International Journal of Minor Fruits, Medicinal and Aromatic Plants
Date palm (Phoenix dactylifera L.) is an important fruit crop in many gulf countries and in recen... more Date palm (Phoenix dactylifera L.) is an important fruit crop in many gulf countries and in recent years it is gaining popularity for cultivation in India. To understand the maturity period for six date palm germplasm a study was conducted at Date palm Research Station, Mundra-Kachchh during 2016-2020. The data were pooled for five years and an average heat unit and number of days required for maturity was identified. The lowest duration and heat unit was required for ADP-1 while highest was found in Barhee.
With rise in demand of organic products because of health benefits and environment concerns, it b... more With rise in demand of organic products because of health benefits and environment concerns, it becomes necessary to produce sufficiently, but unfortunately due to poor productivity, it is currently not possible to fulfil the future nutritional demand. The reason behind is using the same plant cultivar for both intensive and organic farming system and expecting a similar outcome. The major difference lies between the nutrient availability pattern and form in both the cases. The plants suitable for intensive (conventional) farming get high amount of nutrients at its peak stage whereas in organic farming, the manure applied needed to be decomposed first by microorganisms and follow mineralization process on which conversion to available form like NO3 and NH4 +, hence its availability was low when it was highly required. Considering the mentioned problem it is highly desirable to breed the plants for organic conditions such that it can change the plants’ nutrients absorption pattern, i...
In this paper, we propose new variants of Newton's method based on quadrature formula and power m... more In this paper, we propose new variants of Newton's method based on quadrature formula and power mean for solving nonlinear unconstrained optimization problems. It is proved that the order of convergence of the proposed family is three. Numerical comparisons are made to show the performance of the presented methods. Furthermore, numerical experiments demonstrate that the logarithmic mean Newton's method outperform the classical Newton's and other variants of Newton's method. MSC: 65H05.
International Journal of Engineering & Technology, 2018
Carbonaceous compounds being conductive in nature have proved themselves as the best conductive n... more Carbonaceous compounds being conductive in nature have proved themselves as the best conductive network assembly material with Poly (vinylidene fluoride) (PVDF) polymer matrix which forms dielectric medium. Carbon based compounds are conductive in nature and are being used to form conductive channels for the flow of charge for the application of health as soft electronic devices and smart flexible conducting thin films in the form of sensors and actuators. Carbon nano fibers (CNF) play role of conductive filler to form conductive networks for the flow of charge in the polymer matrix. The interesting thing about CNF is its tailorable concentration. It influences the mechanical and electrical properties with different weight percent. In the present study solvent casting technique is used for the development of composite membrane, which is easy to fabricate and less costly. An increase in CNF content leads to deterioration of young’s modulus in comparison with pure PVDF, while with th...
Copperhead snake (Agkistrodon contortrix) envenomation causes limb injury resulting in pain and d... more Copperhead snake (Agkistrodon contortrix) envenomation causes limb injury resulting in pain and disability. It is not known whether antivenom administration improves limb function. We determine whether administration of antivenom improves recovery from limb injury in patients envenomated by copperhead snakes. From August 2013 through November 2015, we performed a multicenter, randomized, double-blind, placebo-controlled, clinical trial to evaluate the effect of ovine Crotalidae polyvalent immune Fab (ovine) (CroFab; FabAV) antivenom therapy on recovery of limb function in patients with copperhead snake envenomation at 14 days postenvenomation. The study setting was 18 emergency departments in regions of the United States where copperhead snakes are endemic. Consecutive patients aged 12 years or older with mild- to moderate-severity envenomation received either FabAV or placebo. The primary outcome was limb function 14 days after envenomation, measured by the Patient-Specific Functio...
Delayed sustained release formulation is to retard release of the drug form the stomach and relea... more Delayed sustained release formulation is to retard release of the drug form the stomach and release in the intestinal pH. Captopril is recommended as first choice of drug. Attacks of the myocardial infarction are generally in the early morning or night. Captopril is showing less bioavailability in presence of food. With enteric coating problem should be solved out. It also minimizes the gastric irritation of the captopril. Captopril is widely used for the arterial hypertension. It also used for myocardial infarction and in diabetic nephropathy. The drug dose is taken three times daily, which may give poor patients compliance. In the present investigation, an attempt was made to decrease dosing frequency by prepare a mucoadhesive tablets using various polymers such as HPMC K4M, bael gum and chitosan. Eudragit RL100 used as enteric coating polymer. Formulations friability, drug content, surface pH, wash off test, mucoadhesive strength and dissolution study. The results of friability tests carried out for all the formulations are within the official limit and acceptable. According to wash off test the formulation containing bael gum showing better results. All the formulation was showing better swelling property. F4 (formulation containing bael gum) was showing best mucoadhesive strength among all the formulations. In in-vitro drug release study formulation (F4) containing bael gum showing better control release among all the formulations i.e. 86.488 % in 12 hrs.
