Papers by Lutvo Sporisevic
Paediatria Croatica, 2019
Medicinski arhiv, 1999
In retrospective study we analyzed 19 patients who were diagnosed and cured because of leukemia a... more In retrospective study we analyzed 19 patients who were diagnosed and cured because of leukemia at Pediatric clinic in Sarajevo during last two years. From that number, 15 children (78.9%) were with acute lymphoblastic leukemia (ALL), 3 (15.7%) were with acute myeloic leukemia (AML) and 1 was with chronic myeloic leukemia. Among all pediatric malignancies percent of leukemias was 40.4%. Most of children with leukemia from Canton of Zenica-Doboj (42.1%) and then from Canton of Sarajevo (31.5%). Illness began mostly in winter months (36.5%), than in early spring (26.3%), and in autumn (26.3%), but there were no newly diagnosed in summer (July and August). More children with leukemia were from rural areas (57.8%), than from urban areas (42.2%).
International Journal of Pediatrics, Apr 1, 2018
Background Preterm born children are at an increased risk for having cognitive and motor impairme... more Background Preterm born children are at an increased risk for having cognitive and motor impairments at preschool age. In addition to this, children born preterm have a number of deficits in executive functioning. Although there are numerous studies examining executive functions (EF) in preterm born children, few used ecologically valid measures of EF. The goal of the present study was to examine EF in preschool children born preterm. Materials and Methods The sample for this study consisted of 40 preschool children aged 5-6 years old born preterm, both sexes (21 boys, 19 girls). EFs were measured with Behavior Rating Inventory of Executive Function-Preschool Version, an ecologically valid instrument for EF assessment. Results The results of this study revealed that the greatest EF deficits were in the area of emotional control and working memory. There were no gender differences in EF except for the domain of emotional control, with boys having larger deficits. Conclusion Given the high rate of EF deficits in preschool children born preterm, it is of utmost importance to provide them with adequate therapeutic modalities early in preschool period. Pediatricians, psychologists and early education specialists should work together in identifying the potential EF problems in preterm born preschool children and in making the programs for ameliorating EF deficits.
Archives of Disease in Childhood
ABSTRACT
BACKGROUND: Nonallergic rhinitis involves chronic sneezing or having a congested, drippy nose wit... more BACKGROUND: Nonallergic rhinitis involves chronic sneezing or having a congested, drippy nose with no apparent cause. Rhinitis is defined as inflammation of the membranes lining the nose, characterized by nasal symptoms, including itching, rhinorrhea, and nasal congestion. AIMS: Alternative hypothesis work is the fact that there were significant, are evident difference between allergic rhinitis and nonallergic rhinitis in children. METHODS: A blood test made measures of children immune system's response to common allergens by measuring the amount of certain antibodies in bloodstream, known as immunoglobulin E (IgE) antibodies for establishing right diagnosis and cause of rhinitis. RESULTS: Authors reported a 19% frequency of nonallergic rhinitis among 1019 children selected for having a history that suggested allergic rhinitis. We determined that nonallergic rhinitis with eosinophilia syndrome (NARES) was found in 13%, blood eosinophilia nonallergic rhinitis syndrome (BENARS) in...
Early Human Development
BACKGROUND: Necrotizing enterocolitis (NEC) is a medical condition primarily seen in premature in... more BACKGROUND: Necrotizing enterocolitis (NEC) is a medical condition primarily seen in premature infants, where portions of the bowel undergo necrosis. In infants with suspected NEC, normal serial CRP values would favor aborted antibiotic therapy and early resumption of feedings. Several strategies for the prevention of NEC have been proposed including delaying of the initiation of feeding, minimal enteral feeding regimens, dietary supplements including egg phospholipid, lactobacillus, oligofructose, and the administration of immunoglobulin G-immunoglobulin. AIMS: Necrotizing enterocolitis is the most common gastrointestinal emergency in newborn premature infants. METHODS: Eleven Bosnian and Herzegovian Cantons centers prospectively evaluated 188 neonates with birth weight of 600 to 1200 g between 2007 and 2008. Birth weight was divided into six categories by 100-g increments. The diagnosis of NEC is usually confirmed by the presence of an abnormal gas pattern as seen on an X-ray. RES...
Evidence-Based Child Health A Cochrane Review Journal
INTRODUCTION: Children involved in sports should be encouraged to participate in a variety of dif... more INTRODUCTION: Children involved in sports should be encouraged to participate in a variety of different activities and develop a wide range of skills. The growing sports participation rate of children and the large number of pediatric primary , secondary and tertiary care visits for sport-related injuries become every day practice. PURPOSE: This study demonstrates the usefulness of injury surveillance in identifying potential prevention strategies METHODS: The eight sports with more then ten injuries in the three years of our surveillance were analyzed ( basketball, handball, voleyball, biking, football, skating, skying and atheltics) in children of age seven to fourteen years. A longitudinal cohort study was performed to determine the effect of risk factors for children in sports during last three years 2007 to 2010 of Canton Sarajevo. RESULTS: Sports are the leading injury-related cause for pediatric primary care visits. Participation of greater numbers of urban youth in organized...
