Papers by Marcos Paulo Silva Maldonado
The FASEB Journal, Apr 1, 2018
Cette contribution porte sur un genre de texte fréquemment demandé dans les formations initiales ... more Cette contribution porte sur un genre de texte fréquemment demandé dans les formations initiales ou continues à l'enseignement : le bilan d'apprentissage (également nommé « bilan de formation » ou « journal d'apprentissage ») visant, entre autres, à susciter chez l'enseignant•e en formation un processus autoévaluatif. Bien que ce genre de texte soit courant, ses différentes déclinaisons font rarement l'objet d'études. Ainsi une douzaine de textes produits par divers étudiant•es (avec ou sans expérience professionnelle, enseignant•e ou formateur•rice), dans plusieurs institutions de formation à l'enseignement et de Suisse romande sont analysés selon une approche discursive. L'analyse met en lumière différentes formes d'évolutions verbalisées par les formé•es, les postures énonciatives et les points de vue qu'ils ou elles adoptent ainsi que les types de segmentation temporelle relatées dans les textes. En montrant une variété de formes d'évolution et une diversité de manières de se mettre en scène et de se regarder, nos résultats révèlent les différentes compréhensions du terme "apprendre", quel que soit le contexte de formation et une tendance des enseignant•es à être plus descriptifs qu'analytiques. Les analyses montrent également les effets des temporalités choisies sur les engagements des enseignant•es en formation. Au final, les analyses questionnent certaines pratiques de formation en les rattachant à une problématique de littéracie universitaire.
Clinical Immunology, 2008
PubMed, Mar 1, 2008
Objective: A cross-sectional study of mixed connective tissue disease (MCTD) was performed to det... more Objective: A cross-sectional study of mixed connective tissue disease (MCTD) was performed to determine if there were identifiable differences in the clinical expression of MCTD associated with race or ethnicity. Methods: Miami, Florida, and Midwestern US (Missouri) Caucasian MCTD cohorts were studied. Clinical and laboratory features of the 2 MCTD cohorts were compared. A concurrently collected cohort of Sm-positive patients with systemic lupus erythematosus (SLE) was studied as a control. Disease activity and severity and functional status were measured. CD4+CD25(high)-expressing T-regulatory cells were enumerated and serum soluble L selectin was measured as biomarkers of disease activity. Results: The Miami and Missouri Caucasian MCTD groups, while differing from the SLE group, were largely similar; however, gastroesophageal reflux, sclerodactyly, and malar rash were significantly more frequent in the Missouri MCTD group and alopecia was more frequent in the Miami MCTD group. Significant clinical and laboratory differences were found between the Miami MCTD and Miami SLE groups despite similar disease duration, activity, severity and functional status. Raynaud's phenomenon (RP), hand swelling, synovitis, myositis, and sclerodactyly were all significantly more common in RNP-positive MCTD versus Sm-positive SLE subjects. CONCLUSION Ethnic differences were observed in the frequency of end-organ involvement in the Miami MCTD versus the Missouri Caucasian MCTD groups. Clinical and laboratory features of all MCTD groups were clearly different from the SLE group, despite similar disease activity, disease severity, and functional status. Disease activity measures appeared to behave similarly as valid measures of disease activity in SLE and MCTD.
Clinical Immunology, Jul 1, 2008
Mixed Connective Tissue Disease (MCTD) was first described 35 years ago by Gordon C. Sharp and hi... more Mixed Connective Tissue Disease (MCTD) was first described 35 years ago by Gordon C. Sharp and his colleagues. In the ensuing decades, a clearer understanding of the clinical and serologic features of MCTD has emerged. Classification criteria now exist to define MCTD for study purposes, the long-term outcome of the disease has been established, and novel genetic associations within the major histocompatibility complex on chromosome 6 and select regions on chromosome 3 have been identified. Studies on immune pathogenesis have made substantial progress in advancing our understanding of MCTD. In MCTD, there is a complex interaction of the innate and adaptive immune system that culminates in autoimmune disease. Antigenic structural modification occurring during apoptosis or other modifications of self antigens leads to an autoantigen driven immune process with innate immune activation, immunoglobulin G autoantibody production directed against select components of the spliceosome, B lymphocyte activation, and CD4 and CD8 T lymphocyte participation. Published by Elsevier Inc.
