Papers by Abdurrahim Koçyiğit
Records of Natural Products, Sep 3, 2019
Proceedings, Nov 14, 2017
Clinical Oral Investigations, Apr 10, 2023
Objectives To evaluate the relationship between pain inflammation due to dental caries and growth... more Objectives To evaluate the relationship between pain inflammation due to dental caries and growth parameters, sleep disturbances, and oral health-related quality of life (OHRQoL) in preschool children before/after dental treatment and compare the results with the control group. Materials and methods Study (pain inflammation due to caries) and control groups were included in this prospective clinical trial. The Child Sleep Habits Questionnaire (CSHQ) assessing sleep disturbances and the Early Childhood Oral Health Impact Scale (ECOHIS) assessing OHRQoL were applied in the corresponding time intervals to the study and control groups, respectively: baseline (T0 study), 7 days after treatment (T1 study), and following 6 months (T2 study); baseline (T0 control), and the following 6 months (T2 control). Biochemical growth parameters (insulin-like growth factor-1 and insulin-like growth factor binding protein-3) and anthropometric measurements (standard deviation score of height, weight, and body mass index) were obtained at T0 study , T2 study , and T0 control. Mann-Whitney U and the Student t-tests were used for statistical analyses. The significance level was set at p < 0.05. Results Data on 45 children (mean age: 55.6 ± 10.37 months) were analyzed. T2 study was statistically higher than T0 study for the anthropometric measurements and biochemical growth parameters (p < 0.05). T0 study was statistically higher than T0 control for biochemical growth parameters (p < 0.05). CSHQ and ECOHIS scores were found statistically significant at T0 study than T0 control (p < 0.05). Statistical scores of CSHQ and ECOHIS in T2 study were significantly reduced compared to T0 study (p < 0.05). Conclusion Children's growth parameters, sleep disturbances, and OHRQoL improved after the elimination of pain and inflammation. Clinical relevance This study's novelty is the observation of drastically increased growth parameters and reduced sleep disturbances following dental treatment.
Cervical cancer, Oct 1, 2022
Marmara Medical Journal, Mar 1, 1998
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects, 2021
European Journal of Biology, 2020
American Journal of Plant Sciences, 2019
Neuro-Oncology, 2019
BACKGROUND Melanoma patients with brain metastasis have poor prognosis. Gamma Knife radiosurgery ... more BACKGROUND Melanoma patients with brain metastasis have poor prognosis. Gamma Knife radiosurgery (GKR) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has gained attention as a potential therapeutic option due to its anti-tumor effects on various cancers. The aim of the study was to invetsigate the effect of GKR in B16-F10 melanoma cells in vitro and in established intracerebral melanoma model in mice in vivo, and the sensitizing efficacy of TQ towards GKR. MATERIAL AND METHODS Effects of GKR and combination treatment of GKR and TQ were studied on B16-F10 melanoma cells via analyzing cytotoxicty by adenosine triphosphate (ATP) assay; apoptosis induction by acridine orange staining and genotoxicity by comet assay. Expression of STAT3, p-STAT3 (Tyr705) and apoptotic pathway proteins was investigated by western blot analysis. Enzyme Linked Immunosorbent Assay (ELISA) was performed to assess the expression of inflammatory cytokines. Also survival w...
Molecular and cellular biochemistry, 2018
Carvacrol is a natural phenolic compound found in essential oils of Lamiaceae species. In the pre... more Carvacrol is a natural phenolic compound found in essential oils of Lamiaceae species. In the present study, an attempt has been made to elucidate the mechanism behind the anti-cancer potential of carvacrol on human gastric adenocarcinomas (AGS) by comparing its effects on cancer cells AGS to those on normal human fibroblast (WS-1) cells, in vitro. Cytotoxicity, reactive oxygen species (ROS) generation, glutathione (GSH) levels, genotoxicity, and apoptotic effects of carvacrol (0-600 µM) were studied in both cell lines. Additionally, the effect of high dose carvacrol (100 mg/kg BW) on the oxidative status was investigated in vivo. For this purpose, carvacrol was administered orally to male Wistar rats over a period of 60 days. Rats were weighed regularly. At the end of the experiment, rats were euthanized. Blood and stomach tissues were collected for biochemical and pathological examinations. The in vitro results showed significant differences in cell viability of AGS compared to WS...
Toxicology and industrial health, 2018
Phenolic compounds of essential oils from the family Lamiaceae are commonly used substances in th... more Phenolic compounds of essential oils from the family Lamiaceae are commonly used substances in the food industry because of their flavouring, antimicrobial and antioxidant properties. In this context, it has become important to have healthy and safe products for consumers who are exposed to these phenolic compounds. The present study was aimed to investigate the toxic effects of carvacrol, thymol and their mixture on human gastric carcinoma (AGS) cells. Cells were analyzed after 24 h of exposure to different concentrations of carvacrol, thymol and their mixture by the ATP cell viability, 2',7' dichlorodihydrofluorescein diacetate (H2DCF-DA), reducte glutatione/oxide glutathione ((GSH)/GSSG-Glo) and comet assays. Apoptosis induction was studied by acridine orange/ethidium bromide staining and western blotting. Carvacrol, thymol and their mixture induced cytotoxicity, genotoxicity, apoptosis, increased reactive oxygen species (ROS) and decreased GSH levels after 24 h of their ...
