Papers by Kazi Khalid Ibne Khalil
Asian-Australasian journal of bioscience and biotechnology, Jun 27, 2024
Cardiac remodeling is a significant issue involving molecular, cellular, and interstitial changes... more Cardiac remodeling is a significant issue involving molecular, cellular, and interstitial changes that affect the size, mass, integrity, and function of the heart following a myocardial infarction (MI). We hypothesized that therapy with mixed herbal extracts has a protective effect in mouse models of MI. The underlying mechanisms are thought to be protective against left ventricular (LV) remodeling through reduced collagen deposition. We therefore studied the effects of mixed herbal extracts commonly used in various ways in the belief that they have beneficial effects on cardiac disease. MI was induced by left anterior descending (LAD) coronary artery ligation in switch albino mice. Ethanol extracts of herbs Arjuna bark, oleander leaves, ginseng root, garlic, cardamom seeds and oregano leaves were prepared by ethanol extraction and rotary evaporation technique of dried herbs and then mixed the extracts to make a therapeutic cocktail. The mixture is then administered orally by lavage for 28 days. At the end of 28 days cardiac tissues were harvested and stored for histopathology analysis and assessment of SOD levels. Survival curve data over a period of 28 days showed significant (P<0.05) differences between groups and mortality was reduced in the herbal extract treated group. Heart mass especially ventricular and atrial space and ratio of infarct to total heart area revealed better improvement in treated group compared to untreated group. Histopathological studies showed that the myocardium of the herbal extract treated group had fewer collagen fibers than the non-treated group. SOD activity levels were up-regulated in animals treated with herbal extracts indicating reduction of oxidative stress by herbal extract mixture. Hence, their effects reduce collagen deposition, reduce LV mass and prevent myocardial tissue damage, reduce structural changes and increase survival by their anti-stress effects. Mixed herbal tonic may provide a new therapeutic approach in ischemic cardiomyopathy and ischemic heart failure.
Veterinary sciences, 2024
Peste des petits ruminants (PPR), a prevalent viral disease of sheep and goats that impacts produ... more Peste des petits ruminants (PPR), a prevalent viral disease of sheep and goats that impacts productivity and international animal trade globally. Meta-analysis serves as the most suitable approach for obtaining pooled data from individual studies. This study aimed at using a random-effects model of metaanalysis to compile the estimates of the global prevalence and potential risk factors of PPR among sheep and goats. Based on the selection criteria and quality assessment score, 40 peer-reviewed publications were included in the final database for the meta-analysis. The prevalence was determined in a forest plot using R studio software with a 95% confidence interval (CI). In addition, the significance of the study publications was shown through a funnel plot. The estimated pooled prevalence of PPR was 39.16 % from 2000-2021 with significant heterogeneity (P < 0.01) among the studies. A subgroup analysis was also performed for species, age, sex, study duration, and sample size for the assessment of the potential risk factors. The prevalence rate was found highest in sheep at 42.91%, female individuals at 32.32%, 500 or below sample size at 43.63%, in the period of 2000-2010 at 42.05% and aged animals at 41.23% non-significantly. This is the meta-analysis of PPR worldwide that offers a comprehensive picture of the prevalence of PPR in small ruminants with possible risk factors. Thus, this study will be useful in raising awareness and advocating engaging in initiatives PPR control and prevention.
Asian Journal of Dairy and Food Research
Background: The high saturated fatty acid content of beef has been linked to obesity and cardiova... more Background: The high saturated fatty acid content of beef has been linked to obesity and cardiovascular diseases. The study investigated the impact of black seed oil (BSO) on beef fat-altered hemato-biochemical and pathophysiological alterations in albino mice. Methods: Twenty four Swiss Albino mice (Mus musculus) of 25-28 days old were equally divided into three groups (n=8) namely A, B and C. Mice of group A was designated as the untreated control group. Groups B and C were fed pellets containing 10% beef fat and 10% BSO, respectively for 9 weeks. Result: The results revealed that beef fat-fed mice gained weight and BSO normalized the weight gain. The hematological values of beef fat supplemented mice improved after being supplemented with 10% BSO. LDL-c, Triglycerides and total cholesterol levels were all significantly lower in mice fed BSO plus beef fat. HDL-c levels were significantly higher in BSO plus beef fat-fed mice. Spleens in BSO plus beef fat-fed mice were slightly enla...
Journal of Bangladesh Agricultural University, 2021
Asian Journal of Dairy and Food Research, 2021
Background: The use of chromium (Cr) and vitamin E (Vit-E) to overcome the detrimental effects of... more Background: The use of chromium (Cr) and vitamin E (Vit-E) to overcome the detrimental effects of heat stress (HS) in broiler chickens has been studied by a few researchers. The study was designed to evaluate the effects of organic chromium picolinate (CrPic) and vit-E on physiological performances and immune responses in broiler chicken exposed to HS. Methods: A total of 120, day old chicks were reared and divided into four equal groups: A, B, C and D at day 13. Group A considered as non-treated control, Group B, C and D were treated with CrPic, Vit-E and both respectively. The birds were exposed heat to 35 ± 3°C for 6 hours for 22 days.Result: CrPic, Vit-E and combined groups had significantly higher live body weight and lower FCR (p less than 0.05). Hematological values were not varied among the groups. Liver enzymes AST but not ALT were increased significantly in the Vit-E group. Creatinine level was significantly (p less than 0.05) higher in CrPic and combined groups. Total pro...
Journal of Advanced Biotechnology and Experimental Therapeutics, 2020
Research in Agriculture Livestock and Fisheries
The experiment was conducted to evaluate the effects of spirulina on production, hematological pa... more The experiment was conducted to evaluate the effects of spirulina on production, hematological parameters and lipid profile in layers. Thirty (30) layer birds of 65 weeks of age were randomly divided into three groups (A, B and C) containing 10 birds in each group. Birds were subjected to treatments for a period of 1 month (30 days) as per fol lowing schedule: Group-A treated with 2gm spirulina/kg feed; Group-B: treated with 4gm spirulina/kg feed and Group-C: without any treatment. With the supplementation of spirulina, feed consumption and body weight were not affected, but egg production was increased significantly. Results showed that total erythrocyte count (TEC), haemoglobin concentration and packed cell volume (PCV) were significantly higher (P<0.05) in treated groups compared to control. Serum total cholesterol (TG), triglyceride (TC)) and low density lipoprotein (LDL) cholesterol were significantly decreased, as well as HDL was increased (P<0.05) with addition of the i...
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Papers by Kazi Khalid Ibne Khalil