Gynecologic and Obstetric Investigation, Dec 24, 2009
Background: To analyze the therapeutic results of recombinant interleukin-2 (rIL-2) left in the c... more Background: To analyze the therapeutic results of recombinant interleukin-2 (rIL-2) left in the cysts after transvaginal ultrasound (US)-guided drainage of endometriomas as an alternative to surgery. Methods: Prospective and randomized clinical trial. A total of 25 consecutive patients were included. Two transvaginal US-guided punctures were performed, and 3 million IU of rIL-2 were left in the aspirated cysts once (group I) or both (group II) times according to randomization. Main Outcome Measures: Clinical results, prevented surgeries, and recurrences. Results: Results were moderate or good in only 16% of subjects at 3 months and in 33% of subjects at 6 months after treatment in group I; these numbers were 66 and 33%, respectively, in group II. Differences were not statistically significant. However, the evolution of symptoms, endometriomas, and CA-125 revealed the low efficacy of rIL-2 left intracyst as well as a poor control of the clinical manifestations. After 1 year, 20% (group I) and 73% (group II) of patients had to be operated; after 2 years, these numbers were 55 and 82%, respectively. Conclusions: Treatment of endometriomas with transvaginal US-guided drainage and rIL-2 left in the cysts, without using endometrial suppressive therapy with GnRH analogues as done in previous studies, has low efficacy. Recurrences are even more frequent after the use of two rIL-2 doses.
We usually read publications communicating exceptional cases [1], new malformations not previousl... more We usually read publications communicating exceptional cases [1], new malformations not previously described and/or which are out of any classification, or even new classifications supposedly not described before [2]. Actually most of the times it is just a wrong interpretation of the anomaly, sometimes due to an incomplete research on it [3,4]. And nevertheless, we still keep on looking for the reference tool or gold standard for the diagnosis of malformations [5,6] trying to relegate others such as the hysterosalpingography, which should hold certain significance [7].
Journal of Obstetrics and Gynaecology, Aug 5, 2014
angle 30 ° ). Th e mean of the bilateral PI values was used for evaluation. Doppler measurement... more angle 30 ° ). Th e mean of the bilateral PI values was used for evaluation. Doppler measurements were performed before and aft er UAE (median 3 days, range 2 – 8) by one of two examiners (GH, HH). Uterine size was assessed before, and at 3 and 6 months aft er UAE with MRI using a 1.5 T unit (Magnetom Vision Plus, Siemens, Germany) (Dorenberg et al. 2005). Th e Mann – Whitney U test and Spearman ’ s rank correlation coeffi cient were used for statistical calculations; p 0.05 was considered signifi cant.
Female genital tract malformations are known to be a frequent cause of reproductive problems. Bes... more Female genital tract malformations are known to be a frequent cause of reproductive problems. Besides, complex malformations also frequently generate serious gynaecological problems, often ones with inappropriate surgical solutions, as the gynecologist does not think of the malformation as either the cause of the symptoms or of its embryonic origin. Apart from analyzing the embryological bases in the development of the female genital and urinary tract, it is presented the update of the clinical and embryological classification for malformations. Knowing the embryological origin of the female genitourinary malformations, the schematic drawing of the malformations and their related symptoms, will allow the gynaecologist to choose the best therapeutical approach for the patient. Therefore, a discussion on ethiopathogenical deductions and therapeutical management of malformations is also done with clinical recommendations for the general gynaecologist.
Female genital tract malformations are frequently a cause of reproductive problems. Besides, comp... more Female genital tract malformations are frequently a cause of reproductive problems. Besides, complex malformations also frequently generate serious gynecological problems, often ones with inappropriate surgical solutions, as the gynecologist does not think of the malformation as either the cause of the symptoms or of its embryonary origin. Apart from analyzing the embryological bases in the development of the female genital tract and insisting on the well known müllerian origin of the uterus, the ratification of the embryological hypothesis about the origin of the human vagina from the Wolff ducts and the Müller tubercle allows us to not only advance in knowledge but to use that knowledge for better clinical management of the problems generated by the complex malformations of the female genital tract. In this review we study the methods and means for the diagnosis of female genital-urinary malformations, their classification and clinical findings, and especially those cases involving unilateral renal agenesis, vaginal ectopic ureter and other complex malformations. We also analyze the related obstetric and gynecologic pathology, and especially that cases of complex genital malformations. We review the related literature and some interesting case reports, as well as our experimental studies in rats. After reasserting our hypothesis about the embryology of the human vagina as derived from the Wolff ducts and the Müller tubercle, we suggest different recommendations for a better approach and management of the malformations of the female genital tract according to the findings observed in different diagnostic procedures.