Background: We tested the hypothesis that maternal interleukin-1β (IL-1β) pretreatment and induct... more Background: We tested the hypothesis that maternal interleukin-1β (IL-1β) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs. Methods: IL-1β was administered subcutaneously daily to timed-pregnant guinea pigs for three days. Fetuses were obtained by abdominal hysterotomy and instilled with isosmolar 5% albumin into the lungs and lung fluid movement was measured over 1 h by mass balance. MAP kinase expression was measured by western blot. Results: Lung fluid absorption was induced at 61 days (D) gestation and stimulated at 68D gestation by IL-1β. Maternal IL-1β pretreatment upregulated ERK and upstream MEK expression at both 61 and 68D gestation, albeit being much more pronounced at 61D gestation. U0126 instillation completely blocked IL-1β-induced lung fluid absorption as well as IL-1β-induced/ stimulated ERK expression. Cortisol synthesis inhibition by metyrapone attenuated ERK expression and lung fluid absorption in IL-1β-pretreated fetal lungs. JNK expression after maternal IL-1β pretreatment remained unaffected at either gestation age. Conclusion: These data implicate the ERK MAP kinase pathway as being important for IL-1β induction/stimulation of lung fluid absorption in fetal guinea pigs.
Population changes among the hyperfine levels of the sodium D1 transition, created by a weakly sa... more Population changes among the hyperfine levels of the sodium D1 transition, created by a weakly saturating narrow-band pump, are detected by a counterpropagating probe in a 10-cm-long cell containing sodium vapor without any buffer gas. All Lamb dips and cross over resonances with linewidths approaching natural widths are clearly resolved. We have applied a five composite level model to interpret the observed probe absorption. The rate equations were solved analytically. The model predicts specific relationships between the frequency integrated probe absorption coefficient of crossover and Lamb dip resonances. We find excellent agreement in the case of crossover resonances that involve a single ground-state hyperfine level. The agreement is not so good for crossover resonances for which both ground hyperfine levels participate.
We present another simple way of deriving several iterative methods for solving nonlinear equatio... more We present another simple way of deriving several iterative methods for solving nonlinear equations numerically. The presented approach of deriving these methods is based on exponentially fitted osculating straight line. These methods are the modifications of Newton's method. Also, we obtain well-known methods as special cases, for example, Halley's method, super-Halley method, Ostrowski's square-root method, Chebyshev's method, and so forth. Further, new classes of third-order multipoint iterative methods free from a second-order derivative are derived by semidiscrete modifications of cubically convergent iterative methods. Furthermore, a simple linear combination of two third-order multipoint iterative methods is used for designing new optimal methods of order four.
