Proceedings of the 2019 European Conference on Computing in Construction, 2019
Evaluating building performances, such as the indoor daylight, is usually based on numerical simu... more Evaluating building performances, such as the indoor daylight, is usually based on numerical simulation and 2D image illustration. It does not take advantage of emerging Augmented Reality (AR) or Mixed Reality (MR) techniques to intuitively aid the building design. The current study probes into the topic bringing building geometry information together with simulation results into AR/MR environments. After introducing some precedent work in the literature, authors recap the typical workflow and report its application on two case studies. The first case study displays the structural simulation of a high-rise building in AR, while the second case study shows the daylight simulation of a two-story house within MR. At last, reflections are conducted and future possibilities are identified. Authors deem that, in the aim of this study, only retrofitting projects are suitable for MR. The present work can help practitioners better understand this new approach, offering the added value of using AR/MR for building design.
Inflammatory bowel disease (IBD) is a group of immune-mediated disorders characterised by a chron... more Inflammatory bowel disease (IBD) is a group of immune-mediated disorders characterised by a chronic, relapsing-remitting inflammation predominantly affecting the gastrointestinal tract. IBD is incurable, affecting people in their most productive years. IBD is historically seen as a disease of Westernised nations although in recent times other countries have seen an exponential rise in cases. Although the exact pathogenesis remains unclear, evidence suggests that microbiota changes play a critical role in IBD pathogenesis. Over the past two decades, IBD has become one of the most studied human conditions linked to the gut microbiota. However, deciphering the intricate link between the gut microbiota and therapeutic efficacy remains elusive. This review will summarise the current evidence relating to the gut microbiota and its involvement in IBD pathogenesis as well as the impact of IBD treatments including pharmaceutical-, nutraceutical- and microbial-focused regimens on the gut micr...
2019 18th IEEE International Conference On Trust, Security And Privacy In Computing And Communications/13th IEEE International Conference On Big Data Science And Engineering (TrustCom/BigDataSE), 2019
Fingerprinting the malware by its behavioural signature has been an attractive approach for malwa... more Fingerprinting the malware by its behavioural signature has been an attractive approach for malware detection due to the homogeneity of dynamic execution patterns across different variants of similar families. Although previous researches show reasonably good performance in dynamic detection using machine learning techniques on a large corpus of training set, decisions must be undertaken based upon a scarce number of observable samples in many practical defence scenarios. This paper demonstrates the effectiveness of generative adversarial autoencoder for dynamic malware detection under outbreak situations where in most cases a single sample is available for training the machine learning algorithm to detect similar samples that are in the wild.
Mantle cell lymphoma (MCL) is an incurable, aggressive B cell malignancy. Ibrutinib, an oral irre... more Mantle cell lymphoma (MCL) is an incurable, aggressive B cell malignancy. Ibrutinib, an oral irreversible Bruton's tyrosine (BTK) inhibitor, was FDA-approved in 2013 for patients with relapsed/refractory MCL. In further support of BTK inhibition for the treatment of MCL, acalabrutinib, an irreversible second-generation BTK inhibitor, was recently approved by the FDA for previously treated MCL. Although BTK inhibition has resulted in remarkable MCL patient outcomes, primary resistance and acquired resistance to ibrutinib remains a challenging hurdle to the treatment of MCL patients. In this study, we aimed to discover alternative therapies to overcome resistance to ibrutinib for MCL patients. To identify therapies that will overcome resistance to BTK inhibition, we performed a combinational screen for ibrutinib with FDA-approved drugs and novel agents and found that combination treatment of ibrutinib with the polo-like kinase 1 (PLK1) inhibitors volasertib or GSK461364 achieved s...
Clinical cancer research : an official journal of the American Association for Cancer Research, Jan 17, 2018
B-cell lymphoma-2 (BCL-2), an anti-apoptotic protein often dysregulated in B-cell lymphomas, prom... more B-cell lymphoma-2 (BCL-2), an anti-apoptotic protein often dysregulated in B-cell lymphomas, promotes cell survival and provides protection from stress. A recent Phase I first-in-human study of the BCL-2 inhibitor venetoclax in non-Hodgkin lymphoma showed an overall response rate of 44%. These promising clinical results prompted our examination of the biological effects and mechanism of action underlying venetoclax activity in aggressive B-cell lymphoma, including mantle cell lymphoma (MCL) and diffuse large B cell lymphoma (DLBCL). MCL and DLBCL cell lines, primary patient samples, and patient-derived xenograft (PDX) models were utilized to examine venetoclax efficacy. Furthermore, the mechanisms underlying venetoclax response and the development of venetoclax resistance were evaluated using proteomics analysis and Western blotting. Potential biomarkers linked to venetoclax activity and targeted combination therapies that can augment venetoclax response were identified. We demonstr...