Ultrasound in Obstetrics & Gynecology, Sep 1, 2017
using HDlive. The four images for each uterus were combined in a single image, and the 100 combin... more using HDlive. The four images for each uterus were combined in a single image, and the 100 combined images (one for each uterus) were anonymised and submitted to 15 experts (5 clinicians, 5 surgeons and 5 sonologists). These experts were asked to judge the image quality of each imaging technique using an 11-point numeric scale (0-10), providing only one vote for each imaging technique. Results were summarised as median and interquartile range (IQR), and comparison across groups performed with Friedman test. Results: Considering the opinion of all fifteen experts, only MP was considered as providing significantly worse imaging quality: MP=7(6-9), VCI=8(8-10), Omniview=8(8-9), and HDlive=9(8-10); p=0.002. Considering only the five clinicians the results were: MP=7(5-9.5), VCI=8(7.5-9.5), Omniview=8(7.5-9.5), and HDlive=8(8-9.5; p=0.39). Considering only the five surgeons, the results were: MP=7(5-9.5), VCI=8(7.5-9.5), Omniview=8(7.5-9.5), and HDlive=8(8-9.5). Considering only the five sonologists, the results were: MP=7(6-8.5), VCI=8(7.5-10), Omniview=9(8.5-9.5), and HDlive=10(9-10). Conclusions: Experts showed a preference for rendered imaging techniques when assessing the coronal plane of the uterus. P26.10 Normal/arcuate vs septate uterus: agreement among experts' subjective impression evaluating the coronal plane of the uterus on 3D ultrasound
Background: To study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levo... more Background: To study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levonorgestrelreleasing intrauterine device (LNG-IUD, Mirena®) in the treatment of endometriosis. Methods: Prospective, randomized clinical trial. Setting: University Hospital (single center). Elegibility criteria: Endometriomas >3×4 cm, CA-125>35 U/mL and endometriosis symptoms. Patients: Thirty-one women randomized to anastrozole+Mirena®+Conservative Surgery(CS) (n=8), anastrozole+Mirena®+transvaginal ultrasound-guided puncture-aspiration (TUGPA) (n=7), Mirena®+CS (n=9), or Mirena®+TUGPA (n=7). Interventions: Anastrozole 1 mg/day and/or only Mirena® for 6 months; CS (ovarian and fertility-sparing) or TUGPA of endometriomas one month after starting medical treatment. Main Outcome Measures: Visual analogic scale for symptoms, CA-125 levels, ultrasound ndings of endometriomas and recurrences. Results: A signi cant improvement in symptoms during the treatment (difference of 43%, 95% CI 29.9-56.2) occurred, which was maintained at 1 and 2 years. It was more signi cant in patients treated with anastrozole (51%, 95% CI 33.3-68.7). For CA-125, the most signi cant decrease was observed without anastrozole (73.8%, 95% CI 64.2-83.4 vs. 53.8%, 95% CI 25.7-81.6 under Mirena®+anastrozole). After CS for endometriosis, a reduction of ndings of endometriomas and long-term recurrences occurred, with or without anastrozole. At 4,2±1,7 years (95% CI 3,57-4,85), 88% of the patients who underwent CS were asymptomatic, without medication or reoperation, compared to only 21% if TUGPA was performed, with or without anastrozole (p=0.019). Conclusions: Dosing anastrozole for 6 months, starting one month before CS of endometriosis, reduces more signi cantly the painful symptoms and delays recurrences, but has no other signi cant advantages over the single insertion of LNG-IUD (Mirena®) during the same time.
An observational, retrospective study was completed to compare the results of the PACIENA clinica... more An observational, retrospective study was completed to compare the results of the PACIENA clinical trial (using the modified McIndoe technique) with a historical control group of nine patients who were operated on at San Juan University Hospital (1992-2015) using the classic technique. The PACIENA clinical trial included seven patients with vaginal agenesis who were operated on at two reference sites (May 2017-May 2018) using a neovaginal polylactic acid (PLA) prosthesis (PACIENA ® prosthesis) and avoiding the use of a skin graft. The results illustrate a reduction in the length of surgery, 86.43 ± 4.75 min in the group with no skin graft compared to 155.56 ± 28.44 in the control group (p < 0.05); and reduction in the length of hospitalization time. Differences were also registered in the length of the neovagina, the average being 8.93 ± 1.42 cm for cases and 6.56 ± 1.13 cm for controls, with no differences in neovaginal epithelialization times or in the satisfaction of sexual relations occurring between groups. The modification of the classical McIndoe technique using the neovaginal PACIENA ® prosthesis appears to be successful, obtaining good clinical results with shorter surgery and hospitalization times.
