Papers by Kerstin Rosander
Transactions of the American Nuclear Society, 1986
The purpose of this study is to compare absorbed doses of /sup 10/B-neutron capture radiation and... more The purpose of this study is to compare absorbed doses of /sup 10/B-neutron capture radiation and x radiation in the brains of head-exposed, body-shielded mice, at LD/sub 50/ for acute (<4 days post exposure) mortality from the central nervous system (CNS) radiation syndrome. This comparison leads to an estimate of the in vivo relative biological effectiveness (RBE) of heavy particle radiation (helium and lithium ions) from the /sup 10/B(n,..cap alpha..)/sup 7/Li nuclear reaction.
OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information), Sep 1, 1989
Acta Paediatrica, Mar 24, 2011
To investigate early oculo-motor development in a population-based cohort of very preterm infants... more To investigate early oculo-motor development in a population-based cohort of very preterm infants. Methods: Early oculo-motor development was prospectively studied by measuring smooth pursuit eye movements at 2 and 4 months corrected age in a population of very preterm infants born in Uppsala County 2004-2007. Eighty-one preterm infants were studied, and 32 healthy term infants constituted the control group. Results: The study group consisted of infants with a mean gestational age of 28 + 5 weeks. At 2 and 4 months corrected age, infants born very preterm showed lower gain (p < 0.001) and proportion of smooth pursuit eye movements (p < 0.001) compared to the control group. The boys showed higher gain of smooth pursuit eye movements at both 2 and 4 months corrected age, compared to girls. Conclusions: Oculo-motor development measured by smooth pursuit eye movements is delayed in very preterm infants at 2 and 4 months corrected age. This might be a risk factor or early indicator of later perceptual and behavioural impairment.
Frontiers in Neurology, Feb 9, 2015
Crawling on hands and knees is an early pattern of human infant locomotion, which offers an inter... more Crawling on hands and knees is an early pattern of human infant locomotion, which offers an interesting way of studying quadrupedalism in one of its simplest form. We investigate how crawling human infants compare to other quadruped mammals, especially primates. We present quantitative data on both the gait and kinematics of seven 10-month-old crawling infants. Body movements were measured with an optoelectronic system giving precise data on 3-dimensional limb movements. Crawling on hands and knees is very similar to the locomotion of non-human primates in terms of the quite protracted arm at touchdown , the coordination between the spine movements in the lateral plane and the limbs, the relatively extended limbs during locomotion and the strong correlation between stance duration and speed of locomotion. However, there are important differences compared to primates, such as the choice of a lateral-sequence walking gait, which is similar to most non-primate mammals and the relatively stiff elbows during stance as opposed to the quite compliant gaits of primates. These finding raise the question of the role of both the mechanical structure of the body and neural control on the determination of these characteristics.
Elsevier eBooks, 2007
Measurements of visual tracking in infants have been performed from 2 weeks of age. Although dire... more Measurements of visual tracking in infants have been performed from 2 weeks of age. Although directed appropriately, the eye movements are saccadic at this age. Over the first 4 months of life, a rapid transition to successively smoother eye movements takes place. Timing develops first and at 7 weeks of age the smooth pursuit is well timed to a sinusoidal motion of 0.25 Hz. From this age, the gain of the smooth pursuit improves rapidly and from 4 months of age, smooth pursuit dominates visual tracking in combination with head movements. This development reflects massive cortical and cerebellar changes. The coordination between eyes-head-body and the external events to be tracked presumes predictive control. One common type of model for explaining the acquisition of such control focuses on the maturation of the cerebellar circuits. A problem with such models, however, is that although Purkinje cells and climbing fibers are present in the newborn, the parallel and mossy fibers, essential for predictive control, grow and mature at 4-7 months postnatally. Therefore, an alternative model that also includes the prefrontal cerebral cortex might better explain the early development of predictive control. The prefrontal cortex functions by 3-4 months of age and provides a site for prediction of eye movements as a part of cerebro-cerebellar nets.
Acta Paediatrica, Sep 23, 2011
To investigate early oculo-motor development in a population-based cohort of very preterm infants... more To investigate early oculo-motor development in a population-based cohort of very preterm infants. Methods: Early oculo-motor development was prospectively studied by measuring smooth pursuit eye movements at 2 and 4 months corrected age in a population of very preterm infants born in Uppsala County 2004-2007. Eighty-one preterm infants were studied, and 32 healthy term infants constituted the control group. Results: The study group consisted of infants with a mean gestational age of 28 + 5 weeks. At 2 and 4 months corrected age, infants born very preterm showed lower gain (p < 0.001) and proportion of smooth pursuit eye movements (p < 0.001) compared to the control group. The boys showed higher gain of smooth pursuit eye movements at both 2 and 4 months corrected age, compared to girls. Conclusions: Oculo-motor development measured by smooth pursuit eye movements is delayed in very preterm infants at 2 and 4 months corrected age. This might be a risk factor or early indicator of later perceptual and behavioural impairment.
Radiation Research, Aug 1, 1983
The induction and repair of DNA damage in single endothelial cells of rat cerebral cortex capilla... more The induction and repair of DNA damage in single endothelial cells of rat cerebral cortex capillaries were studied in vivo and in vitro. Capillaries from the cerebral cortex were prepared in suspension, embedded in agarose on microscope slides, and treated with alkaline solution (unwinding of DNA). After neutralization the slides were stained with the fluorescent dye acridine orange and endothelial cell nuclei were evaluated in a microscope photometer. The intensity of the red fluorescence (from single-stranded DNA) divided by the green fluorescence (from double-stranded DNA) was used as a measured of DNA strand breaks. The results showed that most DNA strand breaks were repaired within 30 min postirradiation. A linear dose-effect relationship was found up to 18 Gy. Similar results were obtained from in vitro and in vivo experiments. Cysteamine administered 20 min before irradiation in vivo gave a protective effect on the cells studied. An EMF of 1.3 was determined.