ACS Applied Materials & Interfaces, Apr 25, 2019
Utilizing polymers in cardiac tissue engineering holds promise for restoring function to the hear... more Utilizing polymers in cardiac tissue engineering holds promise for restoring function to the heart following myocardial infarction (MI), which is associated with grave morbidity and mortality. To properly mimic native cardiac tissue, materials must not only support cardiac cell growth but also have inherent conductive properties. Here, we present an injectable reverse thermal gel (RTG)-based cardiac cell scaffold system that is both biocompatible and conductive. Following synthesis of a highly-functionalizable, biomimetic RTG backbone, gold nanoparticles (AuNPs) were chemically conjugated to the backbone to enhance the system's conductivity. The resulting RTG-AuNPs hydrogel supported targeted survival of neonatal rat ventricular myocytes (NRVMs) for up to 21 days when co-cultured with cardiac fibroblasts, leading to an increase in Cx43 relative to control cultures (NRVMs cultured on traditional gelatincoated dishes and RTG hydrogel without AuNPs). This biomimetic and conductive RTG-AuNPs hydrogel holds promise for future cardiac tissue engineering applications. Introduction. Post-myocardial infarction (MI) cardiomyocyte loss triggers matrix degradation and fibrosis that drives the progression to heart failure (HF) 1-3. HF leads to a poor quality of life and an increased risk of mortality 4. Heart transplantation remains the gold standard treatment for those with end-stage HF, but availability of donor hearts is a major limitation 5-7. Due to the limited supply of donor hearts and the limited regenerative ability of the myocardium, there is an urgent need for novel treatment approaches following MI. Investigators have focused on the development of biomaterials aimed at supporting the infarct site and overall restoring cardiac function 8-12. Injectable hydrogels provide a particularly attractive approach for MI treatment due to their potential to be delivered in a minimally invasive manner, thus minimizing mechanical stress on
The FASEB Journal, Apr 1, 2019
Clinical Immunology, 2006
El estudio de las medidas de posición es muy importante dentro del desarrollo de la Estadística B... more El estudio de las medidas de posición es muy importante dentro del desarrollo de la Estadística Básica; el estudio de la medida de posición tiene que ver con el estudio de Cuartiles, Percentiles y Situaciones de conflicto cognitivo para las diversas aplicaciones prácticas en la resolución de problemas o situaciones didácticas que se presenta al estudiante durante el desarrollo de la clase y este resolución se realiza haciendo uso como material didáctico el emulador Casio fx-570LA-X Classwiz, pero, no es la única herramienta en que se puede utilizar; algunos autores presentan el tema de distintas formas, donde también utilizan herramientas estadísticas como el SPSS y otros. En el presente libro desarrollamos en la estadística básica de Cuartiles y Percentiles haciéndola más sencilla, amena creando y despertando el interés de los estudiantes que llevan la asignatura Estadística aplicada a la investigación en la universidad. El libro termina presentando ejercicios adicionales de situac...
En el proceso de enseñanza-aprendizaje de la Estadística Básica, en primer lugar, se parte del es... more En el proceso de enseñanza-aprendizaje de la Estadística Básica, en primer lugar, se parte del estudio de la Media aritmética, apoyándose con el emulador Casio fx-570LA-X Classwiz, algunos autores presentan el tema otras herramientas estadísticas, como el SPSS, Minitab, etc. En el presente libro desarrollamos los contenidos de Media, Mediana y Moda utilizando en todo momento el emulador Casio fx-570LA-X Classwiz, que les hace muy didáctico abordar cada tema, haciéndola más sencilla, amena, divertida y les crea mucho interés en los temas de estadística que lo abordan en el sílabo de la asignatura. Los contenidos presentados se les hace muy familiar. Los ejemplos y ejercicios desarrollados en clase son situaciones de la vida real y casos motivadores. El libro culmina presentando como ejercicio algunas situaciones de la vida cotidiana.
