Papers by Luis Miguel Mendez Sanchez
Journal of Vascular Surgery, 1998
To develop an ex vivo human carotid artery stenting model that can be used for the quantitative a... more To develop an ex vivo human carotid artery stenting model that can be used for the quantitative analysis of risk for embolization associated with balloon angioplasty and stenting and to correlate this risk with lesion characteristics to define lesions suitable for balloon angioplasty and stenting. Methods: Specimens of carotid plaque (n = 24) were obtained circumferentially intact from patients undergoing standard carotid endarterectomy. Carotid lesions were prospectively characterized on the basis of angiographic and duplex findings before endarterectomy and clinical findings. Specimens were encased in a polytetrafluoroethylene wrap and mounted in a flow chamber that allowed access for endovascular procedures and observations. Balloon angioplasty and stenting were performed under fluoroscopic guidance with either a Palmaz stent or a Wallstent endoprosthesis. Ex vivo angiograms were obtained before and after intervention. Effluent from each specimen was filtered for released embolic particles, which were microscopically examined, counted, and correlated with various plaque characteristics by means of multivariate analysis. Results: Balloon angioplasty and stenting produced embolic particles that consisted of atherosclerotic debris, organized thrombus, and calcified material. The number of embolic particles detected after balloon angioplasty and stenting was not related to preoperative symptoms, sex, plaque ulceration or calcification, or artery size. However, echolucent plaques generated a higher number of particles compared with echogenic plaques (p < 0.01). In addition, increased lesion stenosis also significantly correlated with the total number of particles produced by balloon angioplasty and stenting (r = 0.55). Multivariate analysis revealed that these two characteristics were independent risk factors. Conclusions: Echolucent plaques and plaques with stenosis ≥90% produced a higher number of embolic particles and therefore may be less suitable for balloon angioplasty and stenting. This ex vivo model can be used to identify high-risk lesions for balloon angioplasty and stenting and can aid in the evaluation of new devices being considered for carotid balloon angioplasty and stenting.
2014 IEEE Conference on Computational Intelligence and Games, 2014
This paper presents a mechanism to generate virtual buildings considering designer constraints an... more This paper presents a mechanism to generate virtual buildings considering designer constraints and guidelines. This mechanism is implemented as a pipeline of different Variable Neighborhood Search (VNS) optimization processes in which several subproblems are tackled (1) rooms locations, (2) connectivity graph, and (3) element placement. The core VNS algorithm includes some variants to improve its performance, such as, for example constraint handling and biased operator selection. The optimization process uses a toolkit of construction primitives implemented as "smart objects" providing basic elements such as rooms, doors, staircases and other connectors. The paper also shows experimental results of the application of different designer constraints to a wide range of buildings from small houses to a large castle with several underground levels. I.
Journal of Vascular Surgery, 1990
In patients with aortoiliac occlusive disease interruption of critical coRaterals during another ... more In patients with aortoiliac occlusive disease interruption of critical coRaterals during another nonvasoalar or cardiac operation may threaten limb viability. This occurred in four patients whose limb-threatening ischemia was precipitated by radical cystectomy with bilateral hypogastric artery ligation, left colon resection, or coronary artery revascularizations by means of the internal mammary artery. Important collateral pathways, the interruption of which may account for this phenomenon, are detailed, and approaches are outlined for prevention and management of acute ischemia in this setting. (J VASC SURG 1990;12:645-53.)
Abstract. In recent times there has been an interest in developing automatic techniques to create... more Abstract. In recent times there has been an interest in developing automatic techniques to create and/or populate knowledge bases (KB) and ontologies. One initiative along this line is the Knowledge Base Population (KBP) track of the Text Analysis Conference (TAC), which offers a framework for the evaluation of automatic systems designed to populate ontologies using information found in unstructured text. In KBP, the knowledge base population process has been divided into two complementary tasks: entity linking, whose goal is to detect ...
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Papers by Luis Miguel Mendez Sanchez