A change in hamstring strength and activation is typically seen after injuries or invasive surger... more A change in hamstring strength and activation is typically seen after injuries or invasive surgeries such as anterior cruciate reconstruction or total knee replacement. While many studies have investigated the influence of isometric increases in hamstring load on knee joint kinematics, few have quantified the change in kinematics due to a variation in medial to lateral hamstring force ratio. This study examined the changes in knee joint kinematics on eight cadaveric knees during an open-chain deep knee bend for six different loading configurations: five loaded hamstring configurations that varied the ratio of a total load of 175 N between the semimembranosus and biceps femoris and one with no loads on the hamstring. The anterior-posterior translation of the medial and lateral femoral condyles' lowest points along proximal-distal axis of the tibia, the axial rotation of the tibia, and the quadriceps load were measured at each flexion angle. Unloading the hamstring shifted the medial and lateral lowest points posteriorly and increased tibial internal rotation. The influence of unloading hamstrings on quadriceps load was small in early flexion and increased with knee flexion. The loading configuration with the highest lateral hamstrings force resulted in the most posterior translation of the medial lowest point, most anterior translation of the lateral lowest point, and the highest tibial external rotation of the five loading configurations. As the medial hamstring force ratio increased, the medial lowest point shifted anteriorly, the lateral lowest point shifted posteriorly, and the tibia rotated more internally. The results of this study, demonstrate that variation in mediallateral hamstrings force and force ratio influence tibiofemoral transverse kinematics and quadriceps loads required to extend the knee.
Ankle sprains are a common injury that may need reconstruction and extensive physical therapy. Th... more Ankle sprains are a common injury that may need reconstruction and extensive physical therapy. The purpose of this study was to provide a description of the biomechanics of the ankle joint complex (AJC) after anterior talofibular (ATFL) and calcaneofibular (CFL) ligament rupture to better understand severe ankle injuries. The envelope of motion of ten cadaveric ankles was examined by manual manipulations that served as training data for a radial basis function used to interpolate ankle mobility at flexion angles under load and torque combinations. Moreover, ankle kinematics were examined, while tendons were loaded to identify how their performance is altered by ligament rupture. The increased force required to plantarflex the ankle following ligament rupture was measured by calculating the load through the Achilles. Following ATFL injury, the largest changes were internal rotation (5 deg) in deep plantarflexion and anterior translation (1.5 mm) in early plantarflexion. The combined ...
Quantifying the mechanical environment at the knee is crucial for developing successful rehabilit... more Quantifying the mechanical environment at the knee is crucial for developing successful rehabilitation and surgical protocols. Computational models have been developed to complement in vitro studies, but are typically created to represent healthy conditions, and may not be useful in modeling pathology and repair. Thus, the objective of this study was to create finite element (FE) models of the natural knee, including specimen-specific tibiofemoral (TF) and patellofemoral (PF) soft tissue structures, and to evaluate joint mechanics in intact and ACL-deficient conditions. Simulated gait in a whole joint knee simulator was performed on two cadaveric specimens in an intact state and subsequently repeated following ACL resection. Simulated gait was performed using motor-actuated quadriceps, and loads at the hip and ankle. Specimen-specific FE models of these experiments were developed in both intact and ACL-deficient states. Model simulations compared kinematics and loading of the experi...
As a first step towards reproducing desired three-dimensional joint loading and motion on a dynam... more As a first step towards reproducing desired three-dimensional joint loading and motion on a dynamic knee simulator, the goal of this study was to develop and verify a three-dimensional computational model that generated control profiles for the simulator using desired knee loading and motion as model inputs. The developed model was verified by predicting tibio-femoral loading on an instrumented analog knee for given actuator forces and the ability to generate simulator control profiles was demonstrated using a three-dimensional walking profile. The model predicted axial tibia loading for a sagittal-plane dual-limb squat within 1% of measured peak loading. Adding out-of-sagittal-plane forces decreased the accuracy of load prediction. The model generated control profiles to the simulator that produced axial tibia loading within 16% of desired for walking. Discrepancies in predicted and measured quadriceps forces influenced the accuracy of the generated control profiles. Future work will replace the analog knee in both the model and machine with a prosthetic knee.