International Journal Of Radiation Biology, 1979
Rats, 5, 10 or 25 days old, were 60 Co gamma irradiated. The induction of DNA strand breaks was s... more Rats, 5, 10 or 25 days old, were 60 Co gamma irradiated. The induction of DNA strand breaks was studied after killing the rats within 1 min after irradiation, and the repair of the induced breaks after various intervals up to 180 min. Cell suspensions were prepared from the brain and samples were transferred into alkaline solutions. The fraction of DNA remaining double-stranded after 30 min alkali treatment was estimated after separation of single- and double-stranded DNA on hydroxylapatite. The amount of DNA strand breaks induced per Gray (1--8 Gray) was found to be in accordance with earlier in vivo studies of the mouse small intestine and mouse spleen. The DNA strand breaks in the rat brain induced by 4 Gray 60Co gamma irradiation were repaired 30 min after irradiation in all age groups studied.
International Journal of Psychology, 2000
Journal of Vision, 2007
... urn=urn:nbn:se:uu:diva-95615. Note: Part of urn:nbn:se:uu:diva-7760. In thesis: Kochukhova, O... more ... urn=urn:nbn:se:uu:diva-95615. Note: Part of urn:nbn:se:uu:diva-7760. In thesis: Kochukhova, Olga. When, Where and What: The Development of Perceived Spatio-Temporal Continuity. 2007. Available from: 2007-04-05. Created ...
Archives of Disease in Childhood, Oct 1, 2014
ABSTRACT Background and aims Children born very preterm are at increased risk for visual motor im... more ABSTRACT Background and aims Children born very preterm are at increased risk for visual motor impairment. Our aim was to investigate whether ifmpaired oculomotor function is associated with morphological and ADC (Apparent Diffusion Coefficient) changes on brain MRI. Method Visual tracking ability (eye and head movements) was measured at 4 months corrected age in 32 very preterm infants (mean GA 27 w). The following variables were assessed; Gain of gaze, Smooth pursuit (SP) eye movements, the number of saccades &gt;100 deg/s, and head movements. MRI examinations were performed at 2.5–5 years of age, including ADC measurements at multiple locations. Results There were significant univariate correlations between some gaze parameters, MR abnormalities and asymmetries in ADC values. Moreover, there was a correlation between the number of observed perivascular spaces and SP (rs = -0.407 p = 0.025) Conclusion This is the first study to examine the relationship between young infants’ visual tracking abilities and later MRI. Poorer tracking for gaze and saccades correlated with white matter damage, while SP correlated with ADC values for the pons.
... Reaching kinematics of precise and imprecise tasks in toddlers. by Y Chen, R Keen, K Rosander... more ... Reaching kinematics of precise and imprecise tasks in toddlers. by Y Chen, R Keen, K Rosander, C Von Hofsten. ... Lauren E Sergio, Catherine Hamel-Pâquet, John F Kalaska in Journal of Neurophysiology (2005). Save reference to library · Related research 5 readers. ...
Oxford Research Encyclopedia of Psychology
Gaze control involves eyes, head, and body movements and is guided by mainly three types of infor... more Gaze control involves eyes, head, and body movements and is guided by mainly three types of information: visual, vestibular, and proprioceptive. Appropriate gaze control is a basis for actions such as reaching, grasping, eating, and manipulation, all of which develop during the first year of life. The development of gaze control is about how young infants gain access to these different kinds of information, how they come to use them, and how they come to coordinate head and eyes to accomplish it. This control develops during the first few weeks of life. A major challenge for the gaze controlling system is how gaze is stabilized on a moving target to keep vision clear, including during self-motion or the compensation of other sudden movements. Furthermore, the tracking has to be timed relative to the object motion. This requires prediction, which is a part of smooth pursuit that emerges at around six weeks and is in full function at three months. The smooth eye and head movements mus...
Investigative Ophthalmology & Visual Science, 2006
Archives of Disease in Childhood, 2014
and Behaviour Rating Scale (BRS) scores (estimate =-0.39; p = 0.012). Conclusions Implementation ... more and Behaviour Rating Scale (BRS) scores (estimate =-0.39; p = 0.012). Conclusions Implementation of a neonatal pain and sedation protocol results in an increase in opiate prescription without affecting short-term outcome and neurodevelopmental performance of VLBWI at 12 months corrected age.
Radiation and Environmental Biophysics, Mar 1, 1993
Mice were placed in a cold environment (4 °C) directly after whole-body irradiation. Those irradi... more Mice were placed in a cold environment (4 °C) directly after whole-body irradiation. Those irradiated with a lethal dose showed higher lethality than mice irradiated with the same dose but placed in room temperature. The response was also altered after irradiation with a sublethal dose. At various periods after irradiation mice were injected with 125IUdR, the tissue uptake of which is an index of DNA synthesis. The result showed that cold treatment after irradiation caused slower cell renewal in the spleen and bone marrow, but that the thymus was only marginally affected. Furthermore, the concentrations of erythrocytes in the peripheral blood reached a lower level in the cold-treated group. Finally, the levels of the thyroid hormones T 3 and T 4 in the blood were measured and it was found that the T3/T4 ratio was higher in the cold-treated mice. It is suggested that during prolonged exposure to cold after irradiation the cell recovery in the haemopoietic system is exposed to hormonal action that induces significant alterations in the postirradiation cell kinetics.
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Papers by Kerstin Rosander