Sensors, 2021
Although it is estimated that more than one million Americans have celiac disease (CD), it remain... more Although it is estimated that more than one million Americans have celiac disease (CD), it remains challenging to diagnose. CD, an autoimmune and inflammatory response following the ingestion of gluten-containing foods, has symptoms overlapping with other diseases and requires invasive diagnostics. The gold standard for CD diagnosis involves serologic blood tests followed by invasive confirmatory biopsies. Here, we propose a less invasive method using an electrochemical DNA (E-DNA) biosensor for CD-specific autoantibodies (AABs) circulating in blood. In our approach, CD-specific AABs bind a synthetic neoepitope, causing a conformational change in the biosensor, as well as a change in the environment of an attached redox reporter, producing a measurable current reduction. We assessed the biosensor’s ability to detect CD-specific patient-derived AABs in physiological buffer as well as buffer supplemented with bovine serum. Our biosensor was able to detect AABs in a dose-dependent mann...
Recherches en didactique des langues et des cultures, 2020
Recherches en didactique des langues et des cultures Les cahiers de l'Acedle 17-2 | 2020 Recherch... more Recherches en didactique des langues et des cultures Les cahiers de l'Acedle 17-2 | 2020 Recherches collaboratives en didactique des langues Le stage en enseignant du point de vue de sa didactique : réflexions autour de la constitution du champ disciplinaire en Argentine Las prácticas de enseñanza desde su didáctica : reflexiones en torno a la constitución del campo disciplinar en Argentina
Antimicrobial Agents and Chemotherapy, 2019
We reported the complete nucleotide sequence of a tet (X4)-carrying plasmid, pSTB20-1T, from a ti... more We reported the complete nucleotide sequence of a tet (X4)-carrying plasmid, pSTB20-1T, from a tigecycline-resistant Escherichia coli isolate in China. Sequence analysis indicated that pSTB20-1T contains a hybrid plasmid backbone and a tet (X4)-containing multidrug resistance region, likely originated through recombination of multiple plasmids. tet (X4) was flanked by two IS CR2 , which may be responsible for tet (X4) mobilization.
Iberoforum Revista De Ciencias Sociales De La Universidad Iberoamericana, 2014
Voces y Contextos context), and its ethics based on the principles based in the actions of the so... more Voces y Contextos context), and its ethics based on the principles based in the actions of the social majority.
The Journal of Rheumatology, Mar 1, 2002
Alegatos, 2010
Este trabajo es un abordaje inicial a la temática de la comparación jurídica desde una perspectiv... more Este trabajo es un abordaje inicial a la temática de la comparación jurídica desde una perspectiva que no suele realizarse; sin embargo, no está planteado en ramas del derecho como la laboral, fiscal, penal, etcétera. ALEGATOS 74 final corrección.indd 131 03/06/2010 10:08:05 a.m. Sección Doctrina 132 alegatos, núm. 74, México, enero/abril de 2010 2 N. E. En este periodo podemos ubicar a las escuelas de Pavía y Bolonia, a los Humanistas, a la escuela del Derecho natural y a la escuela histórica. Entre los pensadores que realizaron trabajos comparativos tenemos a Grocio, Comte, Montesquieu, Vico y Leibniz. Aunque fue en Alemania, hacia el siglo xix, donde realmente sobresale la primera y rigurosa formulación del derecho comparado con Pablo Anselmo de Feuerbach. Cf. Mario Sarfatti, Introducción al estudio del derecho comparado, trad.
Comunicar La Ciencia En El Siglo Xxi I Congreso Sobre Comunicacion Social De La Ciencia 25 26 Y 27 De Marzo De 1999 Granada Espana Vol 2 2000 Isbn 84 930639 2 4 Pags 519 522, 2000
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Papers by Marcos Paulo Silva Maldonado