The measurement of relative motion between two moving bones is commonly accomplished for in vitro... more The measurement of relative motion between two moving bones is commonly accomplished for in vitro studies by attaching to each bone a series of either passive or active markers in a fixed orientation to create a rigid body (RB). This work determined the accuracy of motion between two RBs using an Optotrak optical motion capture system with active infrared LEDs. The stationary noise in the system was quantified by recording the apparent change in position with the RBs stationary and found to be 0.04 degrees and 0.03 mm. Incremental 10 degrees rotations and 10-mm translations were made using a more precise tool than the Optotrak. Increasing camera distance decreased the precision or increased the range of values observed for a set motion and increased the error in rotation or bias between the measured and actual rotation. The relative positions of the RBs with respect to the camera-viewing plane had a minimal effect on the kinematics and, therefore, for a given distance in the volume less than or close to the precalibrated camera distance, any motion was similarly reliable. For a typical operating set-up, a 10 degrees rotation showed a bias of 0.05 degrees and a 95% repeatability limit of 0.67 degrees. A 10-mm translation showed a bias of 0.03 mm and a 95% repeatability limit of 0.29 mm. To achieve a high level of accuracy it is important to keep the distance between the cameras and the markers near the distance the cameras are focused to during calibration.
Healthy patellofemoral (PF) joint mechanics are critical to optimal function of the knee joint. P... more Healthy patellofemoral (PF) joint mechanics are critical to optimal function of the knee joint. Patellar maltracking may lead to large joint reaction loads and high stresses on the articular cartilage, increasing the risk of cartilage wear and the onset of osteoarthritis. While the mechanical sources of PF joint dysfunction are not well understood, links have been established between PF tracking and abnormal kinematics of the tibiofemoral (TF) joint, specifically following cruciate ligament injury and repair. The objective of this study was to create a validated finite element (FE) representation of the PF joint in order to predict PF kinematics and quadriceps force across healthy and pathological specimens. Measurements from a series of dynamic in-vitro cadaveric experiments were used to develop finite element models of the knee for three specimens. Specimens were loaded under intact, ACL-resected and both ACL and PCL-resected conditions. Finite element models of each specimen were constructed and calibrated to the outputs of the intact knee condition, and subsequently used to predict PF kinematics, contact mechanics, quadriceps force, patellar tendon moment arm and patellar tendon angle of the cruciate resected conditions. Model results for the intact and cruciate resected trials successfully matched experimental kinematics (avg. RMSE 4.0°, 3.1mm) and peak quadriceps forces (avg. difference 5.6%). Cruciate resections demonstrated either increased patellar tendon loads or increased joint reaction forces. The current study advances the standard for evaluation of PF mechanics through direct validation of cruciate-resected conditions including specimen-specific representations of PF anatomy.
Small variability associated with identifying and locating anatomical landmarks on the knee has t... more Small variability associated with identifying and locating anatomical landmarks on the knee has the potential to affect the joint coordinate systems and reported kinematic descriptions. The objectives of this study were to develop an approach to quantify the effect of landmark location variability on both tibiofemoral and patellofemoral kinematics and to identify the critical landmarks and associated degrees of freedom that most affected the kinematic measures. The commonly used three-cylindric open-chain kinematic description utilized measured rigid body kinematics from a cadaveric specimen during simulated gait. A probabilistic analysis was performed with 11 anatomical landmarks to predict the variability in each kinematic. The model predicted the absolute kinematic bounds and offset kinematic bounds, emphasizing profile shape, for each kinematic over the gait cycle, as well as the range of motion. Standard deviations of up to 2 mm were assumed for the anatomical landmark locations and resulted in significant variability in clinically relevant absolute kinematic parameters of up to 6.5 degrees and 4.4 mm for tibiofemoral and 7.6 degrees and 6.5 mm for patellofemoral kinematics. The location of the femoral epicondylar prominences had the greatest effect on both the tibiofemoral and patellofemoral kinematic descriptions. A quantitative understanding of the potential changes in kinematic description caused by anatomical landmark variability is important not only to the accuracy of kinematic gait studies and the evaluation of total knee arthroplasty implant performance, but also may impact component placement decision-making in computer-assisted surgery.
ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, 2013
ABSTRACT Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Associat... more ABSTRACT Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
In vitro testing of the human knee provides valuable insight that contributes to further understa... more In vitro testing of the human knee provides valuable insight that contributes to further understanding knee biomechanics. Cadaveric testing correlates well with clinical trials because the tissue has similar properties to that of live subjects. In addition, in vitro testing allows studies to be performed that would otherwise be unethical to evaluate in vivo. Due to their many advantages, cadaveric testing has been utilized to evaluate many of medical devices and surgical techniques that have been developed in recent decades. This article aims to review the current technologies and methodologies utilized in experimental in vitro testing of the human knee. The article provides a summary of the different rigs and machines that are currently used to examine the biomechanics of the knee. It also highlights the variable experimental techniques and measurement systems that are used to collect the kinematics and kinetics of the knee joint. As technologies advance so do the measurement syste...
The measurement of relative motion between two moving bones is commonly accomplished for in vitro... more The measurement of relative motion between two moving bones is commonly accomplished for in vitro studies by attaching to each bone a series of either passive or active markers in a fixed orientation to create a rigid body (RB). This work determined the accuracy of motion between two RBs using an Optotrak optical motion capture system with active infrared LEDs.
ASME 2010 Summer Bioengineering Conference, Parts A and B, 2010
Ground liquefaction during earthquakes can produce a significant amount of lateral ground displac... more Ground liquefaction during earthquakes can produce a significant amount of lateral ground displacement. For buried gas pipelines, deformation and strain are likely to be concentrated on the pipe bends. Closing and opening in-plane bending experiments were conducted for various kinds of pipe bends until the measured strain exceeded 25% using pipe specimens of a diameter from 100 to 300 mm. The deformation behavior was different between the closing mode and the opening one. In the closing mode, an ovalization was observed in the central cross section of the bend, and internal pressure was maintained in all experiments. On the other hand, unique behavior was observed in the opening mode. When the pipe diameter was 300 mm (Do/t=43), local buckling was observed at the center of the bend. However, when Do/t was less than 32 (200 mm in diameter), the flexural rigidity of the bend became much higher than that of a straight pipe, and buckling and rupture were observed in the straight pipe. Finite element analyses were carried out using linear shell elements, and the validity of the numerical modeling technique over 25% of plastic strain was confirmed.
A change in hamstring strength and activation is typically seen after injuries or invasive surger... more A change in hamstring strength and activation is typically seen after injuries or invasive surgeries such as anterior cruciate reconstruction or total knee replacement. While many studies have investigated the influence of isometric increases in hamstring load on knee joint kinematics, few have quantified the change in kinematics due to a variation in medial to lateral hamstring force ratio. This study examined the changes in knee joint kinematics on eight cadaveric knees during an open-chain deep knee bend for six different loading configurations: five loaded hamstring configurations that varied the ratio of a total load of 175 N between the semimembranosus and biceps femoris and one with no loads on the hamstring. The anterior-posterior translation of the medial and lateral femoral condyles' lowest points along proximal-distal axis of the tibia, the axial rotation of the tibia, and the quadriceps load were measured at each flexion angle. Unloading the hamstring shifted the medial and lateral lowest points posteriorly and increased tibial internal rotation. The influence of unloading hamstrings on quadriceps load was small in early flexion and increased with knee flexion. The loading configuration with the highest lateral hamstrings force resulted in the most posterior translation of the medial lowest point, most anterior translation of the lateral lowest point, and the highest tibial external rotation of the five loading configurations. As the medial hamstring force ratio increased, the medial lowest point shifted anteriorly, the lateral lowest point shifted posteriorly, and the tibia rotated more internally. The results of this study, demonstrate that variation in mediallateral hamstrings force and force ratio influence tibiofemoral transverse kinematics and quadriceps loads required to extend the knee.
Ankle sprains are a common injury that may need reconstruction and extensive physical therapy. Th... more Ankle sprains are a common injury that may need reconstruction and extensive physical therapy. The purpose of this study was to provide a description of the biomechanics of the ankle joint complex (AJC) after anterior talofibular (ATFL) and calcaneofibular (CFL) ligament rupture to better understand severe ankle injuries. The envelope of motion of ten cadaveric ankles was examined by manual manipulations that served as training data for a radial basis function used to interpolate ankle mobility at flexion angles under load and torque combinations. Moreover, ankle kinematics were examined, while tendons were loaded to identify how their performance is altered by ligament rupture. The increased force required to plantarflex the ankle following ligament rupture was measured by calculating the load through the Achilles. Following ATFL injury, the largest changes were internal rotation (5 deg) in deep plantarflexion and anterior translation (1.5 mm) in early plantarflexion. The combined ...