Computers & Mathematics with Applications, 2012
r i c a l s t u d y °f 3 n n w s p n D n w h W i ' a r i s e problems of singularly perturbed dif... more r i c a l s t u d y °f 3 n n w s p n D n w h W i ' a r i s e problems of singularly perturbed differential difference equations PPDDE) wh ch anse in mmnutational neuroscience in particular in the modeling of neuronal variab y. mathematical modeling of the determination of the expected time for the generation of action potential in the nerve cells by random synaptic-inputs in dendntes boundary-value problem for singularly perturbed differential difference equation w.tn shifts. The problem considered in this paper exhibit turning point!S the probiem complexity in the construction of numerical approximadnn to the ^on of the prob as well as in obtaining theoretical estimates on the solution. Exponentially fitted in difference scheme based on H'in-Allen-Southwell fitting is used on a specially designed mesh. Some numerical examples are given to validate convergence and computational efficiency of the proposed numerical scheme. Effect of the shifts on the layer str illuminated for the considered examples. Elsevier Ltd. A" rights reserved. (t) by ae, whereas inhibitory impulses arrive*at/uronVires" ^impulse when V(r) reaches or'exceeds a threshold value r %, t) and causes V(t) to decrease by a,. The neuron f,rfs an , JJ which imDulses have no effect and the amonS impulses with time constant p. The depolarization in Stein's model
Background. Traditionally, aortic root replacement has most commonly involved mechanical composit... more Background. Traditionally, aortic root replacement has most commonly involved mechanical composite valve grafts, which have excellent durability but necessitate lifelong anticoagulation. Stentless porcine xenografts (bioroots) are a recently developed alternative that enable root replacement without the necessity of long-term anticoagulation. This study examined the early and late outcomes of aortic root replacement with porcine bioroots. Methods. Porcine bioroots were used for root replacement in 132 patients. Of these, 129 (97.7%) required graft extensions for ascending aortic replacement, and 55 (41.7%) underwent aortic arch replacement. Twenty-three operations (17.4%) were reoperations. Twenty-four patients (18.2%) had aortic dissection. Early and late outcomes were ascertained by reviewing medical records. Changes in New York Heart Association (NYHA) class were used to assess improvements in functional status. Follow-up echocardiography results were reviewed to assess bioprosthetic valve function and changes in left ventricular ejection fraction. Results. There were 10 operative deaths (7.6%), 9 of which were directly related to intraoperative ventricular failure. Nine patients (6.8%) had late valve-related complications, including 5 patients with prosthetic endocarditis (3 died), 1 annular pseudoaneurysm, and 3 sudden, unexplained deaths. Survivors' NYHA status and left ventricular ejection fraction improved significantly. No structural valve dysfunction was evident during followup. Actuarial survival was 85.6% ؎ 3.1% at 1 year and 77.8% ؎ 4.8% at 5 years. Conclusions. Aortic root replacement with porcine xenografts can be performed with respectable early and late outcomes, even when combined with aortic arch replacement. Further follow-up is necessary to evaluate long-term bioroot durability.
In this paper, a class of singularly perturbed elliptic partial differential equations posed on a... more In this paper, a class of singularly perturbed elliptic partial differential equations posed on a rectangular domain is studied. The differential equation contains two singular perturbation parameters. The solutions of these singularly perturbed problems are decomposed into a sum of regular, boundary layer and corner layer components. Parameter-explicit bounds on the derivatives of each of these components are derived. A numerical algorithm based on an upwind finite difference operator and a tensor product of piecewise-uniform Shishkin meshes is analysed. Parameter-uniform asymptotic error bounds for the numerical approximations are established.
The astounding ability of plants to make smart decisions in response to environment is evident. A... more The astounding ability of plants to make smart decisions in response to environment is evident. As they have evolved a long list of complex and unique processes that involve photosynthesis, totipotency, long-distance signaling, and ability to restore structural and metabolic memory, recognition, and communication via emission of the selected class of volatiles. In recent years, use of metabolite profiling techniques in detection, unambiguous identification, quantification, and rapid analysis of the minute quantity of cellular micromolecules has increased considerably. Metabolomics is key to understand the chemical footprints during different phases of growth and development of plants. To feed the ever-increasing population with limited inputs and in a rapidly changing environment is the biggest challenges that the world agriculture faces today. To achieve the project genetic gains, the breeding strategies employing marker-assisted selection for high-yielding varieties and identifying germplasm resistant to abiotic and biotic stresses are already in vogue. Henceforth, new approaches are needed to discover and deploy agronomically important gene/s that can help crops better withstand weather extremes and growing pest prevalence worldwide. In this context, metabolic engineering technology looks viable option, with immense potential to deliver the future crops.
ABSTRACTThe role of ethylene in plant development is mostly inferred from its exogenous applicati... more ABSTRACTThe role of ethylene in plant development is mostly inferred from its exogenous application. The usage of the mutants affecting ethylene biosynthesis proffers a better alternative to decipher its role. In tomato, 1-aminocyclopropane carboxylic acid synthase2 (ACS2) is a key enzyme regulating ripening-specific ethylene biosynthesis. We characterized two contrastingacs2mutants;acs2-1overproduces ethylene, has higher ACS activity, and increased protein levels, whileacs2-2is an ethylene under-producer, displays lower ACS activity, and protein levels than wild type. Consistent with high/low ethylene emission, the mutants show opposite phenotypes, physiological responses, and metabolomic profiles than the wild type. Theacs2-1showed early seed germination, faster leaf senescence, and accelerated fruit ripening. Conversely,acs2-2had delayed seed germination, slower leaf senescence, and prolonged fruit ripening. The phytohormone profiles of mutants were mostly opposite in the leaves ...
