, ring-enhancing, intra-axial lesion on standard magnetic resonance imaging (1.5 T system). All tumors were histologically verified glioblastoma or secondary deposit. For qualitative analysis, two regions of inter...
Poster: "ECR 2015 / C-0091 / Fluorodeoxiglucose positron emission tomography (FDG- PET) in t... more Poster: "ECR 2015 / C-0091 / Fluorodeoxiglucose positron emission tomography (FDG- PET) in the diagnosis of mild to moderate dementia" by: "A. Peter, M. A. Lucic, S. Lucic, M. Semnic; Novi Sad/RS"
2.2. Radiologic examinations These examinations were mainly related to magnetic resonance imaging... more 2.2. Radiologic examinations These examinations were mainly related to magnetic resonance imaging (MRI) and angiography (MRA), and rarely to computerized tomography (CT) and angiography (CTA), as well as to digital subtraction angiography (DSA) and Doppler sonography. As regards MRI examination, the following sequences and procedures were applied.
Background/Aim. Although considered rare, gliomas cause morbidity and mortality disproportionate ... more Background/Aim. Although considered rare, gliomas cause morbidity and mortality disproportionate to their incidence. The aim of the study was to determine whether pre and post-therapeutic metric values, derived from the FDG PET/CT maximal standardized uptake value (SU-Vmax) and calculated ratios between tumor and normal brain tissue, may provide a predictive/prognostic biomarker information in estimating overall survival of glioblastoma patients. Methods. In 26 out of 31 patients with glioblastoma treated with standard Stupp protocol after maximal safe reductive surgery, we performed a baseline 18F-FDG PET/CT examination before commencing combined and concomitant chemotherapy/radiotherapy (pre-therapy FDG PET/CT) and a second examination three months after the therapy completion (post-therapy FDG PET/CT). Two-graded SUVmax values and a calculated ratio of uptake in tumor-to-normal-tissue (T/N ratio) value, divided into two grades by the calculated cut-off value, were measured in all...
Цель исследования. Изучалась возможность визуализации рака молочной железы у собак с помощью МРТ ... more Цель исследования. Изучалась возможность визуализации рака молочной железы у собак с помощью МРТ с контрастным усилением вновь предложенным парамагнитным контрастным средством (ПМКС)-Mn-димеркаптосукционатом (Mn-ДМСА 2 , TM Сукциманг). Материалы и методы. У семи животных с впервые выявленным раком молочной железы, в состоянии медикаментозного сна (инфузия пропофола), была выполнена МР-томография с Mn-ДМСА 2 , вводимым внутривенно, в виде 0,5 М раствора, 0,1 ммоль/кг массы тела, в Т1-взвешенном режиме, до и спустя 12-17 мин после введения Mn-ДМСА 2. TR=450-600 мс, TE=12-15 мс, в матрицу 256×256 при размере поля сканирования до 250×380 мм, среза 2,5-4 мм, с использованием Toshiba Titan Vantage (Toshiba Medical, 1,5 Т, у пяти животных) и Magnetom Open (Siemens Medical, 0,2 Т, у двух животных). Накопление Mn-ДМСА 2 оценивалось по индексу усиления, как отношение интенсивности на элемент изображения после введения Mn-ДМСА 2 к исходному. Результаты. Во всех случаях зрительно отмечено накопление Mn-ДМСА 2 в области первичных опухолей, и метастазов в лимфатических узлах и головном мозге. Индексы усиления изображения составили: для первичной опухоли (n=7)-1,52±0,19 (1,35; 1,83), для метастазов в лимфатические узлы (n=12)-1,37±0,14 (1,12; 1,64), для метастазов в головной мозг в периферической зоне метастаза (n=11)-1,48±0,15 (1,29; 2,37), и для центральной зоны метастаза (n=11)-2,76±0,12 (1,48; 3,21). Не отмечалось никаких осложнений и побочных действий введения Mn-ДМСА 2. Заключение. Mn-ДМСА 2 представляет собой парамагнитный негадолиниевый контрастный препарат, пригодный для выявления как первичной опухоли, так и метастатических поражений при раке молочной железы. Ключевые слова: МРТ, парамагнитное контрастное усиление, рак молочной железы, Mn-димеркаптосукцинат Конфликт интересов: авторы заявили об отсутствии конфликта интересов.
