Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma, 2021
Purpose: The aim of this study was to assess the relationship between adrenal incidentaloma size,... more Purpose: The aim of this study was to assess the relationship between adrenal incidentaloma size, cortisol secretion suppressibility by Dexamethasone and relevant clinical and laboratory parameters. Methods: This retrospective study included all patients diagnosed with adrenal incidentaloma and admitted to the single department of the Clinic of endocrinology, Diabetes and Diseases of Metabolism during the period from 2012 till the end of 2019. The inclusion criterion was the presence of an asymptomatic adrenal mass on imaging not performed for suspected adrenal disease. The study group included 197 subjects. Adrenal masses were detected using CT or NMR scan. We analysed the correlation between tumour size and relevant hormonal and clinical parameters. Results: We found a significant positive correlation between incidentaloma size and morning cortisol, cortisol after overnight Dexamethasone, and a significant negative correlation between incidentaloma size and morning ACTH, and hip T...
Background: Although thyroid hormones have significant effect on cardiovascular system, the impac... more Background: Although thyroid hormones have significant effect on cardiovascular system, the impact of subtle thyroid dysfunction such as subclinical hypothyroidism (SCH) remains to be determined. We investigated coronary flow reserve (CFR) in patients with subclinical hypothyroidism. Methods: Thirty two subjects with SCH and eighteen control subjects with normal serum thyroid hormones and thyroid-stimulating hormone (TSH) levels were included in the study. TSH, free thyroxine, free triiodothyronine, glucose, insulin, HbA1c, cholesterol, triglyceride and plasma levels of C-reactive protein were measured. Coronary diastolic peak flow velocities in left anterior descending coronary artery were measured at baseline and after adenosine infusion. CFR was calculated as the ratio of hyperemic to baseline diastolic peak velocity. Results: CFR values were not significantly different between the two groups (SCH 2.76±0.35 vs controls 2.76±0.42). There was a significant correlation of CFR with w...
Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma, 2019
Solitarni fibrozni tumor pleure je najčešći mezenhimalni tumor koji putem ektopične sekrecije IGF... more Solitarni fibrozni tumor pleure je najčešći mezenhimalni tumor koji putem ektopične sekrecije IGF2 uzrokuje non-islet cell hipoglikemiju, nazvanu Doege Potterov sindrom.
There are three basic modalities for the treatment of thyrotoxicosis: thyrosuppresive drug therap... more There are three basic modalities for the treatment of thyrotoxicosis: thyrosuppresive drug therapy, ablation with radioactive iodine and surgical treatment. Patients who do not achieve adequate thyrotoxicosis control, as was the case of described patient, have a high mortality rate due to the possibility of developing a thyroid storm. The use of drug therapy for hyperthyroidism, as the first line of treatment, is associated with the appearance of various side effects, as was the case in our patient. Side effects of Methimazole are dose-dependent, while in the case of Propylthiouracil, the occurrence of side effects is not clearly dose-dependent. In the case of the described patient, all alternative, lesser known modalities for the treatment of hyperthyroidism were applied, after the occurrence of adverse reactions to thyrosuppressive therapy. Sodium perchlorate, ie. Sodium with perchloric acid is rarely used in the treatment of hyperthyroidism, as in cases of severe idiosyncratic re...
Reliability of steam generator is a serious concern in the operation of nuclear power plants, esp... more Reliability of steam generator is a serious concern in the operation of nuclear power plants, especially for steam generator tubes that experience a variety of degradation mechanisms including wear damage. It is necessary to develop a model to accurately predict wear depth of tubes for the assessment and management of steam generator aging. In this article, a non-homogeneous Markov process model of wear is proposed to assess the evaluation of wear depth in steam generator tubes. Based on the analytical solutions of the system of Kolmogorov's forward equations, the transition probability functions are computed to estimate the future wear depth distribution. The parameters are estimated under the assumption that the mean wear depths in the proposed Markov stochastic model are equal to the average of measured depths. The time evolution of wear depth distribution can be predicted. The proposed Markov stochastic model was tested with the in-service inspection records from steam generator tube inspection report, and the results showed a good agreement with future wear depth distribution.
Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma, 2021
Purpose: The aim of this study was to assess the relationship between adrenal incidentaloma size,... more Purpose: The aim of this study was to assess the relationship between adrenal incidentaloma size, cortisol secretion suppressibility by Dexamethasone and relevant clinical and laboratory parameters. Methods: This retrospective study included all patients diagnosed with adrenal incidentaloma and admitted to the single department of the Clinic of endocrinology, Diabetes and Diseases of Metabolism during the period from 2012 till the end of 2019. The inclusion criterion was the presence of an asymptomatic adrenal mass on imaging not performed for suspected adrenal disease. The study group included 197 subjects. Adrenal masses were detected using CT or NMR scan. We analysed the correlation between tumour size and relevant hormonal and clinical parameters. Results: We found a significant positive correlation between incidentaloma size and morning cortisol, cortisol after overnight Dexamethasone, and a significant negative correlation between incidentaloma size and morning ACTH, and hip T...
Background: Although thyroid hormones have significant effect on cardiovascular system, the impac... more Background: Although thyroid hormones have significant effect on cardiovascular system, the impact of subtle thyroid dysfunction such as subclinical hypothyroidism (SCH) remains to be determined. We investigated coronary flow reserve (CFR) in patients with subclinical hypothyroidism. Methods: Thirty two subjects with SCH and eighteen control subjects with normal serum thyroid hormones and thyroid-stimulating hormone (TSH) levels were included in the study. TSH, free thyroxine, free triiodothyronine, glucose, insulin, HbA1c, cholesterol, triglyceride and plasma levels of C-reactive protein were measured. Coronary diastolic peak flow velocities in left anterior descending coronary artery were measured at baseline and after adenosine infusion. CFR was calculated as the ratio of hyperemic to baseline diastolic peak velocity. Results: CFR values were not significantly different between the two groups (SCH 2.76±0.35 vs controls 2.76±0.42). There was a significant correlation of CFR with w...
Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma, 2019
Solitarni fibrozni tumor pleure je najčešći mezenhimalni tumor koji putem ektopične sekrecije IGF... more Solitarni fibrozni tumor pleure je najčešći mezenhimalni tumor koji putem ektopične sekrecije IGF2 uzrokuje non-islet cell hipoglikemiju, nazvanu Doege Potterov sindrom.
There are three basic modalities for the treatment of thyrotoxicosis: thyrosuppresive drug therap... more There are three basic modalities for the treatment of thyrotoxicosis: thyrosuppresive drug therapy, ablation with radioactive iodine and surgical treatment. Patients who do not achieve adequate thyrotoxicosis control, as was the case of described patient, have a high mortality rate due to the possibility of developing a thyroid storm. The use of drug therapy for hyperthyroidism, as the first line of treatment, is associated with the appearance of various side effects, as was the case in our patient. Side effects of Methimazole are dose-dependent, while in the case of Propylthiouracil, the occurrence of side effects is not clearly dose-dependent. In the case of the described patient, all alternative, lesser known modalities for the treatment of hyperthyroidism were applied, after the occurrence of adverse reactions to thyrosuppressive therapy. Sodium perchlorate, ie. Sodium with perchloric acid is rarely used in the treatment of hyperthyroidism, as in cases of severe idiosyncratic re...
Reliability of steam generator is a serious concern in the operation of nuclear power plants, esp... more Reliability of steam generator is a serious concern in the operation of nuclear power plants, especially for steam generator tubes that experience a variety of degradation mechanisms including wear damage. It is necessary to develop a model to accurately predict wear depth of tubes for the assessment and management of steam generator aging. In this article, a non-homogeneous Markov process model of wear is proposed to assess the evaluation of wear depth in steam generator tubes. Based on the analytical solutions of the system of Kolmogorov's forward equations, the transition probability functions are computed to estimate the future wear depth distribution. The parameters are estimated under the assumption that the mean wear depths in the proposed Markov stochastic model are equal to the average of measured depths. The time evolution of wear depth distribution can be predicted. The proposed Markov stochastic model was tested with the in-service inspection records from steam generator tube inspection report, and the results showed a good agreement with future wear depth distribution.
Uploads
Papers by Marija Miletic