The aim of this study was to determine factors affecting paravalvular leak (PVL) in transcatheter... more The aim of this study was to determine factors affecting paravalvular leak (PVL) in transcatheter aortic valve replacement (TAVR) with the Edwards SAPIEN 3 (S3) valve in extremely large annuli. The largest recommended annular area for the 29-mm S3 is 683 mm. However, experience with S3 TAVR in annuli >683 mm has not been widely reported. From December 2013 to July 2017, 74 patients across 16 centers with mean area 721 ± 38 mm (range: 684 to 852 mm) underwent S3 TAVR. The transfemoral approach was used in 95%, and 39% were under conscious sedation. Patient, anatomic, and procedural characteristics were retrospectively analyzed. Valve Academic Research Consortium-2 outcomes were reported. Procedural success was 100%, with 2 deaths, 1 stroke, and 2 major vascular complications at 30 days. Post-dilatation occurred in 32%, with final balloon overfilling (1 to 5 ml extra) in 70% of patients. Implantation depth averaged 22.3 ± 12.4% at the noncoronary cusp and 20.7 ± 9.9% at the left co...
Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual, 2005
Interrupted aortic arch (IAA) is defined as the loss of luminal continuity between the ascending ... more Interrupted aortic arch (IAA) is defined as the loss of luminal continuity between the ascending and descending aorta. It is associated with a multitude of lesions ranging from isolated ventricular septal defects to complex ones. Although results have improved in the modern era, repair of IAA is associated with a significant mortality and morbidity. In recent years, the move to a one-stage repair has become well established, and the optimal technique for aortic repair seems to be partial direct anastomosis with patch augmentation. Left ventricular outflow tract obstruction (LVOTO) continues to be an important factor affecting survival and re-intervention rates after IAA repair. Great variability exists with regard to definition and diagnosis of LVOTO. To guide the decision for left ventricular outflow tract (LVOT) intervention and which type to use, we propose a simple formula based on the baby's weight. We advocate a conservative approach when the LVOT diameter is greater than ...
International Journal of Minor Fruits, Medicinal and Aromatic Plants
Date palm (Phoenix dactylifera L.) is an important fruit crop in many gulf countries and in recen... more Date palm (Phoenix dactylifera L.) is an important fruit crop in many gulf countries and in recent years it is gaining popularity for cultivation in India. To understand the maturity period for six date palm germplasm a study was conducted at Date palm Research Station, Mundra-Kachchh during 2016-2020. The data were pooled for five years and an average heat unit and number of days required for maturity was identified. The lowest duration and heat unit was required for ADP-1 while highest was found in Barhee.
With rise in demand of organic products because of health benefits and environment concerns, it b... more With rise in demand of organic products because of health benefits and environment concerns, it becomes necessary to produce sufficiently, but unfortunately due to poor productivity, it is currently not possible to fulfil the future nutritional demand. The reason behind is using the same plant cultivar for both intensive and organic farming system and expecting a similar outcome. The major difference lies between the nutrient availability pattern and form in both the cases. The plants suitable for intensive (conventional) farming get high amount of nutrients at its peak stage whereas in organic farming, the manure applied needed to be decomposed first by microorganisms and follow mineralization process on which conversion to available form like NO3 and NH4 +, hence its availability was low when it was highly required. Considering the mentioned problem it is highly desirable to breed the plants for organic conditions such that it can change the plants’ nutrients absorption pattern, i...
In this paper, we propose new variants of Newton's method based on quadrature formula and power m... more In this paper, we propose new variants of Newton's method based on quadrature formula and power mean for solving nonlinear unconstrained optimization problems. It is proved that the order of convergence of the proposed family is three. Numerical comparisons are made to show the performance of the presented methods. Furthermore, numerical experiments demonstrate that the logarithmic mean Newton's method outperform the classical Newton's and other variants of Newton's method. MSC: 65H05.