ABSTRACT Due to its ability to control the latent heat and the hysteresis (thermal or magnetic) a... more ABSTRACT Due to its ability to control the latent heat and the hysteresis (thermal or magnetic) at the first-order transition (FOT) without deteriorating the saturation magnetisation, boron substitution in MnFe(P,Si) materials has recently been reported to be an ideal parameter to reach promising magnetocaloric performances: DS � 10 Jkg�1 K�1 and cyclic DT of 2.6 K (and more) at a moderate magnetic field of DB = 1 T. Additionally, an interesting aspect for applications is the improvement of the mechanical stability in B doped materials compared to the pristine MnFe(P,Si) compounds. These improved mechanical properties were initially supported by naked-eye inspection and the observation of a constant DT during a few thousands of magnetic cycles. (Guillou et al., 2014) Here, the evolution upon cycling of MnFe(P,Si,B) materials is studied in a more quantitative and systematic manner. For that purpose transformation temperatures, electrical resistivity, micro-hardness and the microstructure are tracked as a function of the thermal cycling across the FOT for three prototypical compositions in the MnFe(P,Si,B) system. It turns out this set of data confirms the initial finding that B substitution has a positive effect on the mechanical stability. The origin of this improvement is discussed, in particular in respect to the lattice parameter discontinuities at the phase transition.
Mantle cell lymphoma (MCL) is a rare and incurable subtype of B-cell lymphoma. In a phase II stud... more Mantle cell lymphoma (MCL) is a rare and incurable subtype of B-cell lymphoma. In a phase II study of ibrutinib in MCL patients, most of the patients responded and had long durable remissions; however, 22.7% of patients were considered to be non-responsive to ibrutinib, and an additional 22/110 patients displayed initial positive responses to ibrutinib but also experienced disease progression within 12 months of treatment, with both responses classified as primary ibrutinib resistant. Therefore, understanding the mechanisms mediating primary ibrutinib resistance may identify new prognostic and predictive markers and potential therapeutic targets. Bruton's tyrosine kinase (BTK) plays an important role in B-cell development, activation, and differentiation. Upon B-cell receptor (BCR) activation, BTK is phosphorylated and activated by SYK. Phosphoinositide 3-kinase (PI3K) is recruited to the BCR, and the induction of these signaling activities leads to the downstream activation of ...
Mutations and epigenetic alterations are key events in transforming normal cells to cancer cells.... more Mutations and epigenetic alterations are key events in transforming normal cells to cancer cells. Mantle cell lymphoma (MCL), a non-Hodgkin's lymphoma of the B-cell, is an aggressive malignancy with poor prognosis especially for those patients who are resistant to the frontline drugs. There is a great need to describe the molecular basis and mechanism of drug resistance in MCL to develop new strategies for treatment. We reviewed frequent somatic mutations and mutations involving the B-cell pathways in MCL and discussed clinical trials that attempted to disrupt these gene pathways and/or epigenetic events. Recurrent gene mutations were discussed in the light of prognostic and therapeutic opportunity and also the challenges of targeting these lesions. Mutations in the ATM, CCND1, TP53, MLL2, TRAF2 and NOTCH1 were most frequently encountered in mantle cell lymphoma. Translational models should be built that would assess mutations longitudinally to identify important compensatory, prosurvival and anti-apoptic pathways and actionable genetic targets.