Ultrasound in Obstetrics & Gynecology, Sep 30, 2019
Objectives: To summarise the current evidence regarding definitions, diagnosis, prevalence, clini... more Objectives: To summarise the current evidence regarding definitions, diagnosis, prevalence, clinical implications and impact of surgery for t-shaped uterus not related to Diethystilbestrol (DES) exposure. Methods: We searched PubMed, Scopus and EMBASE on Jul-2018. Additionally, we have hand-searched reference list from included studies. We included all studies presenting any data regarding t-shaped uterus not related to DES exposure. Results: Our searches retrieved a total of 2,351 records and we included 28 studies in this systematic review. The general quality of the studies was poor, and there was no universally accepted definition for t-shaped uterus. The prevalence of t-shaped uterus varied from 0.2-10% in the included studies. Regarding etiology of non-DES t-shaped uterus, there was mention to tuberculosis (2 studies), adenomyosis (1 study); Asherman syndrome (1 study). Studies evaluating clinical relevance have associated this condition with worse reproductive outcomes: miscarriage and infertility (8 studies), preterm delivery (4 studies), ectopic pregnancy and recurrent implantation failure (2 studies). From the studies that analysed benefits of surgical treatment by hysteroscopic metroplasty (9 studies), there was mention to improvement on pregnancy and live birth rates (6 and 4 studies), and with a reduction in the risk of preterm delivery and miscarriage (5 and 4 studies). Conclusions: The quality of the evidence regarding the ethicology, prevalence, clinical relevance, and impact of surgery on reproductive outcomes in women with t-shaped uterus is very low. This is very likely to be related to a lack of a widely accepted definition and/or measurable criteria for distinguishing between t-shaped and normal/arcuate uterus.
Ultrasound in Obstetrics & Gynecology, Sep 1, 2017
Poster discussion hub abstracts female offspring of PCOS women already show higher androgen level... more Poster discussion hub abstracts female offspring of PCOS women already show higher androgen levels compared to the female offspring of non-PCOS women. Methods: Androgen levels were determined in maternal serum and umbilical cord blood from PCOS and non-PCOS women and the respective offspring at the Medical University of Graz, Austria, between 2012 and 2015. Results: A total of 79 PCOS and 354 non-PCOS women were recruited. The main results are shown in table 1. Conclusions: The comparison revealed that androgen levels in female offspring of PCOS and non-PCOS women do not differ although maternal hormone levels differ significantly.
Ultrasound in Obstetrics & Gynecology, Sep 1, 2017
Results: From the 3155 volume datasets included in this study, two-hundred and ninety-four cases ... more Results: From the 3155 volume datasets included in this study, two-hundred and ninety-four cases presented with CUA. 95.21% volume datasets were declared by both operators as interpretable. The intraobserver agreement was 0.88 and the interobserver agreement was 0.89 (95% CI:, 0.72, 0.93), representing very good agreement. Conclusions: The subjective assessment of 3D transvaginal US findings (also called the pattern recognition) is an excellent method for discriminating between a normal and an abnormal shaped uterus. These results may support incorporating this tool in routine gynecological scanning. EP27.07 Normal/arcuate vs septate uterus: diagnostic test accuracy and best cutoff values for currently used measurements
Ultrasound in Obstetrics & Gynecology, Sep 30, 2019
Poster discussion Hub abstracts weight tended to be lower in newborns with atypical compared to t... more Poster discussion Hub abstracts weight tended to be lower in newborns with atypical compared to typical neurodevelopment (2940g, IQR 2495-3375 vs 3177g, IQR 3010-3465, p = 0.063), while median Davey Severity Scale score tended to show higher values in those with atypical compared to typical neurodevelopment (4, IQR 4-5 vs 4, IQR 3-4, p = 0.073). Conclusions: Although there were no statistically significant prenatal predictors of poor neurodevelopment, our results show a trend towards an association between atypical neurodevelopment and lower head circumference to abdominal circumference ratio, lower birth weight and more severe cardiac defect. A larger cohort will be necessary to validate these findings. P02.10 Long-term follow up of cardiac defects defined by fetal ultrasound: a longitudinal study
Gynecologic and Obstetric Investigation, Dec 24, 2009
