Papers by MUSHREF ALGARNI
Journal of applied hematology, 2024
Journal of Taibah University Medical Sciences, Dec 31, 2022
Diagnostics, Jan 17, 2024
Value in Health, 2014
A541 and events attributed to OIC including the negative impact on job-related activities. Method... more A541 and events attributed to OIC including the negative impact on job-related activities. Methods: A prospective longitudinal study conducted in the United States (US), Canada (CN), UK (UK), and Germany (GE) of patients with OIC who have been on opioid therapy for at least four weeks was conducted. OIC related medical history and health care resource use was collected from participants self report. The number of hours missed from work and the extent to which the work productivity and regular daily activities were affected was collected using the WPAI-SHP. Results: A total of 489 eligible participants (US: 238; CN: 38;, GE: 115; UK: 98). Back pain (77%) and joint pain (52%) were the most common pain diagnosis with an average duration of chronic pain and opioid medication use of 10 and 6 years respectively. 27% of participants were currently employed. 18% of participants used at least one prescription laxative; 70% reported using at least one over-the-counter (OTC) laxative with the most common being stimulant laxatives (20%), osmotic laxatives (15%) and stool softeners (7%). 63% of participants reported discussing OIC with a health care provider, 3.0% reported a visit to the emergency room and 2.0% reported being admitted to a hospital because of their OIC during a 6-month time period. 9% of employed participants reported missing an average of 4.6 hours per week because of problems associated with constipation and 32% reported impairment while working due to constipation. ConClusions: The cumulative impact of OTC use, physician office visits and the negative impact on work-related activities for OIC may be substantial.
Journal of Evolution of Medical and Dental Sciences, Aug 24, 2020
BACKGROUND Acute cholecystitis is a potentially serious condition and usually needs to be treated... more BACKGROUND Acute cholecystitis is a potentially serious condition and usually needs to be treated in the hospital. Identification of a common bile duct (CBD) stone before cholecystectomy is of concern for the treating physicians as management may change. Magnetic Resonance Cholangiopancreatography (MRCP) can help in identifying causes of biliary obstruction (if present) and adequately delineate biliary tree in selected patients with limited or abnormal ultrasounds and cholestatic liver pattern. Therefore, we aim to demonstrate imaging findings of MRCP in such patients of acute cholecystitis, and highlight the diagnostic ability of MRCP in biliary ductal evaluation as well. METHODS This secondary data analysis from hospital records was performed in Radiology department at our Hospital in Dhahran from August 2017 to 2019. All clinically suspected and ultrasound supported cases of acute cholecystitis who were referred for MRCP studies were included. Dilated CBDs (more than 4 mm in caliber) with partial visualization or non-discernible causes of CBD dilatations, rising or persistently raised LFTs (denoting cholestatic pattern) were the common indications for the MRCP referrals. Patients with chronic cholecystitis, previous hepatobiliary surgery, pregnant patients, and those contraindicated to MRI were excluded. RESULTS Of the 104 patients, majority (60%) were females. The mean age was 43 years. Twothirds of patients were having normal CBDs (68.3%), while nearly one-third (31.7%) had dilated CBDs, and half of these (16.4%) showed identifiable causes of obstruction that were later confirmed on ERCP and histopathology. Thirteen patients (12.5%) had associated anomalies. Sensitivity and specificity of MRCP in CBD evaluation were measured as 90.5% (CI, 79.3-96.8) and 86.2% (CI, 73.7-94.3) respectively. The length of the hospital stay was found to be significantly less in laparoscopic cases compared to open cholecystectomies (P= 0.0005). CONCLUSIONS Magnetic resonance cholangiopancreatography can help in identifying the causes and anomalies in patients with acute cholecystitis having deranged or obstructive liver function.
Value in Health, 2015
A305 only reviewed oncology orphans thereby resulting in inconsistent access. Alternative funding... more A305 only reviewed oncology orphans thereby resulting in inconsistent access. Alternative funding mechanisms sometimes provide a temporary reimbursement fix in the UK. Ex-factory pricing varied by country both at launch and over time. CONCLUSIONS: Significant differences exist between the number of orphan drug approvals and time to access in the US vs. EU. The US is notably faster than the EU5 and Germany is notably faster than other EU5 countries. For pricing, the US is not always the high price country. Furthermore, there appears to be an inverse relationship between size of the indicated patient population and reimbursed price.
Objectives: To highlight spectrum of findings on Magnetic Resonance Cholangiopancreatography (MRC... more Objectives: To highlight spectrum of findings on Magnetic Resonance Cholangiopancreatography (MRCP) in patients with acute cholecystitis. To determine length of hospital stay in operated cases. Method: This retrospective observational study was conducted in Radiology department at our hospital in Dhahran, from August 2016-2018. All patients who presented with acute cholecystitis, obstructive liver pattern or deranged liver tests, and underwent MRCP (on a 1.5 Tesla scanner) were evaluated. Patients with chronic cholecystitis, previous hepatobiliary surgery, pregnant patients and those contraindicated to MRI were excluded. Patterns of MRCP findings were categorized as: (i) acute cholecystitis with normal CBD, (ii) acute cholecystitis with dilated CBD and cause identifiable, (iii) acute cholecystitis with dilated CBD and cause not identifiable. Any associated biliary ductal variants or anomalies (e.g., pancreas divisum, choledochal cyst, low insertion of CBD) were also documented. Oper...