Quantifying the mechanical environment at the knee is crucial for developing successful rehabilit... more Quantifying the mechanical environment at the knee is crucial for developing successful rehabilitation and surgical protocols. Computational models have been developed to complement in vitro studies, but are typically created to represent healthy conditions, and may not be useful in modeling pathology and repair. Thus, the objective of this study was to create finite element (FE) models of the natural knee, including specimen-specific tibiofemoral (TF) and patellofemoral (PF) soft tissue structures, and to evaluate joint mechanics in intact and ACL-deficient conditions. Simulated gait in a whole joint knee simulator was performed on two cadaveric specimens in an intact state and subsequently repeated following ACL resection. Simulated gait was performed using motor-actuated quadriceps, and loads at the hip and ankle. Specimen-specific FE models of these experiments were developed in both intact and ACL-deficient states. Model simulations compared kinematics and loading of the experi...
As a first step towards reproducing desired three-dimensional joint loading and motion on a dynam... more As a first step towards reproducing desired three-dimensional joint loading and motion on a dynamic knee simulator, the goal of this study was to develop and verify a three-dimensional computational model that generated control profiles for the simulator using desired knee loading and motion as model inputs. The developed model was verified by predicting tibio-femoral loading on an instrumented analog knee for given actuator forces and the ability to generate simulator control profiles was demonstrated using a three-dimensional walking profile. The model predicted axial tibia loading for a sagittal-plane dual-limb squat within 1% of measured peak loading. Adding out-of-sagittal-plane forces decreased the accuracy of load prediction. The model generated control profiles to the simulator that produced axial tibia loading within 16% of desired for walking. Discrepancies in predicted and measured quadriceps forces influenced the accuracy of the generated control profiles. Future work will replace the analog knee in both the model and machine with a prosthetic knee.
The measurement of relative motion between two moving bones is commonly accomplished for in vitro... more The measurement of relative motion between two moving bones is commonly accomplished for in vitro studies by attaching to each bone a series of either passive or active markers in a fixed orientation to create a rigid body (RB). This work determined the accuracy of motion between two RBs using an Optotrak optical motion capture system with active infrared LEDs. The stationary noise in the system was quantified by recording the apparent change in position with the RBs stationary and found to be 0.04 degrees and 0.03 mm. Incremental 10 degrees rotations and 10-mm translations were made using a more precise tool than the Optotrak. Increasing camera distance decreased the precision or increased the range of values observed for a set motion and increased the error in rotation or bias between the measured and actual rotation. The relative positions of the RBs with respect to the camera-viewing plane had a minimal effect on the kinematics and, therefore, for a given distance in the volume less than or close to the precalibrated camera distance, any motion was similarly reliable. For a typical operating set-up, a 10 degrees rotation showed a bias of 0.05 degrees and a 95% repeatability limit of 0.67 degrees. A 10-mm translation showed a bias of 0.03 mm and a 95% repeatability limit of 0.29 mm. To achieve a high level of accuracy it is important to keep the distance between the cameras and the markers near the distance the cameras are focused to during calibration.
Healthy patellofemoral (PF) joint mechanics are critical to optimal function of the knee joint. P... more Healthy patellofemoral (PF) joint mechanics are critical to optimal function of the knee joint. Patellar maltracking may lead to large joint reaction loads and high stresses on the articular cartilage, increasing the risk of cartilage wear and the onset of osteoarthritis. While the mechanical sources of PF joint dysfunction are not well understood, links have been established between PF tracking and abnormal kinematics of the tibiofemoral (TF) joint, specifically following cruciate ligament injury and repair. The objective of this study was to create a validated finite element (FE) representation of the PF joint in order to predict PF kinematics and quadriceps force across healthy and pathological specimens. Measurements from a series of dynamic in-vitro cadaveric experiments were used to develop finite element models of the knee for three specimens. Specimens were loaded under intact, ACL-resected and both ACL and PCL-resected conditions. Finite element models of each specimen were constructed and calibrated to the outputs of the intact knee condition, and subsequently used to predict PF kinematics, contact mechanics, quadriceps force, patellar tendon moment arm and patellar tendon angle of the cruciate resected conditions. Model results for the intact and cruciate resected trials successfully matched experimental kinematics (avg. RMSE 4.0°, 3.1mm) and peak quadriceps forces (avg. difference 5.6%). Cruciate resections demonstrated either increased patellar tendon loads or increased joint reaction forces. The current study advances the standard for evaluation of PF mechanics through direct validation of cruciate-resected conditions including specimen-specific representations of PF anatomy.