Background: To analyze the therapeutic results of recombinant interleukin-2 (rIL-2) left in the c... more Background: To analyze the therapeutic results of recombinant interleukin-2 (rIL-2) left in the cysts after transvaginal ultrasound (US)-guided drainage of endometriomas as an alternative to surgery. Methods: Prospective and randomized clinical trial. A total of 25 consecutive patients were included. Two transvaginal US-guided punctures were performed, and 3 million IU of rIL-2 were left in the aspirated cysts once (group I) or both (group II) times according to randomization. Main Outcome Measures: Clinical results, prevented surgeries, and recurrences. Results: Results were moderate or good in only 16% of subjects at 3 months and in 33% of subjects at 6 months after treatment in group I; these numbers were 66 and 33%, respectively, in group II. Differences were not statistically significant. However, the evolution of symptoms, endometriomas, and CA-125 revealed the low efficacy of rIL-2 left intracyst as well as a poor control of the clinical manifestations. After 1 year, 20% (group I) and 73% (group II) of patients had to be operated; after 2 years, these numbers were 55 and 82%, respectively. Conclusions: Treatment of endometriomas with transvaginal US-guided drainage and rIL-2 left in the cysts, without using endometrial suppressive therapy with GnRH analogues as done in previous studies, has low efficacy. Recurrences are even more frequent after the use of two rIL-2 doses.
We usually read publications communicating exceptional cases [1], new malformations not previousl... more We usually read publications communicating exceptional cases [1], new malformations not previously described and/or which are out of any classification, or even new classifications supposedly not described before [2]. Actually most of the times it is just a wrong interpretation of the anomaly, sometimes due to an incomplete research on it [3,4]. And nevertheless, we still keep on looking for the reference tool or gold standard for the diagnosis of malformations [5,6] trying to relegate others such as the hysterosalpingography, which should hold certain significance [7].
Journal of Obstetrics and Gynaecology, Aug 5, 2014
angle 30 ° ). Th e mean of the bilateral PI values was used for evaluation. Doppler measurement... more angle 30 ° ). Th e mean of the bilateral PI values was used for evaluation. Doppler measurements were performed before and aft er UAE (median 3 days, range 2 – 8) by one of two examiners (GH, HH). Uterine size was assessed before, and at 3 and 6 months aft er UAE with MRI using a 1.5 T unit (Magnetom Vision Plus, Siemens, Germany) (Dorenberg et al. 2005). Th e Mann – Whitney U test and Spearman ’ s rank correlation coeffi cient were used for statistical calculations; p 0.05 was considered signifi cant.
Female genital tract malformations are known to be a frequent cause of reproductive problems. Bes... more Female genital tract malformations are known to be a frequent cause of reproductive problems. Besides, complex malformations also frequently generate serious gynaecological problems, often ones with inappropriate surgical solutions, as the gynecologist does not think of the malformation as either the cause of the symptoms or of its embryonic origin. Apart from analyzing the embryological bases in the development of the female genital and urinary tract, it is presented the update of the clinical and embryological classification for malformations. Knowing the embryological origin of the female genitourinary malformations, the schematic drawing of the malformations and their related symptoms, will allow the gynaecologist to choose the best therapeutical approach for the patient. Therefore, a discussion on ethiopathogenical deductions and therapeutical management of malformations is also done with clinical recommendations for the general gynaecologist.
Female genital tract malformations are frequently a cause of reproductive problems. Besides, comp... more Female genital tract malformations are frequently a cause of reproductive problems. Besides, complex malformations also frequently generate serious gynecological problems, often ones with inappropriate surgical solutions, as the gynecologist does not think of the malformation as either the cause of the symptoms or of its embryonary origin. Apart from analyzing the embryological bases in the development of the female genital tract and insisting on the well known müllerian origin of the uterus, the ratification of the embryological hypothesis about the origin of the human vagina from the Wolff ducts and the Müller tubercle allows us to not only advance in knowledge but to use that knowledge for better clinical management of the problems generated by the complex malformations of the female genital tract. In this review we study the methods and means for the diagnosis of female genital-urinary malformations, their classification and clinical findings, and especially those cases involving unilateral renal agenesis, vaginal ectopic ureter and other complex malformations. We also analyze the related obstetric and gynecologic pathology, and especially that cases of complex genital malformations. We review the related literature and some interesting case reports, as well as our experimental studies in rats. After reasserting our hypothesis about the embryology of the human vagina as derived from the Wolff ducts and the Müller tubercle, we suggest different recommendations for a better approach and management of the malformations of the female genital tract according to the findings observed in different diagnostic procedures.