Aim of the study. We have carried out the synthesis of complex of Manganese(II) with dimercaptosu... more Aim of the study. We have carried out the synthesis of complex of Manganese(II) with dimercaptosuccinic acid (DMSA), applied the quantum chemistry analysis for evaluation of most stable form of the Mn- DMSA complex and studied it’s uptake and imaging properties in normal and tumoral tissues in veterinary patients (cats with tumors)Material and methods. The synthesis of the 2.3-dimercaptosuccinic acid (COOH-CHSH-CHSH-COOH) has been carried out using modified technique proposed by A.I. Busev [Busev A.I. 1972]. Using phantoms filled in with 0.05 mM – 16 mM solutions of the agent we quantified the R1 relaxivity. Imaging properties of the 0.5 M solution of the Mn-(DMSA)2 were evaluated when performing the contrastenhanced studies in veterinary patients (cats with adenofibrous tumors and angiofibromas, nine animals) using T1-w spin-echo mode.Results. As result of quantum chemistry analysis it was shown that the most stable complex of Mn(II) with DMSA is the molecule Mn-(DMSA)2. The R1 re...
In the modern ages of rapid technological and computational advances, development of numerous nov... more In the modern ages of rapid technological and computational advances, development of numerous novel diagnostic imaging techniques have enabled not only visual detection of disease processes, but also provided the tools to achieve quantified functional, structural, dynamic, metabolic, and molecular information. A pathway toward the quantitative imaging by use of quantitative imaging biomarkers analysis has been widely opened, enabling further development of radiomics, radiogenomics, and radioproteinomics analysis in addition, and initiating the dawn of theranostics, eventually bringing the wishful personalised medicine concept closer to reality.
Introduction. Dyke-Davidoff-Masson syndrome is an uncommon neurological disorder clinically prese... more Introduction. Dyke-Davidoff-Masson syndrome is an uncommon neurological disorder clinically presented with seizures, various degrees of mental retardation, motor weakness and sometimes body asymmetry. Typical neuroimaging features include cerebral hemiatrophy with ipsilateral hyper pneumatization of paranasal sinuses. The purpose of this report was to present a rare cause of seizures revealed by magnetic resonance imaging. Case Report. We report a case of a 17-year-old boy admitted to hospital due to a severe headache. He had been treated because of partial epileptic seizures for six years. Neuropsychological examination revealed mild mental retardation, mild speech and reading difficulties and discrete right-sided hemiparesis. Typical magnetic resonance imaging features confirmed clinical suspicion of Dyke-Davidoff-Masson syndrome, revealing left frontal lobe atrophy, with consecutive widening of the left lateral ventricle frontal horn, thickening of the near?by frontal squama and ...
Case studies of unusual traits can provide unique snapshots of the effects of modified systems. I... more Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is af...
Pattern of brain asymmetries varies with handedness, gender, age, and with variety of genetic and... more Pattern of brain asymmetries varies with handedness, gender, age, and with variety of genetic and social factors. Large-scale neuroimaging analyses can optimize the detection of asymmetric features and confirm the factors that might modulate pattern of brain asymmetries. We attempted to evaluate eventual differences between genders in hemodynamic responses to a simple language task. 12 healthy right-handed volunteers (age 24-46), 6 men and 6 women underwent fMRI scanning while performing the simple cognitive - language processing task - silent number counting in Serbian. Group analysis of hemodynamic responses shows activation in expected brain language areas of inferior frontal gyrus (IFG) and superior temporal gyrus (STG) in both hemispheres. In the male group, aside from dedicated language areas in IFG and STG, activation was noted in right frontal region and interhemispheric supplementary motor area. On the other hand, in the female group, besides activation in dedicated languag...