International Journal of Engineering & Technology, 2018
Carbonaceous compounds being conductive in nature have proved themselves as the best conductive n... more Carbonaceous compounds being conductive in nature have proved themselves as the best conductive network assembly material with Poly (vinylidene fluoride) (PVDF) polymer matrix which forms dielectric medium. Carbon based compounds are conductive in nature and are being used to form conductive channels for the flow of charge for the application of health as soft electronic devices and smart flexible conducting thin films in the form of sensors and actuators. Carbon nano fibers (CNF) play role of conductive filler to form conductive networks for the flow of charge in the polymer matrix. The interesting thing about CNF is its tailorable concentration. It influences the mechanical and electrical properties with different weight percent. In the present study solvent casting technique is used for the development of composite membrane, which is easy to fabricate and less costly. An increase in CNF content leads to deterioration of young’s modulus in comparison with pure PVDF, while with th...
Copperhead snake (Agkistrodon contortrix) envenomation causes limb injury resulting in pain and d... more Copperhead snake (Agkistrodon contortrix) envenomation causes limb injury resulting in pain and disability. It is not known whether antivenom administration improves limb function. We determine whether administration of antivenom improves recovery from limb injury in patients envenomated by copperhead snakes. From August 2013 through November 2015, we performed a multicenter, randomized, double-blind, placebo-controlled, clinical trial to evaluate the effect of ovine Crotalidae polyvalent immune Fab (ovine) (CroFab; FabAV) antivenom therapy on recovery of limb function in patients with copperhead snake envenomation at 14 days postenvenomation. The study setting was 18 emergency departments in regions of the United States where copperhead snakes are endemic. Consecutive patients aged 12 years or older with mild- to moderate-severity envenomation received either FabAV or placebo. The primary outcome was limb function 14 days after envenomation, measured by the Patient-Specific Functio...
Delayed sustained release formulation is to retard release of the drug form the stomach and relea... more Delayed sustained release formulation is to retard release of the drug form the stomach and release in the intestinal pH. Captopril is recommended as first choice of drug. Attacks of the myocardial infarction are generally in the early morning or night. Captopril is showing less bioavailability in presence of food. With enteric coating problem should be solved out. It also minimizes the gastric irritation of the captopril. Captopril is widely used for the arterial hypertension. It also used for myocardial infarction and in diabetic nephropathy. The drug dose is taken three times daily, which may give poor patients compliance. In the present investigation, an attempt was made to decrease dosing frequency by prepare a mucoadhesive tablets using various polymers such as HPMC K4M, bael gum and chitosan. Eudragit RL100 used as enteric coating polymer. Formulations friability, drug content, surface pH, wash off test, mucoadhesive strength and dissolution study. The results of friability tests carried out for all the formulations are within the official limit and acceptable. According to wash off test the formulation containing bael gum showing better results. All the formulation was showing better swelling property. F4 (formulation containing bael gum) was showing best mucoadhesive strength among all the formulations. In in-vitro drug release study formulation (F4) containing bael gum showing better control release among all the formulations i.e. 86.488 % in 12 hrs.
Background: We tested the hypothesis that maternal interleukin-1β (IL-1β) pretreatment and induct... more Background: We tested the hypothesis that maternal interleukin-1β (IL-1β) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs. Methods: IL-1β was administered subcutaneously daily to timed-pregnant guinea pigs for three days. Fetuses were obtained by abdominal hysterotomy and instilled with isosmolar 5% albumin into the lungs and lung fluid movement was measured over 1 h by mass balance. MAP kinase expression was measured by western blot. Results: Lung fluid absorption was induced at 61 days (D) gestation and stimulated at 68D gestation by IL-1β. Maternal IL-1β pretreatment upregulated ERK and upstream MEK expression at both 61 and 68D gestation, albeit being much more pronounced at 61D gestation. U0126 instillation completely blocked IL-1β-induced lung fluid absorption as well as IL-1β-induced/ stimulated ERK expression. Cortisol synthesis inhibition by metyrapone attenuated ERK expression and lung fluid absorption in IL-1β-pretreated fetal lungs. JNK expression after maternal IL-1β pretreatment remained unaffected at either gestation age. Conclusion: These data implicate the ERK MAP kinase pathway as being important for IL-1β induction/stimulation of lung fluid absorption in fetal guinea pigs.
Population changes among the hyperfine levels of the sodium D1 transition, created by a weakly sa... more Population changes among the hyperfine levels of the sodium D1 transition, created by a weakly saturating narrow-band pump, are detected by a counterpropagating probe in a 10-cm-long cell containing sodium vapor without any buffer gas. All Lamb dips and cross over resonances with linewidths approaching natural widths are clearly resolved. We have applied a five composite level model to interpret the observed probe absorption. The rate equations were solved analytically. The model predicts specific relationships between the frequency integrated probe absorption coefficient of crossover and Lamb dip resonances. We find excellent agreement in the case of crossover resonances that involve a single ground-state hyperfine level. The agreement is not so good for crossover resonances for which both ground hyperfine levels participate.