Ibrutinib is approved in the EU, USA, and other countries for patients with mantle cell lymphoma ... more Ibrutinib is approved in the EU, USA, and other countries for patients with mantle cell lymphoma who received one previous therapy. In a previous phase 2 study with single-agent ibrutinib, the proportion of patients who achieved an objective response was 68%; 38 (34%) of 111 patients had transient lymphocytosis. We hypothesised that adding rituximab could target mantle cell lymphoma cells associated with redistribution lymphocytosis, leading to more potent antitumour activity. Patients with a confirmed mantle cell lymphoma diagnosis (based on CD20-positive and cyclin D1-positive cells in tissue biopsy specimens), no upper limit on the number of previous treatments received, and an Eastern Cooperative Oncology Group performance status score of 2 or less were enrolled in this single-centre, open-label, phase 2 study. Patients received continuous oral ibrutinib (560 mg) daily until progessive disease or unacceptable toxic effects. Rituximab 375 mg/m(2) was given intravenously once per week for 4 weeks during cycle 1, then on day 1 of cycles 3-8, and thereafter once every other cycle up to 2 years. The primary endpoint was the proportion of patients who achieved an objective response in the intention-to-treat population and safety assessed in the as-treated population. The study is registered with ClinicalTrials.gov, number NCT01880567, and is still ongoing, but no longer accruing patients. Between July 15, 2013, and June 30, 2014, 50 patients were enrolled. Median age was 67 years (range 45-86), and the median number of previous regimens was three (range 1-9). At a median follow-up of 16·5 months (IQR 12·09-19·28), 44 (88%, 95% CI 75·7-95·5) patients achieved an objective response, with 22 (44%, 30·0-58·7) patients achieving a complete response, and 22 (44%, 30·0-58·7) a partial response. The only grade 3 adverse event in >=10% of patients was atrial fibrillation, which was noted in six (12%) patients. Grade 4 diarrhoea and neutropenia occurred in one patient each. Adverse events led to discontinuation of therapy in five (10%) patients (atrial fibrillation in three [6%] patients, liver infection in one [2%], and bleeding in one [2%]). Two patients died while on-study from cardiac arrest and septic shock; the latter was deemed possibly related to treatment. Ibrutinib combined with rituximab is active and well tolerated in patients with relapsed or refractory mantle cell lymphoma. Our results provide preliminary evidence for the activity of this combination in clinical practice. A phase 3 trial is warranted for more definitive data. Pharmacyclics LLC, an AbbVie Company.
2004 Asia-Pacific Radio Science Conference, 2004. Proceedings.
The paper demonstrates a 3800 MHz VCO design for a fully integrated PHS transceiver to meet volum... more The paper demonstrates a 3800 MHz VCO design for a fully integrated PHS transceiver to meet volume production requirements. On-chip varactors and inductors are used in the VCO design. The VCO can be calibrated automatically to track process, temperature, and supply variations.
Proceedings. 7th International Conference on Solid-State and Integrated Circuits Technology, 2004.
This paper describes a single chip RF transceiver design for PHS (Xiao-Ling-Tong) phone. A single... more This paper describes a single chip RF transceiver design for PHS (Xiao-Ling-Tong) phone. A single down conversion with low IF structure is used to be compatible with the existing base band device interface. There is no SAW filter requirement for receiver path. The direct up-conversion architecture is adopted for transmitter path. 20 dBm linear power amplifier is also integrated into
Communications in Computer and Information Science, 2014
The Internet of Things is imposing an evolution of the capabilities of wireless sensor networks. ... more The Internet of Things is imposing an evolution of the capabilities of wireless sensor networks. The new IP-based 6LoWPAN standard for low power sensor networks allows an almost seamless connection of local sensor networks to the Internet. This makes it easier to connect local sensor networks to data processing servers or to provide web services for those networks. On the other hand, the connection to the Internet also opens doors for unauthorized nodes to become part of the local network. Therefore, measures need to be taken to protect the information that is captured and communicated within the local network. The most important challenge in doing so, is the implementation of a key management architecture, keeping in mind that the sensor nodes are constrained in power consumption and data storage capacity. This paper builds on a previously proposed symmetric key management scheme for 6LoWPAN networks. The original scheme is based on wired bootstrapping for the enrollment of new nodes, while the paper at hand proposes a wireless method for key pre-distribution. We analyze the original wired scheme and its shortcomings. Next, we propose the new wireless scheme and elaborate on the practical implementation on Zolertia Z1 nodes running Contiki-OS. We show that it is possible to provide end-to-end security using wireless bootstrapping within the constraints of the tiny nodes at hand.