Ultrasonography of the central nervous system is an integral part of a prenatal scan, and the dev... more Ultrasonography of the central nervous system is an integral part of a prenatal scan, and the development of imaging technologies has led to better diagnostic possibilities. Posterior fossa anomalies have traditionally been divided into Dandy Walke malformation, Dandy Walker variation and megacisterna magna, but this approach, due to diversity of the extensive number of possible disorders covered by this classification, unables accurate prognosis and therefore adequate counselling. An alternative approach to the classification of posterior fossa anomalies is to divide them into agenesis of the vermis, which could be partial or complete, cerebellar hypoplasia, pontocerebellar hypoplasia and cerebellar atrophy. Different ultrasonographic and magnetic resonance imagining of appearances of the posterior fossa anomalies in prenatal period are discussed in the article, as well as possible syndromes and prognosis of different entities. Diversity of anomalies of the central nervous system, ...
Journal of Pediatric Endocrinology and Metabolism, 2012
Bloody nipple discharge is an uncommon fi nding in the pediatric population, without clear diagno... more Bloody nipple discharge is an uncommon fi nding in the pediatric population, without clear diagnostic and therapeutic guidelines established. We noted a case of a 3-month-old male infant who presented with bilateral bloodstained nipple discharge, with unremarkable medical history. Sonographic fi ndings revealed bilaterally dilated ducts and cysts with mixed iso-and hypoechoic intraductal content. Possible causes of this condition include hyperlaxity syndrome with decreased function of elastic fi bers and fi brocystic changes in breasts, and unusual response to maternal hormones, transferred to the neonate either transplacentally or through breastfeeding. Given the most probable benign etiology and self-limiting nature of the described condition, a conservative approach is suggested. Unnecessary invasive procedures should be avoided.
Background: Purpose of the study was to determine whether the native and contrast enhanced MRI pa... more Background: Purpose of the study was to determine whether the native and contrast enhanced MRI pattern of detected intraaxial posterior fossa metastatic tumors may potentially suggest the origin of primary malignoma. Materials and methods: In 99 patients ...
Cerebellar involvement in cognitive functions has been revealed in numerous anatomical, clinical ... more Cerebellar involvement in cognitive functions has been revealed in numerous anatomical, clinical and neuroimaging studies and several hypotheses about potential the role of the cerebellum in higher level brain function have been established. The aim of this study was to show involvement of the cerebellum in simple cognitive tasks. For this matter, we contrasted two tasks from the same semantic domain with specific cognitive content and level of practice: counting forward and counting backward. Twelve volunteers participated in this fMRI study and they were asked to perform both tasks within the same number range (1 to 30 and vice versa). Results showed greater activation in the right cerebellum for the task of counting forward than for counting backward, while for counting backward greater activation was found in prefrontal cortex, supplementary motor area, and anterior cingulate of both hemispheres. Our results correlate with already established hypotheses about cerebellar role in precise and smooth control, not only in well-trained motor but in well trained cognitive tasks as well.
Purpose: To estimate the diagnostic possibilities of magnetic resonance imaging (MRI) techniques ... more Purpose: To estimate the diagnostic possibilities of magnetic resonance imaging (MRI) techniques and threedimensional multivoxel proton magnetic resonance spectroscopy (MRS) in patients with clinical suspicion of prostate carcinoma. Materials and methods: 36 patients suspected to have prostate carcinoma underwent MRI with dynamic contrast enhanced study and MRS at 1.5T MRI unit using a pelvic phased array coil. MRI and MRS results were correlated with pathohystological findings after radical prostatectomy and standard biopsy with 12 or 24 cores or guided biopsy. Results: Out of 44 detected prostate carcinomas, 38 (86.36%) demonstrated low T2W signal intensity while pathognomonic contrast enhancement has been detected in 40 (91%) carcinomas. MRS showed (Cho+Cr)/Ci ratio mean value of 3.52 in carcinoma, and 0.14 in normal prostatic tissue (p<0,01). Conclusion: MR techniques, both nonenhanced and contrast enhanced when combined with MRS can provide reliable diagnostic results in the...