Small variability associated with identifying and locating anatomical landmarks on the knee has t... more Small variability associated with identifying and locating anatomical landmarks on the knee has the potential to affect the joint coordinate systems and reported kinematic descriptions. The objectives of this study were to develop an approach to quantify the effect of landmark location variability on both tibiofemoral and patellofemoral kinematics and to identify the critical landmarks and associated degrees of freedom that most affected the kinematic measures. The commonly used three-cylindric open-chain kinematic description utilized measured rigid body kinematics from a cadaveric specimen during simulated gait. A probabilistic analysis was performed with 11 anatomical landmarks to predict the variability in each kinematic. The model predicted the absolute kinematic bounds and offset kinematic bounds, emphasizing profile shape, for each kinematic over the gait cycle, as well as the range of motion. Standard deviations of up to 2 mm were assumed for the anatomical landmark locations and resulted in significant variability in clinically relevant absolute kinematic parameters of up to 6.5 degrees and 4.4 mm for tibiofemoral and 7.6 degrees and 6.5 mm for patellofemoral kinematics. The location of the femoral epicondylar prominences had the greatest effect on both the tibiofemoral and patellofemoral kinematic descriptions. A quantitative understanding of the potential changes in kinematic description caused by anatomical landmark variability is important not only to the accuracy of kinematic gait studies and the evaluation of total knee arthroplasty implant performance, but also may impact component placement decision-making in computer-assisted surgery.
ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation, 2013
ABSTRACT Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Associat... more ABSTRACT Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
In vitro testing of the human knee provides valuable insight that contributes to further understa... more In vitro testing of the human knee provides valuable insight that contributes to further understanding knee biomechanics. Cadaveric testing correlates well with clinical trials because the tissue has similar properties to that of live subjects. In addition, in vitro testing allows studies to be performed that would otherwise be unethical to evaluate in vivo. Due to their many advantages, cadaveric testing has been utilized to evaluate many of medical devices and surgical techniques that have been developed in recent decades. This article aims to review the current technologies and methodologies utilized in experimental in vitro testing of the human knee. The article provides a summary of the different rigs and machines that are currently used to examine the biomechanics of the knee. It also highlights the variable experimental techniques and measurement systems that are used to collect the kinematics and kinetics of the knee joint. As technologies advance so do the measurement syste...
The measurement of relative motion between two moving bones is commonly accomplished for in vitro... more The measurement of relative motion between two moving bones is commonly accomplished for in vitro studies by attaching to each bone a series of either passive or active markers in a fixed orientation to create a rigid body (RB). This work determined the accuracy of motion between two RBs using an Optotrak optical motion capture system with active infrared LEDs.
ASME 2010 Summer Bioengineering Conference, Parts A and B, 2010
Ground liquefaction during earthquakes can produce a significant amount of lateral ground displac... more Ground liquefaction during earthquakes can produce a significant amount of lateral ground displacement. For buried gas pipelines, deformation and strain are likely to be concentrated on the pipe bends. Closing and opening in-plane bending experiments were conducted for various kinds of pipe bends until the measured strain exceeded 25% using pipe specimens of a diameter from 100 to 300 mm. The deformation behavior was different between the closing mode and the opening one. In the closing mode, an ovalization was observed in the central cross section of the bend, and internal pressure was maintained in all experiments. On the other hand, unique behavior was observed in the opening mode. When the pipe diameter was 300 mm (Do/t=43), local buckling was observed at the center of the bend. However, when Do/t was less than 32 (200 mm in diameter), the flexural rigidity of the bend became much higher than that of a straight pipe, and buckling and rupture were observed in the straight pipe. Finite element analyses were carried out using linear shell elements, and the validity of the numerical modeling technique over 25% of plastic strain was confirmed.
Uploads
Papers by Lorin Maletsky