It is shown in the study that Arsenic improves 30% device Idsat variation compared to Ph implanta... more It is shown in the study that Arsenic improves 30% device Idsat variation compared to Ph implantation. SRAM Vccmin value may be improved around 4% too. While it is found that, compared to Ph implantation, Arsenic critically increases junction leakage current, which may account for more than half part of the total off current for high threshold voltage (Vth) device with gate length less than 50nm. The large junction leakage current also leads to 5% device performance degradation and SRAM stand by leakage current (Istby) 15% increasing. Device reliability study exhibits that PMOS negative bias temperature instability (NBTI) performance is deteriorated by Arsenic implantation.
The magnetic properties of single crystals of rare-earth compounds of composition RMn 6 Ge 6−x Ga... more The magnetic properties of single crystals of rare-earth compounds of composition RMn 6 Ge 6−x Ga x ͑x Ϸ 1͒ have been studied. In these compounds, the Mn sublattice orders ferromagnetically with a preferred moment direction perpendicular to the c axis. In the compounds in which also the R component carries a magnetic moment, the latter couple antiparallel to the Mn moments. Upon cooling from room temperature to cryogenic temperatures, the R-sublattice anisotropy becomes the dominant contribution to the total magnetocrystalline anisotropy, which leads to a spin-reorientation transition at intermediate temperatures for R = Tb− Yb. At low temperatures, the preferred moment directions are characterized by an easy axis for R = Tb, Er, Tm, and Yb and by an easy cone for R = Dy and Ho. A satisfactory account of the observed preferred moment directions has been given in terms of crystal-field theory. Measurements of the magnetization in the main crystallographic directions have been made in high magnetic fields, up to about 55 T. The interplay between the antiferromagnetic intersublattice R-Mn coupling and the magnetocrystalline anisotropy leads to field-induced magnetic phase transitions which are particularly pronounced in the compounds with Ho, Er and Tm.
We present a description of the critical behavior at the first-order phase transition in MnFeP 1À... more We present a description of the critical behavior at the first-order phase transition in MnFeP 1Àx As x system in terms of the Bean-Rodbell model. Within the molecular-field approximation, the Gibbs free energy of the system is expressed in terms of the exchange interaction, the elastic energy, the entropy term, the pressure term and the Zeeman energy. A magnetic-state equation has been obtained by minimizing the Gibbs free energy with respect to the volume and the magnetization. The characteristic parameters for the phase transition observed in this system have been obtained by fitting our experimental data. The results show that the magnetoelastic coupling plays a very important role in the mechanism of the phase transition.
We have studied the first-order magnetic phase transition and related physical properties of MnFe... more We have studied the first-order magnetic phase transition and related physical properties of MnFeP0.5As0.4Si0.1 by means of x-ray diffraction, magnetization, thermal expansion, and electrical resistance measurements. The compound crystallizes in the hexagonal structure with Fe2P-type. The temperature dependence of magnetization shows a first-order magnetic phase transition around 299 K. There is no crystallographic structural transition associated with the magnetic phase transition. The linear thermal expansion shows that this magnetic phase transition is accompanied by a negative volume change. The electrical resistance shows an anomalous behavior at the transition, which is probably caused by the change in c/a ratio.
The evolution of the magnetic anisotropy of (Ce,Y) Co compounds with increasing Ce concentration ... more The evolution of the magnetic anisotropy of (Ce,Y) Co compounds with increasing Ce concentration was investigated by magnetic 2 1 7 measurements and X-ray diffraction on magnetically aligned powders. At room temperature the easy magnetization direction changes from perpendicular to the c-axis to parallel to the c-axis with increasing Ce concentration. A spin-reorientation transition from easy-axis anisotropy at higher temperatures to easy-plane anisotropy at lower temperatures arises at about 600, 530 and 320 K in Ce Y Co , 1.3 0.7 17 Ce Y Co and Ce Y Co , respectively. The Curie temperature and spontaneous magnetization decrease with increasing Ce 1.5 0.5 17 1.7 0.3 17 concentration. These magnetic behaviours are discussed in terms of the itinerant 4f states of Ce ion and the hybridization between the cobalt 3d states and the cerium 4f states.
