In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcr... more In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcribed by RNA polymerase I (pol I) instead of RNA pol II, the polymerase committed to the production of mRNA in eukaryotes. This unusual feature might be accomplished by the recruitment of specific subunits or cofactors that allow pol I to transcribe protein-coding RNAs. Here, we report that transcription mediated by pol I requires TbRPB7, a dissociable subunit of the pol II complex. TbRPB7 was found to interact with two pol I-specific subunits, TbRPA1 and TbRPB6z. Pol I-specific transcription was affected on depletion of TbRPB7 in run-on assays, whereas recombinant TbRPB7 increased transcription driven by a pol I promoter. These results represent a unique example of a functional RNA polymerase chimaera consisting of a core pol I complex that recruits a specific pol II subunit.
We consider the induced 2d-gravity in the minisuperspace approach. The general solution to the Wh... more We consider the induced 2d-gravity in the minisuperspace approach. The general solution to the Wheeler-DeWitt equation is given in terms of different kind of Bessel functions of purely real or imaginary orders. We study the properties of the corresponding probability distributions finding a kind of phase transition at the critical point ν = 0. * Work partially supported by the Comisión Interministerial de Ciencia y Tecnología.
The quantization of the induced 2d-gravity on a compact spatial section is carried out in three d... more The quantization of the induced 2d-gravity on a compact spatial section is carried out in three different ways. In the three approaches the supermomentum constraint is solved at the classical level but they differ in the way the hamiltonian constraint is imposed. We compare these approaches establishing an isomorphism between the resulting Hilbert spaces.
In this paper we propose a "second quantization" scheme especially suitable for dealing... more In this paper we propose a "second quantization" scheme especially suitable for dealing with nontrivial, highly symmetric phase spaces, implemented within a more general group approach to quantization, which recovers the standard quantum field theory (QFT) for ordinary relativistic linear fields. We emphasize, among its main virtues, greater suitability in characterizing vacuum states in a QFT on a highly symmetric curved space–time and the absence of the usual requirement of global hyperbolicity. This can be achieved in the special case of the Anti-de Sitter universe, on which we explicitly construct a QFT.
In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcr... more In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcribed by RNA polymerase I (pol I) instead of RNA pol II, the polymerase committed to the production of mRNA in eukaryotes. This unusual feature might be accomplished by the recruitment of specific subunits or cofactors that allow pol I to transcribe protein-coding RNAs. Here, we report that transcription mediated by pol I requires TbRPB7, a dissociable subunit of the pol II complex. TbRPB7 was found to interact with two pol I-specific subunits, TbRPA1 and TbRPB6z. Pol I-specific transcription was affected on depletion of TbRPB7 in run-on assays, whereas recombinant TbRPB7 increased transcription driven by a pol I promoter. These results represent a unique example of a functional RNA polymerase chimaera consisting of a core pol I complex that recruits a specific pol II subunit.
We show that the equations of motion of two-dimensional dilaton gravity conformally coupled to a ... more We show that the equations of motion of two-dimensional dilaton gravity conformally coupled to a scalar field can be reduced to a single nonlinear second-order partial differential equation when the coordinates are chosen to coincide with the two scalar fields, the matter field f and the dilaton φ, which are present in the theory. This result may help solve and understand two-and higher-dimensional classical and quantum gravity.
In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcr... more In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcribed by RNA polymerase I (pol I) instead of RNA pol II, the polymerase committed to the production of mRNA in eukaryotes. This unusual feature might be accomplished by the recruitment of specific subunits or cofactors that allow pol I to transcribe protein-coding RNAs. Here, we report that transcription mediated by pol I requires TbRPB7, a dissociable subunit of the pol II complex. TbRPB7 was found to interact with two pol I-specific subunits, TbRPA1 and TbRPB6z. Pol I-specific transcription was affected on depletion of TbRPB7 in run-on assays, whereas recombinant TbRPB7 increased transcription driven by a pol I promoter. These results represent a unique example of a functional RNA polymerase chimaera consisting of a core pol I complex that recruits a specific pol II subunit.
We consider the induced 2d-gravity in the minisuperspace approach. The general solution to the Wh... more We consider the induced 2d-gravity in the minisuperspace approach. The general solution to the Wheeler-DeWitt equation is given in terms of different kind of Bessel functions of purely real or imaginary orders. We study the properties of the corresponding probability distributions finding a kind of phase transition at the critical point ν = 0. * Work partially supported by the Comisión Interministerial de Ciencia y Tecnología.
The quantization of the induced 2d-gravity on a compact spatial section is carried out in three d... more The quantization of the induced 2d-gravity on a compact spatial section is carried out in three different ways. In the three approaches the supermomentum constraint is solved at the classical level but they differ in the way the hamiltonian constraint is imposed. We compare these approaches establishing an isomorphism between the resulting Hilbert spaces.
In this paper we propose a "second quantization" scheme especially suitable for dealing... more In this paper we propose a "second quantization" scheme especially suitable for dealing with nontrivial, highly symmetric phase spaces, implemented within a more general group approach to quantization, which recovers the standard quantum field theory (QFT) for ordinary relativistic linear fields. We emphasize, among its main virtues, greater suitability in characterizing vacuum states in a QFT on a highly symmetric curved space–time and the absence of the usual requirement of global hyperbolicity. This can be achieved in the special case of the Anti-de Sitter universe, on which we explicitly construct a QFT.
In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcr... more In the protozoan parasite Trypanosoma brucei, the two main surface glycoprotein genes are transcribed by RNA polymerase I (pol I) instead of RNA pol II, the polymerase committed to the production of mRNA in eukaryotes. This unusual feature might be accomplished by the recruitment of specific subunits or cofactors that allow pol I to transcribe protein-coding RNAs. Here, we report that transcription mediated by pol I requires TbRPB7, a dissociable subunit of the pol II complex. TbRPB7 was found to interact with two pol I-specific subunits, TbRPA1 and TbRPB6z. Pol I-specific transcription was affected on depletion of TbRPB7 in run-on assays, whereas recombinant TbRPB7 increased transcription driven by a pol I promoter. These results represent a unique example of a functional RNA polymerase chimaera consisting of a core pol I complex that recruits a specific pol II subunit.
We show that the equations of motion of two-dimensional dilaton gravity conformally coupled to a ... more We show that the equations of motion of two-dimensional dilaton gravity conformally coupled to a scalar field can be reduced to a single nonlinear second-order partial differential equation when the coordinates are chosen to coincide with the two scalar fields, the matter field f and the dilaton φ, which are present in the theory. This result may help solve and understand two-and higher-dimensional classical and quantum gravity.
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Papers by Miguel Navarro