Ultrasound in Obstetrics & Gynecology, Sep 1, 2017
using HDlive. The four images for each uterus were combined in a single image, and the 100 combin... more using HDlive. The four images for each uterus were combined in a single image, and the 100 combined images (one for each uterus) were anonymised and submitted to 15 experts (5 clinicians, 5 surgeons and 5 sonologists). These experts were asked to judge the image quality of each imaging technique using an 11-point numeric scale (0-10), providing only one vote for each imaging technique. Results were summarised as median and interquartile range (IQR), and comparison across groups performed with Friedman test. Results: Considering the opinion of all fifteen experts, only MP was considered as providing significantly worse imaging quality: MP=7(6-9), VCI=8(8-10), Omniview=8(8-9), and HDlive=9(8-10); p=0.002. Considering only the five clinicians the results were: MP=7(5-9.5), VCI=8(7.5-9.5), Omniview=8(7.5-9.5), and HDlive=8(8-9.5; p=0.39). Considering only the five surgeons, the results were: MP=7(5-9.5), VCI=8(7.5-9.5), Omniview=8(7.5-9.5), and HDlive=8(8-9.5). Considering only the five sonologists, the results were: MP=7(6-8.5), VCI=8(7.5-10), Omniview=9(8.5-9.5), and HDlive=10(9-10). Conclusions: Experts showed a preference for rendered imaging techniques when assessing the coronal plane of the uterus. P26.10 Normal/arcuate vs septate uterus: agreement among experts' subjective impression evaluating the coronal plane of the uterus on 3D ultrasound
Background: To study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levo... more Background: To study the effectiveness of an aromatase inhibitor (Anastrozole) associated to levonorgestrelreleasing intrauterine device (LNG-IUD, Mirena®) in the treatment of endometriosis. Methods: Prospective, randomized clinical trial. Setting: University Hospital (single center). Elegibility criteria: Endometriomas >3×4 cm, CA-125>35 U/mL and endometriosis symptoms. Patients: Thirty-one women randomized to anastrozole+Mirena®+Conservative Surgery(CS) (n=8), anastrozole+Mirena®+transvaginal ultrasound-guided puncture-aspiration (TUGPA) (n=7), Mirena®+CS (n=9), or Mirena®+TUGPA (n=7). Interventions: Anastrozole 1 mg/day and/or only Mirena® for 6 months; CS (ovarian and fertility-sparing) or TUGPA of endometriomas one month after starting medical treatment. Main Outcome Measures: Visual analogic scale for symptoms, CA-125 levels, ultrasound ndings of endometriomas and recurrences. Results: A signi cant improvement in symptoms during the treatment (difference of 43%, 95% CI 29.9-56.2) occurred, which was maintained at 1 and 2 years. It was more signi cant in patients treated with anastrozole (51%, 95% CI 33.3-68.7). For CA-125, the most signi cant decrease was observed without anastrozole (73.8%, 95% CI 64.2-83.4 vs. 53.8%, 95% CI 25.7-81.6 under Mirena®+anastrozole). After CS for endometriosis, a reduction of ndings of endometriomas and long-term recurrences occurred, with or without anastrozole. At 4,2±1,7 years (95% CI 3,57-4,85), 88% of the patients who underwent CS were asymptomatic, without medication or reoperation, compared to only 21% if TUGPA was performed, with or without anastrozole (p=0.019). Conclusions: Dosing anastrozole for 6 months, starting one month before CS of endometriosis, reduces more signi cantly the painful symptoms and delays recurrences, but has no other signi cant advantages over the single insertion of LNG-IUD (Mirena®) during the same time.
An observational, retrospective study was completed to compare the results of the PACIENA clinica... more An observational, retrospective study was completed to compare the results of the PACIENA clinical trial (using the modified McIndoe technique) with a historical control group of nine patients who were operated on at San Juan University Hospital (1992-2015) using the classic technique. The PACIENA clinical trial included seven patients with vaginal agenesis who were operated on at two reference sites (May 2017-May 2018) using a neovaginal polylactic acid (PLA) prosthesis (PACIENA ® prosthesis) and avoiding the use of a skin graft. The results illustrate a reduction in the length of surgery, 86.43 ± 4.75 min in the group with no skin graft compared to 155.56 ± 28.44 in the control group (p < 0.05); and reduction in the length of hospitalization time. Differences were also registered in the length of the neovagina, the average being 8.93 ± 1.42 cm for cases and 6.56 ± 1.13 cm for controls, with no differences in neovaginal epithelialization times or in the satisfaction of sexual relations occurring between groups. The modification of the classical McIndoe technique using the neovaginal PACIENA ® prosthesis appears to be successful, obtaining good clinical results with shorter surgery and hospitalization times.