We present another simple way of deriving several iterative methods for solving nonlinear equatio... more We present another simple way of deriving several iterative methods for solving nonlinear equations numerically. The presented approach of deriving these methods is based on exponentially fitted osculating straight line. These methods are the modifications of Newton's method. Also, we obtain well-known methods as special cases, for example, Halley's method, super-Halley method, Ostrowski's square-root method, Chebyshev's method, and so forth. Further, new classes of third-order multipoint iterative methods free from a second-order derivative are derived by semidiscrete modifications of cubically convergent iterative methods. Furthermore, a simple linear combination of two third-order multipoint iterative methods is used for designing new optimal methods of order four.
Computers & Mathematics with Applications, 2012
r i c a l s t u d y °f 3 n n w s p n D n w h W i ' a r i s e problems of singularly perturbed dif... more r i c a l s t u d y °f 3 n n w s p n D n w h W i ' a r i s e problems of singularly perturbed differential difference equations PPDDE) wh ch anse in mmnutational neuroscience in particular in the modeling of neuronal variab y. mathematical modeling of the determination of the expected time for the generation of action potential in the nerve cells by random synaptic-inputs in dendntes boundary-value problem for singularly perturbed differential difference equation w.tn shifts. The problem considered in this paper exhibit turning point!S the probiem complexity in the construction of numerical approximadnn to the ^on of the prob as well as in obtaining theoretical estimates on the solution. Exponentially fitted in difference scheme based on H'in-Allen-Southwell fitting is used on a specially designed mesh. Some numerical examples are given to validate convergence and computational efficiency of the proposed numerical scheme. Effect of the shifts on the layer str illuminated for the considered examples. Elsevier Ltd. A" rights reserved. (t) by ae, whereas inhibitory impulses arrive*at/uronVires" ^impulse when V(r) reaches or'exceeds a threshold value r %, t) and causes V(t) to decrease by a,. The neuron f,rfs an , JJ which imDulses have no effect and the amonS impulses with time constant p. The depolarization in Stein's model
Background. Traditionally, aortic root replacement has most commonly involved mechanical composit... more Background. Traditionally, aortic root replacement has most commonly involved mechanical composite valve grafts, which have excellent durability but necessitate lifelong anticoagulation. Stentless porcine xenografts (bioroots) are a recently developed alternative that enable root replacement without the necessity of long-term anticoagulation. This study examined the early and late outcomes of aortic root replacement with porcine bioroots. Methods. Porcine bioroots were used for root replacement in 132 patients. Of these, 129 (97.7%) required graft extensions for ascending aortic replacement, and 55 (41.7%) underwent aortic arch replacement. Twenty-three operations (17.4%) were reoperations. Twenty-four patients (18.2%) had aortic dissection. Early and late outcomes were ascertained by reviewing medical records. Changes in New York Heart Association (NYHA) class were used to assess improvements in functional status. Follow-up echocardiography results were reviewed to assess bioprosthetic valve function and changes in left ventricular ejection fraction. Results. There were 10 operative deaths (7.6%), 9 of which were directly related to intraoperative ventricular failure. Nine patients (6.8%) had late valve-related complications, including 5 patients with prosthetic endocarditis (3 died), 1 annular pseudoaneurysm, and 3 sudden, unexplained deaths. Survivors' NYHA status and left ventricular ejection fraction improved significantly. No structural valve dysfunction was evident during followup. Actuarial survival was 85.6% ؎ 3.1% at 1 year and 77.8% ؎ 4.8% at 5 years. Conclusions. Aortic root replacement with porcine xenografts can be performed with respectable early and late outcomes, even when combined with aortic arch replacement. Further follow-up is necessary to evaluate long-term bioroot durability.
In this paper, a class of singularly perturbed elliptic partial differential equations posed on a... more In this paper, a class of singularly perturbed elliptic partial differential equations posed on a rectangular domain is studied. The differential equation contains two singular perturbation parameters. The solutions of these singularly perturbed problems are decomposed into a sum of regular, boundary layer and corner layer components. Parameter-explicit bounds on the derivatives of each of these components are derived. A numerical algorithm based on an upwind finite difference operator and a tensor product of piecewise-uniform Shishkin meshes is analysed. Parameter-uniform asymptotic error bounds for the numerical approximations are established.