Evidence-Based Child Health A Cochrane Review Journal
INTRODUCTION: Lyme borreliosis progresses through different stages, in manner similar to that for... more INTRODUCTION: Lyme borreliosis progresses through different stages, in manner similar to that for syphilis. The laboratory diagnosis of Lyme borreliosis is based essentially on the detection of Borrelia specific antibodies. PURPOSE: There have been numerous efforts to improve the sensitivity and specificity of serological tests by employing purified, recombinant antigens which are immunodominant and specific for Borrelia burgdorferi. METHODS AND MATERIALS: An 19 year old female with severe clinical symptoms a flu-like illness with fever, chills, diarrhea, and arthralgia. The typical cardinal symptom , erythema chronicum migrans was mild without typical clinical findings. RESULTS: The results of several studies in which workers used restriction endonycleose analyses , partial sequensing of rRNA , the polymerase chain reaction , plasmid profiles, Western blotting (immunoblotting), reactivity with monoclonal antibodies (MAbs), and ultrastructural characteristics have suggested that Bor...
Evidence-Based Child Health A Cochrane Review Journal
BACKGROUND Ulcerative colitis is idiopathic inflammatory bowel disorder. While there is no cure c... more BACKGROUND Ulcerative colitis is idiopathic inflammatory bowel disorder. While there is no cure currently available, ulcerative colitis can usually be controlled with home treatment and medication. Ulcerative colitis is a disease characterized by remitting and relapsing inflammation of the large intestine in children. PURPOSE: The aim of this study was to investigate the clinical polymorphisms and distribution of diseases in a small cohort of Bosnian ulcerative colitis kids patients. METHODS: Ulcerative colitis is diagnosed by a complete medical history and physical examination along with medical tests. A colonoscopy or sigmoidoscopy are the most accurate methods for making a diagnosis of ulcerative colitis and ruling-out other possible conditions. MATERIALS: Routine generally screening for blood stools and pathologic biopsy made for all suspected children. The pediatrics division maintains several databases that prospectively abstract information from medical records of children wi...
Evidence-Based Child Health A Cochrane Review Journal
Introduction : Nutrition habits are formed in early children period and usually persist until the... more Introduction : Nutrition habits are formed in early children period and usually persist until the adult age. Unhealthy nutrition leads to a thickness that may make hypertension, hyperlipoproteinemia, glucose intolerance, which is associated with cardiovascular risk. Purpose: To evaluate distribution of weight and nutrition habits of preschool children. Material : In the cross-sectional study is included 265 children (136 boys-51, 3% and 129 girls- 48, 7%), average age 4+/- 7, 3 years, range of 3 to 5 years. Methods: We measured the subjects’ body weight (kg) and body height (cm), and determined the body mass index (kg/m2), that we compared with the CDC Growth Charts. By use of questionnaires we estimated weekly frequency of consumption of foods which we compared with the U.S. Dietary Guidelines for Children. Results : Obesity have 15 (5, 6%) children, increased body weight have 29 (10, 9%) children. Proper eating habits have 114 (43, 1%) children, while 151 (56, 9%) children have 0,...
Early Human Development
BACKGROUND: A rare inherited metabolic disorder where an enzyme deficiency , succinic semialdehyd... more BACKGROUND: A rare inherited metabolic disorder where an enzyme deficiency , succinic semialdehyde dehydrogenase, prevents the normal metabolism of gamma-aminobutyric acid. SSADH deficiency causes neurological disorders attributable to the accumulation of γ-hydroxybutyrate (GHB) in the brain. To date, there is no effective treatment for SSADH deficiency. AIMS: SSADH deficiency in the differential diagnosis of children with idiopathic mental retardation and emphasize the need for accurate, quantitative organic acid analysis in such patients and high risk mothers. METHODS: Increased gamma-hydroxybutyric acid in newborns urine, blood and cerebrospinal fluid . Other GABA metabolites can also be identified in urine such as glycine. Prenatal diagnosis was performed in high risk families pregnancies as SSADH enzyme assay in chorionic villus and amniocytes, 4-hydroxybutyric acid acumulation, reverse-transcription-polymerase chain reaction (RT-PCR) and genomic DNA amplification. RESULTS : Si...
ABSTRACT R37 Book of Abstract page 45
Clinical and Translational Allergy, 2015
Clinical and Translational Allergy, 2011
Clinical and Translational Allergy, 2011
Clinical Biochemistry, 2014
Background: Childhood obesity and the metabolic syndrome (MetS) are associated with an increased ... more Background: Childhood obesity and the metabolic syndrome (MetS) are associated with an increased risk for early onset endothelial dysfunction and atherosclerosis. Placental growth factor (PlGF), a member of the vascular endothelial growth factor family, plays an important role in atherosclerosis by stimulating angiogenesis and atherogenic migration of monocytes/macrophages into the arterial wall. We have previously shown increased high-sensitivity troponin (hs-TnT) concentrations in children with MetS from the same cohort. The aim of the study was to investigate differences in circulating PlGF concentrations between children with obesity/metabolic syndrome and non-obese children. Materials and methods: Fifty-seven obese (49 without and 8 with MetS) and 25 non-obese children (controls) were assessed at the Childhood Obesity Clinic of our department. Obesity was defined using the IOTF criteria. MetS was defined based on the IDF criteria. PlGF was measured using an electrochemiluminescence based assay. Results: Mean PIGF concentrations of obese children were significantly higher (p = 0.048) compared with those of the controls. Analysis over the three groups, the obese (without MetS), the MetS and the control, demonstrated a significant difference in PlGF concentrations (p = 0.035). Subgroup analysis revealed increased PlGF concentrations in children with the MetS compared to the controls (p = 0.009). Troponin had a significant positive correlation with PlGF overall (p = 0.003) and in the obese group (p = 0.04). Conclusions: Increased serum concentrations of PlGF, a biomarker of angiogenesis, are found in obese children with the MetS compared to non-obese controls, whereas PlGF correlated positively with troponin. Longitudinal studies may reveal the prognostic role of this biomarker in the progression of atherosclerosis in obese children with the MetS.
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Papers by Lutvo Sporisevic