Ultrasound in Obstetrics & Gynecology, Sep 30, 2019
Objectives: To summarise the current evidence regarding definitions, diagnosis, prevalence, clini... more Objectives: To summarise the current evidence regarding definitions, diagnosis, prevalence, clinical implications and impact of surgery for t-shaped uterus not related to Diethystilbestrol (DES) exposure. Methods: We searched PubMed, Scopus and EMBASE on Jul-2018. Additionally, we have hand-searched reference list from included studies. We included all studies presenting any data regarding t-shaped uterus not related to DES exposure. Results: Our searches retrieved a total of 2,351 records and we included 28 studies in this systematic review. The general quality of the studies was poor, and there was no universally accepted definition for t-shaped uterus. The prevalence of t-shaped uterus varied from 0.2-10% in the included studies. Regarding etiology of non-DES t-shaped uterus, there was mention to tuberculosis (2 studies), adenomyosis (1 study); Asherman syndrome (1 study). Studies evaluating clinical relevance have associated this condition with worse reproductive outcomes: miscarriage and infertility (8 studies), preterm delivery (4 studies), ectopic pregnancy and recurrent implantation failure (2 studies). From the studies that analysed benefits of surgical treatment by hysteroscopic metroplasty (9 studies), there was mention to improvement on pregnancy and live birth rates (6 and 4 studies), and with a reduction in the risk of preterm delivery and miscarriage (5 and 4 studies). Conclusions: The quality of the evidence regarding the ethicology, prevalence, clinical relevance, and impact of surgery on reproductive outcomes in women with t-shaped uterus is very low. This is very likely to be related to a lack of a widely accepted definition and/or measurable criteria for distinguishing between t-shaped and normal/arcuate uterus.
Ultrasound in Obstetrics & Gynecology, Sep 1, 2017
Poster discussion hub abstracts female offspring of PCOS women already show higher androgen level... more Poster discussion hub abstracts female offspring of PCOS women already show higher androgen levels compared to the female offspring of non-PCOS women. Methods: Androgen levels were determined in maternal serum and umbilical cord blood from PCOS and non-PCOS women and the respective offspring at the Medical University of Graz, Austria, between 2012 and 2015. Results: A total of 79 PCOS and 354 non-PCOS women were recruited. The main results are shown in table 1. Conclusions: The comparison revealed that androgen levels in female offspring of PCOS and non-PCOS women do not differ although maternal hormone levels differ significantly.
Ultrasound in Obstetrics & Gynecology, Sep 1, 2017
Results: From the 3155 volume datasets included in this study, two-hundred and ninety-four cases ... more Results: From the 3155 volume datasets included in this study, two-hundred and ninety-four cases presented with CUA. 95.21% volume datasets were declared by both operators as interpretable. The intraobserver agreement was 0.88 and the interobserver agreement was 0.89 (95% CI:, 0.72, 0.93), representing very good agreement. Conclusions: The subjective assessment of 3D transvaginal US findings (also called the pattern recognition) is an excellent method for discriminating between a normal and an abnormal shaped uterus. These results may support incorporating this tool in routine gynecological scanning. EP27.07 Normal/arcuate vs septate uterus: diagnostic test accuracy and best cutoff values for currently used measurements
Ultrasound in Obstetrics & Gynecology, Sep 30, 2019
Poster discussion Hub abstracts weight tended to be lower in newborns with atypical compared to t... more Poster discussion Hub abstracts weight tended to be lower in newborns with atypical compared to typical neurodevelopment (2940g, IQR 2495-3375 vs 3177g, IQR 3010-3465, p = 0.063), while median Davey Severity Scale score tended to show higher values in those with atypical compared to typical neurodevelopment (4, IQR 4-5 vs 4, IQR 3-4, p = 0.073). Conclusions: Although there were no statistically significant prenatal predictors of poor neurodevelopment, our results show a trend towards an association between atypical neurodevelopment and lower head circumference to abdominal circumference ratio, lower birth weight and more severe cardiac defect. A larger cohort will be necessary to validate these findings. P02.10 Long-term follow up of cardiac defects defined by fetal ultrasound: a longitudinal study
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