The astounding ability of plants to make smart decisions in response to environment is evident. A... more The astounding ability of plants to make smart decisions in response to environment is evident. As they have evolved a long list of complex and unique processes that involve photosynthesis, totipotency, long-distance signaling, and ability to restore structural and metabolic memory, recognition, and communication via emission of the selected class of volatiles. In recent years, use of metabolite profiling techniques in detection, unambiguous identification, quantification, and rapid analysis of the minute quantity of cellular micromolecules has increased considerably. Metabolomics is key to understand the chemical footprints during different phases of growth and development of plants. To feed the ever-increasing population with limited inputs and in a rapidly changing environment is the biggest challenges that the world agriculture faces today. To achieve the project genetic gains, the breeding strategies employing marker-assisted selection for high-yielding varieties and identifying germplasm resistant to abiotic and biotic stresses are already in vogue. Henceforth, new approaches are needed to discover and deploy agronomically important gene/s that can help crops better withstand weather extremes and growing pest prevalence worldwide. In this context, metabolic engineering technology looks viable option, with immense potential to deliver the future crops.
ABSTRACTThe role of ethylene in plant development is mostly inferred from its exogenous applicati... more ABSTRACTThe role of ethylene in plant development is mostly inferred from its exogenous application. The usage of the mutants affecting ethylene biosynthesis proffers a better alternative to decipher its role. In tomato, 1-aminocyclopropane carboxylic acid synthase2 (ACS2) is a key enzyme regulating ripening-specific ethylene biosynthesis. We characterized two contrastingacs2mutants;acs2-1overproduces ethylene, has higher ACS activity, and increased protein levels, whileacs2-2is an ethylene under-producer, displays lower ACS activity, and protein levels than wild type. Consistent with high/low ethylene emission, the mutants show opposite phenotypes, physiological responses, and metabolomic profiles than the wild type. Theacs2-1showed early seed germination, faster leaf senescence, and accelerated fruit ripening. Conversely,acs2-2had delayed seed germination, slower leaf senescence, and prolonged fruit ripening. The phytohormone profiles of mutants were mostly opposite in the leaves ...
The aim of this study was to determine factors affecting paravalvular leak (PVL) in transcatheter... more The aim of this study was to determine factors affecting paravalvular leak (PVL) in transcatheter aortic valve replacement (TAVR) with the Edwards SAPIEN 3 (S3) valve in extremely large annuli. The largest recommended annular area for the 29-mm S3 is 683 mm. However, experience with S3 TAVR in annuli >683 mm has not been widely reported. From December 2013 to July 2017, 74 patients across 16 centers with mean area 721 ± 38 mm (range: 684 to 852 mm) underwent S3 TAVR. The transfemoral approach was used in 95%, and 39% were under conscious sedation. Patient, anatomic, and procedural characteristics were retrospectively analyzed. Valve Academic Research Consortium-2 outcomes were reported. Procedural success was 100%, with 2 deaths, 1 stroke, and 2 major vascular complications at 30 days. Post-dilatation occurred in 32%, with final balloon overfilling (1 to 5 ml extra) in 70% of patients. Implantation depth averaged 22.3 ± 12.4% at the noncoronary cusp and 20.7 ± 9.9% at the left co...
Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual, 2005
Interrupted aortic arch (IAA) is defined as the loss of luminal continuity between the ascending ... more Interrupted aortic arch (IAA) is defined as the loss of luminal continuity between the ascending and descending aorta. It is associated with a multitude of lesions ranging from isolated ventricular septal defects to complex ones. Although results have improved in the modern era, repair of IAA is associated with a significant mortality and morbidity. In recent years, the move to a one-stage repair has become well established, and the optimal technique for aortic repair seems to be partial direct anastomosis with patch augmentation. Left ventricular outflow tract obstruction (LVOTO) continues to be an important factor affecting survival and re-intervention rates after IAA repair. Great variability exists with regard to definition and diagnosis of LVOTO. To guide the decision for left ventricular outflow tract (LVOT) intervention and which type to use, we propose a simple formula based on the baby's weight. We advocate a conservative approach when the LVOT diameter is greater than ...
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Papers by Kapil Sharma