Archives of dermatological research, 2018
The relationships of demodex density with systemic oxidative stress, inflammatory response, and c... more The relationships of demodex density with systemic oxidative stress, inflammatory response, and clinical severity in rosacea are not clear. This study aimed to (a) analyze the levels of systemic oxidative stress, antioxidant capacity, inflammatory parameters, and matrix metalloproteinases (MMPs) in systemic circulation in patients with rosacea, (b) identify the relationship between mite density and both oxidative stress and inflammation, and (c) investigate the role of photoaging and sebum secretion in etiopathogenesis. Forty patients with rosacea and 40 age-, sex-, and skin phenotype-matched healthy volunteers were included in the study. Clinical disease severity of the patients was determined. Sebum levels were measured in both the groups, and photoaging was evaluated. Reflectance confocal microscopy was used to calculate demodex density. Serum total antioxidant capacity (TAC), total oxidant capacity (TOC), myeloperoxidase (MPO), MMP-1, MMP-9, arylesterase (ARES), interleukin-1β (...
Medicinal chemistry (Shariqah (United Arab Emirates)), Jan 21, 2018
Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirte... more Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by 1H- and 13C NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner. We have first synthesized compounds 1 and 2 from the reaction of methyl iodide and OA. Compound 1 was reduced with LiAlH4 to give compound 3, and compound 2 gave compound 9 with MOMBr as a new compound. The compound 10 was then obtained from the reduction of compound 9 with LiAlH4 as a new oleanolic acid derivative. A diol derivative 11 was synthesized from OA and LiAlH4 at the room temperature. Compound 4 was obtained from the reaction of compound 3 with CBr4 as a new ana...
Transplantation Proceedings, 2001
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, Jan 25, 2017
The aim of this study is to show if cyclosporine has an antiallergic role in a rat model of ovalb... more The aim of this study is to show if cyclosporine has an antiallergic role in a rat model of ovalbumin-induced allergic rhinitis. The 54 rats were divided into six equal groups. The first group was a negative control group without induced allergic rhinitis; the second group a positive control with induced allergic rhinitis not receiving treatment. The remaining four groups, after induction of allergic rhinitis, received intranasal cyclosporine treatment in doses of 0.05, 0.1, or 0.2% or nasal steroid treatment. In the biochemical examination, on the surface of the tissue tumor necrosis factor (TNF) interferon (IFN), interleukin (IL)-5, IL-13, as well as IL-2, IL-4, IL-17A, and IgE were studied. Histologically, ciliary loss, increase of goblet cells, vascular congestion, and the degree of eosinophil infiltration were rated. In all treatment groups, on average, a significant reduction in all histological and biochemical values was found compared to the positive control group. Comparing...
American Journal of Otolaryngology, 2016
Abstract Objective This study aimed to evaluate the effect of Ginkgo biloba extract (EGb 761) on ... more Abstract Objective This study aimed to evaluate the effect of Ginkgo biloba extract (EGb 761) on noise-induced hearing loss (NIHL) by measuring audiological and biochemical parameters. Materials and methods Thirty-two female rats were divided into four groups (NIHL, EGb 761, NIHL + EGb 761 and control) comprising eight rats each. Groups 1 and 3 were exposed to white noise of a 100 dB sound pressure level (SPL) for 8 h, while rats in groups 2 and 3 were administered 100 mg/kg/day EGb 761 for 21 days after noise exposure. Distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests were performed in all groups before noise exposure and on days 1, 7, 14 and 21 after noise exposure. Intracardiac blood samples were taken on day 21 for assessment of biochemical parameters. Results In group 1, a significant increase was seen in audiological measurements on days 1, 7, 14 and 21 after noise exposure. In group 3, the increased DPOAE and ABR threshold decreased significantly on day 14. The total oxidant status (TOS) value was significantly higher in group 1 than in the other groups. The total antioxidant status (TAS) value was significantly higher in group 2 than in group 1. The DNA damage value was significantly higher in group 1 than in the other groups. Conclusion This study showed that EGb 761 is effective for treating NIHL during the early period.
Cited By (since 1996):5, Export Date: 18 October 2014
Auris Nasus Larynx, 2015
The ability of microbes to accelerate chloramine decay to the same degree as under severe nitrifi... more The ability of microbes to accelerate chloramine decay to the same degree as under severe nitrification, but without the signs of severe nitrification is reported. Traditionally, only nitrification is believed to microbiologically challenge the stability of chloramine. Chloraminated water containing high amount of natural organic matter (10e12 mg L À1 of dissolved organic carbon (DOC)) was fed to four lab scale reactors connected in series. Each reactor had one day retention time with a total of four days in total. The decay coefficient was observed to be a maximum of 0.06 h À1 without substantial changes in ammonia, nitrite or nitrate levels. Despite very low chloramine residuals, nitrite only increased to less than 0.012 mg-N L À1 , indicating a mildly nitrifying condition. Previously reported decay coefficient (0.001e0.006 h À1) for the condition was an order less. Changing of the feed to a new water from the same source, but with a low DOC (of 4 mg L À1) led to the onset of nitrification complying biostability. The maximum observed chloramine decay coefficient with severe nitrification was 0.085 h À1. Therefore, microbes present under mildly nitrifying condition can be as destructive as that in severely nitrifying condition. For better control of chloramine, attention on microbes present under mild nitrification is needed.
Journal of the Egyptian Society of Parasitology, 2000
Forty-two CL patients with 60 lesions were treated with cryotherapy using liquid nitrogen twice f... more Forty-two CL patients with 60 lesions were treated with cryotherapy using liquid nitrogen twice for two months. Another group of fifty-five CL patients. With 73 lesions were treated with intralesional pentostam with pentostam, 67 of 73 lesions (92%) and with cryotherapy 47 of 60 lesions (78%) healed or markedly improved at the end of three months follow-up. This study shows that intralesional pentostam injection was effective than cryotherapy. However, both lines of treatment were well tolerated by the patients. They showed no severe side effects and no significant changes in laboratory values. It is suggested that cryotherapy is an alternative to intralesional pentostam injection.
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Papers by Abdurrahim Koçyiğit