Papers by Meenakshi Singh
Clean Energy Production Technologies
The European Physical Journal Plus
European Journal of Chemistry, 2021
The novel coronavirus, which emerged in China in late December 2019, is officially named as Sever... more The novel coronavirus, which emerged in China in late December 2019, is officially named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The rapid spread of the virus across the continent has disrupted human life in every aspect leading to health and economic crises. The World Health Organization (WHO) declared the novel coronavirus outbreak as a global pandemic on March 11, 2020. In spite of complete lockdown and quarantine efforts in many countries, the occurrence of infections continues to rise, with more than 88 million laboratory-confirmed cases and over 1.9 million deaths worldwide as on January 10, 2021. Since the beginning of the outbreak, lot of intriguing studies about the phylogenetic evolution, epidemiology, pathogenesis, transmission, clinical characteristics, and possible treatment of Corona Virus Disease 2019 (COVID-19) have been published. This review aims to provide an insight into the progress in this regard and provides a reference for future stud...
American journal of blood research, 2021
OBJECTIVES Lenalidomide is an active agent in acute myeloid leukemia (AML); response rates are ab... more OBJECTIVES Lenalidomide is an active agent in acute myeloid leukemia (AML); response rates are about 15-30%. There are no well-defined predictive factors for benefit from lenalidomide in AML. One of the mechanisms of lenalidomide is natural killer (NK) cell activation; hence human leukocyte antigen (HLA) class I alleles (serving as killer immunoglobulin-like receptor ligands) could play a predictive role. We here evaluate the same when lenalidomide was used as a bridge to transplant. METHODS Consecutive AML patients started on lenalidomide as bridge to transplant between Aug-2013 to Aug-2018 were included in this single centre retrospective analysis. The starting dose and schedule of lenalidomide were at the discretion of the treating clinician. Lenalidomide was scheduled to be stopped about 2-4 weeks prior to planned transplant admission (or was stopped earlier if there was intolerance). For this study, event was defined as progression/relapse while on lenalidomide or within 4 week...
The current study attempts to understand the diatom community structure and their role as bio-ind... more The current study attempts to understand the diatom community structure and their role as bio-indicator in the urban wetlands of central Gujarat. The remarkable variation in the composition and distribution of various diatom species were observed. A total of 26 diatom species distributed among 16 genera, highlights rich biodiversity of the region. Among all, high count of certain diatom species namely
Imperial journal of interdisciplinary research, 2016
This investigation reports a comparative account of algal flora of three wetlands of Vadodara cit... more This investigation reports a comparative account of algal flora of three wetlands of Vadodara city for the first time namely, Harni, Gotri and Manjalpur ponds. The preliminary study of phytoplanktons in selected wetlands showed marked difference in the composition and distribution of various algal groups. A total of 30 algal species recorded, belonging to the four clasess; Chlorophyceae, Bacillariophyceae, Cyanophyceae and Euglenophyceae. Out of which, Chlorophyceae found to be most dominated algal group representing 10 genera.
If one studies natural phenomena, it is important to try to understand the underlying principles.... more If one studies natural phenomena, it is important to try to understand the underlying principles. These would ideally not only enable one to explain the range of familiar phenomena but may predict new phenomena or at least explain new phenomena when they are discovered. The method of principles was founded by Newton (1643–1727). Einstein (1879–1955) was a great master of the method of principles. Principles of physics are not a matter of logical explanation. Their confirmation is experience only – they are based on reality, or experimental facts which so far have had no evidence to the contrary. To this end, ”experiment” and ”reality” are herein tautological. Practically, however, these are not the principles themselves – as there aren’t so many – but their logical consequences that are observed in a vast variety of physical experiments and in general reality. Here are the examples of physical principles. The relativity principle – there are no observational consequences of absolute...
HLA, 2021
The novel allele HLA‐DPB1*02:01:61 as compared with HLA‐DPB1*02:01:02 displays polymorphism by a ... more The novel allele HLA‐DPB1*02:01:61 as compared with HLA‐DPB1*02:01:02 displays polymorphism by a single nucleotide at gDNA 9011 C‐>T.
HLA, 2021
The novel HLA‐B*51:01:01:83 allele differs from HLA‐B*51:01:01:01 by A‐ > G nucleotide substit... more The novel HLA‐B*51:01:01:83 allele differs from HLA‐B*51:01:01:01 by A‐ > G nucleotide substitution at gDNA 2569.