Proceedings of the 2019 European Conference on Computing in Construction, 2019
Evaluating building performances, such as the indoor daylight, is usually based on numerical simu... more Evaluating building performances, such as the indoor daylight, is usually based on numerical simulation and 2D image illustration. It does not take advantage of emerging Augmented Reality (AR) or Mixed Reality (MR) techniques to intuitively aid the building design. The current study probes into the topic bringing building geometry information together with simulation results into AR/MR environments. After introducing some precedent work in the literature, authors recap the typical workflow and report its application on two case studies. The first case study displays the structural simulation of a high-rise building in AR, while the second case study shows the daylight simulation of a two-story house within MR. At last, reflections are conducted and future possibilities are identified. Authors deem that, in the aim of this study, only retrofitting projects are suitable for MR. The present work can help practitioners better understand this new approach, offering the added value of using AR/MR for building design.
Inflammatory bowel disease (IBD) is a group of immune-mediated disorders characterised by a chron... more Inflammatory bowel disease (IBD) is a group of immune-mediated disorders characterised by a chronic, relapsing-remitting inflammation predominantly affecting the gastrointestinal tract. IBD is incurable, affecting people in their most productive years. IBD is historically seen as a disease of Westernised nations although in recent times other countries have seen an exponential rise in cases. Although the exact pathogenesis remains unclear, evidence suggests that microbiota changes play a critical role in IBD pathogenesis. Over the past two decades, IBD has become one of the most studied human conditions linked to the gut microbiota. However, deciphering the intricate link between the gut microbiota and therapeutic efficacy remains elusive. This review will summarise the current evidence relating to the gut microbiota and its involvement in IBD pathogenesis as well as the impact of IBD treatments including pharmaceutical-, nutraceutical- and microbial-focused regimens on the gut micr...
2019 18th IEEE International Conference On Trust, Security And Privacy In Computing And Communications/13th IEEE International Conference On Big Data Science And Engineering (TrustCom/BigDataSE), 2019
Fingerprinting the malware by its behavioural signature has been an attractive approach for malwa... more Fingerprinting the malware by its behavioural signature has been an attractive approach for malware detection due to the homogeneity of dynamic execution patterns across different variants of similar families. Although previous researches show reasonably good performance in dynamic detection using machine learning techniques on a large corpus of training set, decisions must be undertaken based upon a scarce number of observable samples in many practical defence scenarios. This paper demonstrates the effectiveness of generative adversarial autoencoder for dynamic malware detection under outbreak situations where in most cases a single sample is available for training the machine learning algorithm to detect similar samples that are in the wild.
Mantle cell lymphoma (MCL) is an incurable, aggressive B cell malignancy. Ibrutinib, an oral irre... more Mantle cell lymphoma (MCL) is an incurable, aggressive B cell malignancy. Ibrutinib, an oral irreversible Bruton's tyrosine (BTK) inhibitor, was FDA-approved in 2013 for patients with relapsed/refractory MCL. In further support of BTK inhibition for the treatment of MCL, acalabrutinib, an irreversible second-generation BTK inhibitor, was recently approved by the FDA for previously treated MCL. Although BTK inhibition has resulted in remarkable MCL patient outcomes, primary resistance and acquired resistance to ibrutinib remains a challenging hurdle to the treatment of MCL patients. In this study, we aimed to discover alternative therapies to overcome resistance to ibrutinib for MCL patients. To identify therapies that will overcome resistance to BTK inhibition, we performed a combinational screen for ibrutinib with FDA-approved drugs and novel agents and found that combination treatment of ibrutinib with the polo-like kinase 1 (PLK1) inhibitors volasertib or GSK461364 achieved s...
Clinical cancer research : an official journal of the American Association for Cancer Research, Jan 17, 2018
B-cell lymphoma-2 (BCL-2), an anti-apoptotic protein often dysregulated in B-cell lymphomas, prom... more B-cell lymphoma-2 (BCL-2), an anti-apoptotic protein often dysregulated in B-cell lymphomas, promotes cell survival and provides protection from stress. A recent Phase I first-in-human study of the BCL-2 inhibitor venetoclax in non-Hodgkin lymphoma showed an overall response rate of 44%. These promising clinical results prompted our examination of the biological effects and mechanism of action underlying venetoclax activity in aggressive B-cell lymphoma, including mantle cell lymphoma (MCL) and diffuse large B cell lymphoma (DLBCL). MCL and DLBCL cell lines, primary patient samples, and patient-derived xenograft (PDX) models were utilized to examine venetoclax efficacy. Furthermore, the mechanisms underlying venetoclax response and the development of venetoclax resistance were evaluated using proteomics analysis and Western blotting. Potential biomarkers linked to venetoclax activity and targeted combination therapies that can augment venetoclax response were identified. We demonstr...