A wide spectrum of nowadays availible radiological and imaging methods in the diagnostic evaluati... more A wide spectrum of nowadays availible radiological and imaging methods in the diagnostic evaluation of patients with colorectal cancer enabled not only the improvement of primary colorectal malignancy detection, precise staging, regional involvement and metastatic spread assessment, but also the posttherapeutical estimation and follow- up. Having in mind that the exact diagnostic assessment of colorectal carcinoma by use of different imaging modalities still raises a lots of contradictories, in this report we have tried to present the possibilities of newer imaging techniques in the diagnostic evaluation of the patients with colorectal cancer.
To establish the possibilities of functional magnetic resonance (fMRI) in the assesment of preser... more To establish the possibilities of functional magnetic resonance (fMRI) in the assesment of preservation of the motor and speech brain functions in the primary brain tumour patients planed for neurosurgery. Methods and material: fMRI of motor and/or speech areas was performed on 3T MRI unit in 17 patients with primary brain tumours and dominant focal epileptic symptomatology. Results: None of the patients demonstrated motor neurologic deficit before the operation, while in one patient a moderate speech disorder was noted. Operative treatment has been performed in 11/17 patients, and in 6/11 patients total tumour resection has been performed. Motor deficit has not been noted in any of the patients. Transitory speech deficit was noted in 3/11 patients, while 1/11 patients demonstrated a permanent but mild speech deficit. Conclusion: fMRI may be of significant help in the assessment of potential postoperative neurological deficit risks, enabling the optimization of neurosurgical resecti...
The paper is aimed at determining diagnostic quality of the images in different chest CT examinat... more The paper is aimed at determining diagnostic quality of the images in different chest CT examination protocols. Two groups of patients underwent scanning based on two different protocols using Siemens Somatom 4 Plus scanner in the spiral mode. The study included the total of 64 patients divided in two groups according to their body weight (BW). Group one included 34 patients weighing above 80 kg and they were scanned according to the standard protocol. Group two comprised 30 patients weighting below 80 kg and they were scanned using the same protocol however with reduction of tube current of 13 mA. All the scans were subsequently reconstructed using noise-reduction filter (enhancement of low contrast resolution).
The aim of the study was to determine the possibilities of two differently acquired two-dimension... more The aim of the study was to determine the possibilities of two differently acquired two-dimensional fast imaging with steady-state precession (FISP 2D) magnetic resonance sequences in estimation of the third ventricle floor fenestration patency after endoscopic third ventriculostomy (ETV) in the subjects with aqueductal stenosis/obstruction. Fifty eight subjects (37 males, 21 females, mean age 27 years) with previously successfully performed ETV underwent brain MRI on 1.5T MR imager 3-6 months after the procedure. Two different FISP 2D sequences (one included in the standard vendor provided software package, and the other, experimentally developed by our team) were performed respectively at two fixed slice positions: midsagittal and perpendicular to the ETV fenestration, and displayed in a closed-loop cinematographic format in order to estimate the patency. The ventricular volume reduction has been observed as well. Cerebrospinal fluid (CSF) flow through the ETV fenestration was obs...
Background: Pretreatment differentiation between glioblastoma and metastasis is a frequently enco... more Background: Pretreatment differentiation between glioblastoma and metastasis is a frequently encountered dilemma in neurosurgical practice. Distinction is required for precise planning of resection or radiotherapy, and also for defining further diagnostic procedures. Morphology and spectroscopy imaging features are not specific and frequently overlap. This limitation of magnetic resonance imaging and magnetic resonance spectroscopy was the reason to initiate this study. The aim of the present study was to determine whether the dataset of diffusion tensor imaging metrics contains information which may be used for the distinction between primary and secondary intra-axial neoplasms. Methods: Two diffusion tensor imaging parameters were measured in 81 patients with an expansive, ring-enhancing, intra-axial lesion on standard magnetic resonance imaging (1.5 T system). All tumors were histologically verified glioblastoma or secondary deposit. For qualitative analysis, two regions of inter...
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