Biomass Conversion and Biorefinery, 2021
Diatoms are the reservoir of bioactive compounds which have immense application in nutrition, ind... more Diatoms are the reservoir of bioactive compounds which have immense application in nutrition, industrial commodities and ecological studies. In the oceans, diatoms form a large bloom of silica under favourable conditions, whereas, in lentic and lotic systems, they colonize according to seasonal disturbances. Notably, the survival of diatoms in a stressed environment is because of their uniqueness; therefore, diatoms serve as an ideal candidate to understand the evolutionary paradigm and successional dynamics. This review outlines the biological uniqueness of diatoms, their role in biogeochemical cycles and the recolonization pattern of diatoms in anthropic disturbed habitats. Furthermore, a detailed discussion on different technologies for extracting valuable biomolecules with an emphasis on lipid extraction has been carried out. Moreover, the diatom-based photosynthetic biorefinery approach for a better understanding of the renewable usage of biomass is done. Graphical abstract
International Journal of Artificial Intelligence, 2020
Alzheimer's disease (AD) is an disorder which is irreversible of the brain related to memory ... more Alzheimer's disease (AD) is an disorder which is irreversible of the brain related to memory loss, mostly found in the old and aged population. Alzheimer's dementia results from the degeneration or loss of brain cells. The brain-imaging technologies most often used to diagnose AD is Magnetic resonance imaging (MRI). MRI or structural magnetic resonance is a very popular and actual technique used to diagnose AD. An MRI uses magnets and powerful radio waves to create a complete view of your brain. To actually detect the presence of Alzheimer’s, the MRI should me studied carefullyImplementation of CBIR Content Based Image Retrival which is a revolutionary computer aided diagnosis technique will create new abilities in MRI Magnetic resonance imaging in related image retrieval and training for recognition of development of AD in early stages
Journal of Physics: Conference Series, 2018
We observed supercurrent through an n-type ferromagnetic semiconductor (In,Fe)As. For the purpose... more We observed supercurrent through an n-type ferromagnetic semiconductor (In,Fe)As. For the purpose we prepared S/F/S (S: superconductor, F: ferromagnet) junctions, which exhibited zero resistance up to 1 µm of junction width with critical current over 1 µA below 1 K. The long reach of the superconducting proximity effect suggests that the induced superconductivity is brought about by spin-triplet paring in (In,Fe)As.
IP International Journal of Medical Microbiology and Tropical Diseases, 2019
Introduction: Aim of the study is isolation and identification of V cholerae followed by study of... more Introduction: Aim of the study is isolation and identification of V cholerae followed by study of clonal relationship between isolates by molecular typing methods, molecular characterization by detection of genes coding for cholera toxin (CTX) & toxin-co-regulated pili (TCP) and study of antibiotic susceptibility pattern of V cholerae isolates Materials and Methods: 74 V cholerae isolates from 620 stool samples were included in study. Isolation, identification and antibiogram done by using standard techniques. Clonal relationship between isolates studied by RAPD assays. Molecular characterization done by detection of CTX and TCP using multiplex PCR. Results: 74 V. cholerae 01 biotype El Tor serotype Ogawa isolated from 620 stool samples with isolation rate of 11.94%. 38 of 46 isolates were positive for CTX-A and TCP-A El Tor by multiplex PCR. All 46 isolates were negative for TCP-A classical. 38 isolates subjected to RAPD typing assays revealed 11 different RAPD types. Antibiotic sensitivity tests for the isolates revealed the presence of diverse sensitivity patterns. 97.3% of isolates were multidrug resistant (MDR). 2.7% of isolates remained sensitive to all tested antibiotics. Conclusion: V. cholerae 01 biotype El Tor serotype Ogawa is currently circulating type in our geographical region. All isolates tested positive for CTX and TCP indicating that circulating strains are pathogenic in nature. Presence of different RAPD types indicates that cholera is endemic in this region with periodic epidemics. Presence of large number of MDR isolates necessitates curbing of irrational use of antibiotics to prevent further spread of drug resistance.
Recent Developments in Myelodysplastic Syndromes, 2019
Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder affecting individuals over t... more Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder affecting individuals over the age of 60 years. It is characterized by ineffective hematopoiesis and extensive apoptosis of hematopoietic cells. MDS patients are at a high risk of transforming in to acute myeloid leukemia. The main cause of apoptosis and escape from immune surveillance in MDS is immune dysregulation caused by a number of factors such as aberrant cytokine production and influence of various immune cells. In the past decade various pro-inflammatory cytokines and a number of immune cells such as Natural Killer cells, regulatory T cells, cytotoxic T cells, mesenchymal stem cells, myeloid derived suppressor cells and dendritic cells have been implicated in immune dysregulation leading to MDS pathogenesis. In this review we focus on the current data available on the role of these immune factors.
HortScience, 2001
Various combinations of glyphosate and 2,4-D (± surfactant) were evaluated for control of Brazil ... more Various combinations of glyphosate and 2,4-D (± surfactant) were evaluated for control of Brazil pusley [Richardia brasiliensis (Moq.) Gomez]. Typical 2,4-D symptoms on plants were manifested within 2 to 3 days after treatment. Application of glyphosate alone had only marginal effects (14%) on Brazil pusley, but the addition of Induce® (nonionic surfactant) significantly increased control to 83% and reduced the fresh weight by 68%. Application of Landmaster®II or a tank-mix of glyphosate + 2,4-D (± surfactants) resulted in 96% to 100% control. Treatment with 2,4-D alone, or with Induce®, or L-77® (organosilicone surfactant) resulted in 84%, 90%, or 100% control, respectively. Very low fresh weights of Brazil pusley were recorded when 2,4-D +Induce® or L-77®, Landmaster®II (± surfactants), or the tank-mix (± surfactants) were applied. In the regrowth studies, shoot weight was greater following application of glyphosate with or without L-77® or Kinetic® (a blend of nonionic and organo...