ABSTRACT Due to its ability to control the latent heat and the hysteresis (thermal or magnetic) a... more ABSTRACT Due to its ability to control the latent heat and the hysteresis (thermal or magnetic) at the first-order transition (FOT) without deteriorating the saturation magnetisation, boron substitution in MnFe(P,Si) materials has recently been reported to be an ideal parameter to reach promising magnetocaloric performances: DS � 10 Jkg�1 K�1 and cyclic DT of 2.6 K (and more) at a moderate magnetic field of DB = 1 T. Additionally, an interesting aspect for applications is the improvement of the mechanical stability in B doped materials compared to the pristine MnFe(P,Si) compounds. These improved mechanical properties were initially supported by naked-eye inspection and the observation of a constant DT during a few thousands of magnetic cycles. (Guillou et al., 2014) Here, the evolution upon cycling of MnFe(P,Si,B) materials is studied in a more quantitative and systematic manner. For that purpose transformation temperatures, electrical resistivity, micro-hardness and the microstructure are tracked as a function of the thermal cycling across the FOT for three prototypical compositions in the MnFe(P,Si,B) system. It turns out this set of data confirms the initial finding that B substitution has a positive effect on the mechanical stability. The origin of this improvement is discussed, in particular in respect to the lattice parameter discontinuities at the phase transition.
Mantle cell lymphoma (MCL) is a rare and incurable subtype of B-cell lymphoma. In a phase II stud... more Mantle cell lymphoma (MCL) is a rare and incurable subtype of B-cell lymphoma. In a phase II study of ibrutinib in MCL patients, most of the patients responded and had long durable remissions; however, 22.7% of patients were considered to be non-responsive to ibrutinib, and an additional 22/110 patients displayed initial positive responses to ibrutinib but also experienced disease progression within 12 months of treatment, with both responses classified as primary ibrutinib resistant. Therefore, understanding the mechanisms mediating primary ibrutinib resistance may identify new prognostic and predictive markers and potential therapeutic targets. Bruton's tyrosine kinase (BTK) plays an important role in B-cell development, activation, and differentiation. Upon B-cell receptor (BCR) activation, BTK is phosphorylated and activated by SYK. Phosphoinositide 3-kinase (PI3K) is recruited to the BCR, and the induction of these signaling activities leads to the downstream activation of ...
Mutations and epigenetic alterations are key events in transforming normal cells to cancer cells.... more Mutations and epigenetic alterations are key events in transforming normal cells to cancer cells. Mantle cell lymphoma (MCL), a non-Hodgkin's lymphoma of the B-cell, is an aggressive malignancy with poor prognosis especially for those patients who are resistant to the frontline drugs. There is a great need to describe the molecular basis and mechanism of drug resistance in MCL to develop new strategies for treatment. We reviewed frequent somatic mutations and mutations involving the B-cell pathways in MCL and discussed clinical trials that attempted to disrupt these gene pathways and/or epigenetic events. Recurrent gene mutations were discussed in the light of prognostic and therapeutic opportunity and also the challenges of targeting these lesions. Mutations in the ATM, CCND1, TP53, MLL2, TRAF2 and NOTCH1 were most frequently encountered in mantle cell lymphoma. Translational models should be built that would assess mutations longitudinally to identify important compensatory, prosurvival and anti-apoptic pathways and actionable genetic targets.
