Papers by Fatemeh Kheradmand
Cancers
Prostate cancer (PC) is the second most common type of cancer and the leading cause of death amon... more Prostate cancer (PC) is the second most common type of cancer and the leading cause of death among men worldwide. Preventing the progression of cancer after treatments such as radical prostatectomy, radiation therapy, and hormone therapy is a major concern faced by prostate cancer patients. Inflammation, which can be caused by various factors such as infections, the microbiome, obesity and a high-fat diet, is considered to be the main cause of PC. Inflammatory cells are believed to play a crucial role in tumor progression. Therefore, nonsteroidal anti-inflammatory drugs along with their effects on the treatment of inflammation-related diseases, can prevent cancer and its progression by suppressing various inflammatory pathways. Recent evidence shows that nonsteroidal anti-inflammatory drugs are effective in the prevention and treatment of prostate cancer. In this review, we discuss the different pathways through which these drugs exert their potential preventive and therapeutic effe...
Food bioscience, Jun 1, 2019
Annals of medicine and surgery, Jun 1, 2022
Urmia medical journal, Mar 15, 2016
Metabolism of several trace elements such as copper and iron in diabetes mellitus has been change... more Metabolism of several trace elements such as copper and iron in diabetes mellitus has been changed which may have an important role in the pathogenesis and progression of the disease. The aim of this study was to evaluate association of serum copper and iron levels with fasting blood glucose (FBG) in patients with type 2 diabetes mellitus (T2DM) and their first-degree relatives (FDRs). Materials &Methods: We studied 46 subjects with T2DM, 46 FDRs and 50 healthy subjects matched for age and sex. Blood glucose and mentioned elements were measured in three groups with standard and colorimetric methods, respectively. The results were evaluated with one-way ANOVA test using statistical software SPSS 16. Correlations between different variables were analyzed using Pearson’s correlation coefficients. Results: FBG levels were positively correlated with iron levels (r=0.650, P<0.001) in patients with T2DM and (r=0.376, P=0.01) in FDRs. On the other hand, there was no significant correlation between FBG with copper levels in these groups. Conclusion: Alterations in iron and copper concentrations in patients with type 2 diabetes mellitus and their first degree relatives may relate to blood glucose level, especially in the case of iron. It seems that it is useful to follow up the concentrations of these elements in diabetic patients and their first degree relatives
Clinical Biochemistry, Sep 1, 2011
International Journal of Biological Macromolecules, Apr 1, 2023
Colorectal cancer is among the frequently diagnosed cancers with high mortality rates around the ... more Colorectal cancer is among the frequently diagnosed cancers with high mortality rates around the world. Polyphenolic compounds such as flavonoids are secondary plant metabolites which exhibit anti-cancer activities along with anti-inflammatory effects. However, due to their hydrophobicity, sensitivity to degradation and low bioavailability, therapeutic effects have shown poor therapeutic effect. Nano delivery systems such as nanoliposomes, nanomicelles, silica nanoparticles have been investigated to overcome these difficulties. This review provides a summary of the efficiency of certain flavonoids and polyphenols (apigenin, genistein, resveratrol, quercetin, silymarin, catechins, luteolin, fisetin, gallic acid, rutin, and curcumin) on colorectal cancer models. It comprehensively discusses the influence of nano-formulation of flavonoids on their biological functions, including cellular uptake rate, bioavailability, solubility, and cytotoxicity, as well as their potential for reducing colorectal cancer tumor size under in vivo situations.
Journal of Kerman University of Medical Sciences
Annals of Medicine & Surgery
DARU Journal of Pharmaceutical Sciences, 2022
PURPOSE Anti-cancer and anti-migration effects of lupeol as a biological pentacyclic triterpenoid... more PURPOSE Anti-cancer and anti-migration effects of lupeol as a biological pentacyclic triterpenoid were investigated individually and in combination with Doxorubicin (DOX) on MCF-7 and MDA-MB-231 breast cancer cells and human foreskin fibroblasts. METHODS To uncover the anticancer effect of lupeol and the impact of its combination with DOX, cell viability and scratch assays and dual acridine-orange apoptotic staining were performed. Moreover, the expression of proapoptotic caspase-3 and metastasis-related MMP-9 at the mRNA and protein levels was analyzed using qPCR and western blot techniques. RESULTS Lupeol synergistically increased the anti-proliferative effect of DOX with IC50 values of 42.55, 62.24 and 65.9 μM on MCF-7, MDA-MB-231 and HFF cells, respectively. Lupeol reduced the cell migration and lowered the DOX-induced cell migration, significantly (p < 0.05). The number of apoptotic cells elevated significantly (p < 0.05) when cancer cells were treated with the combination of lupeol and DOX. Lupeol individually and in combination with DOX up-regulated the expression of caspase-3. The proposed combination therapy synergized (3-4 fold) the down-regulation of MMP-9 expression in MCF-7 and MDA-MB-231 cells. CONCLUSION Our results indicate that lupeol could be considered as an anticancer agent and anticancer adjuvant in breast cancer-therapy. The anticancer properties of lupeol attribute to its antiproliferative, antimigrative and apoptotic effects.
Urmia medical journal, 2016
Metabolism of several trace elements such as copper and iron in diabetes mellitus has been change... more Metabolism of several trace elements such as copper and iron in diabetes mellitus has been changed which may have an important role in the pathogenesis and progression of the disease. The aim of this study was to evaluate association of serum copper and iron levels with fasting blood glucose (FBG) in patients with type 2 diabetes mellitus (T2DM) and their first-degree relatives (FDRs). Materials &Methods: We studied 46 subjects with T2DM, 46 FDRs and 50 healthy subjects matched for age and sex. Blood glucose and mentioned elements were measured in three groups with standard and colorimetric methods, respectively. The results were evaluated with one-way ANOVA test using statistical software SPSS 16. Correlations between different variables were analyzed using Pearson’s correlation coefficients. Results: FBG levels were positively correlated with iron levels (r=0.650, P<0.001) in patients with T2DM and (r=0.376, P=0.01) in FDRs. On the other hand, there was no significant correlati...
Urmia medical journal, 2015
The altered levels of some essential trace elements and antioxidant minerals have been observed i... more The altered levels of some essential trace elements and antioxidant minerals have been observed in diabetic patients. Zinc, as an antioxidant and essential trace element, plays a significant role in the function of many enzymes. Altered zinc content seems to be one of the contributing factors in the pathogenesis of this disease. The purpose of this study was to investigate serum level of zinc (Zn) and the correlation between zinc and fasting blood sugar (FBS) in patients with type 2 diabetes mellitus (T2DM) and their first-degree relatives (FDR). Methods & Materials: 46 subjects with T2DM, 46 FDR and 50 healthy subjects were involved in this study. Serum concentrations of Zn were measured by colorimetric kit (Biorex, UK). Fasting blood sugar was assayed using the standard kit (made by Pars Azmoon Inc., Tehran, Iran). Results: We found decreased levels of Zn (P<0.001) in FDR when compared to healthy controls. FBS levels were negatively correlated with Zn (r=0.431,P=0.003) in patie...
Biomedicine & Pharmacotherapy, 2018
Bratislava Medical Journal, 2019
Urmia Medical Journal, Mar 15, 2015
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Papers by Fatemeh Kheradmand