Ayu
Arsha (hemorrhoids) is engorgement of the hemorrhoidal venous plexus, characterized by bleeding p... more Arsha (hemorrhoids) is engorgement of the hemorrhoidal venous plexus, characterized by bleeding per rectum, constipation, pain in ano, prolapse and discharge per anum. It is a primary disease, with impaired digestion as the underlying pathogenesis. It is manifested due to improper diet, prolonged standing and faulty habits of defecation causing derangement of Tridosha, mainly Vata Dosha. Vitiated Dosha localizes in Houstan's Valve, rectal arteries, fascia and vitiates Skin, muscles, adipose tissue and blood due to Annavaha Srotodushti (vitiation of gastrointestinal tract). A 45-year-old male patient came to the OPD of Dr. Sarvepalli Radhakrishnan Rajasthan Ayurved University hospital, Jodhpur, Rajasthan, with complaints of prolapsing pile mass during defecation, pain per anum with erosion and bleeding per anum while passing stool. On proctoscopy, pile masses were seen at 11 and 3 O'clock positions and few erosions were seen near the 3 O'clock pile mass. The case was diagnosed as "Raktarsha"later stage of 2 nd degree internal hemorrhoids at 11 and 3 O'clock positions, deeply situated, projecting one and caused by Pitta and Rakta Dosha; with bleeding tendency. Ligation of pile mass by surgical linen barbour thread number 20 on 11 O'clock positions and plication by absorbable chromic catgut on 3 O'clock positions of internal hemorrhoid were done under local anesthesia followed by Matra Basti (therapeutic oil enema) with Jatyadi oil. The pile mass and per rectal bleeding resolved in 10 days and the patient got relief from all the symptoms within 4 weeks. No complications were reported after the procedure. The patient was followed up regularly from the registered date onward till 3 months and proctoscopic examination did not revealed any evidence of recurrence of the hemorrhoids.
Asia-Pacific journal of oncology nursing
The objective of the study is to evaluate the use of the Pap smear screening method for detection... more The objective of the study is to evaluate the use of the Pap smear screening method for detection of precancerous lesions. All women who visited the outpatient gynecology clinic of the Department of Obstetrics and Gynaecology at King Georges Medical University, Lucknow, UP, India, over 1 year for different clinical problems were recruited for the study. A total of 1650 women who were sexually active and over 21 years of age were enrolled in the study. A clinical examination, an examination per speculum, and a vaginal examination were performed and a history taken for all women. A Pap smear was used for all women to screen for cervical cancer. The smear was obtained using an Ayre spatula and spread over a marked glass slide, which was placed in 95% ethyl alcohol and sent to the Department of Pathology for cytopathological examination. All data were recorded using a predetermined pro forma. Women who had visible malignant cervical lesions were excluded from the study. Most women were ...
Developmental neurorehabilitation, Jan 20, 2018
To investigate whether Post-Acute Care Inpatient Rehabilitation (PACIR) admission after NICU stay... more To investigate whether Post-Acute Care Inpatient Rehabilitation (PACIR) admission after NICU stay affects the total length of stay (LOS) of very preterm (VPT: ≤30 weeks of gestation) infants. A retrospective case control study of VPT infants d/c'd from the NICU at Maria Fareri Children's Hospital (MFCH) to either a PACIR (Blythedale Children's Hospital: BH) for convalescent care (cases) or directly home (controls). 35 cases and 70 controls. Total LOS (MFCH + BH) was longer for cases [196 vs. 97 days]. At the time of d/c from MFCH, Special Health Care Needs (SHCN) amongst cases were greater than controls, however, became similar at the time of home d/c. The majority of cases achieved habilitation goals at the PACIR. Although LOS was longer for patients transferred to a PACIR, habilitation at BH Hospital reduced the SHCN at the time of home d/c amongst cases.
The Indian journal of medical research, 2017
Clostridium difficile is the primary cause of hospital-acquired colitis in patients receiving ant... more Clostridium difficile is the primary cause of hospital-acquired colitis in patients receiving antibiotics. The pathogenicity of the organism is mainly due to the production of toxins. This study was conducted to investigate the presence of toxigenic C. difficile in the faecal samples of hospitalized patients suspected to have C. difficile infection (CDI) and corroborating the findings with their clinical and demographic data. Diarrhoeic samples obtained from 1110 hospitalized patients were cultured for C. difficile and the isolates confirmed by phenotypic and molecular methods. Toxigenicity of the isolates was determined using enzyme-linked immunosorbent assay for toxins A and B. Details of patients included in the study were noted and analyzed. Of the 1110 patients (mean age 39±19.6 yr), 63.9 per cent were males and 36.1 per cent were females. The major antibiotics received by the patients were nitazoxanide (23.9%), penicillins/penicillin combinations (19.0%), quinolones including ...
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Papers by Meenakshi Singh