Ibrutinib is approved in the EU, USA, and other countries for patients with mantle cell lymphoma ... more Ibrutinib is approved in the EU, USA, and other countries for patients with mantle cell lymphoma who received one previous therapy. In a previous phase 2 study with single-agent ibrutinib, the proportion of patients who achieved an objective response was 68%; 38 (34%) of 111 patients had transient lymphocytosis. We hypothesised that adding rituximab could target mantle cell lymphoma cells associated with redistribution lymphocytosis, leading to more potent antitumour activity. Patients with a confirmed mantle cell lymphoma diagnosis (based on CD20-positive and cyclin D1-positive cells in tissue biopsy specimens), no upper limit on the number of previous treatments received, and an Eastern Cooperative Oncology Group performance status score of 2 or less were enrolled in this single-centre, open-label, phase 2 study. Patients received continuous oral ibrutinib (560 mg) daily until progessive disease or unacceptable toxic effects. Rituximab 375 mg/m(2) was given intravenously once per week for 4 weeks during cycle 1, then on day 1 of cycles 3-8, and thereafter once every other cycle up to 2 years. The primary endpoint was the proportion of patients who achieved an objective response in the intention-to-treat population and safety assessed in the as-treated population. The study is registered with ClinicalTrials.gov, number NCT01880567, and is still ongoing, but no longer accruing patients. Between July 15, 2013, and June 30, 2014, 50 patients were enrolled. Median age was 67 years (range 45-86), and the median number of previous regimens was three (range 1-9). At a median follow-up of 16·5 months (IQR 12·09-19·28), 44 (88%, 95% CI 75·7-95·5) patients achieved an objective response, with 22 (44%, 30·0-58·7) patients achieving a complete response, and 22 (44%, 30·0-58·7) a partial response. The only grade 3 adverse event in >=10% of patients was atrial fibrillation, which was noted in six (12%) patients. Grade 4 diarrhoea and neutropenia occurred in one patient each. Adverse events led to discontinuation of therapy in five (10%) patients (atrial fibrillation in three [6%] patients, liver infection in one [2%], and bleeding in one [2%]). Two patients died while on-study from cardiac arrest and septic shock; the latter was deemed possibly related to treatment. Ibrutinib combined with rituximab is active and well tolerated in patients with relapsed or refractory mantle cell lymphoma. Our results provide preliminary evidence for the activity of this combination in clinical practice. A phase 3 trial is warranted for more definitive data. Pharmacyclics LLC, an AbbVie Company.
2004 Asia-Pacific Radio Science Conference, 2004. Proceedings.
The paper demonstrates a 3800 MHz VCO design for a fully integrated PHS transceiver to meet volum... more The paper demonstrates a 3800 MHz VCO design for a fully integrated PHS transceiver to meet volume production requirements. On-chip varactors and inductors are used in the VCO design. The VCO can be calibrated automatically to track process, temperature, and supply variations.
Proceedings. 7th International Conference on Solid-State and Integrated Circuits Technology, 2004.
This paper describes a single chip RF transceiver design for PHS (Xiao-Ling-Tong) phone. A single... more This paper describes a single chip RF transceiver design for PHS (Xiao-Ling-Tong) phone. A single down conversion with low IF structure is used to be compatible with the existing base band device interface. There is no SAW filter requirement for receiver path. The direct up-conversion architecture is adopted for transmitter path. 20 dBm linear power amplifier is also integrated into
Communications in Computer and Information Science, 2014
The Internet of Things is imposing an evolution of the capabilities of wireless sensor networks. ... more The Internet of Things is imposing an evolution of the capabilities of wireless sensor networks. The new IP-based 6LoWPAN standard for low power sensor networks allows an almost seamless connection of local sensor networks to the Internet. This makes it easier to connect local sensor networks to data processing servers or to provide web services for those networks. On the other hand, the connection to the Internet also opens doors for unauthorized nodes to become part of the local network. Therefore, measures need to be taken to protect the information that is captured and communicated within the local network. The most important challenge in doing so, is the implementation of a key management architecture, keeping in mind that the sensor nodes are constrained in power consumption and data storage capacity. This paper builds on a previously proposed symmetric key management scheme for 6LoWPAN networks. The original scheme is based on wired bootstrapping for the enrollment of new nodes, while the paper at hand proposes a wireless method for key pre-distribution. We analyze the original wired scheme and its shortcomings. Next, we propose the new wireless scheme and elaborate on the practical implementation on Zolertia Z1 nodes running Contiki-OS. We show that it is possible to provide end-to-end security using wireless bootstrapping within the constraints of the tiny nodes at hand.