SAGE Open Medical Case Reports, 2021
Lymphoma is the seventh most common type of malignancy in both males and females. It may develop ... more Lymphoma is the seventh most common type of malignancy in both males and females. It may develop in any location where lymphomatous tissue exists. Although extranodal presentation in the lower limb and pelvis are uncommon, it could present with diverse manifestations. We report an unusual case of primary extranodal large B-cell lymphoma of the ankle joint initially presumed to be a chronic osteomyelitis. This case report discusses the impact of imaging studies on decision-making and highlights the need to consider malignancy in chronic infections.
Journal of Evolution of Medical and Dental Sciences
BACKGROUND Acute cholecystitis is a potentially serious condition and usually needs to be treated... more BACKGROUND Acute cholecystitis is a potentially serious condition and usually needs to be treated in the hospital. Identification of a common bile duct (CBD) stone before cholecystectomy is of concern for the treating physicians as management may change. Magnetic Resonance Cholangiopancreatography (MRCP) can help in identifying causes of biliary obstruction (if present) and adequately delineate biliary tree in selected patients with limited or abnormal ultrasounds and cholestatic liver pattern. Therefore, we aim to demonstrate imaging findings of MRCP in such patients of acute cholecystitis, and highlight the diagnostic ability of MRCP in biliary ductal evaluation as well. METHODS This secondary data analysis from hospital records was performed in Radiology department at our Hospital in Dhahran from August 2017 to 2019. All clinically suspected and ultrasound supported cases of acute cholecystitis who were referred for MRCP studies were included. Dilated CBDs (more than 4 mm in caliber) with partial visualization or non-discernible causes of CBD dilatations, rising or persistently raised LFTs (denoting cholestatic pattern) were the common indications for the MRCP referrals. Patients with chronic cholecystitis, previous hepatobiliary surgery, pregnant patients, and those contraindicated to MRI were excluded. RESULTS Of the 104 patients, majority (60%) were females. The mean age was 43 years. Twothirds of patients were having normal CBDs (68.3%), while nearly one-third (31.7%) had dilated CBDs, and half of these (16.4%) showed identifiable causes of obstruction that were later confirmed on ERCP and histopathology. Thirteen patients (12.5%) had associated anomalies. Sensitivity and specificity of MRCP in CBD evaluation were measured as 90.5% (CI, 79.3-96.8) and 86.2% (CI, 73.7-94.3) respectively. The length of the hospital stay was found to be significantly less in laparoscopic cases compared to open cholecystectomies (P= 0.0005). CONCLUSIONS Magnetic resonance cholangiopancreatography can help in identifying the causes and anomalies in patients with acute cholecystitis having deranged or obstructive liver function.
Biomedical Journal of Scientific and Technical Research, 2018
London health sciences center is a frequent user of Lu-177 Dotatate for the treatment of neuroend... more London health sciences center is a frequent user of Lu-177 Dotatate for the treatment of neuroendocrine disease. We began using this radionuclide therapy as an in-patient procedure, where patients were released at 20 hours’ post therapy administration with minimal restrictions. Over the course of 2013, we worked to transform this therapy into an outpatient procedure, where patients were released at 4-6 hours’ post therapy administration with major restrictions. The previous methods and data we presented in December 17, 2013 were based on dose rates derived from cumulated doses measured over approximately 16 hours, and an assumption of Lu-177 clearance based on radioactive decay only. Since 2013, our hospital has gained more experience with Lu-177 Dotatate, enabling us to develop a better understanding of dosimetry. We describe new dose measurements, a new model we developed to describe our observations, and a revised schedule of patient release and restriction duration. Compared aga...
Novel Approaches in Cancer Study, Feb 23, 2018
London health sciences center is a frequent user of Lu-177 Dotatate for the treatment of neuroend... more London health sciences center is a frequent user of Lu-177 Dotatate for the treatment of neuroendocrine disease. We began using this radionuclide therapy as an in-patient procedure, where patients were released at 20 hours' post therapy administration with minimal restrictions. Over the course of 2013, we worked to transform this therapy into an outpatient procedure, where patients were released at 4-6 hours' post therapy administration with major restrictions. The previous methods and data we presented in December 17, 2013 [1] were based on dose rates derived from cumulated doses measured over approximately 16 hours, and an assumption of Lu-177 clearance based on radioactive decay only. Since 2013, our hospital has gained more experience with Lu-177 Dotatate, enabling us to develop a better understanding of dosimetry. We describe new dose measurements, a new model we developed to describe our observations, and a revised schedule of patient release and restriction duration. Compared against previous measurements from 2013, our new measurements are of instantaneous (not cumulative) dose rates, and we now consider Lu-177 clearance to proceed both by physical decay and biologic excretion. Our new proposed model combines our experimental results with results from literature. The model will state the dose rate from time of discharge can be modeled as a decaying double exponential function.
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Papers by MUSHREF ALGARNI