It is shown in the study that Arsenic improves 30% device Idsat variation compared to Ph implanta... more It is shown in the study that Arsenic improves 30% device Idsat variation compared to Ph implantation. SRAM Vccmin value may be improved around 4% too. While it is found that, compared to Ph implantation, Arsenic critically increases junction leakage current, which may account for more than half part of the total off current for high threshold voltage (Vth) device with gate length less than 50nm. The large junction leakage current also leads to 5% device performance degradation and SRAM stand by leakage current (Istby) 15% increasing. Device reliability study exhibits that PMOS negative bias temperature instability (NBTI) performance is deteriorated by Arsenic implantation.
The magnetic properties of single crystals of rare-earth compounds of composition RMn 6 Ge 6−x Ga... more The magnetic properties of single crystals of rare-earth compounds of composition RMn 6 Ge 6−x Ga x ͑x Ϸ 1͒ have been studied. In these compounds, the Mn sublattice orders ferromagnetically with a preferred moment direction perpendicular to the c axis. In the compounds in which also the R component carries a magnetic moment, the latter couple antiparallel to the Mn moments. Upon cooling from room temperature to cryogenic temperatures, the R-sublattice anisotropy becomes the dominant contribution to the total magnetocrystalline anisotropy, which leads to a spin-reorientation transition at intermediate temperatures for R = Tb− Yb. At low temperatures, the preferred moment directions are characterized by an easy axis for R = Tb, Er, Tm, and Yb and by an easy cone for R = Dy and Ho. A satisfactory account of the observed preferred moment directions has been given in terms of crystal-field theory. Measurements of the magnetization in the main crystallographic directions have been made in high magnetic fields, up to about 55 T. The interplay between the antiferromagnetic intersublattice R-Mn coupling and the magnetocrystalline anisotropy leads to field-induced magnetic phase transitions which are particularly pronounced in the compounds with Ho, Er and Tm.
We present a description of the critical behavior at the first-order phase transition in MnFeP 1À... more We present a description of the critical behavior at the first-order phase transition in MnFeP 1Àx As x system in terms of the Bean-Rodbell model. Within the molecular-field approximation, the Gibbs free energy of the system is expressed in terms of the exchange interaction, the elastic energy, the entropy term, the pressure term and the Zeeman energy. A magnetic-state equation has been obtained by minimizing the Gibbs free energy with respect to the volume and the magnetization. The characteristic parameters for the phase transition observed in this system have been obtained by fitting our experimental data. The results show that the magnetoelastic coupling plays a very important role in the mechanism of the phase transition.
We have studied the first-order magnetic phase transition and related physical properties of MnFe... more We have studied the first-order magnetic phase transition and related physical properties of MnFeP0.5As0.4Si0.1 by means of x-ray diffraction, magnetization, thermal expansion, and electrical resistance measurements. The compound crystallizes in the hexagonal structure with Fe2P-type. The temperature dependence of magnetization shows a first-order magnetic phase transition around 299 K. There is no crystallographic structural transition associated with the magnetic phase transition. The linear thermal expansion shows that this magnetic phase transition is accompanied by a negative volume change. The electrical resistance shows an anomalous behavior at the transition, which is probably caused by the change in c/a ratio.
The evolution of the magnetic anisotropy of (Ce,Y) Co compounds with increasing Ce concentration ... more The evolution of the magnetic anisotropy of (Ce,Y) Co compounds with increasing Ce concentration was investigated by magnetic 2 1 7 measurements and X-ray diffraction on magnetically aligned powders. At room temperature the easy magnetization direction changes from perpendicular to the c-axis to parallel to the c-axis with increasing Ce concentration. A spin-reorientation transition from easy-axis anisotropy at higher temperatures to easy-plane anisotropy at lower temperatures arises at about 600, 530 and 320 K in Ce Y Co , 1.3 0.7 17 Ce Y Co and Ce Y Co , respectively. The Curie temperature and spontaneous magnetization decrease with increasing Ce 1.5 0.5 17 1.7 0.3 17 concentration. These magnetic behaviours are discussed in terms of the itinerant 4f states of Ce ion and the hybridization between the cobalt 3d states and the cerium 4f states.
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Papers by Leo Zhang